{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:38:46Z","timestamp":1774715926900,"version":"3.50.1"},"reference-count":48,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK58538"],"award-info":[{"award-number":["DK58538"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK65066"],"award-info":[{"award-number":["DK65066"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK77148"],"award-info":[{"award-number":["DK77148"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2016\/10114-1"],"award-info":[{"award-number":["2016\/10114-1"]}]},{"name":"Funda\u00e7\u00e3o \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2021\/12746-3"],"award-info":[{"award-number":["2021\/12746-3"]}]},{"name":"PROEX","award":["88881.910035\/2023-01"],"award-info":[{"award-number":["88881.910035\/2023-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>About half of the world population carries at least one allele of the Ala92-DIO2, which slows down the activity of the type 2 deiodinase (D2), the enzyme that activates T4 to T3. Carrying the Ala92-DIO2 allele has been associated with increased body mass index and insulin resistance, but this has not been reproduced in all populations. To test if the genetic background affects the impact of this polymorphism, here we studied the genetically distant C57Bl\/6J (B6) and FVB\/N (FVB) mice carrying the Ala92-Dio2 allele as compared to control mice carrying the Thr92-Dio2 allele. Whereas B6-Ala92-Dio2 and B6-Thr92-Dio2 mice\u2014fed chow or high-fat diet\u2014behaved metabolically similar in studies using indirect calorimetry, glucose- and insulin tolerance tests, and measuring white adipose tissue (WAT) weight and liver steatosis, major differences were observed between FVB-Ala92-Dio2 and FVB-Thr92-Dio2 mice: carrying the Ala92-Dio2 allele (on a chow diet) resulted in hypercholesterolemia, smaller WAT pads, hepatomegaly, steatosis, and transcriptome changes in the interscapular brown adipose tissue (iBAT) typical of ER stress and apoptosis. Acclimatization at thermoneutrality (30 \u00b0C) eliminated most of the metabolic phenotype, indicating that impaired adaptive (BAT) thermogenesis can be involved. In conclusion, the metabolic impact of carrying the Ala92-Dio2 allele depends greatly on the genetic background of the mouse, varying from no phenotype in B6 mice to a major phenotype in FVB mice. These results will help the planning of future clinical trials studying the Thr92Ala-DIO2 polymorphism and may explain why some clinical studies performed in different populations across the globe have obtained inconsistent results.<\/jats:p>","DOI":"10.1210\/endocr\/bqae064","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T22:59:23Z","timestamp":1717541963000},"source":"Crossref","is-referenced-by-count":7,"title":["Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse"],"prefix":"10.1210","volume":"165","author":[{"given":"Guilherme","family":"Gabriel de Almeida","sequence":"first","affiliation":[{"name":"Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center , Chicago, IL 60637 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anaysa P","family":"Bolin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biomedical Science Institute, University of S\u00e3o Paulo , S\u00e3o Paulo 05508 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-7504","authenticated-orcid":false,"given":"Alice","family":"Batistuzzo","sequence":"additional","affiliation":[{"name":"Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center , Chicago, IL 60637 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana L","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center , Chicago, IL 60637 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam O","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Human Developmental Sciences Graduate Program, Center for Biological and Health Sciences, Presbyterian Mackenzie University , S\u00e3o Paulo, SP 01302 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-6813","authenticated-orcid":false,"given":"Antonio C","family":"Bianco","sequence":"additional","affiliation":[{"name":"Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, University of Chicago Medical Center , Chicago, IL 60637 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"issue":"4","key":"2024070101470726300_bqae064-B1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/er.2018-00275","article-title":"Paradigms of dynamic control of thyroid hormone signaling","volume":"40","author":"Bianco","year":"2019","journal-title":"Endocr Rev"},{"issue":"8","key":"2024070101470726300_bqae064-B2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/thy.2005.15.823","article-title":"The roles of the iodothyronine deiodinases in mammalian