{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:33:28Z","timestamp":1790984008432,"version":"4.1.0"},"reference-count":56,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["23H02362"],"award-info":[{"award-number":["23H02362"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["26K01882"],"award-info":[{"award-number":["26K01882"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["24K01905"],"award-info":[{"award-number":["24K01905"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"publisher","award":["21H05031"],"award-info":[{"award-number":["21H05031"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004823","name":"Nagoya University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFS2120"],"award-info":[{"award-number":["JPMJFS2120"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory diseases often suppress reproductive function in mammals. This study investigated whether central fractalkine\u2013CX3CR1 signaling mediates the inhibition of luteinizing hormone (LH) release induced by intravenous administration of lipopolysaccharide (LPS), an endotoxin, in ovariectomized rats treated with diestrous levels of estradiol-17\u03b2 (E2). Double in situ hybridization (ISH) for the fractalkine gene (Cx3cl1) and fos (a cellular activation marker) revealed that LPS significantly increased the percentage of fos-positive Cx3cl1-expressing cells in the lateral mammillary nucleus (LM) and the number of Cx3cl1-expressing cells in the paraventricular nucleus (PVN). Central administration of AZD8797, an CX3CR1 antagonist significantly restored LPS-induced decreases in the mean LH concentrations and the amplitude and baseline of LH pulses. Furthermore, LPS administration significantly increased the percentage of fos-positive fractalkine receptor gene (Cx3cr1)-expressing cells in the arcuate nucleus (ARC), whereas AZD8797 treatment significantly attenuated this LPS-induced increase. ISH for Cx3cr1 and Iba1 (a microglial marker) immunohistochemistry revealed that most Cx3cr1-expressing cells were Iba1-positive. Additionally, Cx3cr1-positive signals were observed adjacent to kisspeptin gene (Kiss1)-expressing cells in the ARC, although a few ARC Kiss1-expressing cells also exhibited Cx3cr1 expression. Collectively, these findings demonstrate that central fractalkine\u2013CX3CR1 signaling, at least in part, mediates the suppression of LH pulses induced by systemic LPS. LM and PVN fractalkine neurons might suppress ARC kisspeptin neurons\u2014the center for gonadotropin-releasing hormone\/LH pulse generation\u2014via neighboring CX3CR1-expressing microglial cells. These findings may contribute to the development of therapeutic strategies to mitigate inflammation-associated reproductive dysfunction in both livestock and humans.<\/jats:p>","DOI":"10.1210\/endocr\/bqag067","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:33:51Z","timestamp":1780400031000},"source":"Crossref","is-referenced-by-count":1,"title":["Central fractalkine\u2013CX3CR1 signaling mediates systemic LPS-induced inhibition of LH pulses in female rats"],"prefix":"10.1210","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-0797","authenticated-orcid":false,"given":"Yuki","family":"Otsuka","sequence":"first","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsaku","family":"Kadoi","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9424-2098","authenticated-orcid":false,"given":"Shunsuke","family":"Seki","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoya","family":"Yabushita","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoma","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Noda","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-216X","authenticated-orcid":false,"given":"Safiullah","family":"Hazim","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-2781","authenticated-orcid":false,"given":"Yoshihisa","family":"Uenoyama","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2775-6652","authenticated-orcid":false,"given":"Hiroko","family":"Tsukamura","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8396-2421","authenticated-orcid":false,"given":"Naoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya, Aichi 464-8601 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"issue":"4","key":"2026061808520087200_bqag067-B1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1262\/jrd.2020-021","article-title":"Lipopolysaccharide-induced mechanisms of ovarian dysfunction in cows with uterine inflammatory diseases","volume":"66","author":"Magata","year":"2020","journal-title":"J Reprod Dev"},{"issue":"Suppl 1","key":"2026061808520087200_bqag067-B2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-0897.2011.01034.x","article-title":"Innate immunity in the human endometrium and ovary","volume":"66","author":"Sheldon","year":"2011","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"2026061808520087200_bqag067-B3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/REP-22-0047","article-title":"Intrauterine LPS inhibited arcuate Kiss1 expression, LH pulses, and ovarian function in rats","volume":"164","author":"Magata","year":"2022","journal-title":"Reprod Camb Engl"},{"key":"2026061808520087200_bqag067-B4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2010.10.026","article-title":"Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus","volume":"1364","author":"Maeda","year":"2010","journal-title":"Brain