{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:06:46Z","timestamp":1791839206494,"version":"4.3.4"},"reference-count":142,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01CA215797"],"award-info":[{"award-number":["1R01CA215797"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anne Moore Breast Cancer Research Fund"},{"name":"Emilie Lippmann and Janice Jacobs McCarthy Research Scholar Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy homeostasis. There is strong evidence linking increased adiposity to the development of 13 types of cancer. With increased adiposity comes metabolic dysfunction and insulin resistance, and increased systemic insulin and glucose support the growth of many cancers, including those of the colon and endometrium. There is also an important direct crosstalk between adipose tissue and various organs. For instance, the healthy development and function of the mammary gland, as well as the development, growth, and progression of breast cancer, are heavily impacted by the breast adipose tissue in which breast epithelial cells are embedded. Cells of the adipose tissue are responsive to external stimuli, including overfeeding, leading to remodeling and important changes in the secretion of factors known to drive the development and growth of cancers. Loss of factors like adiponectin and increased production of leptin, endotrophin, steroid hormones, and inflammatory mediators have been determined to be important mediators of the obesity\u2013cancer link. Obesity is also associated with a structural remodeling of the adipose tissue, including increased localized fibrosis and disrupted angiogenesis that contribute to the development and progression of cancers. Furthermore, tumor cells feed off the adipose tissue, where increased lipolysis within adipocytes leads to the release of fatty acids and stromal cell aerobic glycolysis leading to the increased production of lactate. Both have been hypothesized to support the higher energetic demands of cancer cells. Here, we aim to provide an update on the state of the literature revolving around the role of the adipose tissue in cancer initiation and progression.<\/jats:p>","DOI":"10.1210\/endrev\/bnad015","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T09:58:43Z","timestamp":1685613523000},"page":"961-974","source":"Crossref","is-referenced-by-count":140,"title":["Update on Adipose Tissue and Cancer"],"prefix":"10.1210","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-5546","authenticated-orcid":false,"given":"Kristy A","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine , New York, NY 10065 , USA"},{"name":"Meyer Cancer Center, Weill Cornell Medicine , New York, NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp E","family":"Scherer","sequence":"additional","affiliation":[{"name":"Touchstone Diabetes Center, University of Texas Southwestern Medical Center , Dallas, TX 75390 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"issue":"8","key":"2023111109064208000_bnad015-B1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer\u2014viewpoint of the IARC Working Group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"2023111109064208000_bnad015-B2","doi-asserted-by":"crossref","first-page":"e0193368","DOI":"10.1371\/journal.pone.0193368","article-title":"Joint association between body fat and its distribution with all-cause mortality: a data linkage cohort study based on NHANES (1988\u20132011)","volume":"13","author":"Dong B, Peng Y, Wang Z, et al","year":"2018","journal-title":"PLoS One."},{"key":"2023111109064208000_bnad015-B3","author":"World Health Organization","year":"2022"},{"issue":"7","key":"2023111109064208000_bnad015-B4","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/oby.23444","article-title":"Metabolic dysfunction and obesity-related cancer: beyond obesity and metabolic syndrome","volume":"30","author":"Karra","year":"2022","journal-title":"Obesity (Silver Spring)"},{"issue":"7","key":"2023111109064208000_bnad015-B5","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/ijc.33697","article-title":"Association of body composition with risk of overall and site-specific cancers: a population-based prospective cohort study","volume":"149","author":"He","year":"2021","journal-title":"Int J Cancer"},{"issue":"9","key":"2023111109064208000_bnad015-B6","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41416-020-01210-y","article-title":"The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK biobank","volume":"124","author":"Arthur","year":"2021","journal-title":"Br J Cancer"},{"issue":"4","key":"2023111109064208000_bnad015-B7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ijc.34322","article-title":"Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta-analysis","volume":"152","author":"Chan","year":"2023","journal-title":"Int J Cancer"},{"issue":"10","key":"2023111109064208000_bnad015-B8","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1467-789X.2012.01010.x","article-title":"A systematic review of the impact of weight loss on cancer incidence and mortality","volume":"13","author":"Birks","year":"2012","journal-title":"Obes Rev"},{"issue":"2","key":"2023111109064208000_bnad015-B9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/nu15020467","article-title":"Does bariatric surgery reduce the risk of colorectal cancer in individuals with morbid obesity? A systematic review and meta-analysis","volume":"15","author":"Chierici","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"2023111109064208000_bnad015-B10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","article-title":"Anatomical, physiological, and functional diversity of adipose tissue","volume":"27","author":"Zwick","year":"2018","journal-title":"Cell