{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:49:59Z","timestamp":1792439399825,"version":"4.5.0"},"reference-count":426,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The University of Queensland Graduate School Scholarship"},{"name":"Mater Research Institute Frank Clair Scholarship"},{"name":"Metro South Health Research Support Scheme Project Grants"},{"name":"National Health and Medical Research Council Senior Research Fellowship","award":["APP1136100"],"award-info":[{"award-number":["APP1136100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits, at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor (GR) is the site of action for these hormones and a vast body of work has been conducted understanding its function. Traditionally, it was thought that the anti-inflammatory benefits of glucocorticoids were mediated by transrepression of pro-inflammatory transcription factors, while the adverse metabolic effects resulted from direct transactivation. This canonical understanding of the GR function has been brought into question over the past 2 decades with advances in the resolution of scientific techniques, and the discovery of multiple isoforms of the receptor present in most tissues. Here we review the structure and function of the GR, the nature of the receptor isoforms, and the contribution of the receptor to glucocorticoid sensitivity, or resistance in health and disease.<\/jats:p>","DOI":"10.1210\/endrev\/bnae008","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T09:03:59Z","timestamp":1711703039000},"page":"593-624","source":"Crossref","is-referenced-by-count":139,"title":["The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity"],"prefix":"10.1210","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-985X","authenticated-orcid":false,"given":"Jack","family":"Lockett","sequence":"first","affiliation":[{"name":"Mater Research Institute, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4101 , Australia"},{"name":"Faculty of Medicine, The University of Queensland , Herston, QLD 4006 , Australia"},{"name":"Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Metro South Health , Woolloongabba, QLD 4102 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-4980","authenticated-orcid":false,"given":"Warrick J","family":"Inder","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland , Herston, QLD 4006 , Australia"},{"name":"Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Metro South Health , Woolloongabba, QLD 4102 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4892-6748","authenticated-orcid":false,"given":"Vicki L","family":"Clifton","sequence":"additional","affiliation":[{"name":"Mater Research Institute, The University of Queensland, Translational Research Institute , Woolloongabba, QLD 4101 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"issue":"20","key":"2024071216312222200_bnae008-B1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","article-title":"The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation","volume":"332","author":"Chrousos","year":"1995","journal-title":"N Engl J Med"},{"issue":"1","key":"2024071216312222200_bnae008-B2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.rdc.2015.08.002","article-title":"Corticosteroids: mechanisms of action in health and disease","volume":"42","author":"Ramamoorthy","year":"2016","journal-title":"Rheum Dis Clin North Am"},{"issue":"4","key":"2024071216312222200_bnae008-B3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.beem.2015.04.007","article-title":"Specificity and sensitivity of glucocorticoid signaling in health and disease","volume":"29","author":"Cain","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"2024071216312222200_bnae008-B4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1096\/fj.01-0245com","article-title":"Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells","volume":"16","author":"Galon","year":"2002","journal-title":"FASEB J"},{"issue":"8","key":"2024071216312222200_bnae008-B5","first-page":"1104","article-title":"Glucocorticoids and their receptor isoforms: roles in female reproduction, pregnancy, and foetal development","volume":"12","author":"Bhaumik","year":"2023","journal-title":"Biology (Basel)"},{"issue":"1","key":"2024071216312222200_bnae008-B6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1710-1492-9-30","article-title":"A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"2","key":"2024071216312222200_bnae008-B7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/qjmed\/93.2.105","article-title":"Use of oral corticosteroids in the United Kingdom","volume":"93","author":"van Staa","year":"2000","journal-title":"QJM"},{"issue":"3","key":"2024071216312222200_bnae008-B8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1530\/EJE-19-0305","article-title":"Fifteen-year nationwide trends in systemic glucocorticoid drug use in Denmark","volume":"181","author":"Laugesen","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2024071216312222200_bnae008-B9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s12020-020-02382-6","article-title":"Trends in long-term glucocorticoid use and risk of 5-year mortality: a historical cohort study in South Korea","volume":"69","author":"Oh","year":"2020","journal-title":"Endocrine"},{"issue":"9","key":"2024071216312222200_bnae008-B10","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1210\/jc.2019-00153","article-title":"Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England","volume":"104","author":"Mebrahtu","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B11","doi-asserted-by":"crossref","first-page":"1900804","DOI":"10.1183\/13993003.00804-2019","article-title":"Increased mortality in patients with corticosteroid-dependent asthma: a nationwide population-based study","volume":"54","author":"Lee","year":"2019","journal-title":"Eur Respir J"},{"issue":"10","key":"2024071216312222200_bnae008-B12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s10654-016-0167-1","article-title":"Oral glucocorticoid therapy and all-cause and cause-specific mortality in patients with rheumatoid arthritis: a retrospective cohort study","volume":"31","author":"Movahedi","year":"2016","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"2024071216312222200_bnae008-B13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ajg.2017.479","article-title":"Increased mortality rates with prolonged corticosteroid therapy when compared with antitumor necrosis factor-\u03b1-directed therapy for inflammatory bowel disease","volume":"113","author":"Lewis","year":"2018","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"2024071216312222200_bnae008-B14","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1210\/endrev\/bnad016","article-title":"Treating the side effects of exogenous glucocorticoids; can we separate the good from the bad?","volume":"44","author":"Pofi","year":"2023","journal-title":"Endocr Rev"},{"issue":"4","key":"2024071216312222200_bnae008-B15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11154-007-9052-2","article-title":"Basic concepts and recent developments in human steroid hormone biosynthesis","volume":"8","author":"Ghayee","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"2024071216312222200_bnae008-B16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0889-8529(18)30078-1","article-title":"Physiology of the hypothalamic-pituitary-adrenal axis in health and dysregulation in psychiatric and autoimmune disorders","volume":"23","author":"Tsigos","year":"1994","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"7","key":"2024071216312222200_bnae008-B17","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/nrendo.2009.106","article-title":"Stress and disorders of the stress system","volume":"5","author":"Chrousos","year":"2009","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2024071216312222200_bnae008-B18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/edrv-9-1-135","article-title":"Regulation of proopiomelanocortin gene expression in pituitary","volume":"9","author":"Lundblad","year":"1988","journal-title":"Endocr Rev"},{"issue":"3","key":"2024071216312222200_bnae008-B19","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1210\/endo-113-3-1121","article-title":"Effects of synthetic ovine corticotropin-releasing factor, glucocorticoids, catecholamines, neurohypophysial peptides, and other substances on cultured corticotropic cells","volume":"113","author":"Vale","year":"1983","journal-title":"Endocrinology"},{"issue":"4","key":"2024071216312222200_bnae008-B20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11102-015-0703-0","article-title":"Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system","volume":"19","author":"Rotondo","year":"2016","journal-title":"Pituitary"},{"key":"2024071216312222200_bnae008-B21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fendo.2017.00013","article-title":"ACTH receptor (MC2R) specificity: what do we know about underlying molecular mechanisms?","volume":"8","author":"Fridmanis","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2024071216312222200_bnae008-B22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1677\/joe.0.1750099","article-title":"Plasma binding proteins as mediators of corticosteroid action in vertebrates","volume":"175","author":"Breuner","year":"2002","journal-title":"J Endocrinol"},{"issue":"1-2","key":"2024071216312222200_bnae008-B23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cccn.2005.03.044","article-title":"Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin","volume":"359","author":"Lewis","year":"2005","journal-title":"Clin Chim Acta"},{"issue":"5","key":"2024071216312222200_bnae008-B24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.beem.2015.09.001","article-title":"Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications","volume":"29","author":"Bae","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"2024071216312222200_bnae008-B25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/17446651.2017.1332991","article-title":"Corticosteroid-binding globulin: acute and chronic inflammation","volume":"12","author":"Meyer","year":"2017","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"3","key":"2024071216312222200_bnae008-B26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000125131","article-title":"Corticotropin-releasing factor synapses within the paraventricular nucleus of the hypothalamus","volume":"49","author":"Silverman","year":"1989","journal-title":"Neuroendocrinology"},{"issue":"12","key":"2024071216312222200_bnae008-B27","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1210\/jc.2002-022048","article-title":"Identification of adrenocorticotropin receptor messenger ribonucleic acid in the human pituitary and its loss of expression in pituitary adenomas","volume":"88","author":"Morris","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1210\/jcem-64-5-909","article-title":"A short negative feedback mechanism regulating corticotropin-releasing hormone release","volume":"64","author":"Suda","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024071216312222200_bnae008-B29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/edrv-5-1-1","article-title":"Corticosteroid inhibition of ACTH secretion","volume":"5","author":"Keller-Wood","year":"1984","journal-title":"Endocr Rev"},{"key":"2024071216312222200_bnae008-B30","doi-asserted-by":"crossref","first-page":"100541","DOI":"10.1016\/j.ynstr.2023.100541","article-title":"Intact GR dimerization is critical for restraining plasma ACTH levels during chronic psychosocial stress","volume":"24","author":"Langgartner","year":"2023","journal-title":"Neurobiol Stress"},{"issue":"17","key":"2024071216312222200_bnae008-B31","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1523\/JNEUROSCI.5332-09.2010","article-title":"Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males","volume":"30","author":"Russell","year":"2010","journal-title":"J Neurosci"},{"issue":"8","key":"2024071216312222200_bnae008-B32","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1210\/jc.2013-1394","article-title":"Pituitary-adrenal function after prolonged glucocorticoid therapy for systemic inflammatory disorders: an observational study","volume":"98","author":"Sacre","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024071216312222200_bnae008-B33","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1056\/NEJM199201233260403","article-title":"The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone","volume":"326","author":"Schlaghecke","year":"1992","journal-title":"N Engl J Med"},{"issue":"7521","key":"2024071216312222200_bnae008-B34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0140-6736(67)92592-5","article-title":"Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy","volume":"2","author":"Livanou","year":"1967","journal-title":"Lancet"},{"issue":"9203","key":"2024071216312222200_bnae008-B35","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0140-6736(99)06290-X","article-title":"Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment","volume":"355","author":"Henzen","year":"2000","journal-title":"Lancet"},{"issue":"12","key":"2024071216312222200_bnae008-B36","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1634\/theoncologist.2015-0211","article-title":"A prospective multicenter study evaluating secondary adrenal suppression after antiemetic dexamethasone therapy in cancer patients receiving chemotherapy: a Korean south west oncology group study","volume":"20","author":"Han","year":"2015","journal-title":"Oncologist"},{"issue":"7","key":"2024071216312222200_bnae008-B37","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1210\/jcem.84.7.5811","article-title":"The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin","volume":"84","author":"Korbonits","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2024071216312222200_bnae008-B38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0074-7696(07)63002-2","article-title":"Leptin and the regulation of the hypothalamic-pituitary-adrenal axis","volume":"263","author":"Malendowicz","year":"2007","journal-title":"Int Rev Cytol"},{"issue":"8","key":"2024071216312222200_bnae008-B39","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1172\/JCI118615","article-title":"Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway","volume":"97","author":"Ray","year":"1996","journal-title":"J Clin Invest"},{"issue":"1","key":"2024071216312222200_bnae008-B40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/edrv-10-1-92","article-title":"The immune-hypothalamic-pituitary-adrenal axis","volume":"10","author":"Bateman","year":"1989","journal-title":"Endocr Rev"},{"issue":"1","key":"2024071216312222200_bnae008-B41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1210\/jcem-33-1-14","article-title":"Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects","volume":"33","author":"Weitzman","year":"1971","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024071216312222200_bnae008-B42","first-page":"e230225","article-title":"Age- and sex-adjusted reference intervals for steroid hormones measured by liquid chromatography-tandem mass spectrometry using a widely available kit","volume":"13","author":"Kunz","year":"2024","journal-title":"Endocr Connect"},{"issue":"2","key":"2024071216312222200_bnae008-B43","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0009-8981(97)00142-3","article-title":"Circadian rhythms in plasma cortisone and cortisol and the cortisone\/cortisol ratio","volume":"266","author":"Nomura","year":"1997","journal-title":"Clin Chim Acta"},{"issue":"4","key":"2024071216312222200_bnae008-B44","first-page":"1238","article-title":"Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone","volume":"80","author":"Vermes","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2024071216312222200_bnae008-B45","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1001\/jama.283.8.1038","article-title":"A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin","volume":"283","author":"Annane","year":"2000","journal-title":"JAMA"},{"issue":"8","key":"2024071216312222200_bnae008-B46","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1210\/jc.2005-0354","article-title":"Cortisol