{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:05:49Z","timestamp":1790831149130,"version":"4.1.0"},"reference-count":60,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK105826"],"award-info":[{"award-number":["R01-DK105826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-MH082900"],"award-info":[{"award-number":["R01-MH082900"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To limit excessive glucocorticoid secretion following hypothalamic-pituitary-adrenal (HPA) axis stimulation, circulating glucocorticoids inhibit corticotropin-releasing hormone (CRH) expression in paraventricular nucleus (PVN) neurons. As HPA function differs between sexes and depends on circulating estradiol (E2) levels in females, we investigated sex\/estrous stage-dependent glucocorticoid regulation of PVN Crh. Using NanoString nCounter technology, we first demonstrated that adrenalectomized (ADX\u2019d) diestrous female (low E2), but not male or proestrous female (high E2), mice exhibited a robust decrease in PVN CRH mRNA following 2-day treatment with the glucocorticoid receptor (GR) agonist RU28362. Immunohistochemical analysis of PVN CRH neurons in Crh-IRES-Cre;Ai14 mice, where TdTomato fluorescence permanently tags CRH-expressing neurons, showed similarly abundant co-expression of GR-immunoreactivity in males, diestrous females, and proestrous females. However, we identified sex\/estrous stage-related glucocorticoid regulation or expression of GR transcriptional coregulators. Out of 17 coregulator genes examined using nCounter multiplex analysis, mRNAs that were decreased by RU28362 in ADX\u2019d mice in a sex\/estrous stage-dependent fashion included: GR (males = diestrous females &amp;gt; proestrous females), signal transducer and activator of transcription 3 (STAT3) (males &amp;lt; diestrous = proestrous), and HDAC1 (males &amp;lt; diestrous &amp;gt; proestrous). Steroid receptor coactivator 3 (SRC-3), nuclear corepressor 1 (NCoR1), heterogeneous nuclear ribonucleoprotein U (hnrnpu), CREB binding protein (CBP) and CREB-regulated transcription coactivator 2 (CRTC2) mRNAs were lower in ADX\u2019d diestrous and proestrous females versus males. Additionally, most PVN CRH neurons co-expressed methylated CpG binding protein 2 (MeCP2)-immunoreactivity in diestrous female and male Crh-IRES-Cre;Ai14 mice. Our findings collectively suggest that GR\u2019s sex-dependent regulation of PVN Crh may depend upon differences in the GR transcriptional machinery and an underlying influence of E2 levels in females.<\/jats:p>","DOI":"10.1210\/endocr\/bqz012","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T01:50:25Z","timestamp":1574387425000},"source":"Crossref","is-referenced-by-count":21,"title":["Sex-Dependent Mechanisms of Glucocorticoid Regulation of the Mouse Hypothalamic Corticotropin-Releasing Hormone Gene"],"prefix":"10.1210","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-544X","authenticated-orcid":false,"given":"Ashley L","family":"Heck","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maranda K","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, University of Arizona, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-5574","authenticated-orcid":false,"given":"Rosalie M","family":"Uht","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-2808","authenticated-orcid":false,"given":"Robert J","family":"Handa","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"issue":"5","key":"2020042812155991900_CIT0001","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0301-0082(93)90035-Q","article-title":"Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system","volume":"40","author":"Whitnall","year":"1993","journal-title":"Prog Neurobiol."},{"issue":"3","key":"2020042812155991900_CIT0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yfrne.2003.07.001","article-title":"Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness","volume":"24","author":"Herman","year":"2003","journal-title":"Front Neuroendocrinol."},{"issue":"1","key":"2020042812155991900_CIT0003","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/edrv-5-1-25","article-title":"Physiological functions of glucocorticoids in stress and their relation to pharmacological actions","volume":"5","author":"Munck","year":"1984","journal-title":"Endocr Rev."},{"issue":"1","key":"2020042812155991900_CIT0004","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr Rev."},{"issue":"1\u20132","key":"2020042812155991900_CIT0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0165-0327(00)00352-9","article-title":"Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy","volume":"62","author":"Holsboer","year":"2001","journal-title":"J Affect Disord."},{"issue":"6","key":"2020042812155991900_CIT0006","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat Rev Neurosci."