{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:16:45Z","timestamp":1790914605141,"version":"4.1.0"},"reference-count":57,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Lloyd Cox Obstetrics & Gynaecology Research Fund"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1117976"],"award-info":[{"award-number":["APP1117976"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1110562"],"award-info":[{"award-number":["APP1110562"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-024199"],"award-info":[{"award-number":["INV-024199"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Estrogen signaling plays an important role in normal ovarian functions, including follicle development, ovulation, and ovarian cell identity maintenance. Estrogen acts through the estrogen receptors alpha (ER\u03b1) and beta (ER\u03b2), both of which are involved in ovarian gene regulation. However, the molecular mechanisms that lead to shared and unique receptor actions in the ovary remain poorly understood. Additionally, coregulators that contribute to ER actions in the ovary have remained unexplored. Here, we distinguished the roles of ER\u03b1 and ER\u03b2 at different ovarian stages through characterizing the chromatin binding profile of each receptor in granulosa cells during pre- or peri-ovulation. We found that ER\u03b1\/\u03b2 genomic action was prominent during follicle development prior to ovulation. Loss of ER\u03b1\/\u03b2 binding after LH-stimulus was associated with the downregulation of folliculogenesis genes, while ER\u03b1\/\u03b2 binding contributed little to the activation of genes that are required for ovulation. ER\u03b1 and ER\u03b2 showed highly similar chromatin binding patterns in granulosa cells. Through motif enrichment analysis and integration of other ovarian transcription factor cistromes, we identified potential interactors of ER\u03b1 and ER\u03b2, including a very strong overlap in chromatin binding with androgen receptor (AR) in pre-ovulatory follicles. These findings demonstrate ER\u03b1 and ER\u03b2 to have highly conserved chromatin interaction functions including interaction with AR to mediate gene expression during folliculogenesis.<\/jats:p>","DOI":"10.1210\/endocr\/bqag052","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:06:07Z","timestamp":1777536367000},"source":"Crossref","is-referenced-by-count":3,"title":["Estrogen receptor alpha and beta chromatin interactions govern ovarian folliculogenesis but dissipate during ovulation"],"prefix":"10.1210","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-532X","authenticated-orcid":false,"given":"Doan T","family":"Dinh","sequence":"first","affiliation":[{"name":"Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, University of Adelaide , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R","family":"McPhee","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, University of Adelaide , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J","family":"Foot","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, University of Adelaide , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"Robker","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, University of Adelaide , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-7658","authenticated-orcid":false,"given":"Darryl L","family":"Russell","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, School of Biomedicine, Faculty of Health & Medical Sciences, University of Adelaide , Adelaide ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"issue":"4","key":"2026051905155736000_bqag052-B1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","article-title":"Estrogen receptor alpha and beta in health and disease","volume":"29","author":"Jia","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"2026051905155736000_bqag052-B2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.brainresrev.2007.05.013","article-title":"Estrogen receptor beta in the brain: from form to function","volume":"57","author":"Weiser","year":"2008","journal-title":"Brain Res Rev"},{"issue":"168","key":"2026051905155736000_bqag052-B3","doi-asserted-by":"crossref","first-page":"pe19","DOI":"10.1126\/scisignal.2001991","article-title":"Estrogen receptor \u03b2: switching to a new partner and escaping from estrogen","volume":"4","author":"Leung","year":"2011","journal-title":"Sci Signal"},{"issue":"3","key":"2026051905155736000_bqag052-B4","doi-asserted-by":"crossref","first-page":"e2662","DOI":"10.1038\/cddis.2017.82","article-title":"Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis"},{"issue":"19","key":"2026051905155736000_bqag052-B5","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1242\/dev.127.19.4277","article-title":"Effect of single and compound knockouts of estrogen receptors \u03b1 (ER\u03b1) and \u03b2 (ER\u03b2) on mouse reproductive phenotypes","volume":"127","author":"Dupont","year":"2000","journal-title":"Development"},{"issue":"5","key":"2026051905155736000_bqag052-B6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/bcr79","article-title":"Estrogen