{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:54:07Z","timestamp":1791388447572,"version":"4.3.3"},"reference-count":164,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto Carlos III","doi-asserted-by":"publisher","award":["PMPTA23\/00023"],"award-info":[{"award-number":["PMPTA23\/00023"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CPP2022-010039"],"award-info":[{"award-number":["CPP2022-010039"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-126077OB-I00"],"award-info":[{"award-number":["PID2021-126077OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024-162756OB-100"],"award-info":[{"award-number":["PID2024-162756OB-100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001961","name":"Axa Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Menopause marks the end of a woman's reproductive life, and the transition to this stage is accompanied by profound physiological and metabolic changes. These include alterations in lipoproteins and various metabolites, such as lipids, fatty acids, and amino acids, resulting in a more atherogenic profile and, in some cases, an increased risk in cardiovascular disease (CVD).<\/jats:p>\n                  <jats:p>CVD remains the leading cause of death among women, and lipid profiles change substantially in postmenopause, representing a key sex-specific risk factor. Thus, elucidating the metabolic pathways affected during menopause is crucial to reducing the burden of menopause-related conditions. However, the underlying molecular mechanisms of this increased metabolic burden remain incompletely understood. Recent advances in metabolomic technologies, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and computational tools, have greatly improved our ability to characterize these metabolic shifts. This review summarizes current knowledge on the metabolic changes associated with menopause and their implications for CVD development.<\/jats:p>","DOI":"10.1210\/endrev\/bnag036","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:42:24Z","timestamp":1790682144000},"source":"Crossref","is-referenced-by-count":0,"title":["Menopause-driven metabolomic shifts: unraveling cardiovascular disease risk in women"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-8140","authenticated-orcid":false,"given":"Cristina","family":"Molina-L\u00f3pez","sequence":"first","affiliation":[{"name":"Metabolism, Immunology & Cardiovascular Risk Group, Department of Integrative Pathophysiology and Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) , Seville 41092 ,","place":["Spain"]},{"name":"Andalusian Public Foundation Progress and Health-FPS , Seville 41092 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5290-7785","authenticated-orcid":false,"given":"Marta","family":"Rojas-Torres","sequence":"additional","affiliation":[{"name":"Metabolism, Immunology & Cardiovascular Risk Group, Department of Integrative Pathophysiology and Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) , Seville 41092 ,","place":["Spain"]},{"name":"Andalusian Public Foundation Progress and Health-FPS , Seville 41092 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-612X","authenticated-orcid":false,"given":"Angela","family":"Rubio","sequence":"additional","affiliation":[{"name":"Metabolism, Immunology & Cardiovascular Risk Group, Department of Integrative Pathophysiology and Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) , Seville 41092 ,","place":["Spain"]},{"name":"University of Seville Department of Cell Biology, , Seville 41012 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-2208","authenticated-orcid":false,"given":"In\u00e9s","family":"Pineda-Torra","sequence":"additional","affiliation":[{"name":"Metabolism, Immunology & Cardiovascular Risk Group, Department of Integrative Pathophysiology and Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) , Seville 41092 ,","place":["Spain"]},{"name":"Andalusian Public Foundation Progress and Health-FPS , Seville 41092 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"10292","key":"2026100711215352800_bnag036-B1","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1016\/S0140-6736(21)00684-X","article-title":"The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030","volume":"397","author":"Vogel","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"2026100711215352800_bnag036-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2026100711215352800_bnag036-B3","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/jc.2011-3362","article-title":"Executive summary of the stages of reproductive aging workshop + 10: addressing the unfinished agenda of staging reproductive aging","volume":"97","author":"Harlow","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026100711215352800_bnag036-B4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.maturitas.2009.08.003","article-title":"Premature menopause or early menopause: long-term health consequences","volume":"65","author":"Shuster","year":"2010","journal-title":"Maturitas"},{"key":"2026100711215352800_bnag036-B5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/B978-0-323-47912-7.00014-7","volume-title":"Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management","author":"Lobo","year":"2019","edition":"8"},{"issue":"2","key":"2026100711215352800_bnag036-B6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s43587-024-00762-5","article-title":"Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses","volume":"5","author":"Jin","year":"2025","journal-title":"Nat Aging"},{"key":"2026100711215352800_bnag036-B7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mce.2018.05.003","article-title":"Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain","volume":"476","author":"Long","year":"2018","journal-title":"Mol Cell Endocrinol"},{"issue":"9","key":"2026100711215352800_bnag036-B8","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/humrep\/16.9.2014","article-title":"The role of genetic factors in age at natural menopause","volume":"16","author":"De Bruin","year":"2001","journal-title":"Hum Reprod"},{"key":"2026100711215352800_bnag036-B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113808","article-title":"Estrogen as a key regulator of energy homeostasis and metabolic health","volume":"156","author":"Mahboobifard","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2026100711215352800_bnag036-B10","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/endrev\/bnaf018","article-title":"The impact of estrogen deficiency on liver metabolism: implications for hormone replacement therapy","volume":"46","author":"Dong","year":"2025","journal-title":"Endocr Rev"},{"key":"2026100711215352800_bnag036-B11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.maturitas.2022.08.001","article-title":"Dyslipidemia