{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:51:23Z","timestamp":1792637483192,"version":"4.5.0"},"reference-count":94,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL171494"],"award-info":[{"award-number":["R01HL171494"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL144847"],"award-info":[{"award-number":["R01HL144847"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151407"],"award-info":[{"award-number":["R01HL151407"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P50MD017338"],"award-info":[{"award-number":["P50MD017338"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24PRE1198302"],"award-info":[{"award-number":["24PRE1198302"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development Award","award":["25CDA1451435"],"award-info":[{"award-number":["25CDA1451435"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS) is associated with a high prevalence of insulin resistance (IR) and obesity. Adiponectin, an insulin-sensitizing hormone, is reduced in PCOS and inversely correlated with IR and obesity. This study tested whether androgens reduce adiponectin, and if the adiponectin receptor agonist AdipoRon improves IR and obesity in a PCOS model.<\/jats:p>\n                  <jats:p>Four-week-old female Sprague Dawley rats were implanted with dihydrotestosterone (DHT) or control Silastic tubes for 12 weeks. After 6 weeks of DHT treatment, rats received AdipoRon or vehicle in their food for 6 weeks.<\/jats:p>\n                  <jats:p>DHT increased body weight, fat and lean mass, food intake, serum leptin, adipose mitochondrial oxidative stress, inflammatory markers, HOMA-IR, adipocyte size, and decreased serum adiponectin levels. DHT upregulated GLUT4, PPAR\u03b3, and adiponectin mRNA expression in subcutaneous adipose tissue (SAT), while PPAR\u03b3 was downregulated in visceral adipose tissue (VAT). DHT also reduced Akt protein expression in SAT and p(S473)-Akt phosphorylation in VAT and caused a depot-specific effect on androgen receptor expression. AdipoRon reduced body weight, fat, and lean mass, food intake, serum leptin, adipocyte size, and IR markers in DHT-treated rats. AdipoRon upregulated Akt, AMPK, and AdipoR1 mRNA expression in SAT and increased p(S473)-Akt phosphorylation in both white adipose tissue (WAT) depots. AdipoRon also reduced mitochondrial oxidative stress in both WAT depots and decreased androgen receptor expression in VAT.<\/jats:p>\n                  <jats:p>AdipoRon attenuates hyperandrogenemia-induced adiposity and IR in a PCOS model by improving adipose insulin and adiponectin signaling, reducing mitochondrial oxidative stress and food intake, supporting its therapeutic potential in managing IR and obesity in PCOS women.<\/jats:p>","DOI":"10.1210\/endocr\/bqaf173","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:51:57Z","timestamp":1764075117000},"source":"Crossref","is-referenced-by-count":6,"title":["Adiponectin Receptor Agonist AdipoRon Ameliorates the Metabolic Complications in a Hyperandrogenic Rat Model of PCOS"],"prefix":"10.1210","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-026X","authenticated-orcid":false,"given":"Ahmed M","family":"Abdelhameed","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3664-7984","authenticated-orcid":false,"given":"Manar A","family":"Eissa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-8241","authenticated-orcid":false,"given":"Kristin S","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0624-9686","authenticated-orcid":false,"given":"Ngoc H","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-0686","authenticated-orcid":false,"given":"Samar","family":"Rezq","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-6499","authenticated-orcid":false,"given":"Denise C","family":"Cornelius","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Department of Emergency Medicine, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-9690","authenticated-orcid":false,"given":"Damian G","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-1871","authenticated-orcid":false,"given":"Licy L","family":"Yanes Cardozo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Women's Health Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Cardiovascular-Renal Research Center, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]},{"name":"Department of Medicine, University of Mississippi Medical Center , Jackson, MS 39216 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"4","key":"2025120903312225400_bqaf173-B1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.fertnstert.2023.07.025","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"120","author":"Teede","year":"2023","journal-title":"Fertil