receptor transcription and transactivation: estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action","volume":"2","author":"Curtis Hewitt","year":"2000","journal-title":"Breast Cancer Res"},{"issue":"2","key":"2026051905155736000_bqag052-B7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1095\/biolreprod.113.113316","article-title":"The naturally occurring luteinizing hormone surge is diminished in mice lacking estrogen receptor Beta in the Ovary1","volume":"90","author":"Jayes","year":"2014","journal-title":"Biol Reprod"},{"issue":"6","key":"2026051905155736000_bqag052-B8","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1210\/en.2012-2256","article-title":"The absence of ER-\u03b2 results in altered gene expression in ovarian granulosa cells isolated from in vivo preovulatory follicles","volume":"154","author":"Binder","year":"2013","journal-title":"Endocrinology"},{"key":"2026051905155736000_bqag052-B9","doi-asserted-by":"crossref","first-page":"111212","DOI":"10.1016\/j.mce.2021.111212","article-title":"Granulosa cell genes that regulate ovarian follicle development beyond the antral stage: the role of estrogen receptor \u03b2","volume":"528","author":"Chakravarthi","year":"2021","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"2026051905155736000_bqag052-B10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl0788","article-title":"FOXL2 interaction with different binding partners regulates the dynamics of ovarian development","volume":"10","author":"Migale","year":"2024","journal-title":"Sci Adv"},{"issue":"1","key":"2026051905155736000_bqag052-B11","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1038\/s41467-022-32061-1","article-title":"TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway","volume":"13","author":"Rossitto","year":"2022","journal-title":"Nat Commun"},{"issue":"6","key":"2026051905155736000_bqag052-B12","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2009.11.021","article-title":"Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation","volume":"139","author":"Uhlenhaut","year":"2009","journal-title":"Cell"},{"issue":"9","key":"2026051905155736000_bqag052-B13","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1530\/ERC-21-0038","article-title":"Genome-wide crosstalk between steroid receptors in breast and prostate cancers","volume":"28","author":"Paakinaho","year":"2021","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"2026051905155736000_bqag052-B14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/CM9.0000000000002930","article-title":"Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer","volume":"137","author":"Xu","year":"2024","journal-title":"Chin Med J (Engl)"},{"issue":"18","key":"2026051905155736000_bqag052-B15","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1093\/nar\/gkae714","article-title":"Unexpected nuclear hormone receptor and chromatin dynamics regulate estrous cycle dependent gene expression","volume":"52","author":"Jefferson","year":"2024","journal-title":"Nucleic Acids Res"},{"issue":"1):","key":"2026051905155736000_bqag052-B16","first-page":"148","article-title":"Concentrations of sex steroids in fluid from human antral follicles are dynamic and characterize transition from follicular recruitment to dominance","volume":"125","author":"Johannsen","year":"2025","journal-title":"Fertil Steril"},{"key":"2026051905155736000_bqag052-B17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-031-11836-4_3","volume-title":"Nuclear Receptors in Human Health and Disease","author":"Dinh","year":"2022"},{"key":"2026051905155736000_bqag052-B18","doi-asserted-by":"crossref","unstructured":"Dinh DT, Robker RL, Russell DL. Data from: Estrogen Receptor Alpha and Beta Chromatin Interactions Govern Ovarian Folliculogenesis but Dissipate During Ovulation (supplementary information). Figshare 2026. Deposited 14 January 2026. 10.25909\/31071406.v1.","DOI":"10.1210\/endocr\/bqag052"},{"issue":"7","key":"2026051905155736000_bqag052-B19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"32","key":"2026051905155736000_bqag052-B20","doi-asserted-by":"crossref","first-page":"eadp3000","DOI":"10.1126\/sciadv.adp3000","article-title":"A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates","volume":"10","author":"Mukhopadhyay","year":"2024","journal-title":"Sci Adv"},{"issue":"4","key":"2026051905155736000_bqag052-B21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"9","key":"2026051905155736000_bqag052-B22","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol"},{"key":"2026051905155736000_bqag052-B23","author":"Stark"},{"issue":"14","key":"2026051905155736000_bqag052-B24","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"2026051905155736000_bqag052-B25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/1471-2105-11-237","article-title":"ChIPpeakAnno: a bioconductor package to annotate ChIP-seq and ChIP-chip