{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:54:23Z","timestamp":1787759663355,"version":"build-2784847793"},"reference-count":97,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2307614"],"award-info":[{"award-number":["2307614"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutional Development Award (IDeA) from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health","award":["P20GM103423"],"award-info":[{"award-number":["P20GM103423"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Superconserved receptors expressed in brain (SREB) are a family of orphan G protein\u2013coupled receptors with 3 members in most vertebrates (GPR27 or SREB1, GPR85 or SREB2, and GPR173 or SREB3). They are associated with diverse physiological processes, ranging from glucose homeostasis to ovarian development. Despite a lack of confirmed ligands, our understanding of these receptors has increased based on interactions with putative SREB3 ligands such as phoenixin (PNX) and the development of synthetic SREB1 agonists (A8535 and PT-91). However, to date no studies have used these agonists in any complex vertebrate system. The objective of this study was to compare the in vitro transcriptomic responses to PNX-20, A8535, and PT-91 in the ovaries of 3 fishes with different SREB systems: (1) zebrafish (Danio rerio) that exhibit similar receptors to mammals, (2) mummichog (Fundulus heteroclitus) that lost a receptor but gained a fish-specific member, and (3) pufferfish (Dichotomyctere nigroviridis) that exhibit all 4 receptors. Agonist interactions with fish SREB1s were confirmed using in silico characterizations. Zebrafish exhibited the strongest transcriptome response, including agonist-induced changes in oxidative phosphorylation and cell adhesion pathways. Mummichog exhibited a less robust response, possibly related to receptor evolutionary divergence, while pufferfish exhibited an intermediate transcriptome response. Short-term agonist exposure did not alter ovarian steroid levels ([17]estradiol, 17-hydroxyprogesterone, cortisol, testosterone, or 11-ketotestosterone). Collectively, the data reveal previously unrecognized developmental, metabolic, neural, and vascular gene networks associated with SREB activation and suggest both receptor-specific signaling and functional overlap within this family.<\/jats:p>","DOI":"10.1210\/endocr\/bqag089","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:57:58Z","timestamp":1786017478000},"source":"Crossref","is-referenced-by-count":1,"title":["New insights into SREB orphan receptor roles in the ovary, using comparative transcriptomics across 3 fishes"],"prefix":"10.1210","volume":"167","author":[{"given":"Charles F","family":"Heyder","sequence":"first","affiliation":[{"name":"Tropical Aquaculture Laboratory, Program in Fisheries and Aquatic Sciences, School of Forest, Fisheries, and Geomatics Sciences, Institute of Food and Agricultural Sciences, University of Florida , Ruskin, FL 33570 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-0305","authenticated-orcid":false,"given":"Casey A","family":"Murray","sequence":"additional","affiliation":[{"name":"Tropical Aquaculture Laboratory, Program in Fisheries and Aquatic Sciences, School of Forest, Fisheries, and Geomatics Sciences, Institute of Food and Agricultural Sciences, University of Florida , Ruskin, FL 33570 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9344-8847","authenticated-orcid":false,"given":"Philip","family":"Granith","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Pharmaceutical Science Laboratory (PSL\u2013Pharmacy) and Structural Bioinformatics Laboratory (SBL\u2013Biochemistry), \u00c5bo Akademi University , Turku FI-20500 ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-5180","authenticated-orcid":false,"given":"Mukhriddin","family":"Makhkamov","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Pharmaceutical Science Laboratory (PSL\u2013Pharmacy) and Structural Bioinformatics Laboratory (SBL\u2013Biochemistry), \u00c5bo Akademi University , Turku FI-20500 ,","place":["Finland"]},{"name":"Institute for Advanced Studies, New Uzbekistan University , Tashkent 100000 ,","place":["Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Bourget","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Cain","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breckon","family":"Davidson","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]},{"name":"Department of Biological Sciences, University of Southern Maine , Portland, ME 04104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor-Jeffery","family":"Doone","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Korasadowicz","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Hull","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Martens","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Martin-Hachey","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keira","family":"McGrath","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Stewart","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-0797","authenticated-orcid":false,"given":"Jamoliddin","family":"Razzokov","sequence":"additional","affiliation":[{"name":"Institute of Fundamental and Applied Research, National Research University TIIAME , Tashkent 100000 ,","place":["Uzbekistan"]},{"name":"Department of Natural Sciences, Karshi State Technical University , Kashkadarya 180100 ,","place":["Uzbekistan"]},{"name":"Department of Biotechnology, Tashkent State Technical University , Tashkent 100095 ,","place":["Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-2160","authenticated-orcid":false,"given":"Parthiban","family":"Marimuthu","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Pharmaceutical Science Laboratory (PSL\u2013Pharmacy) and Structural Bioinformatics Laboratory (SBL\u2013Biochemistry), \u00c5bo Akademi University , Turku FI-20500 ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-8896","authenticated-orcid":false,"given":"Thanigaimalai","family":"Pillaiyar","sequence":"additional","affiliation":[{"name":"T\u00fcbingen Center for Academic Drug Discovery and Development, Eberhard Karls University T\u00fcbingen , T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-7590","authenticated-orcid":false,"given":"Julien","family":"Hanson","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, GIGA Research Institute & CIRM, University of Li\u00e8ge , Li\u00e8ge 4000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-4796","authenticated-orcid":false,"given":"Christopher J","family":"Martyniuk","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center for Environmental and Human Toxicology, College of Veterinary Medicine, University of Florida , Gainesville, FL 32611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9148-9785","authenticated-orcid":false,"given":"Matthew A","family":"DiMaggio","sequence":"additional","affiliation":[{"name":"Tropical Aquaculture Laboratory, Program in Fisheries and Aquatic Sciences, School of Forest, Fisheries, and Geomatics Sciences, Institute of Food and Agricultural Sciences, University of Florida , Ruskin, FL 33570 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-5960","authenticated-orcid":false,"given":"Timothy S","family":"Breton","sequence":"additional","affiliation":[{"name":"Biology Department, University of Maine at Farmington , Farmington, ME 04938 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"2","key":"2026082601463020900_bqag089-B1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1006\/bbrc.2000.2829","article-title":"An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous 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of green-spotted pufferfish (Dichotomyctere nigroviridis)","volume":"360","author":"Breton","year":"2025","journal-title":"Gen Comp Endocrinol"},{"key":"2026082601463020900_bqag089-B40","article-title":"Characterization and expression analysis of gpr173a and gpr173b revealed their involvement in reproductive regulation in spotted scat (Scatophagus argus)","volume":"25","author":"Jiang","year":"2022","journal-title":"Aquac Rep"},{"issue":"1","key":"2026082601463020900_bqag089-B41","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/biolre\/ioaf213","article-title":"Activation of cAMP\/PKA and ERK signaling pathways and potential role of phoenixin in the reproductive axis of spotted scat (Scatophagus argus)","volume":"114","author":"Lin","year":"2026","journal-title":"Biol Reprod"},{"key":"2026082601463020900_bqag089-B42","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1570716","article-title":"Goldfish phoenixin: structural characterization, tissue distribution, and 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