{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:38:42Z","timestamp":1792654722642,"version":"4.5.0"},"reference-count":77,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"publisher","award":["152944"],"award-info":[{"award-number":["152944"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N-acetyl-L-cysteine (NAC) is a widely used antioxidant with increasing public interest in its use for treating metabolic disease, yet its effects on pancreatic \u03b2 cells remain incompletely understood. Most studies focus on NAC's benefits under pathological conditions\u2014such as obesity, high-fat diet exposure, and type 2 diabetes\u2014where oxidative stress impairs \u03b2-cell function, identity, and survival. In these contexts, NAC can reduce oxidative damage, preserve insulin secretion, and limit islet fibrosis. However, far fewer studies examine NAC under normal physiological or aging conditions, where moderate reactive oxygen species levels are required for \u03b2-cell signaling and glucose-stimulated insulin secretion. Emerging evidence shows that excessive antioxidant exposure during non-pathological states may disrupt redox-dependent pathways, suppress insulin biosynthesis and exocytosis, and contribute to reductive stress. Here, we review the current evidence of NAC's impact on \u03b2 cells across physiological, aging, and pathological settings. Moreover, we highlight that NAC can be protective or detrimental depending on redox state, metabolic environment, and dosing, which emphasizes the need for careful consideration of antioxidant use in humans.<\/jats:p>","DOI":"10.1210\/endocr\/bqag114","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:51:34Z","timestamp":1791546694000},"source":"Crossref","is-referenced-by-count":0,"title":["Antioxidant therapy, N-acetyl-L-cysteine, effects on pancreatic \u03b2 cells: therapeutic promise or potential harm?"],"prefix":"10.1210","volume":"167","author":[{"given":"Meg","family":"Schuurman","sequence":"first","affiliation":[{"name":"Children's Health Research Institute, University of Western Ontario , London, ON N6C 2V5 ,","place":["Canada"]},{"name":"Department of Physiology & Pharmacology, University of Western Ontario , London, ON N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pharmacology, University of Western Ontario , London, ON N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-7333","authenticated-orcid":false,"given":"Malina","family":"Barillaro","sequence":"additional","affiliation":[{"name":"Children's Health Research Institute, University of Western Ontario , London, ON N6C 2V5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nica","family":"Borradaile","sequence":"additional","affiliation":[{"name":"Department of Physiology & Pharmacology, University of Western Ontario , London, ON N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-5029","authenticated-orcid":false,"given":"Rennian","family":"Wang","sequence":"additional","affiliation":[{"name":"Children's Health Research Institute, University of Western Ontario , London, ON N6C 2V5 ,","place":["Canada"]},{"name":"Department of Physiology & Pharmacology, University of Western Ontario , London, ON N6A 5C1 ,","place":["Canada"]},{"name":"Department of Medicine, University of Western Ontario , London, ON N6A 5C1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"issue":"7","key":"2026102202522572700_bqag114-B1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2337\/db19-1130","article-title":"Glucose-stimulated insulin secretion fundamentally requires H2O2 signaling by NADPH oxidase 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