Steril"},{"issue":"5","key":"2025120903312225400_bqaf173-B2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"issue":"4","key":"2025120903312225400_bqaf173-B3","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/jc.2005-2430","article-title":"Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome","volume":"91","author":"Lo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025120903312225400_bqaf173-B4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/humrep\/16.3.556","article-title":"Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population","volume":"16","author":"Elting","year":"2001","journal-title":"Hum Reprod"},{"issue":"1","key":"2025120903312225400_bqaf173-B5","first-page":"719050","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","volume":"2014","author":"Rojas","year":"2014","journal-title":"Int J Reprod Med"},{"issue":"1","key":"2025120903312225400_bqaf173-B6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Clinical practice. Polycystic ovary syndrome","volume":"375","author":"McCartney","year":"2016","journal-title":"N Engl J Med"},{"issue":"6","key":"2025120903312225400_bqaf173-B7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/cen.13968","article-title":"Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study","volume":"90","author":"Javed","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2025120903312225400_bqaf173-B8","doi-asserted-by":"crossref","first-page":"e16541","DOI":"10.2196\/16541","article-title":"Measures of patient dissatisfaction with health care in polycystic ovary syndrome: retrospective analysis","volume":"22","author":"Hoyos","year":"2020","journal-title":"J Med Internet Res"},{"issue":"11","key":"2025120903312225400_bqaf173-B9","doi-asserted-by":"crossref","first-page":"e21945","DOI":"10.1096\/fj.202002526RR","article-title":"Management of cardiometabolic complications in polycystic ovary syndrome: unmet needs","volume":"35","author":"Yanes Cardozo","year":"2021","journal-title":"FASEB J"},{"issue":"1","key":"2025120903312225400_bqaf173-B10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"issue":"1","key":"2025120903312225400_bqaf173-B11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ejendo\/lvad077","article-title":"Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria-a prospective population-based cohort study","volume":"189","author":"Ollila","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"2025120903312225400_bqaf173-B12","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/nu16071049","article-title":"Food cravings and obesity in women with polycystic ovary syndrome: pathophysiological and therapeutic considerations","volume":"16","author":"Stefanaki","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"2025120903312225400_bqaf173-B13","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis*","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"issue":"1","key":"2025120903312225400_bqaf173-B14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/advances\/nmaa092","article-title":"Effects of dietary glycemic Index and glycemic load on cardiometabolic and reproductive profiles in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Kazemi","year":"2021","journal-title":"Adv Nutr"},{"issue":"24","key":"2025120903312225400_bqaf173-B15","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.3390\/ijms21249554","article-title":"Pharmacological approaches to controlling cardiometabolic risk in women with PCOS","volume":"21","author":"Cignarella","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2025120903312225400_bqaf173-B16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4239\/wjd.v3.i4.71","article-title":"Defining the role of bariatric surgery in polycystic ovarian syndrome patients","volume":"3","author":"Malik","year":"2012","journal-title":"World J Diabetes"},{"issue":"2","key":"2025120903312225400_bqaf173-B17","first-page":"375","article-title":"Worldwide dissatisfaction with the diagnostic process and initial treatment of PCOS","volume":"102","author":"Cree-Green","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025120903312225400_bqaf173-B18","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2337\/db06-0263","article-title":"Adipose tissue: from lipid storage compartment to endocrine organ","volume":"55","author":"Scherer","year":"2006","journal-title":"Diabetes"},{"key":"2025120903312225400_bqaf173-B19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2025120903312225400_bqaf173-B20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1210\/edrv.21.6.0415","article-title":"Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome","volume":"21","author":"Wajchenberg","year":"2000","journal-title":"Endocr Rev"},{"issue":"1","key":"2025120903312225400_bqaf173-B21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Obes Rev"},{"issue":"10","key":"2025120903312225400_bqaf173-B22","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1471-0528.2006.01004.x","article-title":"Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue","volume":"113","author":"Cancello","year":"2006","journal-title":"BJOG"},{"issue":"1","key":"2025120903312225400_bqaf173-B23","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1210\/jc.2012-2953","article-title":"Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots","volume":"98","author":"Karastergiou","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025120903312225400_bqaf173-B24","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ijo.2009.286","article-title":"Gluteofemoral