response in relation to the severity of stress and illness","volume":"90","author":"Widmer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"701","key":"2024071216312222200_bnae008-B47","doi-asserted-by":"crossref","first-page":"eadg8464","DOI":"10.1126\/scitranslmed.adg8464","article-title":"High-resolution daily profiles of tissue adrenal steroids by portable automated collection","volume":"15","author":"Upton","year":"2023","journal-title":"Sci Transl Med"},{"issue":"1","key":"2024071216312222200_bnae008-B48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2265.1990.tb03758.x","article-title":"Patterns of ACTH and cortisol pulsatility over twenty-four hours in normal males and females","volume":"32","author":"Horrocks","year":"1990","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2024071216312222200_bnae008-B49","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tem.2009.12.011","article-title":"Interactions of the circadian CLOCK system and the HPA axis","volume":"21","author":"Nader","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"2024071216312222200_bnae008-B50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fendo.2017.00070","article-title":"Stress-related and circadian secretion and target tissue actions of glucocorticoids: impact on health","volume":"8","author":"Nicolaides","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"52","key":"2024071216312222200_bnae008-B51","doi-asserted-by":"crossref","first-page":"20970","DOI":"10.1073\/pnas.0806962106","article-title":"Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production","volume":"105","author":"Son","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5488","key":"2024071216312222200_bnae008-B52","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1126\/science.289.5488.2344","article-title":"Resetting of circadian time in peripheral tissues by glucocorticoid signaling","volume":"289","author":"Balsalobre","year":"2000","journal-title":"Science"},{"issue":"11","key":"2024071216312222200_bnae008-B53","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/0026-0495(80)90215-2","article-title":"Hormonal and metabolic rhythms in Cushing's syndrome","volume":"29","author":"Johnston","year":"1980","journal-title":"Metabolism"},{"issue":"1","key":"2024071216312222200_bnae008-B54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.biopsycho.2004.11.009","article-title":"Sex differences in HPA axis responses to stress: a review","volume":"69","author":"Kudielka","year":"2005","journal-title":"Biol Psychol"},{"issue":"3","key":"2024071216312222200_bnae008-B55","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/cphy.c130054","article-title":"Sex differences in the HPA axis","volume":"4","author":"Goel","year":"2014","journal-title":"Compr Physiol"},{"issue":"9","key":"2024071216312222200_bnae008-B56","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.3390\/ijms22094889","article-title":"The sexually dimorphic adrenal cortex: implications for adrenal disease","volume":"22","author":"Lyraki","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2024071216312222200_bnae008-B57","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1530\/eje.0.1320705","article-title":"Effects of age and gender on pituitary-adrenocortical responsiveness in humans","volume":"132","author":"Born","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"2024071216312222200_bnae008-B58","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.yfrne.2022.100998","article-title":"HPA axis activity across the menstrual cycle\u2014a systematic review and meta-analysis of longitudinal studies","volume":"66","author":"Klusmann","year":"2022","journal-title":"Front Neuroendocrinol"},{"key":"2024071216312222200_bnae008-B59","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fendo.2020.00311","article-title":"Higher circulating cortisol in the follicular vs. luteal phase of the menstrual cycle: a meta-analysis","volume":"11","author":"Hamidovic","year":"2020","journal-title":"Front Endocrinol"},{"key":"2024071216312222200_bnae008-B60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/9781009030830.015","volume-title":"Hormones and Pregnancy: Basic Science and Clinical Implications","author":"Lockett","year":"2022","edition":"1st ed"},{"issue":"2","key":"2024071216312222200_bnae008-B61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/joe.0.1490313","article-title":"Gender differences in the associations between cortisol and insulin in healthy subjects","volume":"149","author":"Stolk","year":"1996","journal-title":"J Endocrinol"},{"issue":"7","key":"2024071216312222200_bnae008-B62","first-page":"2468","article-title":"Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol","volume":"81","author":"Van Cauter","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024071216312222200_bnae008-B63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006842-199903000-00006","article-title":"Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis","volume":"61","author":"Kirschbaum","year":"1999","journal-title":"Psychosom Med"},{"key":"2024071216312222200_bnae008-B64","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2017.04.007","article-title":"Sex differences in salivary cortisol reactivity to the Trier Social Stress Test (TSST): a meta-analysis","volume":"82","author":"Liu","year":"2017","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"2024071216312222200_bnae008-B65","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.psyneuen.2006.02.003","article-title":"Gender differences in hypothalamic-pituitary-adrenal (HPA) axis reactivity","volume":"31","author":"Uhart","year":"2006","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"2024071216312222200_bnae008-B66","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0006-3223(02)01333-1","article-title":"Sex differences in stress responses: social rejection versus achievement stress","volume":"52","author":"Stroud","year":"2002","journal-title":"Biol Psychiatry"},{"issue":"3","key":"2024071216312222200_bnae008-B67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.biopsycho.2007.03.005","article-title":"Salivary cortisol in response to acute social rejection and acceptance by peers","volume":"75","author":"Blackhart","year":"2007","journal-title":"Biol Psychol"},{"issue":"4","key":"2024071216312222200_bnae008-B68","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/10253890.2011.631154","article-title":"Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students","volume":"15","author":"Linnen","year":"2012","journal-title":"Stress"},{"issue":"6","key":"2024071216312222200_bnae008-B69","first-page":"1526","article-title":"Heritability of cortisol responses to human corticotropin-releasing hormone, ergometry, and psychological stress in humans","volume":"75","author":"Kirschbaum","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"1-2","key":"2024071216312222200_bnae008-B70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02396572","article-title":"Energy metabolism and regulatory hormones in women and men during endurance exercise","volume":"59","author":"Friedmann","year":"1989","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"2024071216312222200_bnae008-B71","first-page":"24","article-title":"Sex-related responses of beta-endorphin, ACTH, GH and PRL to cold exposure in humans","volume":"126","author":"Gerra","year":"1992","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"3","key":"2024071216312222200_bnae008-B72","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1748-1716.1994.tb09689.x","article-title":"Sex differences in endocrine response to hyperthermia in sauna","volume":"150","author":"Jezov\u00e1","year":"1994","journal-title":"Acta Physiol Scand"},{"issue":"4","key":"2024071216312222200_bnae008-B73","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00002508-200307000-00006","article-title":"Sex differences in cortisol response to noxious stress","volume":"19","author":"Zimmer","year":"2003","journal-title":"Clin J Pain"},{"issue":"5","key":"2024071216312222200_bnae008-B74","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0278-6133.12.5.420","article-title":"Sex differences in sensitivity of the hypothalamic-pituitary-adrenal axis","volume":"12","author":"Gallucci","year":"1993","journal-title":"Health Psychol"},{"issue":"2","key":"2024071216312222200_bnae008-B75","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/oby.2006.30","article-title":"Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity","volume":"14","author":"Vicennati","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"2024071216312222200_bnae008-B76","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0197-4580(94)90117-1","article-title":"Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender","volume":"15","author":"Heuser","year":"1994","journal-title":"Neurobiol Aging"},{"issue":"1","key":"2024071216312222200_bnae008-B77","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.psyneuen.2004.06.002","article-title":"A meta-analysis of cortisol response to challenge in human aging: importance of gender","volume":"30","author":"Otte","year":"2005","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"2024071216312222200_bnae008-B78","doi-asserted-by":"crossref","first-page":"M72","DOI":"10.1093\/geronj\/48.3.M72","article-title":"The pituitary-adrenal glucocorticoid response is altered by gender and disease","volume":"48","author":"Greenspan","year":"1993","journal-title":"J Gerontol"},{"issue":"5","key":"2024071216312222200_bnae008-B79","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1210\/jcem-64-5-986","article-title":"Responses of the hypothalamic-pituitary-adrenal and renin-angiotensin axes and the sympathetic system during controlled surgical and anesthetic stress","volume":"64","author":"Udelsman","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024071216312222200_bnae008-B80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00005373-198204000-00001","article-title":"Cortisol and corticotrophin in burned patients","volume":"22","author":"Vaughan","year":"1982","journal-title":"J Trauma"},{"issue":"8","key":"2024071216312222200_bnae008-B81","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0026-0495(86)90245-3","article-title":"Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: a review","volume":"35","author":"Fish","year":"1986","journal-title":"Metabolism"},{"issue":"21","key":"2024071216312222200_bnae008-B82","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJM198705213162105","article-title":"Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training","volume":"316","author":"Luger","year":"1987","journal-title":"N Engl J Med"},{"issue":"4","key":"2024071216312222200_bnae008-B83","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/frne.1994.1013","article-title":"Regulation of pituitary ACTH secretion during chronic stress","volume":"15","author":"Aguilera","year":"1994","journal-title":"Front Neuroendocrinol"},{"issue":"11","key":"2024071216312222200_bnae008-B84","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2024071216312222200_bnae008-B85","first-page":"857","article-title":"The adrenocortical response to surgery and insulin-induced hypoglycemia in corticosteroid-treated and normal subjects","volume":"55","author":"Plumpton","year":"1968","journal-title":"Br J Surg"},{"issue":"6","key":"2024071216312222200_bnae008-B86","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2337\/diabetes.54.6.1846","article-title":"Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism","volume":"54","author":"Watts","year":"2005","journal-title":"Diabetes"},{"issue":"3","key":"2024071216312222200_bnae008-B87","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10409230590935479","article-title":"Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C","volume":"40","author":"Chakravarty","year":"2005","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"6","key":"2024071216312222200_bnae008-B88","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1172\/JCI108231","article-title":"Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes","volume":"56","author":"Olefsky","year":"1975","journal-title":"J Clin Invest"},{"issue":"5","key":"2024071216312222200_bnae008-B89","first-page":"E806","article-title":"Kinetics of dexamethasone-induced alterations of glucose metabolism in healthy humans","volume":"275","author":"Schneiter","year":"1998","journal-title":"Am J Physiol"},{"issue":"6","key":"2024071216312222200_bnae008-B90","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1210\/jc.2010-2729","article-title":"Continuous monitoring of circadian glycemic patterns in patients receiving prednisolone for COPD","volume":"96","author":"Burt","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B91","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI114345","article-title":"Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium","volume":"84","author":"Hauner","year":"1989","journal-title":"J Clin Invest"},{"issue":"6","key":"2024071216312222200_bnae008-B92","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jcem-67-6-1122","article-title":"Muscle and adipose tissue morphology and metabolism in Cushing's syndrome","volume":"67","author":"Rebuff\u00e9-Scrive","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024071216312222200_bnae008-B93","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI2799","article-title":"Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone","volume":"102","author":"Weinstein","year":"1998","journal-title":"J Clin Invest"},{"issue":"3","key":"2024071216312222200_bnae008-B94","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/art.21984","article-title":"Population-based assessment of adverse events associated with long-term glucocorticoid use","volume":"55","author":"Curtis","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"6","key":"2024071216312222200_bnae008-B95","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-2007-981462","article-title":"Stress mechanisms and metabolic complications","volume":"39","author":"Kyrou","year":"2007","journal-title":"Horm Metab Res"},{"issue":"10","key":"2024071216312222200_bnae008-B96","first-page":"3441","article-title":"Clinical review 83: mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis","volume":"81","author":"Canalis","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2024071216312222200_bnae008-B97","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s001980200108","article-title":"The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis","volume":"13","author":"van Staa","year":"2002","journal-title":"Osteoporos Int"},{"issue":"2 Pt 1","key":"2024071216312222200_bnae008-B98","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0091-6749(85)90708-0","article-title":"Steroid myopathy: incidence and detection in a population with asthma","volume":"76","author":"Bowyer","year":"1985","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"2024071216312222200_bnae008-B99","first-page":"71","article-title":"The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum","volume":"78","author":"Leibovich","year":"1975","journal-title":"Am J Pathol"},{"issue":"2","key":"2024071216312222200_bnae008-B100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1210\/jcem-62-2-275","article-title":"Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome","volume":"62","author":"Saruta","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"issue":"2 Pt 2","key":"2024071216312222200_bnae008-B101","first-page":"F111","article-title":"Evidence of corticosteroid action along the nephron","volume":"246","author":"Marver","year":"1984","journal-title":"Am J Physiol"},{"issue":"6","key":"2024071216312222200_bnae008-B102","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1210\/jc.2003-030138","article-title":"Hypertension and the cortisol-cortisone