in midlife women: approach and considerations during the menopausal transition","volume":"166","author":"Torosyan","year":"2022","journal-title":"Maturitas"},{"issue":"5728","key":"2026100711215352800_bnag036-B12","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"Mendelsohn","year":"2005","journal-title":"Science"},{"issue":"7","key":"2026100711215352800_bnag036-B13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41569-023-00979-8","article-title":"Atherosclerotic plaque stabilization and regression: a review of clinical evidence","volume":"21","author":"Sarraju","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"3","key":"2026100711215352800_bnag036-B14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41569-023-00926-7","article-title":"The menopausal transition period and cardiovascular risk","volume":"21","author":"Mehta","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"2026100711215352800_bnag036-B15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1001\/jamainternmed.2016.2761","article-title":"Diagnosis and management of menopause: the National Institute of Health and Care Excellence (NICE) guideline","volume":"176","author":"Lumsden","year":"2016","journal-title":"JAMA Intern Med"},{"issue":"1","key":"2026100711215352800_bnag036-B16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/oby.23289","article-title":"Body composition and cardiometabolic health across the menopause transition","volume":"30","author":"Marlatt","year":"2022","journal-title":"Obesity"},{"key":"2026100711215352800_bnag036-B17","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.626534","article-title":"Can inhibin b reflect ovarian reserve of healthy reproductive age women effectively?","volume":"12","author":"Wen","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2026100711215352800_bnag036-B18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1186\/s12905-024-03448-7","article-title":"Study on gut microbiota and metabolomics in postmenopausal women","volume":"24","author":"Xie","year":"2024","journal-title":"BMC Women's Health"},{"issue":"1","key":"2026100711215352800_bnag036-B19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00042192-200101000-00009","article-title":"Higher values of hepatic lipase activity in postmenopause: relationship with atherogenic intermediate density and low density lipoproteins","volume":"8","author":"Berg","year":"2001","journal-title":"Menopause"},{"issue":"7","key":"2026100711215352800_bnag036-B20","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1194\/jlr.P049064","article-title":"Lipoprotein subclasses and endogenous sex hormones in women at midlife","volume":"55","author":"El Khoudary","year":"2014","journal-title":"J Lipid Res"},{"issue":"2","key":"2026100711215352800_bnag036-B21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cca.2007.03.004","article-title":"Circulating small dense LDL, endothelial injuring factors and fibronectin in healthy postmenopausal women","volume":"381","author":"Muzzio","year":"2007","journal-title":"Clin Chim Acta"},{"issue":"12","key":"2026100711215352800_bnag036-B22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1055\/s-0030-1267173","article-title":"Hepatic VLDL-TG production and MTP gene expression are decreased in ovariectomized rats: effects of exercise training","volume":"42","author":"Barsalani","year":"2010","journal-title":"Horm Metab Res"},{"issue":"4","key":"2026100711215352800_bnag036-B23","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/01.ATV.20.4.1101","article-title":"Mechanisms regulating LDL metabolism in subjects on peroral and transdermal estrogen replacement therapy","volume":"20","author":"Karjalainen","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"2026100711215352800_bnag036-B24","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI118883","article-title":"Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat","volume":"98","author":"Landschulz","year":"1996","journal-title":"J Clin Invest"},{"issue":"1-2","key":"2026100711215352800_bnag036-B25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mce.2005.10.005","article-title":"Estrogen regulation of the scavenger receptor class B gene: anti-atherogenic or steroidogenic, is there a priority?","volume":"247","author":"Lopez","year":"2006","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2026100711215352800_bnag036-B26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/cvr\/cvab017","article-title":"Relationship between lipoproteins, thrombosis, and atrial fibrillation","volume":"118","author":"Ding","year":"2022","journal-title":"Cardiovasc Res"},{"key":"2026100711215352800_bnag036-B27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.addr.2020.08.003","article-title":"Lipoprotein-based drug delivery","volume":"159","author":"Busatto","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"issue":"8","key":"2026100711215352800_bnag036-B28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41581-021-00423-5","article-title":"Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations","volume":"17","author":"Noels","year":"2021","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"2026100711215352800_bnag036-B29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/ATVBAHA.107.160192","article-title":"Overproduction of very low\u2013density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome","volume":"28","author":"Adiels","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"2026100711215352800_bnag036-B30","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and reverse cholesterol transport: basic mechanisms and their roles in vascular health and disease","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ Res"},{"issue":"6","key":"2026100711215352800_bnag036-B31","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1210\/jc.2003-030242","article-title":"The emergence of the metabolic syndrome with menopause","volume":"88","author":"Carr","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2026100711215352800_bnag036-B32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1210\/er.2016-1146","article-title":"Menopausal Hormone Therapy and type 2 diabetes prevention: evidence, mechanisms, and clinical implications","volume":"38","author":"Mauvais-Jarvis","year":"2017","journal-title":"Endocr Rev"},{"issue":"5","key":"2026100711215352800_bnag036-B33","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1172\/JCI108015","article-title":"The effect of estrogen on the lipoprotein lipase activity of rat adipose tissue","volume":"55","author":"Hamosh","year":"1975","journal-title":"J Clin Invest"},{"issue":"9","key":"2026100711215352800_bnag036-B34","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1210\/jc.2001-012034","article-title":"Differences