body fat as a determinant of metabolic health","volume":"34","author":"Manolopoulos","year":"2010","journal-title":"Int J Obes"},{"issue":"3","key":"2025120903312225400_bqaf173-B25","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"issue":"12","key":"2025120903312225400_bqaf173-B26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMra1011035","article-title":"Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease","volume":"371","author":"Shulman","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"2025120903312225400_bqaf173-B27","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1210\/jc.2017-00047","article-title":"How to measure adipose tissue insulin sensitivity","volume":"102","author":"S\u00f8ndergaard","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025120903312225400_bqaf173-B28","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1210\/jc.2006-1055","article-title":"Relationship between adipocyte size and adipokine expression and secretion","volume":"92","author":"Skurk","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2025120903312225400_bqaf173-B29","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.34067\/KID.0002052022","article-title":"Polycystic ovary syndrome: insights from preclinical research","volume":"3","author":"Reckelhoff","year":"2022","journal-title":"Kidney360"},{"issue":"2","key":"2025120903312225400_bqaf173-B30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.genm.2010.11.013","article-title":"Cardiovascular-renal and metabolic characterization of a rat model of polycystic ovary syndrome","volume":"8","author":"Yanes","year":"2011","journal-title":"Gend Med"},{"issue":"7","key":"2025120903312225400_bqaf173-B31","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1210\/en.2015-1617","article-title":"Cardiometabolic effects of chronic hyperandrogenemia in a new model of postmenopausal polycystic ovary syndrome","volume":"157","author":"Dalmasso","year":"2016","journal-title":"Endocrinology"},{"issue":"8","key":"2025120903312225400_bqaf173-B32","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1210\/js.2018-00131","article-title":"Long-lasting androgen-induced cardiometabolic effects in polycystic ovary syndrome","volume":"2","author":"Torres Fernandez","year":"2018","journal-title":"J Endocr Soc"},{"issue":"5","key":"2025120903312225400_bqaf173-B33","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.3390\/ijms22052576","article-title":"Impact of SGLT-2 Inhibition on cardiometabolic abnormalities in a rat model of polycystic ovary syndrome","volume":"22","author":"Pruett","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"45","key":"2025120903312225400_bqaf173-B34","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J Biol Chem"},{"issue":"8","key":"2025120903312225400_bqaf173-B35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat Med"},{"issue":"7","key":"2025120903312225400_bqaf173-B36","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm724","article-title":"Diet-induced insulin resistance in mice lacking adiponectin\/ACRP30","volume":"8","author":"Maeda","year":"2002","journal-title":"Nat Med"},{"issue":"11","key":"2025120903312225400_bqaf173-B37","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/nm788","article-title":"Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase","volume":"8","author":"Yamauchi","year":"2002","journal-title":"Nat Med"},{"issue":"6941","key":"2025120903312225400_bqaf173-B38","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nature01705","article-title":"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects","volume":"423","author":"Yamauchi","year":"2003","journal-title":"Nature"},{"issue":"9","key":"2025120903312225400_bqaf173-B39","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.2337\/db05-1322","article-title":"Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha","volume":"55","author":"Yoon","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"2025120903312225400_bqaf173-B40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endrev\/bnae021","article-title":"Adiponectin and adiponectin receptors in atherosclerosis","volume":"46","author":"Gianopoulos","year":"2024","journal-title":"Endocr Rev"},{"issue":"2","key":"2025120903312225400_bqaf173-B41","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1210\/jc.2010-1290","article-title":"Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance","volume":"96","author":"Manner\u00e5s-Holm","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"9353","key":"2025120903312225400_bqaf173-B42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(03)12255-6","article-title":"Adiponectin and protection against