{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:03:36Z","timestamp":1785600216567,"version":"3.56.0"},"reference-count":98,"publisher":"The Endocrine Society","issue":"1","funder":[{"DOI":"10.13039\/100017540","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Environmental Sciences"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1ZIAES070065"],"award-info":[{"award-number":["1ZIAES070065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Normal ovarian function requires the expression of estrogen receptors \u03b1 (ESR1) and \u03b2 (ESR2) in distinct cell types within the ovary. The double estrogen receptor knockout (\u03b1\u03b2ERKO) ovary had the appearance of seminiferous tubule\u2013like structures that expressed SOX9; this phenotype was lost when the animals were repeatedly backcrossed to the C57BL\/6J genetic background. A new line of ERKO mice, Ex3\u03b1\u03b2ERKO, was developed for targeted disruption on a mixed genetic background. Histological examination of the ovaries in the Ex3\u03b1\u03b2ERKO showed the appearance of seminiferous tubule\u2013like structures in mice aged 6 to 12 months. These dismorphogenic regions have cells that no longer express granulosa cell\u2013specific FOXL2, while other cells express Sertoli cell\u2013specific SOX9 as examined by immunohistochemistry. Whole ovarian gene expression analysis in Ex3\u03b1ERKO, Ex3\u03b2RKO, and Ex3\u03b1\u03b2ERKO found many genes differentially expressed compared to controls with one Esr1 and Esr2 allele. The genes specific to the Ex3\u03b1\u03b2ERKO ovary were compared to other models of postnatal ovarian transdifferentiation, identifying 21 candidate genes. To examine the genetic background contributions, DNA was isolated from \u03b1\u03b2ERKO mice that did not show ovarian transdifferentiation and compared to DNA from Ex3\u03b1\u03b2ERKO using Mouse Diversity Array. A genomic region putatively associated with transdifferentiation was identified on Chr18 (5-15\u2005M) and genes in this region were compared to the genes differentially expressed in models of ovarian transdifferentiation. This work demonstrates the importance of ESRs in maintaining granulosa cell differentiation within the ovary, identifies several potential gene candidates, and suggests that genetic background can be a confounding factor.<\/jats:p>","DOI":"10.1210\/endocr\/bqae157","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:36:24Z","timestamp":1732289784000},"source":"Crossref","is-referenced-by-count":5,"title":["Postnatal Ovarian Transdifferentiation in the Absence of Estrogen Receptor Signaling Is Dependent on Genetic Background"],"prefix":"10.1210","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-4947","authenticated-orcid":false,"given":"April K","family":"Binder","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Central Washington University , Ellensburg, WA 98926 ,","place":["USA"]},{"name":"Center for Reproductive Biology, Washington State University , Pullman, WA 99164 ,","place":["USA"]},{"name":"Reproductive & Developmental Biology Laboratory, NIEHS, NIH , Research Triangle Park, NC 27709 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Burns","sequence":"additional","affiliation":[{"name":"Reproductive & Developmental Biology Laboratory, NIEHS, NIH , Research Triangle Park, NC 27709 ,","place":["USA"]},{"name":"Department of Environmental and Public Health Science, University of Cincinnati College of Medicine , Cincinnati, OH 45267 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina F","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Reproductive & Developmental Biology Laboratory, NIEHS, NIH , Research Triangle Park, NC 27709 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Reproductive & Developmental Biology Laboratory, NIEHS, NIH , Research Triangle Park, NC 27709 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pardo-Manuel de Villena","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-418X","authenticated-orcid":false,"given":"Kenneth S","family":"Korach","sequence":"additional","affiliation":[{"name":"Reproductive & Developmental Biology Laboratory, NIEHS, NIH , Research Triangle Park, NC 27709 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"issue":"5","key":"2024123107462952900_bqae157-B1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/bcr79","article-title":"Estrogen receptor transcription and transactivation: estrogen 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