in adipose tissue metabolism between postmenopausal and perimenopausal women","volume":"87","author":"Ferrara","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026100711215352800_bnag036-B35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12916-018-1008-8","article-title":"Metabolic characterization of menopause: cross-sectional and longitudinal evidence","volume":"16","author":"Wang","year":"2018","journal-title":"BMC Med"},{"issue":"1","key":"2026100711215352800_bnag036-B36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12916-016-0762-8","article-title":"Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study","volume":"15","author":"de Kat","year":"2017","journal-title":"BMC Med"},{"issue":"11","key":"2026100711215352800_bnag036-B37","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/aje\/kwp043","article-title":"Lipid changes during the menopause transition in relation to age and weight: the study of Women's health across the nation","volume":"169","author":"Derby","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"6","key":"2026100711215352800_bnag036-B38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-2796.1999.00547.x","article-title":"Menopausal status and risk factors for cardiovascular disease","volume":"246","author":"Peters","year":"1999","journal-title":"J Intern Med"},{"issue":"4","key":"2026100711215352800_bnag036-B39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1471-0528.2005.00416.x","article-title":"Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study","volume":"112","author":"Kuh","year":"2005","journal-title":"BJOG"},{"issue":"4","key":"2026100711215352800_bnag036-B40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.maturitas.2014.12.016","article-title":"Menopausal stages and serum lipid and lipoprotein abnormalities in middle-aged women","volume":"80","author":"Choi","year":"2015","journal-title":"Maturitas"},{"issue":"10","key":"2026100711215352800_bnag036-B41","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1093\/eurjpc\/zwac060","article-title":"Menopause modulates the circulating metabolome: evidence from a prospective cohort study","volume":"29","author":"Karppinen","year":"2022","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"2026100711215352800_bnag036-B42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.94.1.61","article-title":"Effects of menopause on trends of Serum cholesterol, blood pressure, and body mass Index","volume":"94","author":"Akahoshi","year":"1996","journal-title":"Circulation"},{"issue":"1","key":"2026100711215352800_bnag036-B43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.maturitas.2015.02.262","article-title":"Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions","volume":"81","author":"Anagnostis","year":"2015","journal-title":"Maturitas"},{"issue":"1","key":"2026100711215352800_bnag036-B44","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ije\/19.1.42","article-title":"Menopause-related changes in lipoproteins and some other cardiovascular risk factors","volume":"19","author":"Bonithon-Kopp","year":"1990","journal-title":"Int J Epidemiol"},{"issue":"1","key":"2026100711215352800_bnag036-B45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9150(99)00315-9","article-title":"The effect of menopause on blood lipid and lipoprotein levels. The Icarus Study Group","volume":"147","author":"de Aloysio","year":"1999","journal-title":"Atherosclerosis"},{"issue":"7","key":"2026100711215352800_bnag036-B46","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/gme.0b013e318240f6f3","article-title":"The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa new emerging team group study","volume":"19","author":"Abdulnour","year":"2012","journal-title":"Menopause"},{"issue":"2","key":"2026100711215352800_bnag036-B47","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.maturitas.2012.02.013","article-title":"Menopause with cardiovascular disease and its risk factors among rural Chinese women in Beijing: a population-based study","volume":"72","author":"He","year":"2012","journal-title":"Maturitas"},{"issue":"3","key":"2026100711215352800_bnag036-B48","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyae055","article-title":"Influence of age and sex on longitudinal metabolic profiles and body weight trajectories in the UK Biobank","volume":"53","author":"M\u00e4kinen","year":"2024","journal-title":"Int J Epidemiol"},{"issue":"7","key":"2026100711215352800_bnag036-B49","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/GME.0000000000001532","article-title":"Lipid profile changes during the menopausal transition","volume":"27","author":"Inaraja","year":"2020","journal-title":"Menopause"},{"issue":"11","key":"2026100711215352800_bnag036-B50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141743","article-title":"Plasma metabolic profiles in women are menopause dependent","volume":"10","author":"Ke","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"2026100711215352800_bnag036-B51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.atherosclerosis.2006.03.036","article-title":"Circulating oxidized LDL is associated with parameters of the metabolic syndrome in postmenopausal women","volume":"191","author":"Lapointe","year":"2007","journal-title":"Atherosclerosis"},{"issue":"2","key":"2026100711215352800_bnag036-B52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1155\/2013\/724706","article-title":"Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations","volume":"35","author":"Mascarenhas-Melo","year":"2013","journal-title":"Dis Markers"},{"issue":"20","key":"2026100711215352800_bnag036-B53","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025858","article-title":"Physiological bases for the superiority of apolipoprotein b over low-density lipoprotein cholesterol and non\u2013high-density lipoprotein cholesterol as a marker of Cardiovascular Risk","volume":"11","author":"Glavinovic","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"2026100711215352800_bnag036-B54","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/STROKEAHA.111.641324","article-title":"Lipid and lipoprotein biomarkers and the risk of ischemic stroke in postmenopausal women","volume":"43","author":"Berger","year":"2012","journal-title":"Stroke"},{"issue":"1","key":"2026100711215352800_bnag036-B55","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1038\/ncomms5708","article-title":"A metabolic view on menopause and ageing","volume":"5","author":"Auro","year":"2014","journal-title":"Nat Commun"},{"issue":"2","key":"2026100711215352800_bnag036-B56","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/ATVBAHA.120.315355","article-title":"HDL (High-Density Lipoprotein) subclasses, lipid content, and function trajectories across