type 2 diabetes mellitus","volume":"361","author":"Spranger","year":"2003","journal-title":"Lancet"},{"issue":"9","key":"2025120903312225400_bqaf173-B43","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1172\/JCI31021","article-title":"Obesity-associated improvements in metabolic profile through expansion of adipose tissue","volume":"117","author":"Kim","year":"2007","journal-title":"J Clin Invest"},{"issue":"7477","key":"2025120903312225400_bqaf173-B44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","article-title":"A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity","volume":"503","author":"Okada-Iwabu","year":"2013","journal-title":"Nature"},{"issue":"12","key":"2025120903312225400_bqaf173-B45","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1210\/en.2019-00450","article-title":"Effect of GLP-1 receptor agonists in the cardiometabolic complications in a rat model of postmenopausal PCOS","volume":"160","author":"Torres Fernandez","year":"2019","journal-title":"Endocrinology"},{"issue":"4","key":"2025120903312225400_bqaf173-B46","doi-asserted-by":"crossref","first-page":"e518","DOI":"10.1016\/j.jacl.2024.04.130","article-title":"The triglyceride-glucose index is superior to homeostasis model assessment of insulin resistance in predicting metabolic syndrome in an adult population in the United States","volume":"18","author":"Adams-Huet","year":"2024","journal-title":"J Clin Lipidol"},{"key":"2025120903312225400_bqaf173-B47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/B978-0-12-411619-1.00006-9","article-title":"Quantifying size and number of adipocytes in adipose tissue","volume":"537","author":"Parlee","year":"2014","journal-title":"Methods Enzymol"},{"issue":"12","key":"2025120903312225400_bqaf173-B48","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1194\/jlr.D023788","article-title":"Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections","volume":"53","author":"Galarraga","year":"2012","journal-title":"J Lipid Res"},{"issue":"1","key":"2025120903312225400_bqaf173-B49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13293-022-00455-x","article-title":"Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition","volume":"13","author":"Pruett","year":"2022","journal-title":"Biol Sex Differ"},{"key":"2025120903312225400_bqaf173-B50","doi-asserted-by":"crossref","unstructured":"Abdelhameed AM, Eissa MA, Thompson K, et al \u00a0Supplemental material for \u201cAdiponectin Receptor Agonist AdipoRon Ameliorates the Metabolic Complications in a Hyperandrogenic Rat Model of PCOS\u201d. Figshare. 2025. 10.6084\/m9.figshare.30531563","DOI":"10.1210\/endocr\/bqaf173"},{"key":"2025120903312225400_bqaf173-B51","doi-asserted-by":"crossref","first-page":"1341742","DOI":"10.3389\/fphys.2024.1341742","article-title":"Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced rat model of inflammatory bowel disease","volume":"15","author":"Hoang","year":"2024","journal-title":"Front Physiol"},{"issue":"6","key":"2025120903312225400_bqaf173-B52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00395-018-0707-9","article-title":"Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia\/reperfusion","volume":"113","author":"Edwards","year":"2018","journal-title":"Basic Res Cardiol"},{"issue":"46","key":"2025120903312225400_bqaf173-B53","doi-asserted-by":"crossref","first-page":"17669","DOI":"10.1074\/jbc.RA119.010317","article-title":"Hypoxia-inducible gene domain 1 proteins in yeast mitochondria protect against proton leak through complex IV","volume":"294","author":"Hoang","year":"2019","journal-title":"J Biol Chem"},{"key":"2025120903312225400_bqaf173-B54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"Pesta","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"2","key":"2025120903312225400_bqaf173-B55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem J"},{"issue":"8","key":"2025120903312225400_bqaf173-B56","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/en.2007-0168","article-title":"A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome","volume":"148","author":"Manner\u00e5s","year":"2007","journal-title":"Endocrinology"},{"issue":"6","key":"2025120903312225400_bqaf173-B57","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev"},{"issue":"1","key":"2025120903312225400_bqaf173-B58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1210\/clinem\/dgad356","article-title":"Adipose tissue dysfunction in polycystic ovary syndrome","volume":"109","author":"Bril","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025120903312225400_bqaf173-B59","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/humupd\/dmp006","article-title":"Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis","volume":"15","author":"Toulis","year":"2009","journal-title":"Hum Reprod Update"},{"key":"2025120903312225400_bqaf173-B60","doi-asserted-by":"crossref","first-page":"845165","DOI":"10.3389\/fendo.2022.845165","article-title":"Elevated serum leptin levels