shuttle","volume":"88","author":"Quinkler","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024071216312222200_bnae008-B103","first-page":"F166","article-title":"Mechanism of the glucocorticoid-induced increase in glomerular filtration rate","volume":"234","author":"Baylis","year":"1978","journal-title":"Am J Physiol"},{"issue":"6","key":"2024071216312222200_bnae008-B104","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1165\/ajrcmb.14.6.8652188","article-title":"Transcriptional regulation of human pulmonary surfactant proteins SP-B and SP-C by glucocorticoids","volume":"14","author":"Ballard","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"2024071216312222200_bnae008-B105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2165\/00151829-200403050-00004","article-title":"Effects of glucocorticoids on fetal and neonatal lung development","volume":"3","author":"Grier","year":"2004","journal-title":"Treat Respir Med"},{"issue":"4","key":"2024071216312222200_bnae008-B106","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1152\/physrev.1986.66.4.1121","article-title":"Adrenal steroid receptors and actions in the nervous system","volume":"66","author":"McEwen","year":"1986","journal-title":"Physiol Rev"},{"issue":"10","key":"2024071216312222200_bnae008-B107","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.4065\/81.10.1361","article-title":"Psychiatric adverse effects of corticosteroids","volume":"81","author":"Warrington","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"2024071216312222200_bnae008-B108","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/271","article-title":"Cortisol levels during human aging predict hippocampal atrophy and memory deficits","volume":"1","author":"Lupien","year":"1998","journal-title":"Nat Neurosci"},{"key":"2024071216312222200_bnae008-B109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4939-2895-8_11","article-title":"Glucocorticoid regulation of reproduction","volume":"872","author":"Geraghty","year":"2015","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"2024071216312222200_bnae008-B110","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J Psychosom Res"},{"issue":"3","key":"2024071216312222200_bnae008-B111","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tem.2012.11.005","article-title":"The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore","volume":"24","author":"Busillo","year":"2013","journal-title":"Trends Endocrinol Metab"},{"issue":"1-2","key":"2024071216312222200_bnae008-B112","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2007.04.014","article-title":"Glucocorticoids and the innate immune system: crosstalk with the toll-like receptor signaling network","volume":"275","author":"Chinenov","year":"2007","journal-title":"Mol Cell Endocrinol"},{"issue":"44","key":"2024071216312222200_bnae008-B113","doi-asserted-by":"crossref","first-page":"38703","DOI":"10.1074\/jbc.M111.275370","article-title":"Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome","volume":"286","author":"Busillo","year":"2011","journal-title":"J Biol Chem"},{"issue":"4-6","key":"2024071216312222200_bnae008-B114","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0960-0760(91)90284-C","article-title":"Cytokines as modulators of the hypothalamus-pituitary-adrenal axis","volume":"40","author":"Besedovsky","year":"1991","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2024071216312222200_bnae008-B115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","article-title":"The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights","volume":"335","author":"Coutinho","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"2024071216312222200_bnae008-B116","doi-asserted-by":"crossref","first-page":"120004","DOI":"10.1016\/j.jns.2021.120004","article-title":"Glucocorticoids for therapeutic immunosuppression: clinical pearls for the practicing neurologist","volume":"430","author":"Galati","year":"2021","journal-title":"J Neurol Sci"},{"issue":"3","key":"2024071216312222200_bnae008-B117","doi-asserted-by":"crossref","first-page":"304","DOI":"10.7326\/0003-4819-84-3-304","article-title":"Glucocorticosteroid therapy: mechanisms of action and clinical considerations","volume":"84","author":"Fauci","year":"1976","journal-title":"Ann Intern Med"},{"issue":"3","key":"2024071216312222200_bnae008-B118","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0091-6749(78)90101-X","article-title":"Corticosteroid effect on immunoglobulins","volume":"62","author":"Settipane","year":"1978","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"2024071216312222200_bnae008-B119","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/clinids\/11.6.954","article-title":"Risk of infectious complications in patients taking glucocorticosteroids","volume":"11","author":"Stuck","year":"1989","journal-title":"Rev Infect Dis"},{"issue":"2","key":"2024071216312222200_bnae008-B120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5414\/CNP63068","article-title":"Initial functional status predicts infections during steroid therapy for renal diseases","volume":"63","author":"Sakuma","year":"2005","journal-title":"Clin Nephrol"},{"issue":"2","key":"2024071216312222200_bnae008-B121","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/ard.8.2.97","article-title":"The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocortical hormone in arthritis: preliminary report","volume":"8","author":"Hench","year":"1949","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"2024071216312222200_bnae008-B122","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.21873\/anticanres.14163","article-title":"Prolonged steroid dependence in adult patients with glioma","volume":"40","author":"Mantilla","year":"2020","journal-title":"Anticancer Res"},{"issue":"1","key":"2024071216312222200_bnae008-B123","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.trre.2016.10.006","article-title":"Immunosuppression for kidney transplantation: where are we now and where are we going?","volume":"31","author":"Lim","year":"2017","journal-title":"Transplant Rev (Orlando)"},{"key":"2024071216312222200_bnae008-B124","doi-asserted-by":"crossref","first-page":"j1455","DOI":"10.1136\/bmj.j1455","article-title":"Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS trial)","volume":"357","author":"DREAMS Trial Collaborators and West Midlands Research Collaborative","year":"2017","journal-title":"BMJ"},{"issue":"6181","key":"2024071216312222200_bnae008-B125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/bmj.2.6181.25","article-title":"Addison's disease","volume":"2","author":"Swyer","year":"1979","journal-title":"Br Med J"},{"issue":"2","key":"2024071216312222200_bnae008-B126","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1210\/jc.2015-1710","article-title":"Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline","volume":"101","author":"Bornstein","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B127","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s40618-019-01146-y","article-title":"Towards the tailoring of glucocorticoid replacement in adrenal insufficiency: the Italian Society of Endocrinology Expert Opinion","volume":"43","author":"Isidori","year":"2020","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2024071216312222200_bnae008-B128","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4187\/respcare.06314","article-title":"Clinical pharmacology of corticosteroids","volume":"63","author":"Williams","year":"2018","journal-title":"Respir Care"},{"issue":"4","key":"2024071216312222200_bnae008-B129","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2125.1999.00058.x","article-title":"Short-term dose-response relationships for the relative systemic effects of oral prednisolone and inhaled fluticasone in asthmatic adults","volume":"48","author":"Wilson","year":"1999","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"2024071216312222200_bnae008-B130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00315143","article-title":"Assessment of systemic effects of inhaled glucocorticosteroids: comparison of the effects of inhaled budesonide and oral prednisolone on adrenal function and markers of bone turnover","volume":"40","author":"Jennings","year":"1991","journal-title":"Eur J Clin Pharmacol"},{"key":"2024071216312222200_bnae008-B131","first-page":"497","volume-title":"Williams Textbook of Endocrinology","author":"Newell-Price","year":"2020","edition":"14th ed"},{"issue":"3","key":"2024071216312222200_bnae008-B132","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2265.2004.02106.x","article-title":"Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency","volume":"61","author":"Mah","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"2024071216312222200_bnae008-B133","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1210\/jc.2006-0524","article-title":"The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients","volume":"91","author":"Filipsson","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B134","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1365-2265.2002.01466.x","article-title":"Subjective health status in Norwegian patients with Addison's disease","volume":"56","author":"L\u00f8v\u00e5s","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2024071216312222200_bnae008-B135","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/BF03345773","article-title":"Metabolic and cardiovascular profile in patients with Addison's disease under conventional glucocorticoid replacement","volume":"32","author":"Giordano","year":"2009","journal-title":"J Endocrinol Invest"},{"issue":"12","key":"2024071216312222200_bnae008-B136","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","article-title":"Premature mortality in patients with Addison's disease: a population-based study","volume":"91","author":"Bergthorsdottir","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024071216312222200_bnae008-B137","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11926-020-00964-x","article-title":"Treatment of giant cell arteritis and takayasu arteritis-current and future","volume":"22","author":"Hellmich","year":"2020","journal-title":"Curr Rheumatol Rep"},{"issue":"8","key":"2024071216312222200_bnae008-B138","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.autrev.2017.05.017","article-title":"Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: an observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts","volume":"16","author":"Ruiz-Irastorza","year":"2017","journal-title":"Autoimmun Rev"},{"issue":"4","key":"2024071216312222200_bnae008-B139","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ajg.2011.70","article-title":"Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis","volume":"106","author":"Ford","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"2024071216312222200_bnae008-B140","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/pr.58.4.9","article-title":"International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors","volume":"58","author":"Lu","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"6047","key":"2024071216312222200_bnae008-B141","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/318635a0","article-title":"Primary structure and expression of a functional human glucocorticoid receptor cDNA","volume":"318","author":"Hollenberg","year":"1985","journal-title":"Nature"},{"issue":"2","key":"2024071216312222200_bnae008-B142","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0922-4106(93)90072-H","article-title":"Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands","volume":"247","author":"Rupprecht","year":"1993","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"2024071216312222200_bnae008-B143","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41371-020-0360-2","article-title":"Structural determinants of activation of the mineralocorticoid receptor: an evolutionary perspective","volume":"35","author":"Fuller","year":"2021","journal-title":"J Hum Hypertens"},{"issue":"1-2","key":"2024071216312222200_bnae008-B144","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mce.2003.10.021","article-title":"Mineralocorticoid receptor binding, structure and function","volume":"217","author":"Rogerson","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2024071216312222200_bnae008-B145","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/cphy.c130044","article-title":"The multifaceted mineralocorticoid receptor","volume":"4","author":"Gomez-Sanchez","year":"2014","journal-title":"Compr Physiol"},{"issue":"1","key":"2024071216312222200_bnae008-B146","doi-asserted-by":"crossref","first-page":"T23","DOI":"10.1530\/JOE-17-0060","article-title":"30 YEARS OF THE MINERALOCORTICOID RECEPTOR: coregulators as mediators of mineralocorticoid receptor signalling diversity","volume":"234","author":"Fuller","year":"2017","journal-title":"J Endocrinol"},{"issue":"1","key":"2024071216312222200_bnae008-B147","doi-asserted-by":"crossref","first-page":"2204366","DOI":"10.1080\/10253890.2023.2204366","article-title":"From ligands to behavioral outcomes: understanding the role of mineralocorticoid receptors in brain function","volume":"26","author":"Yang","year":"2023","journal-title":"Stress"},{"issue":"4","key":"2024071216312222200_bnae008-B148","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s10741-021-10158-x","article-title":"New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy","volume":"27","author":"Yang","year":"2022","journal-title":"Heart Fail Rev"},{"issue":"4","key":"2024071216312222200_bnae008-B149","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1210\/er.2014-1010","article-title":"Comprehensive overview of the structure and regulation of the glucocorticoid receptor","volume":"35","author":"Vandevyver","year":"2014","journal-title":"Endocr Rev"},{"issue":"12","key":"2024071216312222200_bnae008-B150","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1210\/jc.2008-1077","article-title":"Expression of glucocorticoid receptor messenger ribonucleic acid transcripts in the human placenta at term","volume":"93","author":"Johnson","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2024071216312222200_bnae008-B151","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1210\/me.2010-0436","article-title":"Differential regulation and function of 5\u2032-untranslated GR-exon 1 transcripts","volume":"25","author":"Bockm\u00fchl","year":"2011","journal-title":"Mol Endocrinol"},{"key":"2024071216312222200_bnae008-B152","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.placenta.2021.03.013","article-title":"A preferential switch between placental GR exon 1 promoter variants in the presence of maternal asthma or inflammation upregulates GR\u03b1 D isoforms","volume":"108","author":"Saif","year":"2021","journal-title":"Placenta"},{"issue":"10","key":"2024071216312222200_bnae008-B153","first-page":"5580","article-title":"The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites","volume":"10","author":"Zong","year":"1990","journal-title":"Mol Cell Biol"},{"issue":"8","key":"2024071216312222200_bnae008-B154","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1210\/mend.15.8.0696","article-title":"Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids","volume":"15","author":"Breslin","year":"2001","journal-title":"Mol Endocrinol"},{"issue":"2","key":"2024071216312222200_bnae008-B155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1677\/jme.1.01822","article-title":"Structure of the glucocorticoid receptor (NR3C1) gene 5\u2032 untranslated region: identification, and tissue distribution of multiple new human exon 1","volume":"35","author":"Turner","year":"2005","journal-title":"J Mol Endocrinol"},{"issue":"1-2","key":"2024071216312222200_bnae008-B156","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1677\/jme.1.02183","article-title":"Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor","volume":"38","author":"Presul","year":"2007","journal-title":"J Mol