{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:46:19Z","timestamp":1788921979774,"version":"build-2803163510"},"reference-count":80,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK056350"],"award-info":[{"award-number":["P30DK056350"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK056350"],"award-info":[{"award-number":["P30DK056350"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017553","name":"Nutrition Obesity Research Center","doi-asserted-by":"publisher","award":["R00-DK129705"],"award-info":[{"award-number":["R00-DK129705"]}],"id":[{"id":"10.13039\/100017553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES010126"],"award-info":[{"award-number":["P30ES010126"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35ES030443"],"award-info":[{"award-number":["R35ES030443"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42ES004699"],"award-info":[{"award-number":["P42ES004699"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D insufficiency (VDI) is primarily determined by serum levels of calcidiol, which serves as a biomarker for the less abundant but most potent bioactive metabolite, calcitriol. However, population studies often show discordance between calcidiol and calcitriol. Here, a genetically diverse population of 7 inbred mouse strains was used to investigate the role of interindividual genetic differences in driving calcidiol-to-calcitriol discordance under vitamin D sufficient (VDS) vs depleted (VDD) conditions. We found high interstrain variability in calcitriol that was discordant with calcidiol under VDS and VDD conditions. However, under VDS conditions, stratification by calcitriol level revealed that strains with serum calcitriol &amp;gt;60\u2005pM (HighC) exhibited the expected positive calcidiol-to-calcitriol association, whereas strains with low calcitriol (&amp;lt;60\u2005pM, LowC) did not. Thus, discordance under VDS was driven by genetically divergent strains with LowC. Discordance under VDD was not associated with LowC. LowC was not caused by increased calcitriol degradation or by transcriptional dysregulation of canonical vitamin D metabolism enzymes. Instead, LowC strains exhibited low renal expression of Lrp2 (megalin), the primary transporter required for renal calcitriol production. LowC strains also exhibited reduced renal expression of the vitamin D receptor (Vdr) and several target genes, demonstrating impaired vitamin D signaling. These findings reveal novel, naturally occurring genetic determinants of VDI that function by disrupting calcitriol production and signaling in a manner that cannot be predicted by calcidiol levels. Cross-species conservation of this phenomenon would have important implications for clinical management of VDI and related disease risks across genetically diverse populations.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf138","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T08:28:21Z","timestamp":1756542501000},"source":"Crossref","is-referenced-by-count":2,"title":["Interindividual Genetic Differences Drive Discordance Between Serum Calcidiol and Calcitriol Concentrations in Females"],"prefix":"10.1210","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9503-9046","authenticated-orcid":false,"given":"Elizabeth K","family":"Hutchins","sequence":"first","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3702-0118","authenticated-orcid":false,"given":"Changran","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Entomology & Nematology, University of California , Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-1159","authenticated-orcid":false,"given":"Carolina V","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"},{"name":"Department of Translational Medicine, State University of Campinas , S\u00e3o Paulo 13083-887 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"},{"name":"Department of Nutrition, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-6036","authenticated-orcid":false,"given":"Megan M","family":"Knuth","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Whalen","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8704-4529","authenticated-orcid":false,"given":"Venkata S","family":"Voruganti","sequence":"additional","affiliation":[{"name":"Department of Nutrition, University of North Carolina , Chapel Hill, NC 27599, USA"},{"name":"Nutrition Research Institute, University of North Carolina , Kannapolis, NC 28081, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-7685","authenticated-orcid":false,"given":"Rafiou","family":"Agoro","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory , Bar Harbor, ME 04609 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-9517","authenticated-orcid":false,"given":"James C","family":"Fleet","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Texas at Austin , Austin, TX 78712, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-8317","authenticated-orcid":false,"given":"Bruce D","family":"Hammock","sequence":"additional","affiliation":[{"name":"Department of Entomology & Nematology, University of California , Davis, CA 95616, USA"},{"name":"UCD Comprehensive Cancer Center, University of California , Davis, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-2615","authenticated-orcid":false,"given":"Folami","family":"Ideraabdullah","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina , Chapel Hill, NC 27599, USA"},{"name":"Department of Nutrition, University of North Carolina , Chapel Hill, NC 27599, USA"},{"name":"Nutrition Research Institute, University of North Carolina , Kannapolis, NC 28081, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, NC 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