Metab"},{"issue":"12","key":"2023111109064208000_bnad015-B11","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41431-020-0681-1","article-title":"Identification of distinct transcriptome signatures of human adipose tissue from fifteen depots","volume":"28","author":"Schleinitz","year":"2020","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"2023111109064208000_bnad015-B12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10555-021-10002-6","article-title":"Adipocytokines and disease progression in endometrial cancer: a systematic review","volume":"41","author":"Ray","year":"2022","journal-title":"Cancer Metastasis Rev"},{"issue":"4","key":"2023111109064208000_bnad015-B13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.orcp.2019.03.006","article-title":"Circulating adipokines and risk of obesity related cancers: a systematic review and meta-analysis","volume":"13","author":"Yoon","year":"2019","journal-title":"Obes Res Clin Pract"},{"issue":"1","key":"2023111109064208000_bnad015-B14","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1186\/s12885-020-07651-1","article-title":"The association of leptin and adiponectin with hepatocellular carcinoma risk and prognosis: a combination of traditional, survival, and dose-response meta-analysis","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Cancer"},{"issue":"28","key":"2023111109064208000_bnad015-B15","doi-asserted-by":"crossref","first-page":"e2203357","DOI":"10.1002\/advs.202203357","article-title":"Adipocyte-derived exosomal MTTP suppresses ferroptosis and promotes chemoresistance in colorectal cancer","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"2023111109064208000_bnad015-B16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/ijo.2017.273","article-title":"Leptin regulation of the p53-HIF1\u03b1\/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link","volume":"42","author":"Zahid","year":"2018","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"2023111109064208000_bnad015-B17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00016348709103653","article-title":"Serum sex hormone binding globulin (SHBG), testosterone\/SHBG index, endometrial pathology and bone mineral density in postmenopausal women","volume":"66","author":"Brody","year":"1987","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"10","key":"2023111109064208000_bnad015-B18","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.3390\/ijms23105307","article-title":"Role of leptin and adiponectin in endometrial cancer","volume":"23","author":"Slabuszewska-Jozwiak","year":"10 2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2023111109064208000_bnad015-B19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12916-022-02322-3","article-title":"Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis","volume":"20","author":"Hazelwood","year":"2022","journal-title":"BMC Med"},{"issue":"12","key":"2023111109064208000_bnad015-B20","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/ijc.23887","article-title":"Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells","volume":"123","author":"Carino","year":"2008","journal-title":"Int J Cancer"},{"issue":"2","key":"2023111109064208000_bnad015-B21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1677\/erc.1.01169","article-title":"Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways","volume":"13","author":"Sharma","year":"2006","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"2023111109064208000_bnad015-B22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11596-011-0382-7","article-title":"Leptin activates STAT3 and ERK1\/2 pathways and induces endometrial cancer cell proliferation","volume":"31","author":"Liu","year":"2011","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"issue":"6","key":"2023111109064208000_bnad015-B23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5306\/wjco.v10.i6.222","article-title":"Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance","volume":"10","author":"Daley-Brown","year":"2019","journal-title":"World J Clin Oncol"},{"issue":"5","key":"2023111109064208000_bnad015-B24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/cen.13830","article-title":"The benefits of adding metformin to tamoxifen to protect the endometrium \u2013 a randomized placebo-controlled trial","volume":"89","author":"Davis","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2023111109064208000_bnad015-B25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1158\/0008-5472.CAN-18-1615","article-title":"Adipokines deregulate cellular communication via epigenetic repression of Gap junction loci in obese endometrial cancer","volume":"79","author":"Polusani","year":"2019","journal-title":"Cancer Res"},{"issue":"3","key":"2023111109064208000_bnad015-B26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10555-022-10058-y","article-title":"Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases","volume":"41","author":"Pellegata","year":"2022","journal-title":"Cancer Metastasis Rev"},{"issue":"6","key":"2023111109064208000_bnad015-B27","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1074\/jbc.M308351200","article-title":"Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK\/STAT and JAK-mediated H2O2-dependant MAPK pathways","volume":"279","author":"Cao","year":"2004","journal-title":"J Biol Chem"},{"issue":"1","key":"2023111109064208000_bnad015-B28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"2023111109064208000_bnad015-B29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41575-021-00551-0","article-title":"Intra-pancreatic fat deposition: bringing hidden fat to the