the menopause transition: SWAN-HDL study","volume":"41","author":"El Khoudary","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026100711215352800_bnag036-B57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104303","article-title":"Menopause is associated with postprandial metabolism, metabolic health and lifestyle: the ZOE PREDICT study","volume":"85","author":"Bermingham","year":"2022","journal-title":"EBioMedicine"},{"issue":"9","key":"2026100711215352800_bnag036-B58","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s44161-022-00131-8","article-title":"Age-dependent sex differences in cardiometabolic risk factors","volume":"1","author":"Zhernakova","year":"2022","journal-title":"Nat Cardiovasc Res"},{"issue":"10","key":"2026100711215352800_bnag036-B59","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/GME.0000000000002245","article-title":"Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies","volume":"30","author":"El Khoudary","year":"2023","journal-title":"Menopause"},{"issue":"11","key":"2026100711215352800_bnag036-B60","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/metabo14110571","article-title":"Earlier age at menopause, plasma metabolome, and risk of premature mortality","volume":"14","author":"Yang","year":"2024","journal-title":"Metabolites"},{"issue":"1","key":"2026100711215352800_bnag036-B61","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41467-023-44459-6","article-title":"The impact of reproductive factors on the metabolic profile of females from menarche to menopause","volume":"15","author":"Clayton","year":"2024","journal-title":"Nat Commun"},{"issue":"1","key":"2026100711215352800_bnag036-B62","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41514-025-00249-6","article-title":"Years since menopause and its metabolomic signature with biological aging in women at midlife: a population-based study","volume":"11","author":"Xie","year":"2025","journal-title":"npj Aging"},{"key":"2026100711215352800_bnag036-B63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.106021","article-title":"Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts","volume":"122","author":"Conde","year":"2025","journal-title":"EBioMedicine"},{"issue":"1","key":"2026100711215352800_bnag036-B64","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41514-025-00323-z","article-title":"Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women","volume":"12","author":"Wang","year":"2026","journal-title":"npj Aging"},{"issue":"25","key":"2026100711215352800_bnag036-B65","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.jacc.2009.10.009","article-title":"Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition?","volume":"54","author":"Matthews","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"2026100711215352800_bnag036-B66","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/GME.0000000000001403","article-title":"Lipid profile differences during menopause: a review with meta-analysis","volume":"26","author":"Ambikairajah","year":"2019","journal-title":"Menopause"},{"issue":"22","key":"2026100711215352800_bnag036-B67","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030388","article-title":"Trajectories of blood lipids profile in midlife women: does menopause matter?","volume":"12","author":"Wu","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"8","key":"2026100711215352800_bnag036-B68","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003609","article-title":"Progression of metabolic syndrome severity during the menopausal transition","volume":"5","author":"Gurka","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"18","key":"2026100711215352800_bnag036-B69","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021362","article-title":"Age at menopause in relationship to lipid changes and subclinical carotid disease across 20 years: study of women's health across the nation","volume":"10","author":"Matthews","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026100711215352800_bnag036-B70","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.maturitas.2022.09.012","article-title":"The effect of menopause on lipoprotein (a) concentrations: a systematic review and meta-analysis","volume":"167","author":"Anagnostis","year":"2023","journal-title":"Maturitas"},{"issue":"2","key":"2026100711215352800_bnag036-B71","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jacc.2008.04.009","article-title":"Lipoprotein (a), hormone replacement therapy, and risk of future cardiovascular events","volume":"52","author":"Suk Danik","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026100711215352800_bnag036-B72","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.maturitas.2019.09.005","article-title":"Changes in lipoprotein subfractions following menopause in the Longitudinal Study of Adult Health (ELSA-Brasil)","volume":"130","author":"Fonseca","year":"2019","journal-title":"Maturitas"},{"issue":"3","key":"2026100711215352800_bnag036-B73","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41366-021-01022-x","article-title":"Metabolic health, menopause, and physical activity\u2014a 4-year follow-up study","volume":"46","author":"Hyv\u00e4rinen","year":"2022","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"2026100711215352800_bnag036-B74","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11306-018-1393-1","article-title":"Serum metabolomic profiles associated with postmenopausal hormone use","volume":"14","author":"Stevens","year":"2018","journal-title":"Metabolomics"},{"issue":"1","key":"2026100711215352800_bnag036-B75","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41598-025-85134-8","article-title":"A mediating role of visceral adipose tissue on the association of health behaviours and metabolic inflammation in menopause: a population-based cross-sectional study","volume":"15","author":"Lankila","year":"2025","journal-title":"Sci Rep"},{"issue":"12","key":"2026100711215352800_bnag036-B76","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/gme.0b013e31821f81c2","article-title":"C-reactive protein is associated with aortic stiffness in a cohort of African American and white women transitioning through menopause","volume":"18","author":"Woodard","year":"2011","journal-title":"Menopause"},{"issue":"1","key":"2026100711215352800_bnag036-B77","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"issue":"3","key":"2026100711215352800_bnag036-B78","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/jamacardio.2021.5080","article-title":"Apolipoprotein B vs low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol as the primary measure of apolipoprotein B lipoprotein-related risk: the debate is over","volume":"7","author":"Sniderman","year":"2022","journal-title":"JAMA