{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:32:06Z","timestamp":1780921926064,"version":"3.54.1"},"reference-count":65,"publisher":"The Endocrine Society","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thyroid hormone (triiodothyronine, T3) promotes neurodevelopment but under strict control because unconstrained exposure to T3 impairs brain and sensory functions. Thyroid hormone\u2013inactivating type 3 deiodinase, encoded by Dio3, critically limits T3 signaling and controls diverse neural functions. Accordingly, understanding the cellular basis of T3 action requires identification of Dio3-expressing cell types but this is difficult because of low level, transient expression within the complexity of the nervous system. Here, we derived a knock-in Dio3Cre driver that sensitively labels Dio3-expressing cells in male and female mice. In this anatomical study, we identified Dio3 expression in the immature amygdala and other brain regions associated with emotion and motivation, and in serotonergic raphe nuclei, which influence many behavioral and physiological systems. Notably, expression in circumventricular organs, including the chemosensory subfornical organ and organum vasculosum laminae terminalis, suggested regulation of centers that lack a blood\u2013brain barrier and directly sense signaling factors in the circulation. Expression in trigeminal, dorsal root, cochleovestibular, and other sensory ganglia highlighted contributions to sensory pathways. Although Dio3 expression declines during maturation, a conditional Dio3CreERt2 driver revealed neurons with T3-inducible expression in the adult brain, suggesting ongoing homeostatic functions. These Cre drivers indicate strategically located neuronal groups for control of T3 signaling in behavioral, chemosensory and sensory systems.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf085","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:02:43Z","timestamp":1745992963000},"source":"Crossref","is-referenced-by-count":4,"title":["Serotonergic and Chemosensory Brain Areas and Sensory Ganglia Expressing Type 3 Deiodinase Mapped With <i>Dio3<\/i>Cre drivers"],"prefix":"10.1210","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-964X","authenticated-orcid":false,"given":"Ye","family":"Liu","sequence":"first","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-9908","authenticated-orcid":false,"given":"Lily","family":"Ng","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-9225","authenticated-orcid":false,"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-4162","authenticated-orcid":false,"given":"Douglas","family":"Forrest","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"2025060301514303700_bqaf085-B1","doi-asserted-by":"crossref","DOI":"10.2174\/97898152742261240101","volume-title":"Thyroid and Brain: Understanding the Actions of Thyroid Hormones in Brain Development and Function","author":"Bernal","year":"2024"},{"issue":"3","key":"2025060301514303700_bqaf085-B2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1469-8749.1985.tb04542.x","article-title":"Neurological signs in congenital iodine-deficiency disorder (endemic cretinism)","volume":"27","author":"DeLong","year":"1985","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"2025060301514303700_bqaf085-B3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrendo.2013.58","article-title":"Making sense with thyroid hormone\u2013the role of T(3) in auditory development","volume":"9","author":"Ng","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"2025060301514303700_bqaf085-B4","first-page":"235","article-title":"Congenital hyperthyroidism: the fetus as a patient","volume":"65","author":"Polak","year":"2006","journal-title":"Horm Res"},{"issue":"1","key":"2025060301514303700_bqaf085-B5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1750-1172-5-17","article-title":"Congenital hypothyroidism","volume":"5","author":"Rastogi","year":"2010","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"2025060301514303700_bqaf085-B6","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/en.2008-1419","article-title":"A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function","volume":"150","author":"Ng","year":"2009","journal-title":"Endocrinology"},{"issue":"9","key":"2025060301514303700_bqaf085-B7","doi-asserted-by":"crossref","first-page":"ENEURO.0058-23.2023","DOI":"10.1523\/ENEURO.0058-23.2023","article-title":"Excessive thyroid hormone signaling induces photoreceptor degeneration in mice","volume":"10","author":"Ma","year":"2023","journal-title":"eNeuro"},{"issue":"10","key":"2025060301514303700_bqaf085-B8","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1172\/JCI29812","article-title":"Deiodinases: implications of the local control of thyroid hormone action","volume":"116","author":"Bianco","year":"2006","journal-title":"J Clin Invest"},{"issue":"3","key":"2025060301514303700_bqaf085-B9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1210\/en.2008-1588","article-title":"Minireview: defining the roles of the iodothyronine deiodinases: current concepts and challenges","volume":"150","author":"St Germain","year":"2009","journal-title":"Endocrinology"},{"key":"2025060301514303700_bqaf085-B10","doi-asserted-by":"crossref","first-page":"e82683","DOI":"10.7554\/eLife.82683","article-title":"Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain","volume":"12","author":"Salas-Lucia","year":"2023","journal-title":"eLife"},{"issue":"1","key":"2025060301514303700_bqaf085-B11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1210\/en.2012-1738","article-title":"Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor alpha1","volume":"154","author":"Peeters","year":"2013","journal-title":"Endocrinology"},{"key":"2025060301514303700_bqaf085-B12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.psyneuen.2016.08.021","article-title":"Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism","volume":"74","author":"Stohn","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"2025060301514303700_bqaf085-B13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI26240","article-title":"Type 3 deiodinase is critical for the maturation and function of the thyroid axis","volume":"116","author":"Hernandez","year":"2006","journal-title":"J Clin Invest"},{"issue":"2","key":"2025060301514303700_bqaf085-B14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1210\/en.2016-1680","article-title":"Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity","volume":"158","author":"Wu","year":"2017","journal-title":"Endocrinology"},{"issue":"9","key":"2025060301514303700_bqaf085-B15","doi-asserted-by":"crossref","first-page":"mjac078","DOI":"10.1093\/jmcb\/mjac078","article-title":"Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation","volume":"14","author":"Wu","year":"2023","journal-title":"J Mol Cell Biol"},{"issue":"9","key":"2025060301514303700_bqaf085-B16","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1523\/JNEUROSCI.5267-09.2010","article-title":"Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors","volume":"30","author":"Ng","year":"2010","journal-title":"J Neurosci"},{"issue":"11","key":"2025060301514303700_bqaf085-B17","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1210\/en.2010-0450","article-title":"Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels","volume":"151","author":"Hernandez","year":"2010","journal-title":"Endocrinology"},{"issue":"4","key":"2025060301514303700_bqaf085-B18","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI110136","article-title":"Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum, and hypothalamus","volume":"67","author":"Kaplan","year":"1981","journal-title":"J Clin Invest"},{"issue":"2","key":"2025060301514303700_bqaf085-B19","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1210\/endo.140.2.6537","article-title":"Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat","volume":"140","author":"Bates","year":"1999","journal-title":"Endocrinology"},{"issue":"1","key":"2025060301514303700_bqaf085-B20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1432-1033.1984.tb08244.x","article-title":"Phenolic and tyrosyl ring deiodination in thyroxine from rat retina during postnatal development","volume":"142","author":"Ientile","year":"1984","journal-title":"Eur J Biochem"},{"issue":"8","key":"2025060301514303700_bqaf085-B21","doi-asserted-by":"crossref","first-page":"bqab091","DOI":"10.1210\/endocr\/bqab091","article-title":"Thyroid hormone deiodinases: dynamic switches in developmental transitions","volume":"162","author":"Hernandez","year":"2021","journal-title":"Endocrinology"},{"issue":"7","key":"2025060301514303700_bqaf085-B22","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1210\/jc.2003-031832","article-title":"Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas","volume":"89","author":"Kester","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2025060301514303700_bqaf085-B23","doi-asserted-by":"crossref","first-page":"104439","DOI":"10.1016\/j.psyneuen.2019.104439","article-title":"Adult onset of type 3 deiodinase deficiency in mice alters brain gene expression and increases locomotor activity","volume":"110","author":"Stohn","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"11","key":"2025060301514303700_bqaf085-B24","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1159\/000541525","article-title":"Thyroid hormone clearance in the paraventricular nucleus of male mice regulates lean mass and physical activity","volume":"114","author":"Wu","year":"2024","journal-title":"Neuroendocrinology"},{"issue":"7","key":"2025060301514303700_bqaf085-B25","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1210\/jc.2004-2567","article-title":"Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus","volume":"90","author":"Alkemade","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2025060301514303700_bqaf085-B26","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1210\/endo.140.11.7244","article-title":"Type 3 iodothyronine deiodinase is selectively expressed in areas related to sexual differentiation in the newborn rat brain","volume":"140","author":"Escamez","year":"1999","journal-title":"Endocrinology"},{"issue":"22","key":"2025060301514303700_bqaf085-B27","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases","volume":"27","author":"Indra","year":"1999","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2025060301514303700_bqaf085-B28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci"},{"key":"2025060301514303700_bqaf085-B29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-4939-8831-0_11","article-title":"Generation of conditional knockout mice by sequential insertion of two loxP sites in cis using CRISPR\/Cas9 and single-stranded DNA oligonucleotides","volume":"1874","author":"Liu","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2025060301514303700_bqaf085-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.90284.2008","article-title":"Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles","volume":"35","author":"de