fore","volume":"19","author":"Petrov","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2023111109064208000_bnad015-B30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cyto.2019.04.011","article-title":"Associations between intra-pancreatic fat deposition and circulating levels of cytokines","volume":"120","author":"Singh","year":"2019","journal-title":"Cytokine"},{"issue":"17","key":"2023111109064208000_bnad015-B31","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3748\/wjg.v27.i17.1936","article-title":"Post-pancreatitis diabetes mellitus and excess intra-pancreatic fat deposition as harbingers of pancreatic cancer","volume":"27","author":"Petrov","year":"2021","journal-title":"World J Gastroenterol"},{"key":"2023111109064208000_bnad015-B32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-016-0163-7","article-title":"Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration","volume":"5","author":"Balaban","year":"2017","journal-title":"Cancer Metab"},{"issue":"4 Suppl 4","key":"2023111109064208000_bnad015-B33","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.1097\/SAP.0000000000001364","article-title":"A 3-dimensional biomimetic platform to interrogate the safety of autologous fat transfer in the setting of breast cancer","volume":"80","author":"Toyoda","year":"2018","journal-title":"Ann Plast Surg"},{"issue":"11","key":"2023111109064208000_bnad015-B34","doi-asserted-by":"crossref","first-page":"111362","DOI":"10.1016\/j.celrep.2022.111362","article-title":"Adipocyte mesenchymal transition contributes to mammary tumor progression","volume":"40","author":"Zhu","year":"2022","journal-title":"Cell Rep"},{"issue":"23","key":"2023111109064208000_bnad015-B35","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma","volume":"8","author":"Pavlides","year":"2009","journal-title":"Cell Cycle"},{"issue":"6","key":"2023111109064208000_bnad015-B36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41574-021-00487-0","article-title":"Metabolic pathways in obesity-related breast cancer","volume":"17","author":"Brown","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"2023111109064208000_bnad015-B37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/0008-5472.CAN-20-1088","article-title":"Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype","volume":"81","author":"Fairfield","year":"2021","journal-title":"Cancer Res"},{"issue":"8","key":"2023111109064208000_bnad015-B38","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.2848","article-title":"Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury","volume":"18","author":"Dulauroy","year":"2012","journal-title":"Nat Med"},{"issue":"1","key":"2023111109064208000_bnad015-B39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2014.11.004","article-title":"Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis","volume":"16","author":"Kramann","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2023111109064208000_bnad015-B40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-bioeng-110220-115419","article-title":"Regulation of tumor invasion by the physical microenvironment: lessons from breast and brain cancer","volume":"24","author":"Beeghly","year":"2022","journal-title":"Annu Rev Biomed Eng"},{"key":"2023111109064208000_bnad015-B41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41366-020-00676-3","article-title":"Associations between markers of mammary adipose tissue dysfunction and breast cancer prognostic factors","volume":"45","author":"Laforest","year":"2020","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"2023111109064208000_bnad015-B42","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/0008-5472.CAN-10-3323","article-title":"Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion","volume":"71","author":"Dirat","year":"2011","journal-title":"Cancer Res"},{"issue":"7","key":"2023111109064208000_bnad015-B43","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.3390\/ijms23073883","article-title":"The mammary gland: basic structure and molecular signaling during development","volume":"23","author":"Biswas","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2023111109064208000_bnad015-B44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/dvdy.10065","article-title":"Adipose tissue: a vital in vivo role in mammary gland development but not differentiation","volume":"223","author":"Couldrey","year":"2002","journal-title":"Dev Dyn"},{"issue":"2","key":"2023111109064208000_bnad015-B45","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.ydbio.2010.06.019","article-title":"Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes","volume":"344","author":"Landskroner-Eiger","year":"2010","journal-title":"Dev Biol"},{"key":"2023111109064208000_bnad015-B46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.semcdb.2020.11.011","article-title":"Pubertal mammary gland development is a key determinant of adult mammographic density","volume":"114","author":"Ghadge","year":"2021","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"2023111109064208000_bnad015-B47","doi-asserted-by":"crossref","first-page":"e13005","DOI":"10.1111\/obr.13005","article-title":"Adipokines: a gear shift in puberty","volume":"21","author":"Nieuwenhuis","year":"2020","journal-title":"Obes Rev"},{"issue":"1","key":"2023111109064208000_bnad015-B48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13058-020-01279-6","article-title":"Investigation of the adolescent female breast transcriptome and the impact of obesity","volume":"22","author":"Burkholder","year":"2020","journal-title":"Breast Cancer Res"},{"issue":"1\u20132","key":"2023111109064208000_bnad015-B49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mce.2012.04.010","article-title":"Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast","volume":"361","author":"Hilton","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"2023111109064208000_bnad015-B50","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1158\/1055-9965.EPI-07-0085","article-title":"Comparison