{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:00:44Z","timestamp":1790805644511,"version":"4.1.0"},"reference-count":399,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Centre of Postgraduate Medical Education","award":["501-1-025-01-23"],"award-info":[{"award-number":["501-1-025-01-23"]}]},{"name":"Centre of Postgraduate Medical Education","award":["501-1-025-01-24"],"award-info":[{"award-number":["501-1-025-01-24"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The thyroid is exposed to DNA damage induced by normal physiological processes (eg, oxidative stress resulting from thyroid hormone synthesis or mitochondrial respiration) or through environmental insults (eg, environmental pollutants, ionizing radiation exposure). Robust antioxidative stress defense and DNA repair mechanisms protect thyrocyte genome integrity, but defective or dysregulated DNA repair pathways have been implicated in thyroid pathology, including autoimmune thyroid disease and thyroid malignancy. In thyroid cancer, disturbed antioxidative stress defense, Mismatch Repair, Non-Homologous End-Joining, or DNA damage response pathways contribute to both the onset and progression of the disease. The insight into mechanisms governing thyrocyte genome integrity may help to gain better understanding of the pathology and suggest novel therapeutic regimens, urgently needed in treatment-refractory disease. In the current review, we provide comprehensive description of the exogenous and endogenous factors, as well as DNA repair mechanisms influencing thyrocyte genome integrity. Moreover, we pinpoint major research avenues that should be pursued in future research. This information will be valuable in directing new discoveries to better understand thyroid disease pathomechanisms, as well as aid development of novel diagnostic and therapeutic tools.<\/jats:p>","DOI":"10.1210\/endrev\/bnaf035","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:53:03Z","timestamp":1757505183000},"page":"121-157","source":"Crossref","is-referenced-by-count":12,"title":["DNA Damage and Repair in Thyroid Physiology and Disease"],"prefix":"10.1210","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-1585","authenticated-orcid":false,"given":"Katarzyna D","family":"Arczewska","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Centre of Translational Research, Centre of Postgraduate Medical Education , Warsaw 01-813 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6829-5947","authenticated-orcid":false,"given":"Dorota","family":"Sys","sequence":"additional","affiliation":[{"name":"Department of Translational Immunology and Experimental Intensive Care, Centre of Translational Research, Centre of Postgraduate Medical Education , Warsaw 01-813 ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-2663","authenticated-orcid":false,"given":"Hilde L","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Insitute of Clinical Medicine, University of Oslo , Oslo 0318 ,","place":["Norway"]},{"name":"Department of Microbiology, Oslo University Hospital and University of Oslo , Oslo 0424 ,","place":["Norway"]},{"name":"Centre for Embryology and Healthy Development (CRESCO), Oslo University Hospital and University of Oslo , Oslo 0424 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