development","volume":"15","author":"Galton","year":"2005","journal-title":"Thyroid"},{"issue":"23","key":"2024070101470726300_bqae064-B3","doi-asserted-by":"crossref","first-page":"e173780","DOI":"10.1172\/jci.insight.173780","article-title":"Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids","volume":"8","author":"Hidalgo-Alvarez","year":"2023","journal-title":"JCI Insight"},{"issue":"1","key":"2024070101470726300_bqae064-B4","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1038\/s41467-021-24748-8","article-title":"Neonatal thyroxine activation modifies epigenetic programming of the liver","volume":"12","author":"Fonseca","year":"2021","journal-title":"Nat Commun"},{"issue":"7","key":"2024070101470726300_bqae064-B5","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/acer.14027","article-title":"Hepatic inactivation of the type 2 deiodinase confers resistance to alcoholic liver steatosis","volume":"43","author":"Fonseca","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"2024070101470726300_bqae064-B6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.celrep.2017.12.053","article-title":"The FoxO1-inducible transcriptional repressor Zfp125 causes hepatic steatosis and hypercholesterolemia","volume":"22","author":"Fernandes","year":"2018","journal-title":"Cell Rep"},{"issue":"45","key":"2024070101470726300_bqae064-B7","doi-asserted-by":"crossref","first-page":"14018","DOI":"10.1073\/pnas.1508943112","article-title":"Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity","volume":"112","author":"Fonseca","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2024070101470726300_bqae064-B8","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2337\/db13-1768","article-title":"Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse","volume":"63","author":"Fonseca","year":"2014","journal-title":"Diabetes"},{"issue":"9","key":"2024070101470726300_bqae064-B9","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1210\/en.2010-0511","article-title":"Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis","volume":"151","author":"Hall","year":"2010","journal-title":"Endocrinology"},{"issue":"9","key":"2024070101470726300_bqae064-B10","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI200113803","article-title":"The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue","volume":"108","author":"de Jesus","year":"2001","journal-title":"J Clin Invest"},{"issue":"5","key":"2024070101470726300_bqae064-B11","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1210\/endo.141.5.7471","article-title":"Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element","volume":"141","author":"Canettieri","year":"2000","journal-title":"Endocrinology"},{"issue":"4","key":"2024070101470726300_bqae064-B12","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1210\/en.2008-0938","article-title":"Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes","volume":"150","author":"Grozovsky","year":"2009","journal-title":"Endocrinology"},{"issue":"51","key":"2024070101470726300_bqae064-B13","doi-asserted-by":"crossref","first-page":"30551","DOI":"10.1074\/jbc.M115.665505","article-title":"Coupling between nutrient availability and thyroid hormone activation","volume":"290","author":"Lartey","year":"2015","journal-title":"J Biol Chem"},{"issue":"3","key":"2024070101470726300_bqae064-B14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2337\/db06-1488","article-title":"The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation","volume":"56","author":"da-Silva","year":"2007","journal-title":"Diabetes"},{"issue":"8","key":"2024070101470726300_bqae064-B15","doi-asserted-by":"crossref","first-page":"bqab059","DOI":"10.1210\/endocr\/bqab059","article-title":"Deiodinases and the metabolic code for thyroid hormone action","volume":"162","author":"Russo","year":"2021","journal-title":"Endocrinology"},{"issue":"1","key":"2024070101470726300_bqae064-B16","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1152\/ajpendo.2001.281.1.E54","article-title":"Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency","volume":"281","author":"Peeters","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"2024070101470726300_bqae064-B17","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1210\/jc.2016-2587","article-title":"DIO2 thr92ala reduces deiodinase-2 activity and serum-T3 levels in thyroid-deficient patients","volume":"102","author":"Castagna","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024070101470726300_bqae064-B18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1172\/JCI123176","article-title":"Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain","volume":"129","author":"Jo","year":"2019","journal-title":"J Clin