Endocrinol"},{"issue":"34","key":"2024071216312222200_bnae008-B157","doi-asserted-by":"crossref","first-page":"10851","DOI":"10.1021\/bi049458u","article-title":"Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line","volume":"43","author":"Pedersen","year":"2004","journal-title":"Biochemistry"},{"issue":"12","key":"2024071216312222200_bnae008-B158","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.bcp.2010.06.037","article-title":"Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more","volume":"80","author":"Turner","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"2024071216312222200_bnae008-B159","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1021\/bi048503v","article-title":"Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506","volume":"44","author":"Davies","year":"2005","journal-title":"Biochemistry"},{"issue":"3","key":"2024071216312222200_bnae008-B160","doi-asserted-by":"crossref","first-page":"e1001813","DOI":"10.1371\/journal.pbio.1001813","article-title":"Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor","volume":"12","author":"Presman","year":"2014","journal-title":"PLoS Biol"},{"issue":"7","key":"2024071216312222200_bnae008-B161","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1074\/jbc.C100531200","article-title":"A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins","volume":"277","author":"Davies","year":"2002","journal-title":"J Biol Chem"},{"issue":"44","key":"2024071216312222200_bnae008-B162","doi-asserted-by":"crossref","first-page":"17826","DOI":"10.1073\/pnas.1316235110","article-title":"A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms","volume":"110","author":"Thomas-Chollier","year":"2013","journal-title":"Proce Natl Acad Sci U S A"},{"issue":"25","key":"2024071216312222200_bnae008-B163","doi-asserted-by":"crossref","first-page":"22748","DOI":"10.1074\/jbc.M212711200","article-title":"The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism","volume":"278","author":"Kauppi","year":"2003","journal-title":"J Biol Chem"},{"issue":"22","key":"2024071216312222200_bnae008-B164","doi-asserted-by":"crossref","first-page":"13063","DOI":"10.1093\/nar\/gkac1119","article-title":"The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities","volume":"50","author":"Jim\u00e9nez-Panizo","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024071216312222200_bnae008-B165","first-page":"4","article-title":"Steroid receptors and their associated proteins","volume":"7","author":"Smith","year":"1993","journal-title":"Mol Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B166","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1074\/jbc.M407498200","article-title":"FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells","volume":"280","author":"Wochnik","year":"2005","journal-title":"J Biol Chem"},{"issue":"7","key":"2024071216312222200_bnae008-B167","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.3390\/ijms22073649","article-title":"Glucocorticoid receptor \u03b2 (GR\u03b2): beyond its dominant-negative function","volume":"22","author":"Ramos-Ram\u00edrez","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2024071216312222200_bnae008-B168","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1128\/MCB.23.6.1922-1934.2003","article-title":"Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity","volume":"23","author":"Schaaf","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"3","key":"2024071216312222200_bnae008-B169","doi-asserted-by":"crossref","first-page":"e90532","DOI":"10.1371\/journal.pone.0090532","article-title":"Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP","volume":"9","author":"Groeneweg","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2024071216312222200_bnae008-B170","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.10.013","article-title":"Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes","volume":"49","author":"Uhlenhaut","year":"2013","journal-title":"Mol Cell"},{"issue":"6","key":"2024071216312222200_bnae008-B171","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1101\/gr.188581.114","article-title":"Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo","volume":"25","author":"Lim","year":"2015","journal-title":"Genome Res"},{"issue":"5925","key":"2024071216312222200_bnae008-B172","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.1164265","article-title":"DNA binding site sequence directs glucocorticoid receptor structure and activity","volume":"324","author":"Meijsing","year":"2009","journal-title":"Science"},{"issue":"2","key":"2024071216312222200_bnae008-B173","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2011.03.027","article-title":"Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor","volume":"145","author":"Surjit","year":"2011","journal-title":"Cell"},{"issue":"1","key":"2024071216312222200_bnae008-B174","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nsmb.2456","article-title":"The structural basis of direct glucocorticoid-mediated transrepression","volume":"20","author":"Hudson","year":"2013","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"2024071216312222200_bnae008-B175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molcel.2012.04.021","article-title":"The Stat3\/GR interaction code: predictive value of direct\/indirect DNA recruitment for transcription outcome","volume":"47","author":"Langlais","year":"2012","journal-title":"Mol Cell"},{"issue":"7","key":"2024071216312222200_bnae008-B176","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1083\/jcb.147.7.1365","article-title":"The DNA binding-independent function of the glucocorticoid receptor mediates repression of Ap-1\u2013dependent genes in skin","volume":"147","author":"Tuckermann","year":"1999","journal-title":"J Cell Biol"},{"issue":"17","key":"2024071216312222200_bnae008-B177","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1002\/j.1460-2075.1994.tb06726.x","article-title":"A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1","volume":"13","author":"Heck","year":"1994","journal-title":"EMBO J"},{"issue":"15","key":"2024071216312222200_bnae008-B178","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1093\/nar\/gkaa565","article-title":"Anti-inflammatory functions of the glucocorticoid receptor require DNA binding","volume":"48","author":"Escoter-Torres","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"2024071216312222200_bnae008-B179","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1093\/nar\/gkx509","article-title":"Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes","volume":"45","author":"Weikum","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"2024071216312222200_bnae008-B180","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1210\/me.2008-0157","article-title":"A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters","volume":"22","author":"Geng","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2024071216312222200_bnae008-B181","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tips.2018.11.002","article-title":"Non-genomic effects of glucocorticoids: an updated view","volume":"40","author":"Panettieri","year":"2019","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"2024071216312222200_bnae008-B182","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nm0502-473","article-title":"Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase","volume":"8","author":"Hafezi-Moghadam","year":"2002","journal-title":"Nat Med"},{"issue":"Pt 1","key":"2024071216312222200_bnae008-B183","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj20030175","article-title":"Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells","volume":"373","author":"Wid\u00e9n","year":"2003","journal-title":"Biochem J"},{"issue":"22","key":"2024071216312222200_bnae008-B184","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1093\/emboj\/cdg590","article-title":"Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids","volume":"22","author":"Bruna","year":"2003","journal-title":"EMBO J"},{"issue":"7","key":"2024071216312222200_bnae008-B185","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.imbio.2009.10.003","article-title":"Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells","volume":"215","author":"Boldizsar","year":"2010","journal-title":"Immunobiology"},{"issue":"7","key":"2024071216312222200_bnae008-B186","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1074\/mcp.M112.022947","article-title":"Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects","volume":"12","author":"Vernocchi","year":"2013","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"2024071216312222200_bnae008-B187","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1096\/fj.03-0328com","article-title":"Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis","volume":"18","author":"Bartholome","year":"2004","journal-title":"FASEB J"},{"issue":"10","key":"2024071216312222200_bnae008-B188","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/sj.embor.7400775","article-title":"Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN","volume":"7","author":"L\u00f6wenberg","year":"2006","journal-title":"EMBO Rep"},{"issue":"4","key":"2024071216312222200_bnae008-B189","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molmed.2007.02.001","article-title":"Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression","volume":"13","author":"L\u00f6wenberg","year":"2007","journal-title":"Trends Mol Med"},{"issue":"2","key":"2024071216312222200_bnae008-B190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.bjp.0703272","article-title":"Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism","volume":"130","author":"Croxtall","year":"2000","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2024071216312222200_bnae008-B191","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.steroids.2005.09.014","article-title":"Rapid anti-secretory effects of glucocorticoids in human airway epithelium","volume":"71","author":"Urbach","year":"2006","journal-title":"Steroids"},{"issue":"4","key":"2024071216312222200_bnae008-B192","doi-asserted-by":"crossref","first-page":"S366","DOI":"10.1097\/00004872-198812040-00114","article-title":"Stimulation of the phosphoinositide signalling system as a possible mechanism for glucocorticoid action in blood pressure control","volume":"6","author":"Steiner","year":"1988","journal-title":"J Hypertens Suppl"},{"issue":"6","key":"2024071216312222200_bnae008-B193","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0039-128X(01)00171-4","article-title":"Rapid glucocorticoid effects on immune cells","volume":"67","author":"Buttgereit","year":"2002","journal-title":"Steroids"},{"issue":"3","key":"2024071216312222200_bnae008-B194","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.molcel.2005.03.025","article-title":"Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes","volume":"18","author":"Lu","year":"2005","journal-title":"Mol Cell"},{"issue":"4","key":"2024071216312222200_bnae008-B195","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1210\/en.2007-1364","article-title":"Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish","volume":"149","author":"Schaaf","year":"2008","journal-title":"Endocrinology"},{"issue":"1","key":"2024071216312222200_bnae008-B196","doi-asserted-by":"crossref","first-page":"24505","DOI":"10.1038\/s41598-021-03451-0","article-title":"Restrained expression of canine glucocorticoid receptor splice variants \u03b1 and P prognosticates fatal disease outcome in SIRS","volume":"11","author":"K\u00e1llai","year":"2021","journal-title":"Sci Rep"},{"issue":"8","key":"2024071216312222200_bnae008-B197","doi-asserted-by":"crossref","first-page":"e0272219","DOI":"10.1371\/journal.pone.0272219","article-title":"Cloning of nine glucocorticoid receptor isoforms from the slender African lungfish (Protopterus dolloi)","volume":"17","author":"Katsu","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"2024071216312222200_bnae008-B198","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.placenta.2014.01.012","article-title":"The human placenta expresses multiple glucocorticoid receptor isoforms that are altered by fetal sex, growth restriction and maternal asthma","volume":"35","author":"Saif","year":"2014","journal-title":"Placenta"},{"issue":"7","key":"2024071216312222200_bnae008-B199","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.placenta.2015.05.001","article-title":"Expression of eight glucocorticoid receptor isoforms in the human preterm placenta vary with fetal sex and birthweight","volume":"36","author":"Saif","year":"2015","journal-title":"Placenta"},{"issue":"2","key":"2024071216312222200_bnae008-B200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1530\/JOE-17-0171","article-title":"Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice","volume":"234","author":"Cuffe","year":"2017","journal-title":"J Endocrinol"},{"issue":"2","key":"2024071216312222200_bnae008-B201","doi-asserted-by":"crossref","first-page":"e0148226","DOI":"10.1371\/journal.pone.0148226","article-title":"Identification of eight different isoforms of the glucocorticoid receptor in Guinea pig placenta: relationship to preterm delivery, sex and betamethasone exposure","volume":"11","author":"Saif","year":"2016","journal-title":"PLoS One"},{"key":"2024071216312222200_bnae008-B202","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.placenta.2019.06.380","article-title":"Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma","volume":"83","author":"Clifton","year":"2019","journal-title":"Placenta"},{"issue":"2","key":"2024071216312222200_bnae008-B203","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrm3742","article-title":"A day in the life of the spliceosome","volume":"15","author":"Matera","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2024071216312222200_bnae008-B204","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative Pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu Rev Biochem"},{"issue":"16","key":"2024071216312222200_bnae008-B205","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1074\/jbc.271.16.9550","article-title":"The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function","volume":"271","author":"Oakley","year":"1996","journal-title":"J Biol Chem"},{"issue":"8","key":"2024071216312222200_bnae008-B206","doi-asserted-by":"crossref","first-page":"e00453-17","DOI":"10.1128\/MCB.00453-17","article-title":"Probing dominant negative behavior of glucocorticoid receptor \u03b2 through a hybrid structural and biochemical approach","volume":"38","author":"Min","year":"2018","journal-title":"Mol Cell Biol"},{"issue":"6","key":"2024071216312222200_bnae008-B207","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1172\/JCI117943","article-title":"Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans","volume":"95","author":"Bamberger","year":"1995","journal-title":"J Clin Invest"},{"issue":"1","key":"2024071216312222200_bnae008-B208","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(02)00817-6","article-title":"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition","volume":"110","author":"Bledsoe","year":"2002","journal-title":"Cell"},{"key":"2024071216312222200_bnae008-B209","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.phrs.2017.03.019","article-title":"Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone","volume":"120","author":"Buoso","year":"2017","journal-title":"Pharmacol Res"},{"issue":"6","key":"2024071216312222200_bnae008-B210","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1128\/MCB.01439-06","article-title":"Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active","volume":"27","author":"Lewis-Tuffin","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"11","key":"2024071216312222200_bnae008-B211","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1210\/endo.138.11.5501","article-title":"Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor","volume":"138","author":"Oakley","year":"1997","journal-title":"Endocrinology"},{"issue":"39","key":"2024071216312222200_bnae008-B212","doi-asserted-by":"crossref","first-page":"27857","DOI":"10.1074\/jbc.274.39.27857","article-title":"The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action","volume":"274","author":"Oakley","year":"1999","journal-title":"J