of a new and existing method of mammographic density measurement: intramethod reliability and associations with known risk factors","volume":"16","author":"McCormack","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"2023111109064208000_bnad015-B51","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cmet.2018.05.022","article-title":"Reversible de-differentiation of mature white adipocytes into preadipocyte-like precursors during lactation","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Metab"},{"issue":"3","key":"2023111109064208000_bnad015-B52","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10911-019-09434-2","article-title":"Remodeling of murine mammary adipose tissue during pregnancy, lactation, and involution","volume":"24","author":"Wang","year":"2019","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"1","key":"2023111109064208000_bnad015-B53","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1038\/s41467-018-05911-0","article-title":"Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation","volume":"9","author":"Zwick","year":"2018","journal-title":"Nat Commun"},{"issue":"22","key":"2023111109064208000_bnad015-B54","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/jnci\/94.22.1704","article-title":"Leptin\u2014a growth factor in normal and malignant breast cells and for normal mammary gland development","volume":"94","author":"Hu","year":"2002","journal-title":"J Natl Cancer Inst"},{"issue":"1\u20132","key":"2023111109064208000_bnad015-B55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0303-7207(01)00678-5","article-title":"Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line","volume":"188","author":"Laud","year":"2002","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2023111109064208000_bnad015-B56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0022-4804(03)00166-5","article-title":"Differential effects of leptin on cancer in vitro","volume":"113","author":"Somasundar","year":"2003","journal-title":"J Surg Res"},{"issue":"2","key":"2023111109064208000_bnad015-B57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0167-4889(02)00276-8","article-title":"Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression","volume":"1592","author":"Okumura","year":"2002","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"2023111109064208000_bnad015-B58","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3390\/biom10121676","article-title":"New actors driving the epithelial-mesenchymal transition in cancer: the role of leptin","volume":"10","author":"Olea-Flores","year":"2020","journal-title":"Biomolecules"},{"issue":"6","key":"2023111109064208000_bnad015-B59","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s13402-017-0342-8","article-title":"Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2","volume":"40","author":"Huang","year":"2017","journal-title":"Cell Oncol (Dordr)"},{"issue":"684","key":"2023111109064208000_bnad015-B60","doi-asserted-by":"crossref","first-page":"eade1857","DOI":"10.1126\/scitranslmed.ade1857","article-title":"Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2","volume":"15","author":"Bhardwaj","year":"2023","journal-title":"Sci Transl Med"},{"issue":"13","key":"2023111109064208000_bnad015-B61","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1158\/0008-5472.CAN-09-0108","article-title":"Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women","volume":"69","author":"Brown","year":"2009","journal-title":"Cancer Res"},{"issue":"3","key":"2023111109064208000_bnad015-B62","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1210\/jc.2006-1858","article-title":"Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies","volume":"92","author":"Korner","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"23","key":"2023111109064208000_bnad015-B63","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.1158\/0008-5472.CAN-06-1969","article-title":"Adiponectin modulates the glycogen synthase kinase-3\u03b2\/\u03b2-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res"},{"key":"2023111109064208000_bnad015-B64","doi-asserted-by":"crossref","first-page":"791696","DOI":"10.3389\/fonc.2021.791696","article-title":"The prostaglandin E2 pathway and breast cancer stem cells: evidence of increased signaling and potential targeting","volume":"11","author":"Walker","year":"2021","journal-title":"Front Oncol"},{"issue":"12","key":"2023111109064208000_bnad015-B65","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1210\/endo.137.12.8940410","article-title":"Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene","volume":"137","author":"Zhao","year":"1996","journal-title":"Endocrinology"},{"issue":"8","key":"2023111109064208000_bnad015-B66","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/labinvest.2012.90","article-title":"Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model","volume":"92","author":"Xin","year":"2012","journal-title":"Lab Invest"},{"key":"2023111109064208000_bnad015-B67","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3389\/fphar.2020.00819","article-title":"Eicosanoids in cancer: prostaglandin E2 receptor 4 in cancer therapeutics and immunotherapy","volume":"11","author":"Ching","year":"2020","journal-title":"Front Pharmacol"},{"issue":"12","key":"2023111109064208000_bnad015-B68","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1158\/0008-5472.CAN-19-3339","article-title":"Induction of DNMT3B by PGE2 and IL6 at distant metastatic sites promotes epigenetic modification and breast cancer colonization","volume":"80","author":"So","year":"2020","journal-title":"Cancer