{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:41:04Z","timestamp":1786963264858,"version":"build-2736575974"},"reference-count":105,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2028578"],"award-info":[{"award-number":["2028578"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2019889"],"award-info":[{"award-number":["2019889"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Salt-inducible kinases (SIKs), a member of the serine\/threonine protein kinase family, have recently garnered considerable research interest as one of the emerging key regulators of metabolism. The 3 SIK isoforms\u2014SIK1, SIK2, and SIK3\u2014exhibit diverse roles both in central and peripheral physiological processes. While early studies focused on their role in inflammation, spurring the development of SIK inhibitors for chronic inflammatory diseases currently in clinical trials, emerging evidence highlights their broader functions in metabolism. In this review, we will summarize the current state of research on the central roles of SIKs in the brain, particularly in regulating energy balance and glucose homeostasis, alongside their peripheral functions in critical metabolic tissues such as the liver, adipose tissue, and pancreas. By integrating insights into their central and peripheral roles, this review underscores the importance of SIKs in maintaining metabolic homeostasis and highlights their therapeutic potential as novel targets for metabolic disease.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf024","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:20:07Z","timestamp":1738729207000},"source":"Crossref","is-referenced-by-count":3,"title":["Central and Peripheral Roles of Salt-inducible Kinases in Metabolic Regulation"],"prefix":"10.1210","volume":"166","author":[{"given":"Danise-Ann","family":"Onda","sequence":"first","affiliation":[{"name":"Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research , Melbourne, VIC 3065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research , Melbourne, VIC 3065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoZhuo","family":"Yuan","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research , Melbourne, VIC 3065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-1926","authenticated-orcid":false,"given":"Kim","family":"Loh","sequence":"additional","affiliation":[{"name":"Diabetes and Metabolic Disease, St. Vincent's Institute of Medical Research , Melbourne, VIC 3065 ,","place":["Australia"]},{"name":"Mary MacKillop Institute for Health Research, Australian Catholic University , Melbourne, VIC 3065 ,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Melbourne, VIC 3010 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