Biol Chem"},{"issue":"5","key":"2024071216312222200_bnae008-B213","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF03401643","article-title":"The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role","volume":"2","author":"de Castro","year":"1996","journal-title":"Mol Med"},{"issue":"1","key":"2024071216312222200_bnae008-B214","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1210\/me.2004-0112","article-title":"The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes","volume":"19","author":"Charmandari","year":"2005","journal-title":"Mol Endocrinol"},{"issue":"4","key":"2024071216312222200_bnae008-B215","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbrc.2009.02.110","article-title":"Glucocorticoid receptor (GR) beta has intrinsic, GRalpha-independent transcriptional activity","volume":"381","author":"Kino","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2024071216312222200_bnae008-B216","doi-asserted-by":"crossref","first-page":"C1324","DOI":"10.1152\/ajpcell.00363.2001","article-title":"Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues","volume":"283","author":"Pujols","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"issue":"11","key":"2024071216312222200_bnae008-B217","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1210\/jc.2005-1042","article-title":"Expression of the human glucocorticoid receptor splice variants alpha, beta, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism","volume":"90","author":"Hagendorf","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B218","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1530\/eje.0.1420472","article-title":"Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome","volume":"142","author":"Huizenga","year":"2000","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2024071216312222200_bnae008-B219","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0006-3223(98)00189-9","article-title":"Glucocorticoid receptors in anorexia nervosa and Cushing's disease","volume":"45","author":"Invitti","year":"1999","journal-title":"Biol Psychiatry"},{"issue":"2","key":"2024071216312222200_bnae008-B220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1507\/endocrj1954.31.109","article-title":"Glucocorticoid receptors in cultured skin fibroblasts of normal and adrenocorticoid disorders","volume":"31","author":"Nawata","year":"1984","journal-title":"Endocrinol Jpn"},{"issue":"1","key":"2024071216312222200_bnae008-B221","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jaci.2007.09.010","article-title":"The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases","volume":"121","author":"Kelly","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2024071216312222200_bnae008-B222","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/MCB.00908-15","article-title":"Human glucocorticoid receptor \u03b2 regulates gluconeogenesis and inflammation in mouse liver","volume":"36","author":"He","year":"2015","journal-title":"Mol Cell Biol"},{"issue":"10","key":"2024071216312222200_bnae008-B223","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1097\/CCM.0b013e31825b8ebc","article-title":"Corticosteroid resistance in sepsis is influenced by microRNA-124\u2013induced downregulation of glucocorticoid receptor-\u03b1","volume":"40","author":"Ledderose","year":"2012","journal-title":"Crit Care Med"},{"issue":"3","key":"2024071216312222200_bnae008-B224","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/cc12774","article-title":"Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay","volume":"17","author":"Guerrero","year":"2013","journal-title":"Crit Care"},{"issue":"2","key":"2024071216312222200_bnae008-B225","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1167\/iovs.11-8497","article-title":"Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells","volume":"53","author":"Jain","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2024071216312222200_bnae008-B226","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.bbamcr.2007.04.016","article-title":"Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells","volume":"1773","author":"Zhu","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2024071216312222200_bnae008-B227","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"19","key":"2024071216312222200_bnae008-B228","doi-asserted-by":"crossref","first-page":"27313","DOI":"10.18632\/oncotarget.8430","article-title":"Glucocorticoid receptor beta increases migration of human bladder cancer cells","volume":"7","author":"McBeth","year":"2016","journal-title":"Oncotarget"},{"issue":"1-2","key":"2024071216312222200_bnae008-B229","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-5793(90)81339-P","article-title":"Two naturall\u00f4 occurring isoforms and their expression of a glucocorticoid receptor gene from an androgen dependent mouse tumor","volume":"274","author":"Kasai","year":"1990","journal-title":"FEBS Lett"},{"issue":"14","key":"2024071216312222200_bnae008-B230","first-page":"3276","article-title":"Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells","volume":"56","author":"Ray","year":"1996","journal-title":"Cancer Res"},{"key":"2024071216312222200_bnae008-B231","doi-asserted-by":"crossref","first-page":"26419","DOI":"10.1038\/srep26419","article-title":"Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production","volume":"6","author":"Morgan","year":"2016","journal-title":"Sci Rep"},{"issue":"11","key":"2024071216312222200_bnae008-B232","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1210\/jcem.84.11.6235","article-title":"Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing","volume":"84","author":"Rivers","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024071216312222200_bnae008-B233","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1046\/j.1365-2141.2003.04426.x","article-title":"Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach","volume":"122","author":"Beger","year":"2003","journal-title":"Br J Haematol"},{"issue":"7","key":"2024071216312222200_bnae008-B234","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/1352458508090666","article-title":"Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex","volume":"14","author":"Matysiak","year":"2008","journal-title":"Mult Scler"},{"issue":"7","key":"2024071216312222200_bnae008-B235","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/10245332.2015.1102371","article-title":"Relationship between expression of glucocorticoid receptor isoforms and glucocorticoid resistance in immune thrombocytopenia","volume":"21","author":"Liang","year":"2016","journal-title":"Hematology"},{"issue":"7","key":"2024071216312222200_bnae008-B236","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s13059-014-0418-y","article-title":"Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes","volume":"15","author":"Schiller","year":"2014","journal-title":"Genome Biol"},{"issue":"17","key":"2024071216312222200_bnae008-B237","first-page":"3877","article-title":"Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells","volume":"53","author":"Moalli","year":"1993","journal-title":"Cancer Res"},{"issue":"1","key":"2024071216312222200_bnae008-B238","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40463-022-00561-1","article-title":"Identification of multiple isoforms of glucocorticoid receptor in nasal polyps of patients with chronic rhinosinusitis","volume":"51","author":"Shao","year":"2022","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"5","key":"2024071216312222200_bnae008-B239","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/mp.2010.28","article-title":"Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development","volume":"16","author":"Sinclair","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2024071216312222200_bnae008-B240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood.V79.1.213.213","article-title":"A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA","volume":"79","author":"Moalli","year":"1992","journal-title":"Blood"},{"issue":"9","key":"2024071216312222200_bnae008-B241","first-page":"1193","article-title":"Glucocorticoid receptor structure and function in an adrenocorticotropin-secreting small cell lung cancer","volume":"9","author":"Gaitan","year":"1995","journal-title":"Mol Endocrinol"},{"issue":"10","key":"2024071216312222200_bnae008-B242","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1158\/0008-5472.3937.61.10","article-title":"Expression in hematological malignancies of a glucocorticoid receptor splice variant that augments glucocorticoid receptor-mediated effects in transfected cells","volume":"61","author":"de Lange","year":"2010","journal-title":"Cancer Res"},{"issue":"1-2","key":"2024071216312222200_bnae008-B243","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1677\/jme.1.02117","article-title":"Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene","volume":"38","author":"Russcher","year":"2007","journal-title":"J Mol Endocrinol"},{"issue":"5","key":"2024071216312222200_bnae008-B244","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s43032-020-00413-1","article-title":"Alterations to placental glucocorticoid receptor expression with alcohol consumption","volume":"28","author":"Young","year":"2021","journal-title":"Reprod Sci"},{"issue":"1","key":"2024071216312222200_bnae008-B245","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41398-023-02345-1","article-title":"Methylation and expression of glucocorticoid receptor exon-1 variants and FKBP5 in teenage suicide-completers","volume":"13","author":"Rizavi","year":"2023","journal-title":"Transl Psychiatry"},{"issue":"5","key":"2024071216312222200_bnae008-B246","first-page":"316","article-title":"Changes of glucocorticoid receptor isoforms expression in acute lymphoblastic leukemia correlate with glucocorticoid resistance","volume":"70","author":"Sun","year":"2015","journal-title":"Pharmazie"},{"issue":"4","key":"2024071216312222200_bnae008-B247","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1172\/JCI117143","article-title":"Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function","volume":"93","author":"Ray","year":"1994","journal-title":"J Clin Invest"},{"issue":"1","key":"2024071216312222200_bnae008-B248","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12863-019-0718-z","article-title":"Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single gene","volume":"20","author":"Leventhal","year":"2019","journal-title":"BMC Genet"},{"issue":"1","key":"2024071216312222200_bnae008-B249","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/SHK.0b013e318257c0c0","article-title":"Enhanced steroid response of a human glucocorticoid receptor splice variant","volume":"38","author":"Baker","year":"2012","journal-title":"Shock"},{"key":"2024071216312222200_bnae008-B250","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1196\/annals.1397.037","article-title":"A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform","volume":"1095","author":"Turner","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"2024071216312222200_bnae008-B251","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-1119(99)00210-3","article-title":"Initiation of translation in prokaryotes and eukaryotes","volume":"234","author":"Kozak","year":"1999","journal-title":"Gene"},{"issue":"10","key":"2024071216312222200_bnae008-B252","doi-asserted-by":"crossref","first-page":"e45947","DOI":"10.15252\/embr.201845947","article-title":"Translation acrobatics: how cancer cells exploit alternate modes of translational initiation","volume":"19","author":"Sriram","year":"2018","journal-title":"EMBO Rep"},{"issue":"11","key":"2024071216312222200_bnae008-B253","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.bbagrm.2015.09.006","article-title":"Cap-dependent, scanning-free translation initiation mechanisms","volume":"1849","author":"Haimov","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"Pt 8","key":"2024071216312222200_bnae008-B254","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1099\/0022-1317-80-8-2217","article-title":"A short open reading frame terminating in front of a stable hairpin is the conserved feature in pregenomic RNA leaders of plant pararetroviruses","volume":"80","author":"Pooggin","year":"1999","journal-title":"J Gen Virol"},{"issue":"7","key":"2024071216312222200_bnae008-B255","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1210\/mend.15.7.0667","article-title":"Molecular identification and characterization of A and B forms of the glucocorticoid receptor","volume":"15","author":"Yudt","year":"2001","journal-title":"Mol Endocrinol"},{"issue":"20","key":"2024071216312222200_bnae008-B256","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1128\/MCB.00253-07","article-title":"Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor","volume":"27","author":"Lu","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2024071216312222200_bnae008-B257","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.1038\/cddis.2012.193","article-title":"Selective glucocorticoid receptor translational isoforms reveal glucocorticoid-induced apoptotic transcriptomes","volume":"4","author":"Wu","year":"2013","journal-title":"Cell Death Dis"},{"issue":"7","key":"2024071216312222200_bnae008-B258","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1210\/me.2010-0051","article-title":"Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance","volume":"25","author":"Gross","year":"2011","journal-title":"Mol Endocrinol"},{"issue":"9","key":"2024071216312222200_bnae008-B259","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1182\/blood-2012-05-432336","article-title":"Glucocorticoid receptor translational isoforms underlie maturational stage-specific glucocorticoid sensitivities of dendritic cells in mice and humans","volume":"121","author":"Cao","year":"2013","journal-title":"Blood"},{"issue":"5","key":"2024071216312222200_bnae008-B260","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/SHK.0000000000002004","article-title":"Bacterial pathogen-associated molecular patterns upregulate human glucocorticoid receptor expression in peripheral blood mononuclear cells","volume":"58","author":"Greenhalgh","year":"2022","journal-title":"Shock"},{"issue":"8","key":"2024071216312222200_bnae008-B261","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/alr.22120","article-title":"Glucocorticoid receptor isoform expression in peripheral blood mononuclear leukocytes of patients with chronic rhinosinusitis","volume":"8","author":"Taylor","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"2024071216312222200_bnae008-B262","doi-asserted-by":"crossref","first-page":"104057","DOI":"10.1016\/j.ebiom.2022.104057","article-title":"Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: a prospective, observational, cross-sectional human and two translational mouse studies","volume":"80","author":"T\u00e9blick","year":"2022","journal-title":"EBioMedicine"},{"key":"2024071216312222200_bnae008-B263","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2016.12.017","article-title":"Review: the role of multiple placental glucocorticoid receptor isoforms in adapting to the maternal environment and regulating fetal growth","volume":"54","author":"Clifton","year":"2017","journal-title":"Placenta"},{"issue":"9","key":"2024071216312222200_bnae008-B264","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1210\/me.2013-1009","article-title":"Determinants of the heightened activity of glucocorticoid receptor translational isoforms","volume":"27","author":"Bender","year":"2013","journal-title":"Mol Endocrinol"},{"issue":"10","key":"2024071216312222200_bnae008-B265","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1096\/fj.201701153R","article-title":"Glucocorticoid receptor isoform-specific regulation of development, circadian rhythm, and inflammation in mice","volume":"32","author":"Oakley","year":"2018","journal-title":"FASEB