{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:40:26Z","timestamp":1784727626376,"version":"3.55.0"},"reference-count":54,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"R\u00e9gion Centre Val de Loire"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Overconsumption of fructose is linked to metabolic diseases, which are often associated with reduced fertility. GLUT5 is the most specific fructose transporter. To investigate its role in the testes, we analyzed the male reproductive phenotype of transgenic male mice deficient in GLUT5 (GLUT5\u2212\/\u2212 or GLUT5 knockout [KO] mice). Glut5 expression was shown in Leydig cells and germ cells, from primary spermatocytes to spermatozoa. We found reduced intratesticular fructose and pyruvate concentrations in GLUT5\u2212\/\u2212 mice. These mice exhibited 30% lower litter sizes compared with control mice. Histological analysis of the testes revealed some seminiferous tubules with a \u201cSertoli cell-only\u201d phenotype, although spermatogenesis occurred normally in most tubules. Reduced fertility in GLUT5 KO mice was linked to lower sperm production and impaired sperm quality. Spermatozoa from these mice displayed reduced motility, head abnormalities, and a diminished acrosome reaction, which was associated with reduced cyclic adenosine monophosphate content and impaired phosphorylation of protein kinase A substrates in the acrosome. Unexpectedly, androgen production in GLUT5 KO mice was 3-fold higher than in controls, despite unchanged luteinizing hormone levels. Electron microscopy of Leydig cells revealed a highly developed smooth endoplasmic reticulum, increased lipid droplets, and abnormal mitochondrial structures, suggesting disrupted mitochondrial dynamics. Proteomic analysis identified 155 deregulated proteins in the testicular tissue of GLUT5 KO mice, nearly half of which were associated with sperm motility, germ cell morphology, glycolysis, mitochondrial dynamics, and oxidative stress. In conclusion, the absence of the specific fructose transporter GLUT5 reduced testicular fructose content and led to an asthenozoospermia phenotype accompanied by hyperandrogenism.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf005","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T07:07:36Z","timestamp":1739603256000},"source":"Crossref","is-referenced-by-count":5,"title":["Mice Lacking the Fructose Transporter Glut5 Exhibit Excessive Androgens and Reduced Sperm Motility"],"prefix":"10.1210","volume":"166","author":[{"given":"Aikaterini","family":"Kallianioti","sequence":"first","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bourdon","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Grandhaye","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chevaleyre","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soulaimane","family":"Aboulouard","sequence":"additional","affiliation":[{"name":"Laboratory PRISM U1192 Inserm, University of Lille , 59655 Villeneuve d\u2019Ascq ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"P\u00e9choux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, GABI , 78350 Jouy-en-Josas ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Ribes","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute , Domaine de Vilvert, 78350 Jouy-en-Josas ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Sellem","sequence":"additional","affiliation":[{"name":"\u0178nsect, R&D Biotech Innovations , Evry 91000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Ram\u00e9","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2539-0087","authenticated-orcid":false,"given":"Ingrid","family":"Plotton","sequence":"additional","affiliation":[{"name":"Medecine et biologie de la Reproduction, Biologie Endocrinienne HCL , 69500 Bron ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fournier","sequence":"additional","affiliation":[{"name":"Laboratory PRISM U1192 Inserm, University of Lille , 59655 Villeneuve d\u2019Ascq ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Salzet","sequence":"additional","affiliation":[{"name":"Laboratory PRISM U1192 Inserm, University of Lille , 59655 Villeneuve d\u2019Ascq ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Dupont","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Douard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Micalis Institute , Domaine de Vilvert, 78350 Jouy-en-Josas ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-9598","authenticated-orcid":false,"given":"Pascal","family":"Froment","sequence":"additional","affiliation":[{"name":"Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Universit\u00e9 de Tours , 37380 Nouzilly ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"issue":"1","key":"2025021911285898100_bqaf005-B1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/obr.12469","article-title":"Obesogens