{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:49:27Z","timestamp":1782208167675,"version":"3.54.5"},"reference-count":87,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA174777"],"award-info":[{"award-number":["R01CA174777"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA262570"],"award-info":[{"award-number":["R01CA262570"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA270539"],"award-info":[{"award-number":["R01CA270539"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prostate cancer development and progression depend on androgen receptor (AR) signaling. Therefore, androgen-deprivation therapy (ADT) and AR signaling inhibitors (ARSIs) are standard therapies for advanced or metastatic disease. Although these treatments are initially effective, prostate cancer inevitably progresses to a lethal stage termed castration-resistant prostate cancer (CRPC). In the majority of patients, CRPC occurs via reactivation of AR signaling (CRPC-AR). However, lineage plasticity is a hallmark of cancer that drives AR-independent CRPC phenotypes in a subset of patients. One subtype of AR-negative CRPC is neuroendocrine prostate cancer (NEPC), which transforms from CRPC-AR by losing the characteristic AR-driven luminal epithelial identity and gaining neuroendocrine identity. Another AR-negative CRPC subtype lacks AR and neuroendocrine features and has therefore been classified as double-negative prostate cancer (DNPC). Chromatin modifications, alterations in three-dimensional (3D) genome structure, and expression of transcriptional regulators are crucial for controlling lineage states and modulating AR-dependent and AR-independent phenotypes in CRPC. Here, we highlight how high-resolution investigations of the 3D genome have revealed interdependence between chromatin architecture and transcriptional regulation, offering novel insights into the mechanisms of CRPC progression and context-specific targets for therapeutic intervention.<\/jats:p>","DOI":"10.1210\/endocr\/bqag068","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:38:57Z","timestamp":1781613537000},"source":"Crossref","is-referenced-by-count":0,"title":["3D genome architecture and epigenetic regulation of lineage identity in advanced prostate cancer"],"prefix":"10.1210","volume":"167","author":[{"given":"Songyan","family":"Qi","sequence":"first","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN 55455 ,","place":["USA"]},{"name":"Graduate Program in Biochemistry, Molecular Biology and Biophysics, University of Minnesota , Minneapolis, MN 55455 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-5579","authenticated-orcid":false,"given":"Scott M","family":"Dehm","sequence":"additional","affiliation":[{"name":"Masonic Cancer Center, University of Minnesota , Minneapolis, MN 55455 ,","place":["USA"]},{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota , Minneapolis, MN 55455 ,","place":["USA"]},{"name":"Department of Urology, University of Minnesota , Minneapolis, MN 55455 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"2026062305162310800_bqag068-B1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ydbio.2020.11.012","article-title":"Progenitors in prostate development and disease","volume":"473","author":"Joseph","year":"2021","journal-title":"Dev 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