{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:36Z","timestamp":1791407016068,"version":"4.3.3"},"reference-count":50,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["21K06192"],"award-info":[{"award-number":["21K06192"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["24K10341"],"award-info":[{"award-number":["24K10341"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["17H03584"],"award-info":[{"award-number":["17H03584"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["18K19484"],"award-info":[{"award-number":["18K19484"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["20H03519"],"award-info":[{"award-number":["20H03519"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["23K18244"],"award-info":[{"award-number":["23K18244"]}]},{"name":"Jikei University Research Fund"},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008672","name":"Yamaguchi Endocrine Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The functional maturation of the pituitary gland requires adequate cell differentiation and vascular network formation. Although spatiotemporal signaling and transcription factors are known to govern pituitary development, the involvement of primary cilia, nonmoving hair-like organelles, remains unclear. In this study, we uncovered the contribution of primary cilia to cell-type determination and vascular network formation during pituitary development. Homozygous knockout mice lacking a ciliary kinase, Dyrk2\u2212\/\u2212, exhibit abnormalities in ciliary structure and pituitary hypoplasia, accompanied by varying degrees of failure in differentiation among all types of hormone-producing cells in the anterior lobe. Aberrations in cell differentiation in Dyrk2\u2212\/\u2212 mice arise from a decrease in the expression of crucial transcription factors, Lhx4, Lhx3, and Prop1, resulting from the inactivity of Hedgehog (Hh) signaling during the early stages of development. Furthermore, the loss of Dyrk2 results in vascular system abnormalities during the middle to late stages of development. Mechanistically, transcriptome analyses revealed the downregulation of vitronectin-integrin \u03b1v\u03b23-VEGFR2 signaling, essential for orchestrating vascular development. Collectively, our findings demonstrate that primary cilia play a pivotal role as critical regulators of cell survival, cell determination, and angiogenesis during pituitary gland development through the activation of Hh signaling. These findings expand our understanding of the potential link between pituitary dysfunction in human disorders and ciliopathies.<\/jats:p>","DOI":"10.1210\/endocr\/bqae085","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T15:05:15Z","timestamp":1720796715000},"source":"Crossref","is-referenced-by-count":7,"title":["Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development"],"prefix":"10.1210","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-6410","authenticated-orcid":false,"given":"Saishu","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Biochemistry, The Jikei University School of Medicine , Tokyo 105-8461 , Japan"},{"name":"Department of Biomolecular Science, Toho University , Chiba 274-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Tsuneoka","sequence":"additional","affiliation":[{"name":"Department of 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