as a predictive marker for polycystic ovary syndrome","volume":"13","author":"Peng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025120903312225400_bqaf173-B61","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsbmb.2014.04.008","article-title":"Understanding androgen action in adipose tissue","volume":"143","author":"O\u2019Reilly","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3-5","key":"2025120903312225400_bqaf173-B62","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jsbmb.2007.09.001","article-title":"Androgens and body fat distribution","volume":"108","author":"Blouin","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2025120903312225400_bqaf173-B63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.steroids.2017.12.009","article-title":"Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome","volume":"130","author":"Echibur\u00fa","year":"2018","journal-title":"Steroids"},{"issue":"11","key":"2025120903312225400_bqaf173-B64","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1210\/jc.2016-2586","article-title":"Hyperandrogenism accompanies increased intra-abdominal fat storage in normal weight polycystic ovary syndrome women","volume":"101","author":"Dumesic","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025120903312225400_bqaf173-B65","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1210\/en.2011-1754","article-title":"Reproductive and metabolic phenotype of a mouse model of PCOS","volume":"153","author":"van Houten","year":"2012","journal-title":"Endocrinology"},{"issue":"34","key":"2025120903312225400_bqaf173-B66","doi-asserted-by":"crossref","first-page":"E7187","DOI":"10.1073\/pnas.1708854114","article-title":"Adiponectin protects against development of metabolic disturbances in a PCOS mouse model","volume":"114","author":"Benrick","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"10","key":"2025120903312225400_bqaf173-B67","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1159\/000521236","article-title":"Androgen excess increases food intake in a rat polycystic ovary syndrome model by downregulating hypothalamus insulin and leptin signaling pathways preceding weight gain","volume":"112","author":"Liu","year":"2022","journal-title":"Neuroendocrinology"},{"issue":"1","key":"2025120903312225400_bqaf173-B68","first-page":"e240401","article-title":"Serum adiponectin level is negatively related to insulin resistance in women with polycystic ovary syndrome","volume":"14","author":"Yang","year":"2025","journal-title":"Endocr Connect"},{"issue":"1","key":"2025120903312225400_bqaf173-B69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1099800410371824","article-title":"Adiponectin and polycystic ovary syndrome","volume":"12","author":"Groth","year":"2010","journal-title":"Biol Res Nurs"},{"issue":"1","key":"2025120903312225400_bqaf173-B70","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/humrep\/deh014","article-title":"Reply: adiponectin levels in women with polycystic ovary syndrome reflect increased adiposity rather than insulin resistance","volume":"19","author":"Panidis","year":"2004","journal-title":"Hum Reprod"},{"issue":"1","key":"2025120903312225400_bqaf173-B71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s42003-020-01579-9","article-title":"Adipor agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice","volume":"4","author":"Iwabu","year":"2021","journal-title":"Commun Biol"},{"issue":"7121","key":"2025120903312225400_bqaf173-B72","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"issue":"7","key":"2025120903312225400_bqaf173-B73","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J Clin Invest"},{"issue":"1","key":"2025120903312225400_bqaf173-B74","doi-asserted-by":"crossref","first-page":"4092470","DOI":"10.1155\/2020\/4092470","article-title":"Inflammatory markers in women with polycystic ovary syndrome","volume":"2020","author":"Rudnicka","year":"2020","journal-title":"Biomed Res Int"},{"key":"2025120903312225400_bqaf173-B75","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejogrb.2015.06.022","article-title":"Obesity and inflammatory biomarkers in women with polycystic ovary syndrome","volume":"192","author":"Shen","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2025120903312225400_bqaf173-B76","doi-asserted-by":"crossref","first-page":"103628","DOI":"10.1016\/j.jri.2022.103628","article-title":"Systemic and ovarian inflammation in women with polycystic ovary syndrome","volume":"151","author":"Zhai","year":"2022","journal-title":"J Reprod Immunol"},{"issue":"10","key":"2025120903312225400_bqaf173-B77","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.3390\/ijms24108566","article-title":"Anti-inflammatory effects of adiponectin receptor agonist AdipoRon against intervertebral disc degeneration","volume":"24","author":"Ohnishi","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2025120903312225400_bqaf173-B78","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/JME-21-0177","article-title":"The