Invest"},{"issue":"3","key":"2024070101470726300_bqae064-B19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2337\/diabetes.51.3.880","article-title":"Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor","volume":"51","author":"Mentuccia","year":"2002","journal-title":"Diabetes"},{"issue":"3","key":"2024070101470726300_bqae064-B20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/thy.2006.0298","article-title":"The type 2 deiodinase (DIO2) A\/G polymorphism is not associated with glycemic traits: the Framingham Heart Study","volume":"17","author":"Maia","year":"2007","journal-title":"Thyroid"},{"issue":"11","key":"2024070101470726300_bqae064-B21","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/thy.2005.15.1223","article-title":"The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish","volume":"15","author":"Mentuccia","year":"2005","journal-title":"Thyroid"},{"issue":"2","key":"2024070101470726300_bqae064-B22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12020-023-03528-y","article-title":"Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism","volume":"84","author":"Penna","year":"2023","journal-title":"Endocrine"},{"issue":"1","key":"2024070101470726300_bqae064-B23","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1038\/s41467-018-06023-5","article-title":"The complex underpinnings of genetic background effects","volume":"9","author":"Mullis","year":"2018","journal-title":"Nat Commun"},{"key":"2024070101470726300_bqae064-B24","doi-asserted-by":"crossref","first-page":"e1007075","DOI":"10.1371\/journal.pgen.1007075","article-title":"How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects","volume":"13","author":"Chandler","year":"2017","journal-title":"PLoS Genet"},{"issue":"9","key":"2024070101470726300_bqae064-B25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/bies.201300014","article-title":"SNP ascertainment bias in population genetic analyses: why it is important, and how to correct it","volume":"35","author":"Lachance","year":"2013","journal-title":"Bioessays"},{"issue":"7","key":"2024070101470726300_bqae064-B26","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1210\/en.2004-0219","article-title":"Genetic background (C57BL\/6J versus FVB\/N) strongly influences the severity of diabetes and insulin resistance in ob\/ob mice","volume":"145","author":"Haluzik","year":"2004","journal-title":"Endocrinology"},{"issue":"1","key":"2024070101470726300_bqae064-B27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2337\/db15-0982","article-title":"Attention to background strain is essential for metabolic research: C57BL\/6 and the international knockout mouse consortium","volume":"65","author":"Fontaine","year":"2016","journal-title":"Diabetes"},{"issue":"9","key":"2024070101470726300_bqae064-B28","doi-asserted-by":"crossref","first-page":"e13271","DOI":"10.14814\/phy2.13271","article-title":"Is the FVB\/N mouse strain truly resistant to diet-induced obesity?","volume":"5","author":"Nascimento-Sales","year":"2017","journal-title":"Physiol Rep"},{"issue":"1","key":"2024070101470726300_bqae064-B29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/71641","article-title":"Genealogies of mouse inbred strains","volume":"24","author":"Beck","year":"2000","journal-title":"Nat Genet"},{"issue":"7","key":"2024070101470726300_bqae064-B30","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s00125-002-0880-z","article-title":"Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice","volume":"45","author":"Chua","year":"2002","journal-title":"Diabetologia"},{"issue":"4","key":"2024070101470726300_bqae064-B31","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2337\/db10-0758","article-title":"Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality","volume":"60","author":"Castillo","year":"2011","journal-title":"Diabetes"},{"issue":"4","key":"2024070101470726300_bqae064-B32","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1172\/JCI73780","article-title":"S-nitrosoglutathione reductase-dependent PPARgamma denitrosylation participates in MSC-derived adipogenesis and osteogenesis","volume":"125","author":"Cao","year":"2015","journal-title":"J Clin Invest"},{"issue":"1","key":"2024070101470726300_bqae064-B33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1089\/thy.2013.0109","article-title":"American thyroid association guide to investigating thyroid hormone economy and action in rodent and cell models: report of the American Thyroid Association Task Force on Approaches and Strategies to investigate thyroid hormone economy and action","volume":"24","author":"Bianco","year":"2014","journal-title":"Thyroid"},{"issue":"1","key":"2024070101470726300_bqae064-B34","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"Qupath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"2024070101470726300_bqae064-B35","doi-asserted-by":"crossref","unstructured":"Gabriel de Almeida G, Bolin AP, Batistuzzo A, Fonseca TL, Ribeiro MO, Bianco AC. Genetic background (FVB\/N versus C57BL\/6J) strongly influences the impact of carrying the Thr92Ala-DIO2 polymorphism in the male mouse. Zenodo. 