J"},{"issue":"13","key":"2024071216312222200_bnae008-B266","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1038\/npp.2011.160","article-title":"Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness","volume":"36","author":"Sinclair","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"2024071216312222200_bnae008-B267","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-244X-12-84","article-title":"Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder","volume":"12","author":"Sinclair","year":"2012","journal-title":"BMC Psychiatry"},{"issue":"5","key":"2024071216312222200_bnae008-B268","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jnr.25032","article-title":"Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice","volume":"100","author":"Aleksic","year":"2022","journal-title":"J Neurosci Res"},{"issue":"1-2","key":"2024071216312222200_bnae008-B269","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0303-7207(01)00676-1","article-title":"Characterization of promoter 1B in the human glucocorticoid receptor gene","volume":"189","author":"Nunez","year":"2002","journal-title":"Mol Cell Endocrinol"},{"issue":"37","key":"2024071216312222200_bnae008-B270","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1021\/bi034651u","article-title":"Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines","volume":"42","author":"Pedersen","year":"2003","journal-title":"Biochemistry"},{"issue":"4","key":"2024071216312222200_bnae008-B271","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1210\/me.2003-0157","article-title":"Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter","volume":"18","author":"Geng","year":"2004","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2024071216312222200_bnae008-B272","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1128\/MCB.00552-09","article-title":"Site-specific phosphorylation induces functionally active conformation in the intrinsically disordered N-terminal activation function (AF1) domain of the glucocorticoid receptor","volume":"30","author":"Garza","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"1-2","key":"2024071216312222200_bnae008-B273","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jsbmb.2008.01.002","article-title":"Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes","volume":"109","author":"Blind","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2024071216312222200_bnae008-B274","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000342502","article-title":"Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance","volume":"24","author":"Ramamoorthy","year":"2013","journal-title":"Endocr Dev"},{"issue":"9678","key":"2024071216312222200_bnae008-B275","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(09)60326-3","article-title":"Glucocorticoid resistance in inflammatory diseases","volume":"373","author":"Barnes","year":"2009","journal-title":"Lancet"},{"issue":"10","key":"2024071216312222200_bnae008-B276","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1210\/me.2007-0101","article-title":"Steroid receptor phosphorylation: a key modulator of multiple receptor functions","volume":"21","author":"Weigel","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"2","key":"2024071216312222200_bnae008-B277","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncprheum0701","article-title":"Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis","volume":"4","author":"Ayoub","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"12","key":"2024071216312222200_bnae008-B278","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1172\/JCI1524","article-title":"Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). potential role in asthma","volume":"101","author":"Rossi","year":"1998","journal-title":"J Clin Invest"},{"issue":"46","key":"2024071216312222200_bnae008-B279","doi-asserted-by":"crossref","first-page":"42714","DOI":"10.1074\/jbc.M106033200","article-title":"Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids","volume":"276","author":"Wallace","year":"2001","journal-title":"J Biol Chem"},{"issue":"12","key":"2024071216312222200_bnae008-B280","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.steroids.2010.06.015","article-title":"Lysine 419 targets human glucocorticoid receptor for proteasomal degradation","volume":"75","author":"Wallace","year":"2010","journal-title":"Steroids"},{"issue":"7-12","key":"2024071216312222200_bnae008-B281","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2119\/2005-00026.Kino","article-title":"Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function","volume":"10","author":"Kino","year":"2004","journal-title":"Mol Med"},{"issue":"1","key":"2024071216312222200_bnae008-B282","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1084\/jem.20050466","article-title":"Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression","volume":"203","author":"Ito","year":"2006","journal-title":"J Exp Med"},{"key":"2024071216312222200_bnae008-B283","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2015.01.044","article-title":"Helix 8 of the ligand binding domain of the glucocorticoid receptor (GR) is essential for ligand binding","volume":"408","author":"Deng","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"40","key":"2024071216312222200_bnae008-B284","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.1102821108","article-title":"Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation","volume":"108","author":"Samarasinghe","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2024071216312222200_bnae008-B285","first-page":"3","article-title":"The role of S-palmitoylation of the human glucocorticoid receptor (hGR) in mediating the nongenomic glucocorticoid actions","volume":"6","author":"Nicolaides","year":"2017","journal-title":"J Mol Biochem"},{"issue":"12","key":"2024071216312222200_bnae008-B286","doi-asserted-by":"crossref","first-page":"9847","DOI":"10.3390\/ijms24129847","article-title":"Folate and cobalamin deficiencies during pregnancy disrupt the glucocorticoid response in hypothalamus through N-homocysteinilation of the glucocorticoid receptor","volume":"24","author":"Michel","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"2024071216312222200_bnae008-B287","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrendo.2013.183","article-title":"Glucocorticoid sensitivity in health and disease","volume":"9","author":"Quax","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"2024071216312222200_bnae008-B288","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.1210\/jc.2005-0067","article-title":"Glucocorticoid sensitivity in young healthy individuals: in vitro and in vivo studies","volume":"90","author":"Chriguer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024071216312222200_bnae008-B289","first-page":"47","article-title":"Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals","volume":"83","author":"Huizenga","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B290","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1046\/j.1365-2265.2001.01383.x","article-title":"Seasonal variation in glucocorticoid receptor binding characteristics in human mononuclear leucocytes","volume":"55","author":"Blackhurst","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"8","key":"2024071216312222200_bnae008-B291","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1210\/jc.2009-2720","article-title":"Biological and diurnal variation in glucocorticoid sensitivity detected with a sensitive in vitro dexamethasone suppression of cytokine production assay","volume":"95","author":"Cardinal","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B292","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1210\/jc.2008-0040","article-title":"Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder","volume":"93","author":"Charmandari","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2024071216312222200_bnae008-B293","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1365-2362.2010.02336.x","article-title":"Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes","volume":"40","author":"Charmandari","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"12","key":"2024071216312222200_bnae008-B294","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1210\/jc.2008-0892","article-title":"A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression","volume":"93","author":"Charmandari","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024071216312222200_bnae008-B295","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/eci.12554","article-title":"Transient generalized glucocorticoid hypersensitivity","volume":"45","author":"Nicolaides","year":"2015","journal-title":"Eur J Clin Invest"},{"issue":"6 Pt 2","key":"2024071216312222200_bnae008-B296","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1164\/ajrccm\/152.6_Pt_2.S125","article-title":"Glucocorticoid resistance in asthma","volume":"152","author":"Barnes","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"2024071216312222200_bnae008-B297","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1172\/JCI116963","article-title":"Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy","volume":"93","author":"Sher","year":"1994","journal-title":"J Clin Invest"},{"issue":"11","key":"2024071216312222200_bnae008-B298","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/rheumatology\/keh333","article-title":"Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives","volume":"43","author":"Chikanza","year":"2004","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"2024071216312222200_bnae008-B299","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1053\/gast.2001.26279","article-title":"The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study","volume":"121","author":"Faubion","year":"2001","journal-title":"Gastroenterology"},{"issue":"3","key":"2024071216312222200_bnae008-B300","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/gut.35.3.360","article-title":"Frequency of glucocorticoid resistance and dependency in Crohn's disease","volume":"35","author":"Munkholm","year":"1994","journal-title":"Gut"},{"issue":"2","key":"2024071216312222200_bnae008-B301","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1365-2036.2006.02974.x","article-title":"The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5-year UK inception cohort","volume":"24","author":"Ho","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"2024071216312222200_bnae008-B302","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/1529-0131(199805)41:5<823::AID-ART8>3.0.CO;2-#","article-title":"Apoptosis of lymphocytes induced by glucocorticoids and relationship to therapeutic efficacy in patients with systemic lupus erythematosus","volume":"41","author":"Seki","year":"1998","journal-title":"Arthritis Rheum"},{"issue":"4","key":"2024071216312222200_bnae008-B303","doi-asserted-by":"crossref","first-page":"R108","DOI":"10.1186\/ar2763","article-title":"Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus","volume":"11","author":"Du","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"1-2","key":"2024071216312222200_bnae008-B304","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jneuroim.2004.02.009","article-title":"Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production","volume":"151","author":"DeRijk","year":"2004","journal-title":"J Neuroimmunol"},{"issue":"2","key":"2024071216312222200_bnae008-B305","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jaci.2006.11.639","article-title":"Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's severe Asthma Research Program","volume":"119","author":"Moore","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2024071216312222200_bnae008-B306","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1183\/09031936.04.00039004","article-title":"Asthma and cigarette smoking","volume":"24","author":"Thomson","year":"2004","journal-title":"Eur Respir J"},{"issue":"2","key":"2024071216312222200_bnae008-B307","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1164\/rccm.200512-1930OC","article-title":"Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma","volume":"174","author":"Hew","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"2024071216312222200_bnae008-B308","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1677\/joe.0.1780339","article-title":"Glucocorticoid resistance in inflammatory bowel disease","volume":"178","author":"Farrell","year":"2003","journal-title":"J Endocrinol"},{"issue":"8","key":"2024071216312222200_bnae008-B309","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/s41375-020-0748-6","article-title":"Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia","volume":"34","author":"Wandler","year":"2020","journal-title":"Leukemia"},{"issue":"2","key":"2024071216312222200_bnae008-B310","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/pbc.20308","article-title":"Differential mRNA expression of glucocorticoid receptor alpha and beta is associated with glucocorticoid sensitivity of acute lymphoblastic leukemia in children","volume":"45","author":"Koga","year":"2005","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"2024071216312222200_bnae008-B311","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1097\/CCM.0b013e31817603ba","article-title":"Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine","volume":"36","author":"Marik","year":"2008","journal-title":"Crit Care Med"},{"key":"2024071216312222200_bnae008-B312","doi-asserted-by":"crossref","first-page":"110656","DOI":"10.1016\/j.mce.2019.110656","article-title":"Longitudinal evaluation of glucocorticoid receptor alpha\/beta expression and signalling, adrenocortical function and cytokines in critically ill steroid-free patients","volume":"501","author":"Vassiliou","year":"2020","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B313","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1210\/clinem\/dgac035","article-title":"Corticosteroid-Binding globulin deficiency independently predicts mortality in septic shock","volume":"107","author":"Meyer","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024071216312222200_bnae008-B314","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1152\/physrev.00020.2012","article-title":"11\u03b2-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action","volume":"93","author":"Chapman","year":"2013","journal-title":"Physiol Rev"},{"issue":"6","key":"2024071216312222200_bnae008-B315","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2265.2006.02669.x","article-title":"11Beta hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle","volume":"65","author":"Jang","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"2024071216312222200_bnae008-B316","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1210\/endo.136.12.7588309","article-title":"LLC-PK1 cells model 11 beta-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors","volume":"136","author":"Leckie","year":"1995","journal-title":"Endocrinology"},{"issue":"6","key":"2024071216312222200_bnae008-B317","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/ard.2009.107466","article-title":"Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss","volume":"69","author":"Kaur","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"2024071216312222200_bnae008-B318","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1210\/en.2003-0780","article-title":"Enhancement of glucocorticoid-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by proinflammatory cytokines in cultured human amnion fibroblasts","volume":"144","author":"Sun","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"2024071216312222200_bnae008-B319","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1096\/fj.01-0582com","article-title":"Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation","volume":"16","author":"Rabbitt","year":"2002","journal-title":"FASEB J"},{"issue":"12","key":"2024071216312222200_bnae008-B320","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.leukres.2011.07.002","article-title":"Expression of 11beta-hydroxysteroid dehydrogenase 2 contributes to glucocorticoid resistance in