Cardiol"},{"key":"2026100711215352800_bnag036-B79","doi-asserted-by":"crossref","DOI":"10.1093\/eurjpc\/zwaf750","article-title":"Impact of LDL-C and Apolipoprotein B level discordance and associated lipoprotein particle alterations on Cardiovascular outcomes in a large primary prevention population","author":"Du","year":"2025","journal-title":"Eur J Prev Cardiol"},{"issue":"10","key":"2026100711215352800_bnag036-B80","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1161\/CIRCRESAHA.119.315019","article-title":"Apob: the power of physiology to transform the prevention of cardiovascular disease","volume":"124","author":"Sniderman","year":"2019","journal-title":"Circ Res"},{"issue":"24","key":"2026100711215352800_bnag036-B81","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1016\/j.jacc.2018.11.003","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Grundy","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026100711215352800_bnag036-B82","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2018.11.001","article-title":"Apob in clinical care: pro and con","volume":"282","author":"Sniderman","year":"2019","journal-title":"Atherosclerosis"},{"issue":"2","key":"2026100711215352800_bnag036-B83","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/10408363.2014.992063","article-title":"Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases","volume":"52","author":"Trpkovic","year":"2015","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2026100711215352800_bnag036-B84","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3389\/fendo.2019.00589","article-title":"Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women: cross-sectional and longitudinal evidence","volume":"10","author":"Karvinen","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"2026100711215352800_bnag036-B85","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/heartjnl-2019-315754","article-title":"Age at period cessation and trajectories of cardiovascular risk factors across mid and later life","volume":"106","author":"O\u2019Keeffe","year":"2020","journal-title":"Heart"},{"issue":"4","key":"2026100711215352800_bnag036-B86","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/MOL.0000000000000432","article-title":"HDL and the menopause","volume":"28","author":"El Khoudary","year":"2017","journal-title":"Curr Opin Lipidol"},{"issue":"suppl 1","key":"2026100711215352800_bnag036-B87","doi-asserted-by":"crossref","first-page":"i19","DOI":"10.1136\/jech.56.suppl_1.i19","article-title":"Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe","volume":"56","author":"Bots","year":"2002","journal-title":"J Epidemiol Community Health"},{"issue":"4","key":"2026100711215352800_bnag036-B88","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/gme.0b013e3181f6480e","article-title":"Lipids, menopause, and early atherosclerosis in Study of Women's Health Across the Nation Heart women","volume":"18","author":"Woodard","year":"2011","journal-title":"Menopause"},{"issue":"4","key":"2026100711215352800_bnag036-B89","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jacl.2016.04.008","article-title":"Increase HDL-C level over the menopausal transition is associated with greater atherosclerotic progression","volume":"10","author":"El Khoudary","year":"2016","journal-title":"J Clin Lipidol"},{"issue":"5","key":"2026100711215352800_bnag036-B90","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1365-2796.2006.01643.x","article-title":"The apoB\/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy \u2013 a review of the evidence","volume":"259","author":"Walldius","year":"2006","journal-title":"J Intern Med"},{"issue":"12","key":"2026100711215352800_bnag036-B91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003853","article-title":"Long-term risk of a major cardiovascular event by apoB, apoA-1, and the apoB\/apoA-1 ratio\u2014experience from the Swedish AMORIS cohort: a cohort study","volume":"18","author":"Walldius","year":"2021","journal-title":"PLoS Med"},{"issue":"7","key":"2026100711215352800_bnag036-B92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040878","article-title":"Comparison of apolipoprotein (apoB\/apoA-I) and lipoprotein (Total Cholesterol\/HDL) ratio determinants. Focus on obesity, diet and alcohol intake","volume":"7","author":"Tognon","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"2026100711215352800_bnag036-B93","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/labinvest.2016.51","article-title":"Apolipoprotein A-1 regulates osteoblast and lipoblast precursor cells in mice","volume":"96","author":"Blair","year":"2016","journal-title":"Lab Invest"},{"issue":"2","key":"2026100711215352800_bnag036-B94","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s11357-023-00977-1","article-title":"Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women","volume":"46","author":"Aparicio-Bautista","year":"2024","journal-title":"Geroscience"},{"issue":"1","key":"2026100711215352800_bnag036-B95","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12891-023-06264-6","article-title":"Association of apolipoprotein A1 with osteoporosis: a cross-sectional study","volume":"24","author":"Sun","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"2026100711215352800_bnag036-B96","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12944-017-0619-y","article-title":"ApoA-I\/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator","volume":"16","author":"Kido","year":"2017","journal-title":"Lipids Health Dis"},{"issue":"11","key":"2026100711215352800_bnag036-B97","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1359\/JBMR.050711","article-title":"Relationship between osteoporosis and cardiovascular disease in postmenopausal women","volume":"20","author":"Tank\u00f3","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2026100711215352800_bnag036-B98","first-page":"19","article-title":"The link between osteoporosis and cardiovascular disease","volume":"5","author":"Farhat","year":"2008","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"5","key":"2026100711215352800_bnag036-B99","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3390\/jcm9051422","article-title":"Association between very low-density lipoprotein cholesterol (VLDL-C) and carotid intima-media thickness in postmenopausal women without overt cardiovascular disease and on LDL-C target levels","volume":"9","author":"Gentile","year":"2020","journal-title":"J Clin