2024. Doi:10.5281\/zenodo.11521673.","DOI":"10.1210\/endocr\/bqae064"},{"issue":"3","key":"2024070101470726300_bqae064-B36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/diabetes.53.3.577","article-title":"Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis","volume":"53","author":"Christoffolete","year":"2004","journal-title":"Diabetes"},{"issue":"6","key":"2024070101470726300_bqae064-B37","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/cells9061403","article-title":"Aquaporin-11 contributes to TGF-(1-induced endoplasmic reticulum stress in human visceral adipocytes: role in obesity-associated inflammation","volume":"9","author":"Fr\u00fchbeck","year":"2020","journal-title":"Cells"},{"issue":"8","key":"2024070101470726300_bqae064-B38","doi-asserted-by":"crossref","first-page":"E945","DOI":"10.1152\/ajpendo.00473.2013","article-title":"Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice","volume":"306","author":"Rosell","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2024070101470726300_bqae064-B39","doi-asserted-by":"crossref","first-page":"101749","DOI":"10.1016\/j.molmet.2023.101749","article-title":"Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice","volume":"74","author":"Laiglesia","year":"2023","journal-title":"Mol Metab"},{"issue":"5","key":"2024070101470726300_bqae064-B40","doi-asserted-by":"crossref","first-page":"268","DOI":"10.14348\/molcells.2023.2195","article-title":"The role of splicing factors in adipogenesis and thermogenesis","volume":"46","author":"Naing","year":"2023","journal-title":"Mol Cells"},{"issue":"2","key":"2024070101470726300_bqae064-B41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13105-019-00708-1","article-title":"The role of autophagy in brown and beige adipose tissue plasticity","volume":"76","author":"Cair\u00f3","year":"2020","journal-title":"J Physiol Biochem"},{"issue":"3","key":"2024070101470726300_bqae064-B42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1210\/jc.2014-4092","article-title":"Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes","volume":"100","author":"McAninch","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024070101470726300_bqae064-B43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2008.12.014","article-title":"UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality","volume":"9","author":"Feldmann","year":"2009","journal-title":"Cell Metab"},{"issue":"1","key":"2024070101470726300_bqae064-B44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1172\/JCI112798","article-title":"Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue","volume":"79","author":"Bianco","year":"1987","journal-title":"J Clin Invest"},{"issue":"3 Pt 1","key":"2024070101470726300_bqae064-B45","first-page":"E255","article-title":"Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation","volume":"253","author":"Bianco","year":"1987","journal-title":"Am J Physiol"},{"issue":"1","key":"2024070101470726300_bqae064-B46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1210\/endo-120-1-55","article-title":"Nuclear 3,5,3(-triiiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques","volume":"120","author":"Bianco","year":"1987","journal-title":"Endocrinology"},{"issue":"1","key":"2024070101470726300_bqae064-B47","doi-asserted-by":"crossref","first-page":"40215","DOI":"10.1038\/srep40215","article-title":"Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction","volume":"7","author":"Qiang","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"2024070101470726300_bqae064-B48","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/metabo12070629","article-title":"Age worsens the cognitive phenotype in mice carrying the Thr92Ala-DIO2 polymorphism","volume":"12","author":"Lorena","year":"2022","journal-title":"Metabolites"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqae064\/58104466\/bqae064.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/7\/bqae064\/58358636\/bqae064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/165\/7\/bqae064\/58358636\/bqae064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T01:47:52Z","timestamp":1719798472000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqae064\/7688133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,5,27]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqae064","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,5,27]]},"article-number":"bqae064"}}