Res"},{"issue":"9","key":"2026061808520087200_bqag067-B5","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1210\/en.2018-00505","article-title":"Synaptic innervation of the GnRH neuron distal dendron in female mice","volume":"159","author":"Moore","year":"2018","journal-title":"Endocrinology"},{"issue":"11","key":"2026061808520087200_bqag067-B6","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1210\/en.2018-00653","article-title":"The gonadotropin-releasing hormone pulse generator","volume":"159","author":"Herbison","year":"2018","journal-title":"Endocrinology"},{"issue":"4","key":"2026061808520087200_bqag067-B7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1262\/jrd.2019-164","article-title":"Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice","volume":"66","author":"Minabe","year":"2020","journal-title":"J Reprod Dev"},{"issue":"4","key":"2026061808520087200_bqag067-B8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1262\/jrd.2020-026","article-title":"Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice","volume":"66","author":"Ikegami","year":"2020","journal-title":"J Reprod Dev"},{"issue":"8","key":"2026061808520087200_bqag067-B9","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1210\/en.2010-0022","article-title":"Minireview: Kisspeptin\/Neurokinin B\/Dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion","volume":"151","author":"Lehman","year":"2010","journal-title":"Endocrinology"},{"issue":"5","key":"2026061808520087200_bqag067-B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.2009156118","article-title":"Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator","volume":"118","author":"Nagae","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2026061808520087200_bqag067-B11","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1210\/en.2014-1756","article-title":"Kisspeptin is a component of the pulse generator for GnRH secretion in female sheep but not THE pulse generator","volume":"156","author":"Ezzat","year":"2015","journal-title":"Endocrinology"},{"issue":"10","key":"2026061808520087200_bqag067-B12","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1365-2826.2009.01909.x","article-title":"Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat","volume":"21","author":"Ohkura","year":"2009","journal-title":"J Neuroendocrinol"},{"issue":"10","key":"2026061808520087200_bqag067-B13","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1210\/en.2017-00500","article-title":"Kisspeptin and neurokinin B signaling network underlies the pubertal increase in GnRH release in female rhesus monkeys","volume":"158","author":"Garcia","year":"2017","journal-title":"Endocrinology"},{"key":"2026061808520087200_bqag067-B14","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2019.110578","article-title":"Mechanism of pulsatile GnRH release in primates: unresolved questions","volume":"498","author":"Terasawa","year":"2019","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2026061808520087200_bqag067-B15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2826.2008.01807.x","article-title":"Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat","volume":"21","author":"Kinsey-Jones","year":"2009","journal-title":"J Neuroendocrinol"},{"issue":"11","key":"2026061808520087200_bqag067-B16","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1210\/en.2017-00301","article-title":"Acute psychosocial stress inhibits LH pulsatility and Kiss1 neuronal activation in female mice","volume":"158","author":"Yang","year":"2017","journal-title":"Endocrinology"},{"issue":"5","key":"2026061808520087200_bqag067-B17","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13098","article-title":"Regulation of the gonadotropin-releasing hormone neuron during stress","volume":"34","author":"McCosh","year":"2022","journal-title":"J Neuroendocrinol"},{"issue":"11","key":"2026061808520087200_bqag067-B18","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa161","article-title":"Paraventricular dynorphin A neurons mediate LH pulse suppression induced by hindbrain glucoprivation in female rats","volume":"161","author":"Tsuchida","year":"2020","journal-title":"Endocrinology"},{"issue":"7","key":"2026061808520087200_bqag067-B19","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1210\/en.2003-1516","article-title":"Further evidence for the role of glucose as a metabolic regulator of hypothalamic gonadotropin-releasing hormone pulse generator activity in goats","volume":"145","author":"Ohkura","year":"2004","journal-title":"Endocrinology"},{"key":"2026061808520087200_bqag067-B20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2021.113755","article-title":"Kobayashi award 2019: the neuroendocrine regulation of the mammalian reproduction","volume":"315","author":"Tsukamura","year":"2022","journal-title":"Gen Comp Endocrinol"},{"issue":"7","key":"2026061808520087200_bqag067-B21","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/BF03345620","article-title":"Decreased expression of kisspeptin mediates acute immune\/inflammatory stress-induced suppression of gonadotropin secretion in female rat","volume":"31","author":"Iwasa","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"2026061808520087200_bqag067-B22","doi-asserted-by":"crossref","DOI":"10.1111\/jne.70004","article-title":"Prostaglandin