Lange","year":"2008","journal-title":"Physiol Genomics"},{"issue":"12","key":"2025060301514303700_bqaf085-B31","doi-asserted-by":"crossref","first-page":"bqab179","DOI":"10.1210\/endocr\/bqab179","article-title":"Cochlear fibrocyte and osteoblast lineages expressing type 2 deiodinase identified with a Dio2CreERt2 allele","volume":"162","author":"Ng","year":"2021","journal-title":"Endocrinology"},{"issue":"3","key":"2025060301514303700_bqaf085-B32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1089\/thy.2012.0338","article-title":"Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function","volume":"23","author":"Hamidi","year":"2013","journal-title":"Thyroid"},{"issue":"6","key":"2025060301514303700_bqaf085-B33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0023677219856918","article-title":"Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo","volume":"53","author":"Ved","year":"2019","journal-title":"Lab Anim"},{"issue":"11","key":"2025060301514303700_bqaf085-B34","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1210\/me.2014-1210","article-title":"Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions","volume":"28","author":"Martinez","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"21","key":"2025060301514303700_bqaf085-B35","doi-asserted-by":"crossref","first-page":"e161214","DOI":"10.1172\/jci.insight.161214","article-title":"DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities","volume":"7","author":"Martinez","year":"2022","journal-title":"JCI Insight"},{"issue":"9","key":"2025060301514303700_bqaf085-B36","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1210\/en.2010-0511","article-title":"Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis","volume":"151","author":"Hall","year":"2010","journal-title":"Endocrinology"},{"issue":"3","key":"2025060301514303700_bqaf085-B37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/dvdy.21449","article-title":"Expression patterns and cell cycle profiles of PCNA, MCM6, cyclin D1, cyclin A2, cyclin B1, and phosphorylated histone H3 in the developing mouse retina","volume":"237","author":"Barton","year":"2008","journal-title":"Dev Dyn"},{"issue":"3","key":"2025060301514303700_bqaf085-B38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuron.2019.03.003","article-title":"A motivational and neuropeptidergic hub: anatomical and functional diversity within the nucleus Accumbens shell","volume":"102","author":"Castro","year":"2019","journal-title":"Neuron"},{"issue":"1","key":"2025060301514303700_bqaf085-B39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41380-024-02679-2","article-title":"Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity","volume":"30","author":"Maddox","year":"2025","journal-title":"Mol Psychiatry"},{"issue":"5","key":"2025060301514303700_bqaf085-B40","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00429-012-0456-8","article-title":"Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains","volume":"218","author":"Alonso","year":"2013","journal-title":"Brain Struct Funct"},{"issue":"2 Suppl","key":"2025060301514303700_bqaf085-B41","doi-asserted-by":"crossref","first-page":"S33\u2013","DOI":"10.1038\/sj.npp.1395346","article-title":"Serotonin neurons, neuroplasticity, and homeostasis of neural tissue","volume":"21","author":"Azmitia","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"2025060301514303700_bqaf085-B42","doi-asserted-by":"crossref","first-page":"691711","DOI":"10.3389\/fncel.2021.691711","article-title":"Anatomical organization of the rat subfornical organ","volume":"15","author":"Hicks","year":"2021","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"2025060301514303700_bqaf085-B43","doi-asserted-by":"crossref","first-page":"R324","DOI":"10.1152\/ajpregu.00134.2015","article-title":"Anatomical organization of the rat organum vasculosum laminae terminalis","volume":"309","author":"Prager-Khoutorsky","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"11","key":"2025060301514303700_bqaf085-B44","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.tins.2013.08.004","article-title":"Central regulation of body-fluid homeostasis","volume":"36","author":"Noda","year":"2013","journal-title":"Trends Neurosci"},{"key":"2025060301514303700_bqaf085-B45","doi-asserted-by":"crossref","first-page":"587699","DOI":"10.3389\/fcell.2020.587699","article-title":"Vertebrate sensory ganglia: common and divergent features of the transcriptional programs generating their functional specialization","volume":"8","author":"Vermeiren","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"7991","key":"2025060301514303700_bqaf085-B46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41586-023-06812-z","article-title":"A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain","volume":"624","author":"Yao","year":"2023","journal-title":"Nature"},{"issue":"6","key":"2025060301514303700_bqaf085-B47","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1210\/en.2011-1905","article-title":"Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T(3)in the mouse cerebral cortex","volume":"153","author":"Hernandez","year":"2012","journal-title":"Endocrinology"},{"issue":"2","key":"2025060301514303700_bqaf085-B48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-3476(80)80487-2","article-title":"Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years","volume":"97","author":"Daneman","year":"1980","journal-title":"J