and male fertility","volume":"18","author":"Cardoso","year":"2017","journal-title":"Obes Rev"},{"issue":"12","key":"2025021911285898100_bqaf005-B2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/obr.12226","article-title":"High-energy diets: a threat for male fertility?","volume":"15","author":"Rato","year":"2014","journal-title":"Obes Rev"},{"issue":"2","key":"2025021911285898100_bqaf005-B3","doi-asserted-by":"crossref","first-page":"e23992","DOI":"10.4161\/tisb.23992","article-title":"Diabetes, insulin-mediated glucose metabolism and Sertoli\/blood-testis barrier function","volume":"1","author":"Alves","year":"2013","journal-title":"Tissue Barriers"},{"issue":"5","key":"2025021911285898100_bqaf005-B4","first-page":"499","article-title":"New insights on hormones and factors that modulate Sertoli cell metabolism","volume":"31","author":"Rato","year":"2016","journal-title":"Histol Histopathol"},{"issue":"2","key":"2025021911285898100_bqaf005-B5","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/aja202350","article-title":"Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis","volume":"26","author":"Qian","year":"2024","journal-title":"Asian J Androl"},{"issue":"1","key":"2025021911285898100_bqaf005-B6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pros.24631","article-title":"Biological role of fructose in the male reproductive system: potential implications for prostate cancer","volume":"84","author":"Echeverr\u00eda","year":"2024","journal-title":"Prostate"},{"key":"2025021911285898100_bqaf005-B7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/cphy.c110024","volume-title":"Comprehensive Physiology. 1st ed","author":"Cura","year":"2012"},{"issue":"2","key":"2025021911285898100_bqaf005-B8","doi-asserted-by":"crossref","first-page":"E227","DOI":"10.1152\/ajpendo.90245.2008","article-title":"Regulation of the fructose transporter GLUT5 in health and disease","volume":"295","author":"Douard","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9","key":"2025021911285898100_bqaf005-B9","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3390\/nu11091987","article-title":"Dietary fructose and the metabolic syndrome","volume":"11","author":"Taskinen","year":"2019","journal-title":"Nutrients"},{"issue":"1-2","key":"2025021911285898100_bqaf005-B10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0167-4781(02)00284-1","article-title":"Cloning and functional characterization of the mouse fructose transporter, GLUT5","volume":"1576","author":"Corpe","year":"2002","journal-title":"Biochim Biophys Acta (BBA)\u2014Gene Struct Exp"},{"issue":"9","key":"2025021911285898100_bqaf005-B11","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1096\/fj.15-272195","article-title":"Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption","volume":"29","author":"Patel","year":"2015","journal-title":"FASEB J"},{"key":"2025021911285898100_bqaf005-B12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2008.02.094","article-title":"Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification","volume":"1210","author":"Wu","year":"2008","journal-title":"Brain Res"},{"issue":"5","key":"2025021911285898100_bqaf005-B13","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/schbul\/sbw037","article-title":"Dietary fructose and GLUT5 transporter activity contribute to antipsychotic-induced weight gain","volume":"42","author":"Palavicino-Maggio","year":"2016","journal-title":"SCHBUL"},{"issue":"5","key":"2025021911285898100_bqaf005-B14","doi-asserted-by":"crossref","first-page":"R499","DOI":"10.1152\/ajpregu.00128.2015","article-title":"Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK","volume":"309","author":"Patel","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"10","key":"2025021911285898100_bqaf005-B15","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1210\/me.2012-1122","article-title":"Regulation of adipose differentiation by fructose and GluT5","volume":"26","author":"Du","year":"2012","journal-title":"Molecular Endocrinology"},{"issue":"21","key":"2025021911285898100_bqaf005-B16","doi-asserted-by":"crossref","first-page":"14523","DOI":"10.1016\/S0021-9258(18)42067-4","article-title":"Fructose transporter in human spermatozoa and small intestine is GLUT5","volume":"267","author":"Burant","year":"1992","journal-title":"J Biol Chem"},{"issue":"6","key":"2025021911285898100_bqaf005-B17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4103\/1008-682X.150844","article-title":"The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis","volume":"17","author":"Ding","year":"2015","journal-title":"Asian J Androl"},{"key":"2025021911285898100_bqaf005-B18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ygcen.2013.05.016","article-title":"The expression pattern of the glucose transporter GLUT-5 in the testis during the spermatogenic cycle of