{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:54:54Z","timestamp":1753883694885,"version":"3.41.2"},"reference-count":56,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center","award":["HC22C0022","HC21C0090"],"award-info":[{"award-number":["HC22C0022","HC21C0090"]}]},{"name":"Korea Health Technology"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI22C1650"],"award-info":[{"award-number":["HI22C1650"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Premature rupture of membranes (PROM) is defined as rupture of fetal membranes before the onset of labor. Prolactin (PRL) is secreted by decidual membranes and accumulated significantly in the amniotic fluid during pregnancy. PRL could ameliorate inflammation and collagen degradation in fetal membranes. However, the role of PRL in amniotic membrane is not well characterized. We isolated human amniotic epithelial stem cells (hAESCs) from human fetal membranes to study the effect of PRL on proliferation, migration, and antioxidative stress. Amniotic pore culture technique (APCT) model was constructed to evaluate the tissue regeneration effect in vitro. The potential targets and pathways of PRL acting in amnion via integrated bioinformatic methods. PRL had a dose-dependent effect on hAESCs in vitro. PRL (500\u2005ng\/mL) significantly improved the viability of hAESCs and inhibited cell apoptosis, related to the upregulation of CCN2 expression and downregulation of Bax, Caspase 3, and Caspase 8. PRL accelerated migration process in hAESCs via downregulation of MMP2, MMP3, and MMP9. PRL attenuated the cellular damage and mitochondrial dysfunction induced by hydrogen peroxide in hAESCs. PRL accelerated the healing process in the APCT model significantly. The top 10 specific targets (IGF1R, SIRT1, MAP2K1, CASP8, MAPK14, MCL1, NFKB1, HIF1A, MTOR, and HSP90AA1) and signaling pathways (such as HIF signaling pathway) were selected using an integrated bioinformatics approach. PRL improves the viability and antioxidative stress function of hAESCs and the regeneration of ruptured amniotic membranes in vitro. Thus, PRL has great therapeutic potential for prevention and treatment of ruptured membranes.<\/jats:p>","DOI":"10.1210\/endocr\/bqae095","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:55:09Z","timestamp":1722362109000},"source":"Crossref","is-referenced-by-count":1,"title":["The Role of Prolactin in Amniotic Membrane Regeneration: Therapeutic Potential for Premature Rupture of Membranes"],"prefix":"10.1210","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-2686","authenticated-orcid":false,"given":"Deqi","family":"Kong","sequence":"first","affiliation":[{"name":"Biomedical Sciences Department, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heeryun","family":"Cho","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soowon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Research Institute, Designed Cells Co., Ltd. , Cheongju 28576 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uk","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Research Institute, Designed Cells Co., Ltd. , Cheongju 28576 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Central Research Institute, Designed Cells Co., Ltd. , Cheongju 28576 , Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong 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Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine , Seoul 02841 , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee 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