synthesis mediates the suppression of arcuate Kiss1 neuron activation and pulsatile luteinizing hormone secretion during immune\/inflammatory stress in female mice","volume":"37","author":"Carrasco","year":"2025","journal-title":"J Neuroendocrinol"},{"key":"2026061808520087200_bqag067-B23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fncel.2019.00414","article-title":"Fractalkine modulates microglia metabolism in brain ischemia","volume":"13","author":"Lauro","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"2026061808520087200_bqag067-B24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endocr\/bqab064","article-title":"CX3CL1-CX3CR1 signaling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice","volume":"162","author":"Nagashimada","year":"2021","journal-title":"Endocrinology"},{"issue":"9","key":"2026061808520087200_bqag067-B25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045250","article-title":"The neuron-astrocyte-microglia triad in normal brain ageing and in a model of neuroinflammation in the rat hippocampus","volume":"7","author":"Cerbai","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"2026061808520087200_bqag067-B26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"issue":"1","key":"2026061808520087200_bqag067-B27","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1038\/s41598-019-42286-8","article-title":"Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"2026061808520087200_bqag067-B28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-4522(98)00368-6","article-title":"Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain","volume":"89","author":"Konsman","year":"1999","journal-title":"Neuroscience"},{"issue":"1-2","key":"2026061808520087200_bqag067-B29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jneuroim.2008.08.015","article-title":"Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain","volume":"205","author":"Tyagi","year":"2008","journal-title":"J Neuroimmunol"},{"issue":"2","key":"2026061808520087200_bqag067-B30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000026454","article-title":"Blood interleukin-6 and tumor necrosis factor-alpha elevation after intracerebroventricular injection of Escherichia coli endotoxin in the rat is determined by two opposing factors: peripheral induction by LPS transferred from brain to blood and inhibition of peripheral response by a brain-mediated mechanism","volume":"8","author":"Chen","year":"2000","journal-title":"Neuroimmunomodulation"},{"issue":"1","key":"2026061808520087200_bqag067-B31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12974-020-01857-7","article-title":"CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats","volume":"17","author":"Ho","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"5","key":"2026061808520087200_bqag067-B32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-2007-1004900","article-title":"Effect of food deprivation on the pulsatile LH release in the cycling and ovariectomized female rat","volume":"22","author":"Cagampang","year":"1990","journal-title":"Horm Metab Res"},{"issue":"4","key":"2026061808520087200_bqag067-B33","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqae028","article-title":"Neonatal aromatase inhibition blocked defeminization of AVPV Kiss1 neurons and LH surge-generating system in male rats","volume":"165","author":"Yamada","year":"2024","journal-title":"Endocrinology"},{"key":"2026061808520087200_bqag067-B34","unstructured":"Yuki O, Kadoi S, Seki S, et al \u00a02025. Supplementary Data for \u201cCentral fractalkine-CX3CR1 signaling mediates systemic LPS-induced inhibition of LH pulses in female rats\u201d. Figshare. 10.6084\/m9.figshare.29858810"},{"key":"2026061808520087200_bqag067-B35","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007","edition":"6th ed"},{"issue":"14","key":"2026061808520087200_bqag067-B36","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1073\/pnas.1316510111","article-title":"Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis","volume":"111","author":"Ridderstad Wollberg","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026061808520087200_bqag067-B37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnmol.2020.00075","article-title":"Modified in situ hybridization chain reaction using short hairpin DNAs","volume":"13","author":"Tsuneoka","year":"2020","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"2026061808520087200_bqag067-B38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00441-022-03596-y","article-title":"Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP","volume":"388","author":"Katayama","year":"2022","journal-title":"Cell Tissue Res"},{"issue":"5","key":"2026061808520087200_bqag067-B39","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1210\/en.2006-1529","article-title":"Inhibition of metastin (Kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats","volume":"148","author":"Yamada","year":"2007","journal-title":"Endocrinology"},{"issue":"4","key":"2026061808520087200_bqag067-B40","first-page":"E310","article-title":"Algorithms for the study of episodic hormone secretion","volume":"6","author":"Merriam","year":"1982","journal-title":"Am J Physiol"},{"issue":"11","key":"2026061808520087200_bqag067-B41","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2026061808520087200_bqag067-B42","article-title":"CUBIC-cloud