Pediatr"},{"issue":"4","key":"2025060301514303700_bqaf085-B49","doi-asserted-by":"crossref","first-page":"471","DOI":"10.31887\/DCNS.2010.12.4\/ycharnay","article-title":"Brain serotonergic circuitries","volume":"12","author":"Charnay","year":"2010","journal-title":"Dialogues Clin Neurosci"},{"issue":"2","key":"2025060301514303700_bqaf085-B50","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/sj.mp.4000963","article-title":"Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain","volume":"7","author":"Bauer","year":"2002","journal-title":"Mol Psychiatry"},{"issue":"11","key":"2025060301514303700_bqaf085-B51","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2165\/00023210-200620110-00003","article-title":"Psychiatric manifestations of Graves' hyperthyroidism: pathophysiology and treatment options","volume":"20","author":"Bunevicius","year":"2006","journal-title":"CNS Drugs"},{"issue":"3","key":"2025060301514303700_bqaf085-B52","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ecl.2013.05.005","article-title":"Neuropsychiatric manifestations of thyroid disease","volume":"42","author":"Feldman","year":"2013","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025060301514303700_bqaf085-B53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0166-2236(79)90091-2","article-title":"Morphogenetic actions of thyroid hormones","volume":"2","author":"Legrand","year":"1979","journal-title":"Trends Neurosci"},{"issue":"6","key":"2025060301514303700_bqaf085-B54","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1073\/pnas.062413299","article-title":"Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism","volume":"99","author":"Morte","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2025060301514303700_bqaf085-B55","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1210\/me.2011-1316","article-title":"A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation","volume":"26","author":"Picou","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2025060301514303700_bqaf085-B56","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1242\/dev.103226","article-title":"Purkinje cells and Bergmann glia are primary targets of the TRalpha1 thyroid hormone receptor during mouse cerebellum postnatal development","volume":"141","author":"Fauquier","year":"2014","journal-title":"Development"},{"issue":"1-2","key":"2025060301514303700_bqaf085-B57","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(91)90194-Z","article-title":"Transport of iodothyronines from bloodstream to brain: contributions by blood:brain and choroid plexus:cerebrospinal fluid barriers","volume":"554","author":"Dratman","year":"1991","journal-title":"Brain Res"},{"issue":"3","key":"2025060301514303700_bqaf085-B58","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1210\/en.2015-1910","article-title":"The type 3 deiodinase is a critical determinant of appropriate thyroid hormone action in the developing testis","volume":"157","author":"Martinez","year":"2016","journal-title":"Endocrinology"},{"issue":"1","key":"2025060301514303700_bqaf085-B59","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/gbb.12400","article-title":"Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems","volume":"17","author":"Stohn","year":"2018","journal-title":"Genes Brain Behav"},{"issue":"2","key":"2025060301514303700_bqaf085-B60","first-page":"423","article-title":"Vasopressin and oxytocin release and the thyroid function","volume":"55","author":"Ciosek","year":"2004","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"2025060301514303700_bqaf085-B61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2826.1999.00250.x","article-title":"Thyroid hormones and estrogen affect oxytocin gene expression in hypothalamic neurons","volume":"11","author":"Dellovade","year":"1999","journal-title":"J Neuroendocrinol"},{"key":"2025060301514303700_bqaf085-B62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2017.01.018","article-title":"Hypothalamic effects of thyroid hormone","volume":"458","author":"Zhang","year":"2017","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"2025060301514303700_bqaf085-B63","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physrev.00030.2013","article-title":"Thyroid hormone regulation of metabolism","volume":"94","author":"Mullur","year":"2014","journal-title":"Physiol Rev"},{"issue":"2","key":"2025060301514303700_bqaf085-B64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-510X(94)00229-H","article-title":"Effect of thyroxine on the development of somatosensory and visual evoked potentials in the rat","volume":"128","author":"Freeman","year":"1995","journal-title":"J Neurol Sci"},{"issue":"3","key":"2025060301514303700_bqaf085-B65","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/jcem-37-3-415","article-title":"Transport of thyroid hormones in serum and cerebrospinal fluid","volume":"37","author":"Hagen","year":"1973","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqaf085\/63031304\/bqaf085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/166\/7\/bqaf085\/63031304\/bqaf085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/166\/7\/bqaf085\/63031304\/bqaf085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T05:52:02Z","timestamp":1748929922000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqaf085\/8122498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,5,19]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqaf085","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,4,30]]},"article-number":"bqaf085"}}