the vespertilionid bat Scotophilus heathi","volume":"191","author":"Roy","year":"2013","journal-title":"Gen Comp Endocrinol"},{"issue":"2","key":"2025021911285898100_bqaf005-B19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/(SICI)1097-4644(19981101)71:2<189::AID-JCB5>3.0.CO;2-R","article-title":"Hexose transporter expression and function in mammalian spermatozoa: cellular localization and transport of hexoses and vitamin C","volume":"71","author":"Angulo","year":"1998","journal-title":"J Cell Biochem"},{"issue":"3","key":"2025021911285898100_bqaf005-B20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/REP-08-0167","article-title":"Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression","volume":"136","author":"Kim","year":"2008","journal-title":"Reproduction"},{"issue":"3","key":"2025021911285898100_bqaf005-B21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/09687680701855405","article-title":"Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa","volume":"25","author":"Gawlik","year":"2008","journal-title":"Mol Membr Biol"},{"key":"2025021911285898100_bqaf005-B22","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13637","article-title":"The human infertility single-cell testis atlas (HISTA): an interactive molecular scRNA-Seq reference of the human testis","author":"Mahyari","year":"2024","journal-title":"Andrology"},{"issue":"4","key":"2025021911285898100_bqaf005-B23","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1210\/en.2003-0956","article-title":"Reproductive abnormalities in human insulin-like growth factor-binding protein-1 transgenic male mice","volume":"145","author":"Froment","year":"2004","journal-title":"Endocrinology"},{"issue":"7","key":"2025021911285898100_bqaf005-B24","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1210\/en.2011-1911","article-title":"Inactivation of AMPK\u03b11 induces asthenozoospermia and alters spermatozoa morphology","volume":"153","author":"Tartarin","year":"2012","journal-title":"Endocrinology"},{"issue":"5","key":"2025021911285898100_bqaf005-B25","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1210\/clinem\/dgac656","article-title":"Steroid profiling in the amniotic fluid: reference range for 12 steroids and interest in 21-hydroxylase deficiency","volume":"108","author":"Pourquet","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2025021911285898100_bqaf005-B26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"issue":"7","key":"2025021911285898100_bqaf005-B27","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1021\/pr200019m","article-title":"High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers","volume":"10","author":"Wi\u015bniewski","year":"2011","journal-title":"J Proteome Res"},{"issue":"11","key":"2025021911285898100_bqaf005-B28","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1074\/mcp.TIR118.000853","article-title":"A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics","volume":"17","author":"Bache","year":"2018","journal-title":"Mol Cell Proteomics"},{"issue":"12","key":"2025021911285898100_bqaf005-B29","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"9","key":"2025021911285898100_bqaf005-B30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods"},{"issue":"9","key":"2025021911285898100_bqaf005-B31","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"D1","key":"2025021911285898100_bqaf005-B32","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2025021911285898100_bqaf005-B33"},{"issue":"11","key":"2025021911285898100_bqaf005-B34","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1093\/humrep\/dem292","article-title":"Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response","volume":"22","author":"Spiess","year":"2007","journal-title":"Hum Reprod"},{"issue":"8","key":"2025021911285898100_bqaf005-B35","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.1074\/jbc.M808128200","article-title":"Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension","volume":"284","author":"Barone","year":"2009","journal-title":"J Biol Chem"},{"issue":"3","key":"2025021911285898100_bqaf005-B36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1095\/biolreprod.114.124495","article-title":"Targeted disruption of glycogen synthase kinase 3A (GSK3A) in mice affects sperm motility resulting in male infertility","volume":"92","author":"Bhattacharjee","year":"2015","journal-title":"Biol Reprod"},{"issue":"16","key":"2025021911285898100_bqaf005-B37","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1016\/j.cub.2021.05.062","article-title":"A drastic shift in the energetic landscape of toothed whale sperm cells","volume":"31","author":"Alves","year":"2021","journal-title":"Curr Biol"},{"issue":"1","key":"2025021911285898100_bqaf005-B38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1042\/BST20150188","article-title":"Galactokinase