Res"},{"issue":"27","key":"2023111109064208000_bnad015-B69","doi-asserted-by":"crossref","first-page":"16449","DOI":"10.1074\/jbc.270.27.16449","article-title":"Aromatase P450 gene expression in human adipose tissue. Role of a Jak\/STAT pathway in regulation of the adipose-specific promoter","volume":"270","author":"Zhao","year":"1995","journal-title":"J Biol Chem"},{"issue":"1","key":"2023111109064208000_bnad015-B70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10549-014-3223-0","article-title":"Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production","volume":"149","author":"Bowers","year":"2015","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"2023111109064208000_bnad015-B71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tem.2018.10.006","article-title":"Crosstalk between estrogen signaling and breast cancer metabolism","volume":"30","author":"Kulkoyluoglu-Cotul","year":"2019","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"2023111109064208000_bnad015-B72","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3390\/ijms19020611","article-title":"The role of the estrogen pathway in the tumor microenvironment","volume":"19","author":"Rothenberger","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2023111109064208000_bnad015-B73","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1210\/jcem-53-2-412","article-title":"Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture","volume":"53","author":"Ackerman","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"issue":"23","key":"2023111109064208000_bnad015-B74","doi-asserted-by":"crossref","first-page":"20591","DOI":"10.1074\/jbc.M201117200","article-title":"Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes","volume":"277","author":"Clyne","year":"2002","journal-title":"J Biol Chem"},{"issue":"4","key":"2023111109064208000_bnad015-B75","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/0008-5472.CAN-14-2164","article-title":"Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res"},{"issue":"1","key":"2023111109064208000_bnad015-B76","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10549-014-3060-1","article-title":"Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism","volume":"147","author":"Docanto","year":"2014","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"2023111109064208000_bnad015-B77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13058-021-01433-8","article-title":"Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant","volume":"23","author":"Jacquemetton","year":"2021","journal-title":"Breast Cancer Res"},{"issue":"2","key":"2023111109064208000_bnad015-B78","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.stemcr.2016.12.022","article-title":"SCA-1 Labels a subset of estrogen-responsive bipotential repopulating cells within the CD24+ CD49fhi mammary stem cell-enriched compartment","volume":"8","author":"Dall","year":"2017","journal-title":"Stem Cell Reports"},{"key":"2023111109064208000_bnad015-B79","doi-asserted-by":"crossref","first-page":"638918","DOI":"10.3389\/fonc.2021.638918","article-title":"Obese adipose tissue as a driver of breast cancer growth and development: update and emerging evidence","volume":"11","author":"Bhardwaj","year":"2021","journal-title":"Front Oncol"},{"issue":"Pt A","key":"2023111109064208000_bnad015-B80","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.steroids.2014.08.003","article-title":"Estrogen metabolites and breast cancer","volume":"99","author":"Santen","year":"2015","journal-title":"Steroids"},{"issue":"4","key":"2023111109064208000_bnad015-B81","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2217\/fon.13.278","article-title":"Breast cancer prevention for BRCA1 and BRCA2 mutation carriers: is there a role for tamoxifen?","volume":"10","author":"Phillips","year":"2014","journal-title":"Future Oncol"},{"key":"2023111109064208000_bnad015-B82","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2407-12-421","article-title":"Hypoxic enhancement of exosome release by breast cancer cells","volume":"12","author":"King","year":"2012","journal-title":"BMC Cancer"},{"issue":"14","key":"2023111109064208000_bnad015-B83","doi-asserted-by":"crossref","first-page":"e12144","DOI":"10.1002\/jev2.12144","article-title":"A brief history of nearly EV-erything\u2014the rise and rise of extracellular vesicles","volume":"10","author":"Couch","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"2023111109064208000_bnad015-B84","doi-asserted-by":"crossref","first-page":"975334","DOI":"10.3389\/fendo.2022.975334","article-title":"The emerging roles and mechanisms of exosomal non-coding RNAs in the mutual regulation between adipose tissue and other related tissues in obesity and metabolic diseases","volume":"13","author":"Pan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023111109064208000_bnad015-B85","doi-asserted-by":"crossref","first-page":"e2200358","DOI":"10.1002\/mnfr.202200358","article-title":"Role of exosomes derived from adipose tissue under obese conditions in skeletal muscle and liver cells: commonalities and differences","volume":"66","author":"Kim","year":"2022","journal-title":"Mol Nutr Food Res"},{"issue":"6430","key":"2023111109064208000_bnad015-B86","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.aaw2586","article-title":"A lipase-independent pathway of lipid release and immune modulation by