Med"},{"issue":"4","key":"2026100711215352800_bnag036-B100","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/01.CIR.87.4.1135","article-title":"Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study","volume":"87","author":"Jenner","year":"1993","journal-title":"Circulation"},{"issue":"1","key":"2026100711215352800_bnag036-B101","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14093","article-title":"Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease","volume":"54","author":"Tada","year":"2024","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"2026100711215352800_bnag036-B102","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jacc.2018.04.060","article-title":"Lipoprotein(a) and cardiovascular risk prediction among women","volume":"72","author":"Cook","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"2026100711215352800_bnag036-B103","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/jamacardio.2020.2413","article-title":"Effect of C-reactive protein on lipoprotein(a)-associated cardiovascular risk in optimally treated patients with high-risk vascular disease: a prespecified secondary analysis of the ACCELERATE trial","volume":"5","author":"Puri","year":"2020","journal-title":"JAMA Cardiol"},{"issue":"5","key":"2026100711215352800_bnag036-B104","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jamacardio.2022.0716","article-title":"Lipoprotein(a), menopausal hormone therapy, and risk of coronary heart disease in postmenopausal individuals","volume":"7","author":"Honigberg","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"6","key":"2026100711215352800_bnag036-B105","doi-asserted-by":"crossref","first-page":"e957","DOI":"10.1016\/j.jacl.2024.04.126","article-title":"Discrimination and net-reclassification of cardiovascular disease risk with lipoprotein (a) levels: the ATTICA study (2002\u20132022)","volume":"18","author":"Giannakopoulou","year":"2024","journal-title":"J Clin Lipidol"},{"issue":"8","key":"2026100711215352800_bnag036-B106","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/jamacardio.2025.1603","article-title":"AHA PREVENT equations and lipoprotein (a) for cardiovascular disease risk: insights from MESA and the UK Biobank","volume":"10","author":"Bhatia","year":"2025","journal-title":"JAMA Cardiol"},{"issue":"9","key":"2026100711215352800_bnag036-B107","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jacc.2014.03.061","article-title":"Discrimination and net reclassification of cardiovascular risk with lipoprotein (a) prospective 15-year outcomes in the Bruneck study","volume":"64","author":"Willeit","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2026100711215352800_bnag036-B108","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.124.004631","article-title":"Lipoprotein (a) atherosclerotic cardiovascular disease risk score development and prediction in primary prevention from real-world data","volume":"18","author":"Fan","year":"2025","journal-title":"Circ Genom Precis Med"},{"issue":"8","key":"2026100711215352800_bnag036-B109","doi-asserted-by":"crossref","first-page":"22i\u2013","DOI":"10.1016\/S0002-9149(02)02632-2","article-title":"Measurement issues related to lipoprotein heterogeneity","volume":"90","author":"Otvos","year":"2002","journal-title":"Am J Cardiol"},{"key":"2026100711215352800_bnag036-B110","article-title":"Determining the status of small dense low-density lipoprotein cholesterol level in women undergoing menopausal transition","volume":"15","author":"He","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"24","key":"2026100711215352800_bnag036-B111","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Boren","year":"2020","journal-title":"Eur Heart J"},{"issue":"7","key":"2026100711215352800_bnag036-B112","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1161\/CIRCULATIONAHA.108.816181","article-title":"Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women","volume":"119","author":"Mora","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"2026100711215352800_bnag036-B113","doi-asserted-by":"crossref","first-page":"R116","DOI":"10.1186\/ar3842","article-title":"High-density lipoprotein cholesterol subfractions HDL2 and HDL3 are reduced in women with rheumatoid arthritis and may augment the cardiovascular risk of women with RA: a cross-sectional study","volume":"14","author":"Arts","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"2026100711215352800_bnag036-B114","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002258","article-title":"Menopausal status and abdominal obesity are significant determinants of hepatic lipid metabolism in women","volume":"4","author":"Hodson","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"2026100711215352800_bnag036-B115","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","article-title":"Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology","volume":"118","author":"Nordestgaard","year":"2016","journal-title":"Circ Res"},{"key":"2026100711215352800_bnag036-B116","article-title":"Triglyceride-rich lipoproteins and cardiovascular diseases","volume":"15","author":"Xu","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2026100711215352800_bnag036-B117","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.tcm.2017.03.004","article-title":"Triglycerides: a reappraisal","volume":"27","author":"Wiesner","year":"2017","journal-title":"Trends Cardiovasc Med"},{"key":"2026100711215352800_bnag036-B118","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.maturitas.2021.10.004","article-title":"Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study","volume":"155","author":"Watanabe","year":"2022","journal-title":"Maturitas"},{"issue":"2","key":"2026100711215352800_bnag036-B119","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/GME.0b013e318296431a","article-title":"Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women","volume":"21","author":"Yamatani","year":"2014","journal-title":"Menopause"},{"issue":"8","key":"2026100711215352800_bnag036-B120","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCULATIONAHA.117.029468","article-title":"Metabolic predictors of incident coronary heart disease in women","volume":"137","author":"Paynter","year":"2018","journal-title":"Circulation"},{"issue":"9","key":"2026100711215352800_bnag036-B121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203027","article-title":"Alterations in postmenopausal plasmatic lipidome","volume":"13","author":"Nogueira","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"2026100711215352800_bnag036-B122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0222353","article-title":"Differential metabolomics networks analysis of menopausal status","volume":"14","author":"Cui","year":"2019","journal-title":"PLoS One"},{"issue":"9","key":"2026100711215352800_bnag036-B123","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000870","article-title":"High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: evidence from two large population cohort studies","volume":"18","author":"Beyene","year":"2020","journal-title":"PLoS