provides an integrative computational framework toward community-driven whole-mouse-brain mapping","volume":"1","author":"Mano","year":"2021","journal-title":"Cell Rep Methods"},{"key":"2026061808520087200_bqag067-B43","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.926807","article-title":"Upregulation of chemokines in the paraventricular nucleus of the hypothalamus in rats with stress-induced hypertension","volume":"26","author":"Wu","year":"2020","journal-title":"Med Sci Monit"},{"issue":"4738","key":"2026061808520087200_bqag067-B44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.3003907","article-title":"Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor","volume":"231","author":"Rivier","year":"1986","journal-title":"Science"},{"issue":"2","key":"2026061808520087200_bqag067-B45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1210\/en.2010-1003","article-title":"The role of the medial and central amygdala in stress-induced suppression of pulsatile LH secretion in female rats","volume":"152","author":"Lin","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"2026061808520087200_bqag067-B46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/expphysiol.1997.sp004022","article-title":"Identification of projections from the central nucleus of the amygdala to the paraventricular nucleus of the hypothalamus which are immunoreactive for corticotrophin-releasing hormone in the rat","volume":"82","author":"Marcilhac","year":"1997","journal-title":"Exp Physiol"},{"issue":"2","key":"2026061808520087200_bqag067-B47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/brainsci12020135","article-title":"Inflammatory stress induced by intraperitoneal injection of LPS increases phoenixin expression and activity in distinct rat brain nuclei","volume":"12","author":"Friedrich","year":"2022","journal-title":"Brain Sci"},{"issue":"8017","key":"2026061808520087200_bqag067-B48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-024-07469-y","article-title":"A body\u2013brain circuit that regulates body inflammatory responses","volume":"630","author":"Jin","year":"2024","journal-title":"Nature"},{"key":"2026061808520087200_bqag067-B49","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3389\/fimmu.2017.01452","article-title":"The vagus nerve in the neuro-immune axis: implications in the pathology of the gastrointestinal tract","volume":"8","author":"Bonaz","year":"2017","journal-title":"Front Immunol"},{"issue":"4","key":"2026061808520087200_bqag067-B50","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1210\/endo.137.4.8625885","article-title":"Reduction of glucose availability suppresses pulsatile luteinizing hormone release in female and male rats","volume":"137","author":"Nagatani","year":"1996","journal-title":"Endocrinology"},{"issue":"3","key":"2026061808520087200_bqag067-B51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1262\/jrd.11-001S","article-title":"Central injection of ketone body suppresses luteinizing hormone release via the catecholaminergic pathway in female rats","volume":"57","author":"Iwata","year":"2011","journal-title":"J Reprod Dev"},{"issue":"7","key":"2026061808520087200_bqag067-B52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069123","article-title":"A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1\u03b2, TNF-\u03b1 and IL-6 challenges in C57BL\/6 mice","volume":"8","author":"Skelly","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"2026061808520087200_bqag067-B53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/1096-9861(20001204)428:1<5::AID-CNE2>3.0.CO;2-M","article-title":"Distribution of the EP3 prostaglandin E2 receptor subtype in the rat brain: relationship to sites of interleukin-1\u2013induced cellular responsiveness","volume":"428","author":"Ek","year":"2000","journal-title":"J Comp Neurol"},{"issue":"1","key":"2026061808520087200_bqag067-B54","article-title":"Biomedical data annotation: an OCT imaging case study","volume":"2023","author":"Anderson","year":"2023","journal-title":"J Ophthalmol"},{"key":"2026061808520087200_bqag067-B55","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.brainresbull.2018.05.024","article-title":"Central fractalkine stimulates central prostaglandin E2 production and induces systemic inflammatory responses","volume":"140","author":"Mota","year":"2018","journal-title":"Brain Res Bull"},{"issue":"5","key":"2026061808520087200_bqag067-B56","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2826.2000.00466.x","article-title":"Effect of interleukin-1beta on gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in castrated male rats","volume":"12","author":"Kang","year":"2000","journal-title":"J Neuroendocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqag067\/68465591\/bqag067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/7\/bqag067\/68465591\/bqag067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/167\/7\/bqag067\/68465591\/bqag067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:52:18Z","timestamp":1781787138000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqag067\/8701146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,5,26]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqag067","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,5,26]]},"article-number":"bqag067"}}