{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T09:47:12Z","timestamp":1767260832716,"version":"3.41.2"},"reference-count":55,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["DK073911","DK007028"],"award-info":[{"award-number":["DK073911","DK007028"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer Ingelheim Fonds MD"},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["P30 AR066261"],"award-info":[{"award-number":["P30 AR066261"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibroblast growth factor-23 (FGF23) is critical for phosphate and vitamin D homeostasis. Cellular and molecular mechanisms underlying FGF23 production remain poorly defined. The extra-large G\u03b1 subunit (XL\u03b1s) is a variant of the stimulatory G protein alpha-subunit (Gs\u03b1), which mediates the stimulatory action of parathyroid hormone in skeletal FGF23 production. XL\u03b1s ablation causes diminished FGF23 levels in early postnatal mice. Herein we found that plasma FGF23 levels were comparable in adult XL\u03b1s knockout (XLKO) and wild-type littermates. Upon adenine-rich diet-induced renal injury, a model of chronic kidney disease, both mice showed increased levels of plasma FGF23. Unexpectedly, XLKO mice had markedly higher FGF23 levels than WT mice, with higher blood urea nitrogen and more severe tubulopathy. FGF23 mRNA levels increased substantially in bone and bone marrow in both genotypes; however, the levels in bone were markedly higher than in bone marrow. In XLKO mice, a positive linear correlation was observed between plasma FGF23 and bone, but not bone marrow, FGF23 mRNA levels, suggesting that bone, rather than bone marrow, is an important contributor to severely elevated FGF23 levels in this model. Upon folic acid injection, a model of acute kidney injury, XLKO and WT mice exhibited similar degrees of tubulopathy; however, plasma phosphate and FGF23 elevations were modestly blunted in XLKO males, but not in females, compared to WT counterparts. Our findings suggest that XL\u03b1s ablation does not substantially alter FGF23 production in adult mice but increases susceptibility to adenine-induced kidney injury, causing severe FGF23 elevations in plasma and bone.<\/jats:p>","DOI":"10.1210\/endocr\/bqz025","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T05:21:33Z","timestamp":1574486493000},"source":"Crossref","is-referenced-by-count":6,"title":["Extra-Large G\u03b1 Protein (XL\u03b1s) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation"],"prefix":"10.1210","volume":"161","author":[{"given":"Julia","family":"Matthias","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuxia","family":"Cui","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren T","family":"Shumate","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonius","family":"Plagge","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"He","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-3504","authenticated-orcid":false,"given":"Murat","family":"Bastepe","sequence":"first","affiliation":[{"name":"Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2019,11,23]]},"reference":[{"issue":"4","key":"2020042812160004400_CIT0001","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J Clin Invest."},{"issue":"3","key":"2020042812160004400_CIT0002","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23","volume":"26","author":"Consortium A","year":"2000","journal-title":"Nat Genet."},{"issue":"11","key":"2020042812160004400_CIT0003","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"2","key":"2020042812160004400_CIT0004","doi-asserted-by":"crossref","first-page":"F282","DOI":"10.1152\/ajprenal.90742.2008","article-title":"FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1","volume":"297","author":"Gattineni","year":"2009","journal-title":"Am J Physiol Renal Physiol."},{"key":"2020042812160004400_CIT0005","doi-asserted-by":"crossref","first-page":"17101","DOI":"10.1038\/nrdp.2017.101","article-title":"Rickets","volume":"3","author":"Carpenter","year":"2017","journal-title":"Nat Rev Dis Primers."},{"key":"2020042812160004400_CIT0006","article-title":"Hyperphosphatemic familial tumoral calcinosis","volume-title":"GeneReviews((R))","author":"Ramnitz","year":"1993"},{"issue":"6","key":"2020042812160004400_CIT0007","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1046\/j.1523-1755.2003.00328.x","article-title":"Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers","volume":"64","author":"Larsson","year":"2003","journal-title":"Kidney Int."},{"issue":"11","key":"2020042812160004400_CIT0008","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest."},{"issue":"2","key":"2020042812160004400_CIT0009","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1681\/ASN.2013050465","article-title":"Fibroblast growth factor-23 and cardiovascular events in CKD","volume":"25","author":"Scialla","year":"2014","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"2020042812160004400_CIT0010","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jbmr.2792","article-title":"Conditional deletion of murine Fgf23: interruption of the normal skeletal responses to phosphate challenge and rescue of genetic hypophosphatemia","volume":"31","author":"Clinkenbeard","year":"2016","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2020042812160004400_CIT0011","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/ndt\/gfw376","article-title":"Spleen contributes significantly to increased circulating levels of fibroblast growth factor 23 in response to lipopolysaccharide-induced inflammation","volume":"32","author":"Bansal","year":"2017","journal-title":"Nephrol Dial Transplant."},{"issue":"1","key":"2020042812160004400_CIT0012","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.kint.2017.01.015","article-title":"Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia","volume":"92","author":"Mace","year":"2017","journal-title":"Kidney Int."},{"issue":"3","key":"2020042812160004400_CIT0013","doi-asserted-by":"crossref","first-page":"e0191706","DOI":"10.1371\/journal.pone.0191706","article-title":"Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model","volume":"13","author":"Sugiura","year":"2018","journal-title":"PLoS One."},{"issue":"5","key":"2020042812160004400_CIT0014","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.kint.2017.11.018","article-title":"Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury","volume":"93","author":"Toro","year":"2018","journal-title":"Kidney Int."},{"issue":"1","key":"2020042812160004400_CIT0015","doi-asserted-by":"crossref","first-page":"F132","DOI":"10.1152\/ajprenal.00081.2017","article-title":"Acute blood loss stimulates fibroblast growth factor 23 production","volume":"314","author":"Rabadi","year":"2018","journal-title":"Am J Physiol Renal Physiol."},{"issue":"11","key":"2020042812160004400_CIT0016","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.3324\/haematol.2017.167882","article-title":"Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow","volume":"102","author":"Clinkenbeard","year":"2017","journal-title":"Haematologica."},{"key":"2020042812160004400_CIT0017","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3389\/fphys.2018.01494","article-title":"Fibroblast growth factor 23 expression is increased in multiple organs in mice with folic acid-induced acute kidney injury","volume":"9","author":"Egli-Spichtig","year":"2018","journal-title":"Front Physiol."},{"issue":"12","key":"2020042812160004400_CIT0018","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J Clin Invest."},{"issue":"12","key":"2020042812160004400_CIT0019","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1210\/en.2013-1627","article-title":"Calcium regulates FGF-23 expression in bone","volume":"154","author":"David","year":"2013","journal-title":"Endocrinology."},{"issue":"8","key":"2020042812160004400_CIT0020","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/jbmr.65","article-title":"Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice","volume":"25","author":"Tsuji","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2020042812160004400_CIT0021","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.kint.2018.02.026","article-title":"Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease","volume":"94","author":"Durlacher-Betzer","year":"2018","journal-title":"Kidney Int."},{"issue":"4","key":"2020042812160004400_CIT0022","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MNH.0000000000000232","article-title":"Inflammation regulates fibroblast growth factor 23 production","volume":"25","author":"Francis","year":"2016","journal-title":"Curr Opin Nephrol Hypertens."},{"issue":"4","key":"2020042812160004400_CIT0023","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00360.2010","article-title":"PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"Lavi-Moshayoff","year":"2010","journal-title":"Am J Physiol Renal Physiol."},{"issue":"4","key":"2020042812160004400_CIT0024","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bone.2011.06.025","article-title":"Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo","volume":"49","author":"Rhee","year":"2011","journal-title":"Bone."},{"issue":"1","key":"2020042812160004400_CIT0025","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1096\/fj.15-278184","article-title":"Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis","volume":"30","author":"Fan","year":"2016","journal-title":"Faseb J."