Biol"},{"issue":"1","key":"2026100711215352800_bnag036-B124","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ije\/dyz211","article-title":"Metabolomic profiles associated with all-cause mortality in the Women's Health Initiative","volume":"49","author":"Balasubramanian","year":"2020","journal-title":"Int J Epidemiol"},{"key":"2026100711215352800_bnag036-B125","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.637317","article-title":"Serum metabolic profiles of Chinese women with perimenopausal obesity explored by the untargeted metabolomics approach","volume":"12","author":"Ding","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2026100711215352800_bnag036-B126","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jcm6020022","article-title":"CVD and oxidative stress","volume":"6","author":"Cervantes Gracia","year":"2017","journal-title":"J Clin Med"},{"issue":"1","key":"2026100711215352800_bnag036-B127","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41467-019-08936-1","article-title":"Assessing the causal association of glycine with risk of cardio-metabolic diseases","volume":"10","author":"Wittemans","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"2026100711215352800_bnag036-B128","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002621","article-title":"Plasma glycine and risk of acute myocardial infarction in patients with suspected stable angina pectoris","volume":"5","author":"Ding","year":"2015","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"2026100711215352800_bnag036-B129","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.2337\/db11-1355","article-title":"Metabolic signatures of insulin resistance in 7,098 young adults","volume":"61","author":"W\u00fcrtz","year":"2012","journal-title":"Diabetes"},{"issue":"4","key":"2026100711215352800_bnag036-B130","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.118.002157","article-title":"Circulating branched-chain amino acids and incident cardiovascular disease in a prospective cohort of US women","volume":"11","author":"Tobias","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"9","key":"2026100711215352800_bnag036-B131","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/GME.0000000000002016","article-title":"Evaluating the association between amino acid and acylcarnitine profiles and different levels of coronary artery disease risk in postmenopausal women using targeted metabolomics technique","volume":"29","author":"Hosseinkhani","year":"2022","journal-title":"Menopause"},{"issue":"18","key":"2026100711215352800_bnag036-B132","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/eurheartj\/ehs020","article-title":"High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis","volume":"33","author":"W\u00fcrtz","year":"2012","journal-title":"Eur Heart J"},{"issue":"4","key":"2026100711215352800_bnag036-B133","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI44442","article-title":"Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans","volume":"121","author":"Rhee","year":"2011","journal-title":"J Clin Invest"},{"issue":"1","key":"2026100711215352800_bnag036-B134","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13073-024-01322-7","article-title":"Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause","volume":"16","author":"Yazdanpanah","year":"2024","journal-title":"Genome Med"},{"issue":"3","key":"2026100711215352800_bnag036-B135","first-page":"162","article-title":"Proinflammatory and anti-inflammatory cytokine changes related to menopause","volume":"13","author":"Malutan","year":"2014","journal-title":"Prz Menopauzalny"},{"issue":"1","key":"2026100711215352800_bnag036-B136","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12967-017-1321-6","article-title":"Glyca, a novel biomarker of systemic inflammation and cardiovascular disease risk","volume":"15","author":"Connelly","year":"2017","journal-title":"J Transl Med"},{"issue":"5","key":"2026100711215352800_bnag036-B137","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/joim.12953","article-title":"Glyca, a novel pro-inflammatory glycoprotein biomarker is associated with mortality: results from the PREVEND study and meta-analysis","volume":"286","author":"Gruppen","year":"2019","journal-title":"J Intern Med"},{"issue":"4","key":"2026100711215352800_bnag036-B138","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/imm.13739","article-title":"Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation","volume":"171","author":"Crick","year":"2024","journal-title":"Immunology"},{"issue":"21","key":"2026100711215352800_bnag036-B139","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/CIRCULATIONAHA.116.023233","article-title":"Plasma lipidomic profiles improve on traditional risk factors for the prediction of cardiovascular events in type 2 diabetes mellitus","volume":"134","author":"Alshehry","year":"2016","journal-title":"Circulation"},{"key":"2026100711215352800_bnag036-B140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jsbmb.2013.12.003","article-title":"The \u201cnewer\u201d progestogens and postmenopausal hormone therapy (HRT)","volume":"142","author":"Schindler","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"2026100711215352800_bnag036-B141","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrendo.2016.164","article-title":"Hormone-replacement therapy: current thinking","volume":"13","author":"Lobo","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"2026100711215352800_bnag036-B142","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ijc.20710","article-title":"Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort","volume":"114","author":"Fournier","year":"2005","journal-title":"Int J Cancer"},{"issue":"1","key":"2026100711215352800_bnag036-B143","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10549-007-9523-x","article-title":"Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study","volume":"107","author":"Fournier","year":"2008","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"2026100711215352800_bnag036-B144","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/13697137.2017.1421925","article-title":"The impact of micronized progesterone on breast cancer risk: a systematic review","volume":"21","author":"Stute","year":"2018","journal-title":"Climacteric"},{"issue":"1","key":"2026100711215352800_bnag036-B145","article-title":"Relationship between menopausal hormone therapy and incidence risk of breast cancer: systematic review and meta-analysis","volume":"58","author":"Wu","year":"2026","journal-title":"Ann Med"},{"issue":"7","key":"2026100711215352800_bnag036-B146","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/09513590701382104","article-title":"Breast cancer incidence and hormone replacement therapy: results