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Preeclampsia (PE), a multifaceted and systemic gestational complication, stands as a primary contributor to maternal and perinatal morbidity and mortality. Defective placental development has been extensively acknowledged as the fundamental pathological foundation underlying this condition. Accumulating evidence has unveiled a disruption in the balance of steroid hormone production within placentas affected by early-onset PE (E-PE). Considerable endeavors have been undertaken to decipher the endocrine mechanisms driving E-PE. Recent investigations have illuminated a complex, multitiered regulatory system that governs placental steroidogenesis, encompassing epigenetic controls such as microRNA activity and metabolic flux-conjugated histone acetylation, posttranslational modifications including O-linked \u03b2-N-acetylglucosamine, as well as intricate endocrine feedback loops among steroids and other signaling molecules like melatonin. Notably, a growing body of evidence robustly supports a causal link between elevated placental testosterone synthesis and the onset of PE. Nevertheless, comprehensive studies exploring the endocrine pathophysiology of PE remain essential to illuminate novel therapeutic avenues for mitigating this adverse pregnancy outcome.<\/jats:p>","DOI":"10.1210\/endrev\/bnaf039","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:06:44Z","timestamp":1762002404000},"page":"244-263","source":"Crossref","is-referenced-by-count":5,"title":["Placental Steroid Hormones in Preeclampsia: Multilayered Regulation of Endocrine Pathogenesis"],"prefix":"10.1210","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-5997","authenticated-orcid":false,"given":"Yun","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 101408 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