},{"issue":"17","key":"2020042812160004400_CIT0026","doi-asserted-by":"crossref","first-page":"10038","DOI":"10.1073\/pnas.95.17.10038","article-title":"The human GNAS1 gene is imprinted and encodes distinct paternally and biallelically expressed G proteins","volume":"95","author":"Hayward","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"6508","key":"2020042812160004400_CIT0027","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/372804a0","article-title":"XL alpha s is a new type of G protein","volume":"372","author":"Kehlenbach","year":"1994","journal-title":"Nature."},{"issue":"8","key":"2020042812160004400_CIT0028","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1210\/me.2002-0054","article-title":"Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit","volume":"16","author":"Bastepe","year":"2002","journal-title":"Mol Endocrinol."},{"issue":"5","key":"2020042812160004400_CIT0029","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1210\/en.2005-1487","article-title":"Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3\u2019,5\u2019-monophosphate formation mediated by human XLalphas","volume":"147","author":"Linglart","year":"2006","journal-title":"Endocrinology."},{"issue":"2","key":"2020042812160004400_CIT0030","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bone.2010.09.032","article-title":"Potent constitutive cyclic AMP-generating activity of XL\u03b1s implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone","volume":"48","author":"Mariot","year":"2011","journal-title":"Bone."},{"issue":"11","key":"2020042812160004400_CIT0031","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1002\/jbmr.481","article-title":"Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification","volume":"26","author":"Pignolo","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"391","key":"2020042812160004400_CIT0032","doi-asserted-by":"crossref","first-page":"ra84","DOI":"10.1126\/scisignal.aaa9953","article-title":"The G protein alpha subunit variant XLalphas promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo","volume":"8","author":"He","year":"2015","journal-title":"Sci Signal."},{"issue":"17","key":"2020042812160004400_CIT0033","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.1117608109","article-title":"Loss of XL\u03b1s (extra-large \u03b1s) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib","volume":"109","author":"Fern\u00e1ndez-Rebollo","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"17","key":"2020042812160004400_CIT0034","doi-asserted-by":"crossref","first-page":"e125007","DOI":"10.1172\/jci.insight.125007","article-title":"A G protein\u2013coupled, IP3\/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23","volume":"4","author":"He","year":"2019","journal-title":"JCI Insight."},{"issue":"1","key":"2020042812160004400_CIT0035","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/s41598-017-02351-6","article-title":"Development of a novel chronic kidney disease mouse model to evaluate the progression of hyperphosphatemia and associated mineral bone disease","volume":"7","author":"Tani","year":"2017","journal-title":"Sci Rep."},{"key":"2020042812160004400_CIT0036","first-page":"1707","article-title":"APRT deficiency and 2,8-DHA urolithiasis.","volume-title":"Metabolic and Molecular Bases of Inherited Disease","author":"Simmonds","year":"1995","edition":"7th ed"},{"issue":"12","key":"2020042812160004400_CIT0037","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1681\/ASN.V12122721","article-title":"Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice","volume":"12","author":"Long","year":"2001","journal-title":"J Am Soc Nephrol."},{"issue":"8","key":"2020042812160004400_CIT0038","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng1397","article-title":"The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding","volume":"36","author":"Plagge","year":"2004","journal-title":"Nat Genet."},{"issue":"11","key":"2020042812160004400_CIT0039","doi-asserted-by":"crossref","first-page":"F1169","DOI":"10.1152\/ajprenal.00676.2013","article-title":"Gender differences in adenine-induced chronic kidney disease and cardiovascular complications in rats","volume":"307","author":"Diwan","year":"2014","journal-title":"Am J Physiol Renal Physiol."},{"key":"2020042812160004400_CIT0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2369-11-20","article-title":"Gender differences in age-related decline in glomerular filtration rates in healthy people and chronic kidney disease patients","volume":"11","author":"Xu","year":"2010","journal-title":"BMC Nephrol."},{"issue":"4","key":"2020042812160004400_CIT0041","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ki.2013.150","article-title":"Plasma FGF23 levels increase rapidly after acute kidney injury","volume":"84","author":"Christov","year":"2013","journal-title":"Kidney Int."