lymphoblastic leukemia cells","volume":"35","author":"Sai","year":"2011","journal-title":"Leuk Res"},{"issue":"6","key":"2024071216312222200_bnae008-B321","first-page":"2728","article-title":"Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors","volume":"86","author":"Korbonits","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"13","key":"2024071216312222200_bnae008-B322","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.steroids.2012.08.014","article-title":"The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic women","volume":"77","author":"Feldman","year":"2012","journal-title":"Steroids"},{"issue":"12","key":"2024071216312222200_bnae008-B323","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/sj.jhh.1001116","article-title":"Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension","volume":"14","author":"Melander","year":"2000","journal-title":"J Hum Hypertens"},{"issue":"2","key":"2024071216312222200_bnae008-B324","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0016-5085(00)70210-1","article-title":"High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy","volume":"118","author":"Farrell","year":"2000","journal-title":"Gastroenterology"},{"issue":"3","key":"2024071216312222200_bnae008-B325","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/ard.2007.070821","article-title":"Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis","volume":"67","author":"Tsujimura","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"2024071216312222200_bnae008-B326","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/art.21032","article-title":"Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus","volume":"52","author":"Tsujimura","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"9","key":"2024071216312222200_bnae008-B327","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ncb1922","article-title":"Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription","volume":"11","author":"Stavreva","year":"2009","journal-title":"Nat Cell Biol"},{"issue":"8","key":"2024071216312222200_bnae008-B328","doi-asserted-by":"crossref","first-page":"e105204","DOI":"10.1371\/journal.pone.0105204","article-title":"Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells","volume":"9","author":"Nenseth","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"2024071216312222200_bnae008-B329","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.molcel.2019.06.042","article-title":"Transcriptional bursting and co-bursting regulation by steroid hormone release pattern and transcription factor mobility","volume":"75","author":"Stavreva","year":"2019","journal-title":"Mol Cell"},{"issue":"4","key":"2024071216312222200_bnae008-B330","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1210\/endo-127-4-1689","article-title":"Glucocorticoid receptor messenger ribonucleic acid in different regions of human adipose tissue","volume":"127","author":"Br\u00f6nneg\u00e5rd","year":"1990","journal-title":"Endocrinology"},{"issue":"2","key":"2024071216312222200_bnae008-B331","doi-asserted-by":"crossref","first-page":"bvac188","DOI":"10.1210\/jendso\/bvac188","article-title":"Do corticosteroid receptor mRNA levels predict the expression of their target genes?","volume":"7","author":"Koorneef","year":"2022","journal-title":"J Endocr Soc"},{"issue":"6","key":"2024071216312222200_bnae008-B332","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1164\/rccm.200507-1046OC","article-title":"Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma","volume":"173","author":"Goleva","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"2024071216312222200_bnae008-B333","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1067\/mai.2000.106486","article-title":"Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform","volume":"105","author":"Sousa","year":"2000","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2024071216312222200_bnae008-B334","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1006\/bbrc.1998.9980","article-title":"Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia","volume":"254","author":"Shahidi","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"2024071216312222200_bnae008-B335","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1055\/s-2007-978661","article-title":"Low glucocorticoid receptor alpha\/beta ratio in T-cell lymphoblastic leukemia","volume":"32","author":"Longui","year":"2000","journal-title":"Horm Metab Res"},{"issue":"3","key":"2024071216312222200_bnae008-B336","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/sj.leu.2403225","article-title":"Glucocorticoid receptor alpha, beta and gamma expression vs in vitro glucocorticod resistance in childhood leukemia","volume":"18","author":"Haarman","year":"2004","journal-title":"Leukemia"},{"issue":"3","key":"2024071216312222200_bnae008-B337","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jaci.2011.12.001","article-title":"Usefulness of PBMCs to predict clinical response to corticosteroids in asthmatic patients","volume":"129","author":"Goleva","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2024071216312222200_bnae008-B338","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/SHK.0000000000000289","article-title":"Hyperactive human glucocorticoid receptor isoforms and their implications for the stress response","volume":"43","author":"Lasker","year":"2015","journal-title":"Shock"},{"key":"2024071216312222200_bnae008-B339","first-page":"140","article-title":"A novel human glucocorticoid receptor SNP results in increased transactivation potential","volume":"9","author":"Green","year":"2017","journal-title":"Biochem Biophys Rep"},{"key":"2024071216312222200_bnae008-B340","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.steroids.2014.07.015","article-title":"Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease","volume":"92","author":"Koper","year":"2014","journal-title":"Steroids"},{"key":"2024071216312222200_bnae008-B341","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1749-6632.2009.05013.x","article-title":"Clinical features associated with glucocorticoid receptor polymorphisms. An overview","volume":"1179","author":"Manenschijn","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"2024071216312222200_bnae008-B342","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1210\/jc.2005-0646","article-title":"Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression","volume":"90","author":"Russcher","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2024071216312222200_bnae008-B343","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/me.2004-0467","article-title":"Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22\/23EK polymorphism","volume":"19","author":"Russcher","year":"2005","journal-title":"Mol Endocrinol"},{"issue":"10","key":"2024071216312222200_bnae008-B344","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.2337\/diabetes.51.10.3128","article-title":"A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels","volume":"51","author":"van Rossum","year":"2002","journal-title":"Diabetes"},{"issue":"3","key":"2024071216312222200_bnae008-B345","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.amjmed.2004.01.027","article-title":"Association of the ER22\/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men","volume":"117","author":"van Rossum","year":"2004","journal-title":"Am J Med"},{"issue":"8","key":"2024071216312222200_bnae008-B346","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1210\/jc.2003-031422","article-title":"The ER22\/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults","volume":"89","author":"van Rossum","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024071216312222200_bnae008-B347","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1210\/jc.2007-1290","article-title":"The 23\u2005K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth","volume":"92","author":"Finken","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024071216312222200_bnae008-B348","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.neurobiolaging.2006.11.016","article-title":"Glucocorticoid receptor variant and risk of dementia and white matter lesions","volume":"29","author":"van Rossum","year":"2008","journal-title":"Neurobiol Aging"},{"issue":"6","key":"2024071216312222200_bnae008-B349","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1086\/506367","article-title":"Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms","volume":"194","author":"van den Akker","year":"2006","journal-title":"J Infect Dis"},{"issue":"1","key":"2024071216312222200_bnae008-B350","first-page":"144","article-title":"A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo","volume":"83","author":"Huizenga","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2024071216312222200_bnae008-B351","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1210\/jc.2007-0642","article-title":"Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression","volume":"92","author":"Jewell","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2024071216312222200_bnae008-B352","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1210\/mend.11.8.9949","article-title":"Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants","volume":"11","author":"de Lange","year":"1997","journal-title":"Mol Endocrinol"},{"issue":"4","key":"2024071216312222200_bnae008-B353","doi-asserted-by":"crossref","first-page":"E741","DOI":"10.1152\/ajpendo.00105.2016","article-title":"Healthy glucocorticoid receptor N363S carriers dysregulate gene expression associated with metabolic syndrome","volume":"311","author":"Jewell","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2024071216312222200_bnae008-B354","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1365-2265.2003.01798.x","article-title":"The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients","volume":"59","author":"Di Blasio","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"2024071216312222200_bnae008-B355","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/oby.2003.111","article-title":"Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant","volume":"11","author":"Lin","year":"2003","journal-title":"Obes Res"},{"issue":"7221","key":"2024071216312222200_bnae008-B356","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1136\/bmj.319.7221.1337","article-title":"High penetrance, overweight, and glucocorticoid receptor variant: case-control study","volume":"319","author":"Lin","year":"1999","journal-title":"BMJ"},{"issue":"2","key":"2024071216312222200_bnae008-B357","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2265.2003.01831.x","article-title":"The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type 2 diabetes mellitus","volume":"59","author":"Roussel","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2024071216312222200_bnae008-B358","first-page":"2270","article-title":"The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus","volume":"86","author":"Dobson","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024071216312222200_bnae008-B359","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10522-006-9021-2","article-title":"Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus study","volume":"7","author":"Kuningas","year":"2006","journal-title":"Biogerontology"},{"issue":"3","key":"2024071216312222200_bnae008-B360","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/01.HYP.0000055342.40301.DC","article-title":"Association of coronary artery disease with glucocorticoid receptor N363S variant","volume":"41","author":"Lin","year":"2003","journal-title":"Hypertension"},{"issue":"6","key":"2024071216312222200_bnae008-B361","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/EJE-16-0534","article-title":"Glucocorticoid receptor haplotype and metabolic syndrome: the lifelines cohort study","volume":"175","author":"Wester","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B362","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1530\/eje.1.02162","article-title":"Potential advantage of N363S glucocorticoid receptor polymorphism in 21-hydroxylase deficiency","volume":"154","author":"Luczay","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B363","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/ki.2013.531","article-title":"Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome","volume":"85","author":"Teeninga","year":"2014","journal-title":"Kidney Int"},{"issue":"4","key":"2024071216312222200_bnae008-B364","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0b013e318228eca7","article-title":"Novel hyperactive glucocorticoid receptor isoform identified within a human population","volume":"36","author":"Tung","year":"2011","journal-title":"Shock"},{"issue":"3","key":"2024071216312222200_bnae008-B365","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2265.2001.01323.x","article-title":"Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance","volume":"55","author":"Ruiz","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2024071216312222200_bnae008-B366","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1210\/jc.2005-1893","article-title":"Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance","volume":"91","author":"Charmandari","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024071216312222200_bnae008-B367","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/00365513.2013.764573","article-title":"Further characterization of human glucocorticoid receptor mutants, R477H and G679S, associated with primary generalized glucocorticoid resistance","volume":"73","author":"Ruiz","year":"2013","journal-title":"Scand J Clin Lab Invest"},{"issue":"5","key":"2024071216312222200_bnae008-B368","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.molcel.2007.08.012","article-title":"Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation","volume":"27","author":"Lonard","year":"2007","journal-title":"Mol Cell"},{"issue":"3","key":"2024071216312222200_bnae008-B369","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tibs.2005.01.001","article-title":"Expanding functional diversity of the coactivators","volume":"30","author":"Lonard","year":"2005","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"2024071216312222200_bnae008-B370","first-page":"321","article-title":"Nuclear receptor coregulators: cellular and molecular biology","volume":"20","author":"McKenna","year":"1999","journal-title":"Endocr Rev"},{"issue":"3","key":"2024071216312222200_bnae008-B371","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)80218-4","article-title":"Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase","volume":"89","author":"Nagy","year":"1997","journal-title":"Cell"},{"issue":"5","key":"2024071216312222200_bnae008-B372","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1753465809348648","article-title":"Histone deacetylase-2 and airway disease","volume":"3","author":"Barnes","year":"2009","journal-title":"Ther Adv Respir Dis"},{"issue":"1-2","key":"2024071216312222200_bnae008-B373","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mce.2013.06.007","article-title":"Variable steroid receptor responses: intrinsically disordered AF1 is the key","volume":"376","author":"Simons","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B374","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1210\/me.2003-0421","article-title":"Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors","volume":"18","author":"Wang","year":"2004","journal-title":"Mol Endocrinol"},{"issue":"26","key":"2024071216312222200_bnae008-B375","doi-asserted-by":"crossref","first-page":"12942","DOI":"10.1073\/pnas.1821565116","article-title":"TNF-\u03b1 inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile","volume":"116","author":"Dendoncker","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2024071216312222200_bnae008-B376","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1093\/nar\/gkac488","article-title":"Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression","volume":"50","author":"Portuguez","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"5564","key":"2024071216312222200_bnae008-B377","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1126\/science.1068537","article-title":"Molecular