adipocytes","volume":"363","author":"Flaherty","year":"2019","journal-title":"Science"},{"issue":"18","key":"2023111109064208000_bnad015-B87","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.7150\/thno.43968","article-title":"Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"2023111109064208000_bnad015-B88","article-title":"Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism","author":"Liu","journal-title":"BiorRxiv"},{"issue":"1\u20132","key":"2023111109064208000_bnad015-B89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11010-013-1746-z","article-title":"Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model","volume":"383","author":"Lin","year":"2013","journal-title":"Mol Cell Biochem"},{"issue":"710","key":"2023111109064208000_bnad015-B90","doi-asserted-by":"crossref","first-page":"eabj2807","DOI":"10.1126\/scisignal.abj2807","article-title":"Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes","volume":"14","author":"Jafari","year":"2021","journal-title":"Sci Signal"},{"issue":"301","key":"2023111109064208000_bnad015-B91","doi-asserted-by":"crossref","first-page":"301ra130","DOI":"10.1126\/scitranslmed.3010467","article-title":"Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis","volume":"7","author":"Seo","year":"2015","journal-title":"Sci Transl Med"},{"issue":"48","key":"2023111109064208000_bnad015-B92","doi-asserted-by":"crossref","first-page":"1910650","DOI":"10.1002\/adfm.201910650","article-title":"Obesity-associated adipose stromal cells promote breast cancer invasion through direct cell contact and ECM remodeling","volume":"30","author":"Ling","year":"2020","journal-title":"Adv Funct Mater"},{"issue":"6","key":"2023111109064208000_bnad015-B93","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/MCB.01300-08","article-title":"Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI","volume":"29","author":"Khan","year":"2009","journal-title":"Mol Cell Biol"},{"key":"2023111109064208000_bnad015-B94","doi-asserted-by":"crossref","first-page":"e125094","DOI":"10.1172\/jci.insight.125094","article-title":"Human endotrophin as a driver of malignant tumor growth","volume":"5","author":"Bu","year":"2019","journal-title":"JCI Insight"},{"key":"2023111109064208000_bnad015-B95","doi-asserted-by":"crossref","first-page":"903925","DOI":"10.3389\/fendo.2022.903925","article-title":"Adipocyte-cancer cell interactions in the bone microenvironment","volume":"13","author":"Otley","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"2023111109064208000_bnad015-B96","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neo.2015.11.005","article-title":"Breast cancer cell colonization of the human bone marrow adipose tissue niche","volume":"17","author":"Templeton","year":"2015","journal-title":"Neoplasia"},{"issue":"11","key":"2023111109064208000_bnad015-B97","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.18632\/oncotarget.1482","article-title":"Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms","volume":"4","author":"Herroon","year":"2013","journal-title":"Oncotarget"},{"issue":"10","key":"2023111109064208000_bnad015-B98","first-page":"707","article-title":"Fatty acid synthase expression defines distinct molecular signatures in prostate cancer","volume":"1","author":"Rossi","year":"2003","journal-title":"Mol Cancer Res"},{"issue":"4","key":"2023111109064208000_bnad015-B99","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/emmm.201302734","article-title":"A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis","volume":"6","author":"Zadra","year":"2014","journal-title":"EMBO Mol Med"},{"issue":"2","key":"2023111109064208000_bnad015-B100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1073\/pnas.1808834116","article-title":"Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer","volume":"116","author":"Zadra","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2023111109064208000_bnad015-B101","first-page":"369","article-title":"Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach","volume":"30","author":"Liu","year":"2010","journal-title":"Anticancer Res"},{"issue":"2","key":"2023111109064208000_bnad015-B102","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/pcan.2015.12","article-title":"Metabolic syndrome, dyslipidemia and prostate cancer recurrence after primary surgery or radiation in a veterans cohort","volume":"18","author":"Macleod","year":"2015","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"3","key":"2023111109064208000_bnad015-B103","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/aje\/kwr520","article-title":"Dietary fatty acid intake and prostate cancer survival in Orebro County, Sweden","volume":"176","author":"Epstein","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"5\u20136","key":"2023111109064208000_bnad015-B104","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1159\/000019913","article-title":"Dietary fat and prostate cancer progression and survival","volume":"35","author":"Fradet","year":"1999","journal-title":"Eur Urol"},{"issue":"14","key":"2023111109064208000_bnad015-B105","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1001\/jamainternmed.2013.6536","article-title":"Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality","volume":"173","author":"Richman","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"478","key":"2023111109064208000_bnad015-B106","doi-asserted-by":"crossref","first-page":"eaau5758","DOI":"10.1126\/scitranslmed.aau5758","article-title":"Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer","volume":"11","author":"Watt","year":"2019","journal-title":"Sci Transl Med"},{"issue":"20","key":"2023111109064208000_bnad015-B107","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.3390\/cancers14205077","article-title":"Obesity-Related cross-talk between prostate cancer and peripheral fat: potential role of exosomes","volume":"14","author":"Feng","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"15","key":"2023111109064208000_bnad015-B108","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.3390\/cells11152388","article-title":"Adipocyte-derived