{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:22:19Z","timestamp":1783768939594,"version":"3.55.0"},"reference-count":100,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009878","name":"Regione Veneto","doi-asserted-by":"publisher","award":["863\/01\/98"],"award-info":[{"award-number":["863\/01\/98"]}],"id":[{"id":"10.13039\/501100009878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018331","name":"CORIS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An altered secretion of adrenocortical and adrenomedullary hormones plays a role in the clinical syndromes of primary aldosteronism (PA), Cushing, and pheochromocytoma.<\/jats:p>\n               <jats:p>Moreover, an altered production of adrenocortical hormones and\/or an abnormal release of factors by the adrenal medulla are involved in several other diseases, including high blood pressure, congestive heart failure, liver cirrhosis, nephrotic syndrome, primary reninism, renovascular hypertension, Addison disease, Bartter, Gitelman, and virilization syndromes. Understanding the regulation of adrenal function and the interactions between adrenal cortex and medulla is, therefore, the prerequisite for mechanistic understanding of these disorders.<\/jats:p>\n               <jats:p>Accumulating evidence indicates that the modulation of adrenal hormone biosynthesis is a process far more complex than originally thought, as it involves several factors, each cooperating with the other. Moreover, the tight vascular and neural interconnections between the adrenal cortex and medulla underlie physiologically relevant autocrine\/paracrine interactions involving several peptides. Besides playing a pathophysiological role in common adrenal diseases, these complex mechanisms could intervene also in rare diseases, such as pheochromocytoma concomitant with adrenal Cushing or with PA, and PA co-occurring with Cushing, through mechanisms that remain to be fully understood at the molecular levels. Heterodimerization of G protein\u2013coupled receptors (GPCRs) induced by peptide signaling is a further emerging new modulatory mechanism capable of finely tuning adrenal hormones synthesis and release.<\/jats:p>\n               <jats:p>In this review we will examine current knowledge on the role of peptides that act via GPCRs in the regulation of adrenal hormone secretion with a particular focus on autocrine-paracrine signals.<\/jats:p>","DOI":"10.1210\/endrev\/bnac011","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T17:52:01Z","timestamp":1650304321000},"page":"1038-1050","source":"Crossref","is-referenced-by-count":12,"title":["Peptidergic G Protein\u2013Coupled Receptor Regulation of Adrenal Function: Bench to Bedside and Back"],"prefix":"10.1210","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6146-3015","authenticated-orcid":false,"given":"Livia","family":"Lenzini","sequence":"first","affiliation":[{"name":"Emergency Medicine Unit, Center for blood pressure disorders -Regione Veneto and Specialized Center of Excellence for Hypertension of the European Society of Hypertension, Department of Medicine\u2013DIMED, University of Padua , 35126 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brasilina","family":"Caroccia","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit, Center for blood pressure disorders -Regione Veneto and Specialized Center of Excellence for Hypertension of the European Society of Hypertension, Department of Medicine\u2013DIMED, University of Padua , 35126 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Maria","family":"Seccia","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit, Center for blood pressure disorders -Regione Veneto and Specialized Center of Excellence for Hypertension of the European Society of Hypertension, Department of Medicine\u2013DIMED, University of Padua , 35126 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-0931","authenticated-orcid":false,"given":"Gian Paolo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit, Center for blood pressure disorders -Regione Veneto and Specialized Center of Excellence for Hypertension of the European Society of Hypertension, Department of Medicine\u2013DIMED, University of Padua , 35126 Padua , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2022112513593173200_CIT0001","first-page":"S21","article-title":"The concise guide to pharmacology 2019\/20: G protein-coupled receptors","volume":"176","author":"Alexander","year":"2019","journal-title":"Br J 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