},{"issue":"5","key":"2020042812155991900_CIT0007","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2826.1992.tb00200.x","article-title":"Stress, feedback and facilitation in the hypothalamo-pituitary-adrenal axis","volume":"4","author":"Dallman","year":"1992","journal-title":"J Neuroendocrinol."},{"issue":"6","key":"2020042812155991900_CIT0008","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/endo-117-6-2505","article-title":"Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation","volume":"117","author":"Reul","year":"1985","journal-title":"Endocrinology."},{"issue":"6","key":"2020042812155991900_CIT0009","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/endo.130.6.1597154","article-title":"The unliganded glucocorticoid receptor is localized in the nucleus, not in the cytoplasm","volume":"130","author":"Brink","year":"1992","journal-title":"Endocrinology."},{"issue":"3","key":"2020042812155991900_CIT0010","first-page":"269","article-title":"Brain corticosteroid receptor balance in health and disease","volume":"19","author":"De Kloet","year":"1998","journal-title":"Endocr Rev."},{"issue":"7","key":"2020042812155991900_CIT0011","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1210\/me.2013-1079","article-title":"Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter","volume":"27","author":"Sharma","year":"2013","journal-title":"Mol Endocrinol."},{"issue":"48","key":"2020042812155991900_CIT0012","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.0608702103","article-title":"Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome","volume":"103","author":"McGill","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"issue":"2","key":"2020042812155991900_CIT0013","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.physbeh.2011.03.026","article-title":"Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression","volume":"104","author":"Miller","year":"2011","journal-title":"Physiol Behav."},{"issue":"19","key":"2020042812155991900_CIT0014","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1073\/pnas.0812062106","article-title":"Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids","volume":"106","author":"Lachize","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"issue":"4","key":"2020042812155991900_CIT0015","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1073\/pnas.1114122109","article-title":"BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus","volume":"109","author":"Jeanneteau","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2020042812155991900_CIT0016","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41386-018-0167-9","article-title":"Sex differences in the hypothalamic-pituitary-adrenal axis\u2019 response to stress: an important role for gonadal hormones","volume":"44","author":"Heck","year":"2019","journal-title":"Neuropsychopharmacology."},{"issue":"8","key":"2020042812155991900_CIT0017","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1210\/en.2015-1276","article-title":"Neuroendocrine function after hypothalamic depletion of glucocorticoid receptors in male and female mice","volume":"156","author":"Solomon","year":"2015","journal-title":"Endocrinology."},{"issue":"7","key":"2020042812155991900_CIT0018","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1210\/en.2019-00238","article-title":"Androgens drive sex biases in hypothalamic corticotropin-releasing hormone gene expression after adrenalectomy of mice","volume":"160","author":"Heck","year":"2019","journal-title":"Endocrinology."},{"issue":"3","key":"2020042812155991900_CIT0019","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.yfrne.2014.03.008","article-title":"Sex differences in stress-related psychiatric disorders: neurobiological perspectives","volume":"35","author":"Bangasser","year":"2014","journal-title":"Front Neuroendocrinol."},{"issue":"5","key":"2020042812155991900_CIT0020","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1210\/endo-129-5-2503","article-title":"Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat","volume":"129","author":"Viau","year":"1991","journal-title":"Endocrinology."},{"issue":"3","key":"2020042812155991900_CIT0021","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1210\/endo.131.3.1324155","article-title":"Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats","volume":"131","author":"Burgess","year":"1992","journal-title":"Endocrinology."},{"issue":"3","key":"2020042812155991900_CIT0022","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.neuroscience.2006.04.067","article-title":"Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis","volume":"141","author":"Francis","year":"2006","journal-title":"Neuroscience."