{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:47:43Z","timestamp":1792219663430,"version":"4.4.0"},"reference-count":272,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BSV1-0034-01"],"award-info":[{"award-number":["ANR-12-BSV1-0034-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006005","name":"Agence de la Biom\u00e9decine","doi-asserted-by":"publisher","award":["RPS18006DDA"],"award-info":[{"award-number":["RPS18006DDA"]}],"id":[{"id":"10.13039\/501100006005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["RS16\/75-41"],"award-info":[{"award-number":["RS16\/75-41"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["EQU201903007868"],"award-info":[{"award-number":["EQU201903007868"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anti-M\u00fcllerian hormone (AMH), also called M\u00fcllerian inhibiting substance, was shown to be synthesized by the ovary in the 1980s. This article reviews the main findings of the past 20 years on the regulation of the expression of AMH and its specific receptor AMHR2 by granulosa cells, the mechanism of action of AMH, the different roles it plays in the reproductive organs, its clinical utility, and its involvement in the principal pathological conditions affecting women. The findings in respect of regulation tell us that AMH and AMHR2 expression is mainly regulated by bone morphogenetic proteins, gonadotropins, and estrogens. It has now been established that AMH regulates the different steps of folliculogenesis and that it has neuroendocrine effects. On the other hand, the importance of serum AMH as a reliable marker of ovarian reserve and as a useful tool in the prediction of the polycystic ovary syndrome (PCOS) and primary ovarian failure has also been acknowledged. Last but not least, a large body of evidence points to the involvement of AMH in the pathogenesis of PCOS.<\/jats:p>","DOI":"10.1210\/endrev\/bnab012","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T19:57:34Z","timestamp":1618603054000},"page":"753-782","source":"Crossref","is-referenced-by-count":195,"title":["Anti-M\u00fcllerian Hormone in Female Reproduction"],"prefix":"10.1210","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-3486","authenticated-orcid":false,"given":"Nathalie","family":"di Clemente","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France"},{"name":"Institut Hospitalo-Universitaire ICAN, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryst\u00e8le","family":"Racine","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France"},{"name":"Institut Hospitalo-Universitaire ICAN, Paris, France"},{"name":"Sorbonne Paris Cit\u00e9, Paris-Diderot Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Pierre","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l\u2019Axe Gonadotrope U1133, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Taieb","sequence":"additional","affiliation":[{"name":"Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l\u2019Axe Gonadotrope U1133, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"issue":"4","key":"2021111803563755700_CIT0001","first-page":"347","article-title":"Testicular anti-M\u00fcllerian hormone: history, genetics, regulation and clinical applications","volume":"3","author":"Josso","year":"2006","journal-title":"Pediatr Endocrinol Rev."},{"key":"2021111803563755700_CIT0002","first-page":"271","article-title":"Recherches sur la diff\u00e9renciation sexuelle de l\u2019embryon de lapin. 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