{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:17:13Z","timestamp":1791933433575,"version":"4.3.4"},"reference-count":75,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162343"],"award-info":[{"award-number":["PJT-162343"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-191766"],"award-info":[{"award-number":["PJT-191766"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2023-04812"],"award-info":[{"award-number":["RGPIN-2023-04812"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Fonds de Recherche du Qu\u00e9bec\u2013Nature et technologies, Doctoral Scholarship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"The Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["BIDEB-2219"],"award-info":[{"award-number":["BIDEB-2219"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Follicle-stimulating hormone (FSH) is an essential regulator of ovarian function. Inhibins are transforming growth factor \u03b2 (TGF\u03b2) family ligands produced in the gonads that suppress FSH synthesis by pituitary gonadotrope cells. Inhibins require a coreceptor, betaglycan or TGFBR3L, to mediate their actions. Female mice with a gonadotrope-specific knockout (KO) of betaglycan or global deletion of Tgfbr3l have increased FSH activity or levels and produce larger litters compared to controls. Females with both coreceptors knocked out (hereafter dKO) have dramatically increased circulating FSH, ovulate about 4 times as many eggs in natural cycles as controls but are infertile. Here, we show that dKO females show an increased number of implanted embryos at 7.5 days post coitum (dpc) but that their pregnancies fail around mid-gestation. Wild-type surrogates give birth to live young following transplantation of embryos from control or dKO females. Conversely, control but not dKO females can carry wild-type embryos to term, suggesting that the maternal environment in dKO mice cannot support full-term pregnancies. Elevated estradiol (E2) levels are deleterious to pregnancy in mice, and we detected increased E2 production in ovaries of pregnant dKOs. Treatment of these animals with aromatase inhibitors or a selective estrogen receptor degrader increased fetal survival. The results indicate that loss of inhibin action in murine gonadotropes results in excess E2 during pregnancy that precludes successful pregnancy.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf142","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:43:06Z","timestamp":1758696186000},"source":"Crossref","is-referenced-by-count":4,"title":["Loss of Inhibin Negative Feedback to Pituitary Gonadotropes Leads to Enhanced Ovulation but Pregnancy Failure in Mice"],"prefix":"10.1210","volume":"166","author":[{"given":"Yeu-Farn","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6149-6861","authenticated-orcid":false,"given":"Emilie","family":"Br\u00fbl\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5449-2894","authenticated-orcid":false,"given":"Luisina","family":"Ongaro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Cowan","sequence":"additional","affiliation":[{"name":"McGill Integrated Core for Animal Modeling (MICAM), McGill University , Montr\u00e9al, QC H3A 1A3 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Stouffer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6815-6181","authenticated-orcid":false,"given":"Richard J","family":"Auchus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]},{"name":"Department of Pharmacology, University of Michigan , Ann Arbor, MI 48109 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-6907","authenticated-orcid":false,"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine , Homburg 66421 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-5586","authenticated-orcid":false,"given":"Daniel J","family":"Bernard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]},{"name":"Department of Anatomy and Cell Biology, McGill University , Montr\u00e9al, QC H3G 1Y6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"issue":"6","key":"2025093009014899600_bqaf142-B1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/er.2009-0012","article-title":"The mammalian ovary from genesis to revelation","volume":"30","author":"Edson","year":"2009","journal-title":"Endocr Rev"},{"issue":"4","key":"2025093009014899600_bqaf142-B2","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/endo.137.4.8625923","article-title":"Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival 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