mitochondrial profile in women with polycystic ovary syndrome: impact of exercise","volume":"68","author":"Malamouli","year":"2022","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"2025120903312225400_bqaf173-B79","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12958-019-0509-4","article-title":"Polycystic ovary syndrome and mitochondrial dysfunction","volume":"17","author":"Zhang","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"2025120903312225400_bqaf173-B80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"2025120903312225400_bqaf173-B81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1172\/JCI1244","article-title":"PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C\/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes","volume":"101","author":"Wu","year":"1998","journal-title":"J Clin Invest"},{"issue":"1","key":"2025120903312225400_bqaf173-B82","doi-asserted-by":"crossref","first-page":"818945","DOI":"10.1155\/2009\/818945","article-title":"Cross-talk between PPARgamma and insulin signaling and modulation of insulin sensitivity","volume":"2009","author":"Leonardini","year":"2009","journal-title":"PPAR Res"},{"issue":"3","key":"2025120903312225400_bqaf173-B83","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr Rev"},{"issue":"4","key":"2025120903312225400_bqaf173-B84","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2025120903312225400_bqaf173-B85","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.stemcr.2020.10.008","article-title":"Insulin promotes mitochondrial respiration and survival through PI3K\/AKT\/GSK3 pathway in human embryonic stem cells","volume":"15","author":"Ren","year":"2020","journal-title":"Stem Cell Reports"},{"issue":"2","key":"2025120903312225400_bqaf173-B86","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signalling pathways: insights into insulin action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2025120903312225400_bqaf173-B87","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tibs.2006.02.007","article-title":"Bridging the GAP between insulin signaling and GLUT4 translocation","volume":"31","author":"Watson","year":"2006","journal-title":"Trends Biochem Sci"},{"issue":"6","key":"2025120903312225400_bqaf173-B88","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/diabetes.52.6.1355","article-title":"Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes","volume":"52","author":"Wu","year":"2003","journal-title":"Diabetes"},{"issue":"5","key":"2025120903312225400_bqaf173-B89","doi-asserted-by":"crossref","first-page":"e250126","DOI":"10.1530\/REP-25-0126","article-title":"Polycystic ovary syndrome: origins and implications: genetics of polycystic ovary syndrome (PCOS)","volume":"170","author":"Louwers","year":"2025","journal-title":"Reproduction"},{"issue":"6","key":"2025120903312225400_bqaf173-B90","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2265.1992.tb02262.x","article-title":"Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance","volume":"36","author":"Robinson","year":"1992","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"2025120903312225400_bqaf173-B91","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1210\/clinem\/dgae462","article-title":"Increased prevalence of binge eating disorder and bulimia Nervosa in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"109","author":"Cooney","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025120903312225400_bqaf173-B92","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0002-9378(92)91671-V","article-title":"Phase II trial of ifosfamide and mesna in leiomyosarcoma of the uterus: a gynecologic oncology group study","volume":"166","author":"Sutton","year":"1992","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"2025120903312225400_bqaf173-B93","doi-asserted-by":"crossref","first-page":"bnaa010","DOI":"10.1210\/endrev\/bnaa010","article-title":"Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome","volume":"41","author":"Stener-Victorin","year":"2020","journal-title":"Endocr Rev"},{"key":"2025120903312225400_bqaf173-B94","unstructured":"Abdelhameed AM, Eissa MA, Thompson K, et al \u00a0Raw Data for \u201cAdiponectin Receptor Agonist AdipoRon Ameliorates the Metabolic Complications in a Hyperandrogenic Rat Model of PCOS\u201d. Figshare. 2025. 10.6084\/m9.figshare.30347617"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqaf173\/65533863\/bqaf173.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/1\/bqaf173\/65533863\/bqaf173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/1\/bqaf173\/65533863\/bqaf173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:32:00Z","timestamp":1765269120000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqaf173\/8342953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,5]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqaf173","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,11,26]]},"article-number":"bqaf173"}}