from the MISSION study, prospective phase","volume":"23","author":"Espi\u00e9","year":"2007","journal-title":"Gynecol Endocrinol"},{"issue":"10","key":"2026100711215352800_bnag036-B147","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/eurheartj\/ehaa1044","article-title":"Cardiovascular health after menopause transition, pregnancy disorders, and other gynaecologic conditions: a consensus document from European cardiologists, gynaecologists, and endocrinologists","volume":"42","author":"Maas","year":"2021","journal-title":"Eur Heart J"},{"issue":"7","key":"2026100711215352800_bnag036-B148","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/GME.0000000000002028","article-title":"The 2022 hormone therapy position statement of The North American Menopause Society","volume":"29","author":"Faubion","year":"2022","journal-title":"Menopause"},{"issue":"7","key":"2026100711215352800_bnag036-B149","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1001\/jamacardio.2016.2415","article-title":"Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes, intermediate vascular traits, and all-cause mortality: a systematic review and meta-analysis","volume":"1","author":"Muka","year":"2016","journal-title":"JAMA Cardiol"},{"issue":"1","key":"2026100711215352800_bnag036-B150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12905-023-02788-0","article-title":"The benefits and risks of menopause hormone therapy for the cardiovascular system in postmenopausal women: a systematic review and meta-analysis","volume":"24","author":"Gu","year":"2024","journal-title":"BMC Women's Health"},{"issue":"5","key":"2026100711215352800_bnag036-B151","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/GME.0000000000002335","article-title":"Use of menopausal hormone therapy beyond age 65 years and its effects on women's health outcomes by types, routes, and doses","volume":"31","author":"Baik","year":"2024","journal-title":"Menopause"},{"issue":"5","key":"2026100711215352800_bnag036-B152","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0015-0282(01)01699-5","article-title":"Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974\u20132000","volume":"75","author":"Godsland","year":"2001","journal-title":"Fertil Steril"},{"issue":"3","key":"2026100711215352800_bnag036-B153","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0008-6363(01)00466-7","article-title":"Estrogen replacement therapy, atherosclerosis, and vascular function","volume":"53","author":"Mikkola","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"3","key":"2026100711215352800_bnag036-B154","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1210\/jc.2014-3301","article-title":"Effects of low-dose versus placebo or conventional-dose postmenopausal hormone therapy on variables related to cardiovascular risk: a systematic review and meta-analyses of randomized clinical trials","volume":"100","author":"Casanova","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026100711215352800_bnag036-B155","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/clinem\/dgab042","article-title":"Menopausal hormone therapy and cardiovascular disease: the role of formulation, dose, and route of delivery","volume":"106","author":"Shufelt","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2026100711215352800_bnag036-B156","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/13697137.2024.2394950","article-title":"Menopause and MHT in 2024: addressing the key controversies \u2013 an International Menopause Society White Paper","volume":"27","author":"Panay","year":"2024","journal-title":"Climacteric"},{"key":"2026100711215352800_bnag036-B157","doi-asserted-by":"crossref","first-page":"e078784","DOI":"10.1136\/bmj-2023-078784","article-title":"Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial","volume":"387","author":"Johansson","year":"2024","journal-title":"BMJ"},{"issue":"1","key":"2026100711215352800_bnag036-B158","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/gme.0b013e3182611787","article-title":"Progression rates of carotid intima-media thickness and adventitial diameter during the menopausal transition","volume":"20","author":"El Khoudary","year":"2013","journal-title":"Menopause"},{"issue":"4","key":"2026100711215352800_bnag036-B159","doi-asserted-by":"crossref","DOI":"10.1530\/EC-21-0537","article-title":"Menopause-associated risk of cardiovascular disease","volume":"11","author":"Anagnostis","year":"2022","journal-title":"Endocr Connect"},{"issue":"8","key":"2026100711215352800_bnag036-B160","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/GME.0000000000001143","article-title":"Menopause versus chronologic aging: their roles in women's health","volume":"25","author":"Thurston","year":"2018","journal-title":"Menopause"},{"issue":"1","key":"2026100711215352800_bnag036-B161","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12916-022-02454-6","article-title":"Cardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors","volume":"20","author":"Clayton","year":"2022","journal-title":"BMC Med"},{"key":"2026100711215352800_bnag036-B162","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.maturitas.2018.08.012","article-title":"Age at natural menopause and mortality: a survival analysis of elderly residents of S\u00e3o Paulo, Brazil","volume":"117","author":"Lay","year":"2018","journal-title":"Maturitas"},{"issue":"40","key":"2026100711215352800_bnag036-B163","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1093\/eurheartj\/ehac364","article-title":"Age at menopause and risk of heart failure and atrial fibrillation: a nationwide cohort study","volume":"43","author":"Shin","year":"2022","journal-title":"Eur Heart J"},{"issue":"11","key":"2026100711215352800_bnag036-B164","doi-asserted-by":"crossref","first-page":"e553","DOI":"10.1016\/S2468-2667(19)30155-0","article-title":"Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data","volume":"4","author":"Zhu","year":"2019","journal-title":"Lancet Public Health"}],"container-title":["Endocrine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/edrv\/advance-article-pdf\/doi\/10.1210\/endrev\/bnag036\/71528322\/bnag036.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/edrv\/advance-article-pdf\/doi\/10.1210\/endrev\/bnag036\/71528322\/bnag036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:22:21Z","timestamp":1791386541000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/edrv\/advance-article\/doi\/10.1210\/endrev\/bnag036\/8854743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":164,"URL":"https:\/\/doi.org\/10.1210\/endrev\/bnag036","relation":{},"ISSN":["0163-769X","1945-7189"],"issn-type":[{"value":"0163-769X","type":"print"},{"value":"1945-7189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"bnag036"}}