},{"key":"2020042812155991900_CIT0023","first-page":"94","article-title":"Brain corticosteroid receptor balance and homeostatic control","volume":"12","author":"De Kloet","year":"1990","journal-title":"Front. Neuroendocrinol"},{"key":"2020042812155991900_CIT0024","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-802175-0.00037-1","article-title":"Manipulating the brain corticosteroid receptor balance: focus on ligands and modulators","volume-title":"Stress: Neuroendocrinology and Neurobiology","author":"De Kloet","year":"2017"},{"key":"2020042812155991900_CIT0025"},{"key":"2020042812155991900_CIT0026"},{"issue":"6","key":"2020042812155991900_CIT0027","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuron.2011.07.026","article-title":"A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex","volume":"71","author":"Taniguchi","year":"2011","journal-title":"Neuron."},{"issue":"1","key":"2020042812155991900_CIT0028","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat Neurosci."},{"issue":"5","key":"2020042812155991900_CIT0029","doi-asserted-by":"crossref","first-page":"e64943","DOI":"10.1371\/journal.pone.0064943","article-title":"Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice","volume":"8","author":"Wamsteeker Cusulin","year":"2013","journal-title":"Plos One."},{"key":"2020042812155991900_CIT0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.physbeh.2014.03.027","article-title":"Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic-pituitary-adrenal axis in male mice","volume":"136","author":"Smith","year":"2014","journal-title":"Physiol Behav."},{"key":"2020042812155991900_CIT0031","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neuropharm.2018.09.037","article-title":"The effect of acute or repeated stress on the corticotropin releasing factor system in the CRH-IRES-Cre mouse: a validation study","volume":"154","author":"Walker","year":"2019","journal-title":"Neuropharmacology."},{"issue":"2","key":"2020042812155991900_CIT0032","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/bdrb.20106","article-title":"The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies","volume":"80","author":"Goldman","year":"2007","journal-title":"Birth Defects Res B Dev Reprod Toxicol."},{"key":"2020042812155991900_CIT0033","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainres.2010.03.098","article-title":"Estrogen receptor beta activation prevents glucocorticoid receptor-dependent effects of the central nucleus of the amygdala on behavior and neuroendocrine function","volume":"1336","author":"Weiser","year":"2010","journal-title":"Brain Res."},{"key":"2020042812155991900_CIT0034"},{"key":"2020042812155991900_CIT0035"},{"key":"2020042812155991900_CIT0036"},{"key":"2020042812155991900_CIT0037"},{"key":"2020042812155991900_CIT0038"},{"issue":"12","key":"2020042812155991900_CIT0039","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.tins.2012.09.005","article-title":"The Allen Human Brain Atlas: comprehensive gene expression mapping of the human brain","volume":"35","author":"Shen","year":"2012","journal-title":"Trends Neurosci."},{"key":"2020042812155991900_CIT0040","volume-title":"Paxinos and Franklin\u2019s The Mouse Brain in Stereotaxic Coordinates.","author":"Paxinos","year":"2013"},{"issue":"1-2","key":"2020042812155991900_CIT0041","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0169-328X(94)90083-3","article-title":"Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on AVP and CRH mRNA in the rat hypothalamus","volume":"26","author":"Albeck","year":"1994","journal-title":"Brain Res Mol Brain Res."},{"key":"2020042812155991900_CIT0042","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yfrne.2017.12.003","article-title":"The metamorphosis of adolescent hormonal stress reactivity: a focus on animal models","volume":"49","author":"Romeo","year":"2018","journal-title":"Front Neuroendocrinol."},{"key":"2020042812155991900_CIT0043","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ygcen.2016.02.004","article-title":"Sex and stress steroids in adolescence: gonadal regulation of the hypothalamic-pituitary-adrenal axis in the rat","volume":"234","author":"Green","year":"2016","journal-title":"Gen Comp Endocrinol."},{"issue":"5488","key":"2020042812155991900_CIT0044","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1126\/science.289.5488.2344","article-title":"Resetting of circadian time in peripheral tissues by glucocorticoid signaling","volume":"289","author":"Balsalobre","year":"2000","journal-title":"Science."},{"issue":"41","key":"2020042812155991900_CIT0045","doi-asserted-by":"crossref","first-page":"17582","DOI":"10.1073\/pnas.0909733106","article-title":"Glucocorticoid regulation of the circadian clock modulates glucose homeostasis","volume":"106","author":"So","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"issue":"8","key":"2020042812155991900_CIT0046","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1210\/endo.136.8.7628364","article-title":"Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels","volume":"136","author":"Makino","year":"1995","journal-title":"Endocrinology."