data","volume":"11","author":"Zhu","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"2026051905155736000_bqag052-B26","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol Cell"},{"issue":"5","key":"2026051905155736000_bqag052-B27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"W1","key":"2026051905155736000_bqag052-B28","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2026051905155736000_bqag052-B29","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1093\/nar\/gkad271","article-title":"Progesterone receptor mediates ovulatory transcription through RUNX transcription factor interactions and chromatin remodelling","volume":"51","author":"Dinh","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2026051905155736000_bqag052-B30","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.celrep.2019.07.088","article-title":"The ovulatory signal precipitates LRH-1 transcriptional switching mediated by differential chromatin accessibility","volume":"28","author":"Bianco","year":"2019","journal-title":"Cell Rep"},{"key":"2026051905155736000_bqag052-B31","doi-asserted-by":"crossref","first-page":"930227","DOI":"10.3389\/fendo.2022.930227","article-title":"ER\u03b1 and ER\u03b2 homodimers in the same cellular context regulate distinct transcriptomes and functions","volume":"13","author":"Song","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2026051905155736000_bqag052-B32","doi-asserted-by":"crossref","first-page":"15840","DOI":"10.1038\/ncomms15840","article-title":"Insufficient antibody validation challenges oestrogen receptor beta research","volume":"8","author":"Andersson","year":"2017","journal-title":"Nat Commun"},{"issue":"6","key":"2026051905155736000_bqag052-B33","doi-asserted-by":"crossref","DOI":"10.1242\/dev.197459","article-title":"Blocking estrogen-induced AMH expression is crucial for normal follicle formation","volume":"148","author":"Tanimoto","year":"2021","journal-title":"Development"},{"issue":"1","key":"2026051905155736000_bqag052-B34","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqae157","article-title":"Postnatal ovarian transdifferentiation in the absence of estrogen receptor signaling is dependent on genetic background","volume":"166","author":"Binder","year":"2024","journal-title":"Endocrinology"},{"key":"2026051905155736000_bqag052-B35","doi-asserted-by":"crossref","first-page":"e04207","DOI":"10.7554\/eLife.04207","article-title":"The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells","volume":"3","author":"Georges","year":"2014","journal-title":"eLife"},{"issue":"4","key":"2026051905155736000_bqag052-B36","first-page":"306","article-title":"Transcriptomic profiling of the oocyte-cumulus-granulosa cell complex from estrogen receptor \u03b2 knockout mice","volume":"5","author":"T\u00f6h\u00f6nen","year":"2024","journal-title":"F S Sci"},{"issue":"6","key":"2026051905155736000_bqag052-B37","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/en.2004-1108","article-title":"In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER)\u03b1 and ER\u03b2 null mice indicate a role for ER\u03b2 in follicular maturation","volume":"146","author":"Emmen","year":"2005","journal-title":"Endocrinology"},{"issue":"7","key":"2026051905155736000_bqag052-B38","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.0712085105","article-title":"The genome landscape of ER\u03b1- and ER\u03b2-binding DNA regions","volume":"105","author":"Liu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2026051905155736000_bqag052-B39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2164-12-36","article-title":"Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation","volume":"12","author":"Grober","year":"2011","journal-title":"BMC Genomics"},{"issue":"27","key":"2026051905155736000_bqag052-B40","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.2364-19.2020","article-title":"Estrogen receptor \u03b1 regulates ethanol excitation of ventral tegmental area neurons and binge drinking in female mice","volume":"40","author":"Vandegrift","year":"2020","journal-title":"J Neurosci"},{"issue":"12","key":"2026051905155736000_bqag052-B41","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1210\/me.2011-1145","article-title":"In vitro and in vivo molecular imaging of estrogen receptor \u03b1 and \u03b2 homo- and heterodimerization: exploration of new modes of receptor regulation","volume":"25","author":"Paulmurugan","year":"2011","journal-title":"Molecular Endocrinology"},{"issue":"1","key":"2026051905155736000_bqag052-B42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12915-023-01773-1","article-title":"Ovarian ER\u03b2 cistrome and transcriptome reveal chromatin interaction with LRH-1","volume":"21","author":"Birgersson","year":"2023","journal-title":"BMC Biol"},{"issue":"6","key":"2026051905155736000_bqag052-B43","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1095\/biolreprod.108.069435","article-title":"Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian Granulosa