extracellular vesicles promote prostate cancer cell aggressiveness by enabling multiple phenotypic and metabolic changes","volume":"11","author":"Fontana","year":"2022","journal-title":"Cells"},{"key":"2023111109064208000_bnad015-B109","first-page":"249741","article-title":"Proinflammatory cytokines in prostate cancer development and progression promoted by high-fat diet","volume":"2015","author":"Xu","year":"2015","journal-title":"Biomed Res Int"},{"issue":"9","key":"2023111109064208000_bnad015-B110","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.3390\/cancers13092281","article-title":"Melanoma progression under obesity: focus on adipokines","volume":"13","author":"Olszanska","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"2023111109064208000_bnad015-B111","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/pcmr.12584","article-title":"Obesity and melanoma: could fat be fueling malignancy?","volume":"30","author":"Clement","year":"2017","journal-title":"Pigment Cell Melanoma Res"},{"key":"2023111109064208000_bnad015-B112","doi-asserted-by":"crossref","first-page":"680536","DOI":"10.5402\/2013\/680536","article-title":"The association between obesity and cancer risk: a meta-analysis of observational studies from 1985 to 2011","volume":"2013","author":"Dobbins","year":"2013","journal-title":"ISRN Prev Med"},{"issue":"9612","key":"2023111109064208000_bnad015-B113","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","article-title":"Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies","volume":"371","author":"Renehan","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"2023111109064208000_bnad015-B114","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ejca.2012.08.028","article-title":"Obesity and risk of malignant melanoma: a meta-analysis of cohort and case-control studies","volume":"49","author":"Sergentanis","year":"2013","journal-title":"Eur J Cancer"},{"issue":"1","key":"2023111109064208000_bnad015-B115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/01.cmr.0000194429.77643.76","article-title":". Anthropometric measures and risk of cutaneous malignant melanoma: a case-control study from Italy","volume":"16","author":"Gallus","year":"2006","journal-title":"Melanoma Res"},{"issue":"5","key":"2023111109064208000_bnad015-B116","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/01.cej.0000178074.42995.47","article-title":"Comparison of self-reported height and weight by cancer type among men from Montreal, Canada","volume":"14","author":"Rousseau","year":"2005","journal-title":"Eur J Cancer Prev"},{"issue":"7","key":"2023111109064208000_bnad015-B117","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/A:1011211615524","article-title":"Melanoma risk in relation to height, weight, and exercise (United States)","volume":"12","author":"Shors","year":"2001","journal-title":"Cancer Causes Control"},{"issue":"5","key":"2023111109064208000_bnad015-B118","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/ijc.23214","article-title":"Anthropometric factors and risk of melanoma in women: a pooled analysis","volume":"122","author":"Olsen","year":"2008","journal-title":"Int J Cancer"},{"issue":"2","key":"2023111109064208000_bnad015-B119","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/annonc\/mdm464","article-title":"Melanoma risk in association with serum leptin levels and lifestyle parameters: a case-control study","volume":"19","author":"Gogas","year":"2008","journal-title":"Ann Oncol"},{"issue":"9","key":"2023111109064208000_bnad015-B120","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.ejca.2007.03.026","article-title":"Circulating adiponectin levels in relation to melanoma: a case-control study","volume":"43","author":"Mantzoros","year":"2007","journal-title":"Eur J Cancer"},{"issue":"4","key":"2023111109064208000_bnad015-B121","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3892\/or_00000713","article-title":"Promotion of melanoma growth by the metabolic hormone leptin","volume":"23","author":"Ellerhorst","year":"2010","journal-title":"Oncol Rep"},{"issue":"2","key":"2023111109064208000_bnad015-B122","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/ijc.28983","article-title":"High-fat diet-induced obesity increases lymphangiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: roles of adipocytes and M2-macrophages","volume":"136","author":"Jung","year":"2015","journal-title":"Int J Cancer"},{"issue":"3","key":"2023111109064208000_bnad015-B123","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molonc.2014.11.006","article-title":"Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: role of adipokines","volume":"9","author":"Malvi","year":"2015","journal-title":"Mol Oncol"},{"issue":"3","key":"2023111109064208000_bnad015-B124","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ijc.26048","article-title":"Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN","volume":"130","author":"Pandey","year":"2012","journal-title":"Int J Cancer"},{"issue":"44","key":"2023111109064208000_bnad015-B125","doi-asserted-by":"crossref","first-page":"30525","DOI":"10.1074\/jbc.M114.593210","article-title":"Subcutaneous adipocytes promote melanoma cell growth by activating the Akt signaling pathway: role of palmitic acid","volume":"289","author":"Kwan","year":"2014","journal-title":"J Biol Chem"},{"issue":"14","key":"2023111109064208000_bnad015-B126","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1158\/0008-5472.CAN-16-0651","article-title":"Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer","volume":"76","author":"Lazar","year":"2016","journal-title":"Cancer Res"},{"key":"2023111109064208000_bnad015-B127","doi-asserted-by":"crossref","first-page":"976056","DOI":"10.3389\/fendo.2022.976056","article-title":"Implications