},{"issue":"2","key":"2020042812155991900_CIT0047","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/cphy.c150015","article-title":"Regulation of the hypothalamic-pituitary-adrenocortical stress response","volume":"6","author":"Herman","year":"2016","journal-title":"Compr Physiol."},{"issue":"2","key":"2020042812155991900_CIT0048","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/joe.0.1440311","article-title":"The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat","volume":"144","author":"Carey","year":"1995","journal-title":"J Endocrinol."},{"issue":"2","key":"2020042812155991900_CIT0049","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuroscience.2008.12.058","article-title":"Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus","volume":"159","author":"Weiser","year":"2009","journal-title":"Neuroscience."},{"issue":"1","key":"2020042812155991900_CIT0050","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.22698","article-title":"Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL\/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing","volume":"520","author":"Biag","year":"2012","journal-title":"J Comp Neurol."},{"issue":"4","key":"2020042812155991900_CIT0051","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jnr.490190404","article-title":"Demonstration of glucocorticoid receptor-like immunoreactivity in glucocorticoid-sensitive vasopressin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus","volume":"19","author":"Uht","year":"1988","journal-title":"J Neurosci Res."},{"key":"2020042812155991900_CIT0052","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jchemneu.2013.05.003","article-title":"CRH: the link between hormonal-, metabolic- and behavioral responses to stress","volume":"54","author":"Kov\u00e1cs","year":"2013","journal-title":"J Chem Neuroanat."},{"issue":"1-2","key":"2020042812155991900_CIT0053","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0303-7207(94)90069-8","article-title":"Regulation of HSP90 and corticosteroid receptor mRNA by corticosterone levels in vivo","volume":"103","author":"Patchev","year":"1994","journal-title":"Mol Cell Endocrinol."},{"issue":"1","key":"2020042812155991900_CIT0054","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0006-8993(85)91153-9","article-title":"Sexual dimorphism of glucocorticoid binding in rat brain","volume":"343","author":"Turner","year":"1985","journal-title":"Brain Res."},{"issue":"2","key":"2020042812155991900_CIT0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/mcne.1993.1023","article-title":"Estrogen-induced alterations in the regulation of mineralocorticoid and glucocorticoid receptor messenger RNA expression in the female rat anterior pituitary gland and brain","volume":"4","author":"Burgess","year":"1993","journal-title":"Mol Cell Neurosci."},{"issue":"2","key":"2020042812155991900_CIT0056","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MMBR.00064-15","article-title":"The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases","volume":"80","author":"Petta","year":"2016","journal-title":"Microbiol Mol Biol Rev."},{"issue":"4","key":"2020042812155991900_CIT0057","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1210\/me.2015-1005","article-title":"Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism","volume":"29","author":"Rollins","year":"2015","journal-title":"Mol Endocrinol."},{"issue":"45","key":"2020042812155991900_CIT0058","doi-asserted-by":"crossref","first-page":"28471","DOI":"10.1074\/jbc.272.45.28471","article-title":"The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U","volume":"272","author":"Eggert","year":"1997","journal-title":"J Biol Chem."},{"issue":"2","key":"2020042812155991900_CIT0059","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1210\/en.2007-1234","article-title":"Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene","volume":"149","author":"van der Laan","year":"2008","journal-title":"Endocrinology."},{"issue":"13","key":"2020042812155991900_CIT0060","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-15-0262","article-title":"Evaluating robustness and sensitivity of the nanostring technologies nCounter platform to enable multiplexed gene expression analysis of clinical samples","volume":"75","author":"Veldman-Jones","year":"2015","journal-title":"Cancer Res."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqz012\/31081173\/bqz012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/161\/1\/bqz012\/33139158\/bqz012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/161\/1\/bqz012\/33139158\/bqz012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T16:46:15Z","timestamp":1588092375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqz012\/5637506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqz012","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,11,22]]},"article-number":"bqz012"}}