{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:58:28Z","timestamp":1793314708582,"version":"4.5.0"},"reference-count":344,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01-AG059779"],"award-info":[{"award-number":["NIH R01-AG059779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mouse models of growth hormone deficiency (GHD) have provided important tools for uncovering the various actions of GH. Nearly 100 years of research using these mouse lines has greatly enhanced our knowledge of the GH\/IGF-1 axis. Some of the shared phenotypes of the 5 \u201ccommon\u201d mouse models of GHD include reduced body size, delayed sexual maturation, decreased fertility, reduced muscle mass, increased adiposity, and enhanced insulin sensitivity. Since these common mouse lines outlive their normal-sized littermates\u2014and have protection from age-associated disease\u2014they have become important fixtures in the aging field. On the other hand, the 12 \u201cuncommon\u201d mouse models of GHD described herein have tremendously divergent health outcomes ranging from beneficial aging phenotypes (similar to those described for the common models) to extremely detrimental features (such as improper development of the central nervous system, numerous sensory organ defects, and embryonic lethality). Moreover, advancements in next-generation sequencing technologies have led to the identification of an expanding array of genes that are recognized as causative agents to numerous rare syndromes with concomitant GHD. Accordingly, this review provides researchers with a comprehensive up-to-date collection of the common and uncommon mouse models of GHD that have been used to study various aspects of physiology and metabolism associated with multiple forms of GHD. For each mouse line presented, the closest comparable human syndromes are discussed providing important parallels to the clinic.<\/jats:p>","DOI":"10.1210\/endrev\/bnae017","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T22:50:40Z","timestamp":1717800640000},"page":"818-842","source":"Crossref","is-referenced-by-count":10,"title":["Common and Uncommon Mouse Models of Growth Hormone Deficiency"],"prefix":"10.1210","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-6331","authenticated-orcid":false,"given":"Edward O","family":"List","sequence":"first","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University , Athens, OH 45701 ,","place":["USA"]},{"name":"Department of Specialty Medicine, Heritage College of Osteopathic Medicine , Athens, OH 45701 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-1356","authenticated-orcid":false,"given":"Reetobrata","family":"Basu","sequence":"additional","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University , Athens, OH 45701 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-9229","authenticated-orcid":false,"given":"Darlene E","family":"Berryman","sequence":"additional","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University , Athens, OH 45701 ,","place":["USA"]},{"name":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine , Athens, OH 45701 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-4077","authenticated-orcid":false,"given":"Silvana","family":"Duran-Ortiz","sequence":"additional","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University , Athens, OH 45701 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-2646","authenticated-orcid":false,"given":"Gabriel \u00c1","family":"Martos-Moreno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Pediatrics, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, IIS La Princesa & Universidad Aut\u00f3noma de Madrid. CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III , Madrid, E28009 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4561-2177","authenticated-orcid":false,"given":"John J","family":"Kopchick","sequence":"additional","affiliation":[{"name":"Edison Biotechnology Institute, Ohio University , Athens, OH 45701 ,","place":["USA"]},{"name":"Department of Biomedical Sciences, Heritage College of Osteopathic Medicine , Athens, OH 45701 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"Suppl 1","key":"2025052406572853700_bnae017-B1","first-page":"2","article-title":"Growth hormone discovery and structure","volume":"16","author":"Buchman","year":"2018","journal-title":"Pediatr Endocrinol 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