determinants for the tissue specificity of SERMs","volume":"295","author":"Shang","year":"2002","journal-title":"Science"},{"issue":"2","key":"2024071216312222200_bnae008-B378","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1210\/me.2005-0061","article-title":"Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes","volume":"20","author":"Grenier","year":"2006","journal-title":"Mol Endocrinol"},{"issue":"2","key":"2024071216312222200_bnae008-B379","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.mce.2008.10.008","article-title":"Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction","volume":"299","author":"Ronacher","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"2-3","key":"2024071216312222200_bnae008-B380","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bpc.2007.03.013","article-title":"Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor","volume":"128","author":"Kroe","year":"2007","journal-title":"Biophys Chem"},{"key":"2024071216312222200_bnae008-B381","doi-asserted-by":"crossref","first-page":"108587","DOI":"10.1016\/j.jmgm.2023.108587","article-title":"Influence of dexamethasone on the interaction between glucocorticoid receptor and SOX9: a molecular dynamics study","volume":"125","author":"Stojceski","year":"2023","journal-title":"J Mol Graph Model"},{"issue":"5","key":"2024071216312222200_bnae008-B382","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.molcel.2008.02.010","article-title":"Interaction of the glucocorticoid receptor with the chromatin landscape","volume":"29","author":"John","year":"2008","journal-title":"Mol Cell"},{"issue":"3","key":"2024071216312222200_bnae008-B383","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ng.759","article-title":"Chromatin accessibility pre-determines glucocorticoid receptor binding patterns","volume":"43","author":"John","year":"2011","journal-title":"Nat Genet"},{"issue":"4","key":"2024071216312222200_bnae008-B384","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/nar\/gkw1163","article-title":"Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation","volume":"45","author":"Love","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"2024071216312222200_bnae008-B385","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1038\/emboj.2011.210","article-title":"DNA methylation status predicts cell type-specific enhancer activity","volume":"30","author":"Wiench","year":"2011","journal-title":"EMBO J"},{"issue":"1","key":"2024071216312222200_bnae008-B386","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molcel.2013.08.037","article-title":"Distinct properties of cell-type-specific and shared transcription factor binding sites","volume":"52","author":"Gertz","year":"2013","journal-title":"Mol Cell"},{"issue":"36","key":"2024071216312222200_bnae008-B387","doi-asserted-by":"crossref","first-page":"13795","DOI":"10.1074\/jbc.R117.001232","article-title":"Pioneer transcription factors shape the epigenetic landscape","volume":"293","author":"Mayran","year":"2018","journal-title":"J Biol Chem"},{"issue":"1","key":"2024071216312222200_bnae008-B388","doi-asserted-by":"crossref","first-page":"e22709","DOI":"10.1096\/fj.202201199RR","article-title":"The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes","volume":"37","author":"Carceller-Zazo","year":"2023","journal-title":"FASEB J"},{"issue":"10","key":"2024071216312222200_bnae008-B389","doi-asserted-by":"crossref","first-page":"e1000224","DOI":"10.1371\/journal.pgen.1000224","article-title":"Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response","volume":"4","author":"Langlais","year":"2008","journal-title":"PLoS Genet"},{"issue":"1-2","key":"2024071216312222200_bnae008-B390","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mce.2007.07.003","article-title":"Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects","volume":"275","author":"Kassel","year":"2007","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"2024071216312222200_bnae008-B391","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.clinthera.2020.03.002","article-title":"Chronic stress and glucocorticoid receptor resistance in asthma","volume":"42","author":"Palumbo","year":"2020","journal-title":"Clin Ther"},{"issue":"2","key":"2024071216312222200_bnae008-B392","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jaci.2006.04.055","article-title":"Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients","volume":"118","author":"Loke","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"2024071216312222200_bnae008-B393","doi-asserted-by":"crossref","first-page":"111855","DOI":"10.1016\/j.mce.2023.111855","article-title":"Glucocorticoids and medroxyprogesterone acetate synergize with inflammatory stimuli to selectively upregulate CCL20 transcription","volume":"563","author":"Moliki","year":"2023","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"2024071216312222200_bnae008-B394","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2005.06.029","article-title":"Molecular determinants of crosstalk between nuclear receptors and toll-like receptors","volume":"122","author":"Ogawa","year":"2005","journal-title":"Cell"},{"issue":"1-2","key":"2024071216312222200_bnae008-B395","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2012.12.014","article-title":"How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering","volume":"380","author":"Ratman","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"5740","key":"2024071216312222200_bnae008-B396","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.1117806","article-title":"The functional genomics of noncoding RNA","volume":"309","author":"Mattick","year":"2005","journal-title":"Science"},{"issue":"2","key":"2024071216312222200_bnae008-B397","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/BC20070090","article-title":"Non-coding RNAs regulating the transcriptional machinery","volume":"100","author":"Barrandon","year":"2008","journal-title":"Biol Cell"},{"issue":"107","key":"2024071216312222200_bnae008-B398","doi-asserted-by":"crossref","first-page":"ra8","DOI":"10.1126\/scisignal.2000568","article-title":"Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor","volume":"3","author":"Kino","year":"2010","journal-title":"Sci Signal"},{"key":"2024071216312222200_bnae008-B399","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/ncomms6395","article-title":"Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate","volume":"5","author":"Hudson","year":"2014","journal-title":"Nat Commun"},{"issue":"15","key":"2024071216312222200_bnae008-B400","doi-asserted-by":"crossref","first-page":"8180","DOI":"10.1093\/nar\/gkz486","article-title":"The glucocorticoid receptor DNA-binding domain recognizes RNA hairpin structures with high affinity","volume":"47","author":"Parsonnet","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2024071216312222200_bnae008-B401","doi-asserted-by":"crossref","first-page":"9385","DOI":"10.1038\/s41598-023-35549-y","article-title":"RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation","volume":"13","author":"Lammer","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"2024071216312222200_bnae008-B402","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4049\/jimmunol.1001794","article-title":"The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif","volume":"186","author":"Ishmael","year":"2011","journal-title":"J Immunol"},{"issue":"3","key":"2024071216312222200_bnae008-B403","first-page":"306","article-title":"Steroid receptor interactions with heat shock protein and immunophilin chaperones","volume":"18","author":"Pratt","year":"1997","journal-title":"Endocr Rev"},{"issue":"6","key":"2024071216312222200_bnae008-B404","first-page":"994","article-title":"Mechanisms of glucocorticoid resistance in human leukemic cells: implication of abnormal 90 and 70\u2005kDa heat shock proteins","volume":"10","author":"Kojika","year":"1996","journal-title":"Leukemia"},{"issue":"10","key":"2024071216312222200_bnae008-B405","first-page":"1051","article-title":"Glucocorticoid receptor and heat shock protein 90 in peripheral blood mononuclear cells from asthmatics","volume":"114","author":"Qian","year":"2001","journal-title":"Chin Med J (Engl)"},{"issue":"5","key":"2024071216312222200_bnae008-B406","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/sj.leu.2403681","article-title":"mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL","volume":"19","author":"Tissing","year":"2005","journal-title":"Leukemia"},{"issue":"8","key":"2024071216312222200_bnae008-B407","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/sj.leu.2403027","article-title":"Expression of heat-shock protein 90 in glucocorticoid-sensitive and -resistant childhood acute lymphoblastic leukaemia","volume":"17","author":"Lauten","year":"2003","journal-title":"Leukemia"},{"issue":"4","key":"2024071216312222200_bnae008-B408","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1128\/CVI.13.4.496-500.2006","article-title":"Abnormal expression and distribution of heat shock protein 90: potential etiologic immunoendocrine mechanism of glucocorticoid resistance in idiopathic nephrotic syndrome","volume":"13","author":"Ouyang","year":"2006","journal-title":"Clin Vaccine Immunol"},{"issue":"1-2","key":"2024071216312222200_bnae008-B409","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2008.10.001","article-title":"Molecular mechanisms regulating glucocorticoid sensitivity and resistance","volume":"300","author":"Gross","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"2024071216312222200_bnae008-B410","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/eji.201847699","article-title":"FKBP51 modulates steroid sensitivity and NF\u03baB signalling: a novel anti-inflammatory drug target","volume":"48","author":"K\u00e4stle","year":"2018","journal-title":"Eur J Immunol"},{"issue":"1","key":"2024071216312222200_bnae008-B411","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10875-010-9463-9","article-title":"Dexamethasone-induced FKBP51 expression in peripheral blood mononuclear cells could play a role in predicting the response of asthmatics to treatment with corticosteroids","volume":"31","author":"Chun","year":"2011","journal-title":"J Clin Immunol"},{"issue":"6","key":"2024071216312222200_bnae008-B412","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1476-5381.2011.01620.x","article-title":"Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide","volume":"165","author":"Kelly","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"6","key":"2024071216312222200_bnae008-B413","doi-asserted-by":"crossref","first-page":"e00076","DOI":"10.1002\/prp2.76","article-title":"Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation","volume":"2","author":"Hinds","year":"2014","journal-title":"Pharmacol Res Perspect"},{"key":"2024071216312222200_bnae008-B414","first-page":"1","article-title":"The animal and cell models that uncovered FKBP51 as a regulator of glucocorticoid receptor function","volume":"2023","author":"Scammell","journal-title":"J Cell Biochem"},{"issue":"7","key":"2024071216312222200_bnae008-B415","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1056\/NEJMra022219","article-title":"Selective estrogen-receptor modulators\u2014mechanisms of action and application to clinical practice","volume":"348","author":"Riggs","year":"2003","journal-title":"N Engl J Med"},{"key":"2024071216312222200_bnae008-B416","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2147\/JEP.S237480","article-title":"Experimental glucocorticoid receptor agonists for the treatment of asthma: a systematic review","volume":"12","author":"Rogliani","year":"2020","journal-title":"J Exp Pharmacol"},{"issue":"12","key":"2024071216312222200_bnae008-B417","doi-asserted-by":"crossref","first-page":"e0188810","DOI":"10.1371\/journal.pone.0188810","article-title":"Efficacy and safety of selective glucocorticoid receptor modulators in comparison to glucocorticoids in arthritis, a systematic review","volume":"12","author":"Safy","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"2024071216312222200_bnae008-B418","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1164\/rccm.201404-0623OC","article-title":"A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses","volume":"191","author":"Gauvreau","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"2024071216312222200_bnae008-B419","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/bcpt.12768","article-title":"Efficacy and tolerability of an inhaled selective glucocorticoid receptor modulator\u2014AZD5423\u2014in chronic obstructive pulmonary disease patients: phase II study results","volume":"121","author":"Kuna","year":"2017","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"2024071216312222200_bnae008-B420","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-019-1000-7","article-title":"Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial","volume":"20","author":"Brown","year":"2019","journal-title":"Respir Res"},{"issue":"1","key":"2024071216312222200_bnae008-B421","doi-asserted-by":"crossref","first-page":"e000889","DOI":"10.1136\/rmdopen-2018-000889","article-title":"Fosdagrocorat (PF-04171327) versus prednisone or placebo in rheumatoid arthritis: a randomised, double-blind, multicentre, phase IIb study","volume":"5","author":"Buttgereit","year":"2019","journal-title":"RMD Open"},{"issue":"8","key":"2024071216312222200_bnae008-B422","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/1756-185X.13053","article-title":"Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a phase 2 randomized study","volume":"20","author":"Stock","year":"2017","journal-title":"Int J Rheum Dis"},{"issue":"4","key":"2024071216312222200_bnae008-B423","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1476-5381.2009.00238.x","article-title":"Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases","volume":"158","author":"Sch\u00e4cke","year":"2009","journal-title":"Br J Pharmacol"},{"key":"2024071216312222200_bnae008-B424","doi-asserted-by":"crossref","first-page":"662865","DOI":"10.3389\/fendo.2021.662865","article-title":"Relacorilant, a selective glucocorticoid receptor modulator, induces clinical improvements in patients with cushing syndrome: results from a prospective, open-label phase 2 study","volume":"12","author":"Pivonello","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"2024071216312222200_bnae008-B425","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1210\/endo.140.5.6680","article-title":"Salsola tuberculatiformis botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female wistar rats","volume":"140","author":"Louw","year":"1999","journal-title":"Endocrinology"},{"key":"2024071216312222200_bnae008-B426","doi-asserted-by":"crossref","first-page":"408","DOI":"10.18632\/oncotarget.28191","article-title":"The long winding road to the safer glucocorticoid receptor (GR) targeting therapies","volume":"13","author":"Lesovaya","year":"2022","journal-title":"Oncotarget"}],"container-title":["Endocrine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/edrv\/advance-article-pdf\/doi\/10.1210\/endrev\/bnae008\/57137981\/bnae008.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/edrv\/article-pdf\/45\/4\/593\/58530139\/bnae008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/edrv\/article-pdf\/45\/4\/593\/58530139\/bnae008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T16:35:25Z","timestamp":1720802125000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/edrv\/article\/45\/4\/593\/7637244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":426,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,3,29]]},"published-print":{"date-parts":[[2024,7,12]]}},"URL":"https:\/\/doi.org\/10.1210\/endrev\/bnae008","relation":{},"ISSN":["0163-769X","1945-7189"],"issn-type":[{"value":"0163-769X","type":"print"},{"value":"1945-7189","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,3,29]]}}}