},{"key":"2020042812160004400_CIT0042","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2369-14-116","article-title":"A novel model of adenine-induced tubulointerstitial nephropathy in mice","volume":"14","author":"Jia","year":"2013","journal-title":"BMC Nephrol."},{"issue":"5","key":"2020042812160004400_CIT0043","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI18399","article-title":"FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting","volume":"112","author":"Riminucci","year":"2003","journal-title":"J Clin Invest."},{"issue":"10","key":"2020042812160004400_CIT0044","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00424-018-2171-7","article-title":"Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men","volume":"470","author":"Daryadel","year":"2018","journal-title":"Pflugers Arch."},{"key":"2020042812160004400_CIT0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2014.10.007","article-title":"Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli","volume":"399","author":"Ito","year":"2015","journal-title":"Mol Cell Endocrinol."},{"issue":"1","key":"2020042812160004400_CIT0046","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int."},{"issue":"11","key":"2020042812160004400_CIT0047","doi-asserted-by":"crossref","first-page":"e0142924","DOI":"10.1371\/journal.pone.0142924","article-title":"Characterization of FGF23-dependent Egr-1 cistrome in the mouse renal proximal tubule","volume":"10","author":"Portale","year":"2015","journal-title":"Plos One."},{"issue":"7","key":"2020042812160004400_CIT0048","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1373\/clinchem.2015.239731","article-title":"Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence","volume":"61","author":"Zierk","year":"2015","journal-title":"Clin Chem."},{"issue":"28","key":"2020042812160004400_CIT0049","doi-asserted-by":"crossref","first-page":"18989","DOI":"10.1074\/jbc.M511752200","article-title":"The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice","volume":"281","author":"Xie","year":"2006","journal-title":"J Biol Chem."},{"issue":"43","key":"2020042812160004400_CIT0050","doi-asserted-by":"crossref","first-page":"33622","DOI":"10.1074\/jbc.M001335200","article-title":"Characterization of the extra-large G protein alpha-subunit XLalphas. I. Tissue distribution and subcellular localization","volume":"275","author":"Pasolli","year":"2000","journal-title":"J Biol Chem."},{"issue":"18","key":"2020042812160004400_CIT0051","doi-asserted-by":"crossref","first-page":"8803","DOI":"10.1016\/S0021-9258(18)68377-2","article-title":"Purine accumulation in human fat cell suspensions. Evidence that human adipocytes release inosine and hypoxanthine rather than adenosine","volume":"263","author":"Kather","year":"1988","journal-title":"J Biol Chem."},{"issue":"8","key":"2020042812160004400_CIT0052","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1359\/jbmr.060507","article-title":"Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women","volume":"21","author":"Burnett","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2020042812160004400_CIT0053","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00198-008-0780-2","article-title":"Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men","volume":"20","author":"Marsell","year":"2009","journal-title":"Osteoporos Int."},{"issue":"4","key":"2020042812160004400_CIT0054","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/jc.2016-4038","article-title":"FGF23 is not associated with age-related changes in phosphate, but enhances renal calcium reabsorption in girls","volume":"102","author":"Mitchell","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2020042812160004400_CIT0055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123817","article-title":"Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD","volume":"4","author":"Clinkenbeard","year":"2019","journal-title":"JCI Insight"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqz025\/31089915\/bqz025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/161\/1\/bqz025\/33139184\/bqz025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/161\/1\/bqz025\/33139184\/bqz025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T19:57:30Z","timestamp":1665086250000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqz025\/5638044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,23]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqz025","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"type":"print","value":"0013-7227"},{"type":"electronic","value":"1945-7170"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,11,23]]},"article-number":"bqz025"}}