promiscuity: a question of flexibility?","volume":"44","author":"McAuley","year":"2016","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"2025021911285898100_bqaf005-B39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1677\/JOE-10-0025","article-title":"Hormonal regulation of male germ cell development","volume":"205","author":"Ruwanpura","year":"2010","journal-title":"J Endocrinol"},{"issue":"7","key":"2025021911285898100_bqaf005-B40","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.steroids.2008.11.017","article-title":"Molecular mechanisms of testosterone action in spermatogenesis","volume":"74","author":"Walker","year":"2009","journal-title":"Steroids"},{"issue":"11","key":"2025021911285898100_bqaf005-B41","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s41419-021-04277-4","article-title":"MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating ROR\u03b1","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis"},{"issue":"1","key":"2025021911285898100_bqaf005-B42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1152\/physiolgenomics.00260.2007","article-title":"A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice","volume":"33","author":"MacLean","year":"2008","journal-title":"Physiol Genomics"},{"issue":"1-2","key":"2025021911285898100_bqaf005-B43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2010.01.014","article-title":"The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells","volume":"319","author":"Li","year":"2010","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2025021911285898100_bqaf005-B44","doi-asserted-by":"crossref","first-page":"159433","DOI":"10.1016\/j.bbalip.2023.159433","article-title":"Taste receptor type 1 member 3 regulates Western diet-induced male infertility","volume":"1869","author":"Seong","year":"2024","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"2","key":"2025021911285898100_bqaf005-B45","doi-asserted-by":"crossref","first-page":"e24577","DOI":"10.1016\/j.heliyon.2024.e24577","article-title":"Taste receptor type 1 member 3 is required for the fertility of male mice","volume":"10","author":"Shon","year":"2024","journal-title":"Heliyon"},{"key":"2025021911285898100_bqaf005-B46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnins.2015.00235","article-title":"AMPK: a master energy regulator for gonadal function","volume":"9","author":"Bertoldo","year":"2015","journal-title":"Front Neurosci"},{"issue":"6","key":"2025021911285898100_bqaf005-B47","first-page":"55","article-title":"Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation","volume":"2","author":"Bertoldo","year":"2014","journal-title":"Ann Transl Med"},{"issue":"3","key":"2025021911285898100_bqaf005-B48","doi-asserted-by":"crossref","first-page":"e131596","DOI":"10.1172\/jci.insight.131596","article-title":"GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK\/mTORC1 signaling","volume":"5","author":"Chen","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"2025021911285898100_bqaf005-B49","first-page":"101","article-title":"Hyperandrogenemia alters mitochondrial structure and function in the oocytes of obese mouse with polycystic ovary syndrome","volume":"2","author":"Chappell","year":"2021","journal-title":"F S Sci"},{"issue":"1","key":"2025021911285898100_bqaf005-B50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Sig Transduct Target Ther"},{"key":"2025021911285898100_bqaf005-B51","doi-asserted-by":"crossref","first-page":"862506","DOI":"10.3389\/fcell.2022.862506","article-title":"MFN2 deficiency impairs mitochondrial functions and PPAR pathway during spermatogenesis and meiosis in mice","volume":"10","author":"Wang","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"1","key":"2025021911285898100_bqaf005-B52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"2025021911285898100_bqaf005-B53","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.fertnstert.2010.11.044","article-title":"Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology","volume":"95","author":"Bakos","year":"2011","journal-title":"Fertil Steril"},{"issue":"1","key":"2025021911285898100_bqaf005-B54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ucl.2013.08.006","article-title":"The epidemiology of male infertility","volume":"41","author":"Winters","year":"2014","journal-title":"Urol Clin North Am"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/166\/3\/bqaf005\/61901493\/bqaf005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/166\/3\/bqaf005\/61901493\/bqaf005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:29:36Z","timestamp":1739964576000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqaf005\/8015888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,5]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqaf005","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,2,5]]},"article-number":"bqaf005"}}