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Many EDCs act as \u201cobesogens\u201d by promoting adipogenesis and disrupting metabolism; however, little is known about their effects on neural circuits that regulate food reward and motivation. EDCs cause neurobiological and behavioral changes, implicating them in central energy balance regulation. In this experiment, we tested whether developmental exposure to the environmentally relevant EDC mixture NeuroMix (NMX) may have obesogenic-like effects in rats through central mechanisms. Using a dose-response approach, male and female rats were exposed perinatally to NMX (0, 0.1 \u00d7, 1 \u00d7, 10 \u00d7 doses) and assessed for adult high-fat food and sucrose preference, thyroid hormones, and transcriptomics in reward and hypothalamic nuclei. Females exposed to the 1 \u00d7 dose exhibited an increase in fatty food preference and consumption accompanied by appreciable weight gain. Males showed reduced thyroid hormone levels at the highest 10 \u00d7 dose. NMX antagonized thyroid hormone receptor \u03b2 in vitro, suggesting a potential molecular mechanism underlying the observed neuroendocrine effects. Transcriptomic analyses in 1 \u00d7 rats identified the nucleus accumbens (NAc) as a key neural substrate in both sexes, with spliceosomal complex eigengenes in the NAc acting as correlates of high-fat food behaviors, and individual splicing factors emerging as possible neuromolecular mechanisms linking endocrine disruption to obesogenic eating. Together, this research demonstrates that environmentally relevant EDC mixtures exert sex- and dose-specific effects on food choice, thyroid hormones, and gene expression, highlighting neuromolecular reward mechanisms as potential contributors to environmentally mediated obesity risk.<\/jats:p>","DOI":"10.1210\/endocr\/bqag084","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:37:26Z","timestamp":1784979446000},"source":"Crossref","is-referenced-by-count":1,"title":["The EDC mixture \u201cNeuroMix\u201d alters neuroendocrine physiology, fatty food preference, and the central reward transcriptome"],"prefix":"10.1210","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-4919","authenticated-orcid":false,"given":"Emily N","family":"Hilz","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Morales-Grahl","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahnabi","family":"Deka","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L","family":"Sheinhaus","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Division of Pharmacology and Toxicology, The University of Texas at Austin , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-2428","authenticated-orcid":false,"given":"Christopher D","family":"Kassotis","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health Sciences and Department of Pharmacology, Wayne State University , Detroit, MI 48202 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