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CCAAT\/enhancer-binding proteins \u03b1 and \u03b2 (C\/EBP\u03b1\/\u03b2) are transcription factors acutely induced by the LH surge and crucial for ovulation and granulosa cell luteinization. However, biological processes (BPs) and their regulatory mechanisms downstream of C\/EBP\u03b1\/\u03b2 in the preovulatory ovary are not completely understood. To address this knowledge gap, we generated Cebpa\/bfl\/fl;Pgr-Cre mutants and compared them with Cebpa\/bfl\/fl;Cyp19a1-Cre mutant female mice: Cebpa\/bfl\/fl;Cyp19a1-Cre mutants have undetectable levels of C\/EBP\u03b1\/\u03b2 throughout the preovulatory stages and do not ovulate, aligning with previous reports; and Cebpa\/bfl\/fl;Pgr-Cre mutants present gradual depletion of C\/EBP\u03b1\/\u03b2 during the late preovulatory stage and a reduced ovulation rate. Comparison of these two models indicates that sustained expression of C\/EBP\u03b1\/\u03b2 throughout the preovulatory stages is necessary for successful ovulation and provides a unique opportunity to interrogate gene regulatory mechanisms by C\/EBP\u03b1\/\u03b2 during different preovulatory time windows and the effect of dysregulating C\/EBP\u03b1\/\u03b2 on ovulation-associated BPs. Our study revealed that C\/EBP\u03b1\/\u03b2 regulate gene expression and distinct biological functions such as vascular remodeling via dose- and preovulatory stage\u2013dependent mechanisms. These findings shed new light on the intricate mechanisms of gene regulation by C\/EBP\u03b1\/\u03b2 downstream of the LH surge.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf081","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T18:07:23Z","timestamp":1745863643000},"source":"Crossref","is-referenced-by-count":2,"title":["CCAAT\/Enhancer-Binding Proteins \u03b1 and \u03b2 Regulate Ovulation and Gene Expression via Dose- and Stage-Dependent Mechanisms"],"prefix":"10.1210","volume":"166","author":[{"given":"Hanxue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Animal Science, College of Agriculture and Life Sciences, Cornell University , Ithaca, NY 14853 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer B","family":"Lanz","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine , Houston, TX 77030 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