Cells1","volume":"79","author":"Pelusi","year":"2008","journal-title":"Biol Reprod"},{"issue":"4","key":"2026051905155736000_bqag052-B44","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1530\/REP-14-0517","article-title":"Role of androgens in normal and pathological ovarian function","volume":"149","author":"Walters","year":"2015","journal-title":"Reproduction"},{"issue":"5","key":"2026051905155736000_bqag052-B45","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00432-019-02872-9","article-title":"Estrogen receptor beta increases sensitivity to enzalutamide in androgen receptor-positive triple-negative breast cancer","volume":"145","author":"Anestis","year":"2019","journal-title":"J Cancer Res Clin Oncol"},{"issue":"2","key":"2026051905155736000_bqag052-B46","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41591-020-01168-7","article-title":"The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer","volume":"27","author":"Hickey","year":"2021","journal-title":"Nat Med"},{"issue":"3","key":"2026051905155736000_bqag052-B47","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1470-2045(24)00004-4","article-title":"Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial","volume":"25","author":"Palmieri","year":"2024","journal-title":"Lancet Oncol"},{"issue":"3","key":"2026051905155736000_bqag052-B48","doi-asserted-by":"crossref","first-page":"e1009483","DOI":"10.1371\/journal.pgen.1009483","article-title":"Androgens regulate ovarian gene expression by balancing Ezh2-Jmjd3 mediated H3K27me3 dynamics","volume":"17","author":"Roy","year":"2021","journal-title":"PLoS Genet"},{"issue":"2","key":"2026051905155736000_bqag052-B49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/me.2009-0429","article-title":"Long-range transcriptional control of progesterone receptor gene expression","volume":"24","author":"Bone\u0301y-Montoya","year":"2010","journal-title":"Molecular Endocrinology"},{"issue":"7560","key":"2026051905155736000_bqag052-B50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature14583","article-title":"Progesterone receptor modulates ER\u03b1 action in breast cancer","volume":"523","author":"Mohammed","year":"2015","journal-title":"Nature"},{"issue":"6","key":"2026051905155736000_bqag052-B51","doi-asserted-by":"crossref","first-page":"e1501924","DOI":"10.1126\/sciadv.1501924","article-title":"Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer","volume":"2","author":"Singhal","year":"2016","journal-title":"Sci Adv"},{"issue":"1","key":"2026051905155736000_bqag052-B52","doi-asserted-by":"crossref","first-page":"11966","DOI":"10.1038\/s41598-019-48333-8","article-title":"Tissue-specific progesterone receptor-chromatin binding and the regulation of progesterone-dependent gene expression","volume":"9","author":"Dinh","year":"2019","journal-title":"Sci Rep"},{"issue":"16","key":"2026051905155736000_bqag052-B53","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1158\/0008-5472.CAN-13-0742","article-title":"Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level","volume":"73","author":"Miranda","year":"2013","journal-title":"Cancer Res"},{"issue":"7","key":"2026051905155736000_bqag052-B54","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1093\/nar\/gkt100","article-title":"Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses","volume":"41","author":"Bolt","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"33","key":"2026051905155736000_bqag052-B55","doi-asserted-by":"crossref","first-page":"24020","DOI":"10.1074\/jbc.M113.473819","article-title":"Interaction of glucocorticoid receptor (GR) with estrogen receptor (ER) \u03b1 and activator protein 1 (AP1) in dexamethasone-mediated interference of ER\u03b1 activity *","volume":"288","author":"Karmakar","year":"2013","journal-title":"J Biol Chem"},{"issue":"1","key":"2026051905155736000_bqag052-B56","doi-asserted-by":"crossref","first-page":"46222","DOI":"10.1038\/srep46222","article-title":"A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty","volume":"7","author":"Fran\u00e7ois","year":"2017","journal-title":"Sci Rep"},{"issue":"8","key":"2026051905155736000_bqag052-B57","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1210\/en.2005-0213","article-title":"Estrogen receptor-\u03b2 is critical to Granulosa cell differentiation and the ovulatory response to gonadotropins","volume":"146","author":"Couse","year":"2005","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqag052\/68191231\/bqag052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/6\/bqag052\/68191231\/bqag052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/6\/bqag052\/68191231\/bqag052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:16:10Z","timestamp":1779182170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqag052\/8665306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,5,6]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqag052","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,4,30]]},"article-number":"bqag052"}}