of metabolic health status and obesity on the risk of kidney cancer: a nationwide population-based cohort study","volume":"13","author":"Cho","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"44","key":"2023111109064208000_bnad015-B128","doi-asserted-by":"crossref","first-page":"e12860","DOI":"10.1097\/MD.0000000000012860","article-title":"The association between BMI and kidney cancer risk: an updated dose-response meta-analysis in accordance with PRISMA guideline","volume":"97","author":"Liu","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"2023111109064208000_bnad015-B129","doi-asserted-by":"crossref","first-page":"e1003786","DOI":"10.1371\/journal.pmed.1003786","article-title":"The blood metabolome of incident kidney cancer: a case-control study nested within the MetKid consortium","volume":"18","author":"Guida","year":"2021","journal-title":"PLoS Med"},{"issue":"1","key":"2023111109064208000_bnad015-B130","doi-asserted-by":"crossref","first-page":"1747731","DOI":"10.1080\/2162402X.2020.1747731","article-title":"The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients","volume":"9","author":"Margaroli","year":"2020","journal-title":"OncoImmunology"},{"issue":"2","key":"2023111109064208000_bnad015-B131","first-page":"358","article-title":"Twist2 and CD24 expression alters renal microenvironment in obesity associated kidney cancer","volume":"22","author":"Yang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"55","key":"2023111109064208000_bnad015-B132","doi-asserted-by":"crossref","first-page":"94223","DOI":"10.18632\/oncotarget.21666","article-title":"Human renal adipose tissue induces the invasion and progression of renal cell carcinoma","volume":"8","author":"Campo-Verde-Arbocco","year":"2017","journal-title":"Oncotarget"},{"issue":"52","key":"2023111109064208000_bnad015-B133","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.18632\/oncotarget.27157","article-title":"Human renal adipose tissue from normal and tumor kidney: its influence on renal cell carcinoma","volume":"10","author":"Bruna","year":"2019","journal-title":"Oncotarget"},{"issue":"22","key":"2023111109064208000_bnad015-B134","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1182\/blood-2011-01-330407","article-title":"Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease","volume":"118","author":"Fowler","year":"2011","journal-title":"Blood"},{"issue":"2","key":"2023111109064208000_bnad015-B135","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/leu.2014.295","article-title":"Diet-induced obesity promotes a myeloma-like condition in vivo","volume":"29","author":"Lwin","year":"2015","journal-title":"Leukemia"},{"issue":"1","key":"2023111109064208000_bnad015-B136","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.canlet.2016.06.010","article-title":"Adipocytes contribute to the growth and progression of multiple myeloma: unraveling obesity related differences in adipocyte signaling","volume":"380","author":"Bullwinkle","year":"2016","journal-title":"Cancer Lett"},{"issue":"3","key":"2023111109064208000_bnad015-B137","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose-tissue plasticity in health and disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"issue":"2","key":"2023111109064208000_bnad015-B138","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI60433","article-title":"Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans","volume":"122","author":"Ouellet","year":"2012","journal-title":"J Clin Invest"},{"issue":"1","key":"2023111109064208000_bnad015-B139","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1158\/1541-7786.MCR-15-0151","article-title":"Increased expression of beige\/brown adipose markers from host and breast cancer cells influence xenograft formation in mice","volume":"14","author":"Singh","year":"2016","journal-title":"Mol Cancer Res"},{"issue":"4","key":"2023111109064208000_bnad015-B140","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00256-019-03322-w","article-title":"Brown adipose tissue and cancer progression","volume":"49","author":"Chu","year":"2020","journal-title":"Skeletal Radiol"},{"issue":"1","key":"2023111109064208000_bnad015-B141","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF00402783","article-title":"Brown adipose tissue in cancer patients: possible cause of cancer-induced cachexia","volume":"111","author":"Shellock","year":"1986","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"2023111109064208000_bnad015-B142","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s11307-020-01482-z","article-title":"Brown adipose tissue in breast cancer evaluated by [18F] FDG-PET\/CT","volume":"22","author":"Pace","year":"2020","journal-title":"Mol Imaging Biol"}],"container-title":["Endocrine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/edrv\/advance-article-pdf\/doi\/10.1210\/endrev\/bnad015\/50720770\/bnad015.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/edrv\/article-pdf\/44\/6\/961\/53180366\/bnad015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/edrv\/article-pdf\/44\/6\/961\/53180366\/bnad015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T04:08:29Z","timestamp":1699675709000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/edrv\/article\/44\/6\/961\/7187918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":142,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,1]]},"published-print":{"date-parts":[[2023,11,9]]}},"URL":"https:\/\/doi.org\/10.1210\/endrev\/bnad015","relation":{},"ISSN":["0163-769X","1945-7189"],"issn-type":[{"value":"0163-769X","type":"print"},{"value":"1945-7189","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12]]},"published":{"date-parts":[[2023,6,1]]}}}