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Characterization of mice rendered deficient in eukaryotic initiation factors has provided model systems to study the involvement of translation in regulating insulin synthesis and secretion, hepatic function, peripheral insulin resistance, and diabetic complications. Recent progress in the understanding of endoplasmic reticulum overload by unfolded proteins has begun to uncover mechanisms leading to pancreatic \u03b2-cell exhaustion. Future advances in this area may lead to identification of the missing links in the pathogenesis of \u03b2-cell failures due to conditions such as hyperinsulinemia, hyperglycemia, and long-term treatment with sulfonylureas, and thus may identify novel therapeutic targets for diabetes.<\/jats:p>","DOI":"10.1210\/er.2002-0018","type":"journal-article","created":{"date-parts":[[2003,2,14]],"date-time":"2003-02-14T17:45:21Z","timestamp":1045244721000},"page":"91-101","source":"Crossref","is-referenced-by-count":71,"title":["When Translation Meets Metabolism: Multiple Links to Diabetes"],"prefix":"10.1210","volume":"24","author":[{"given":"Yuguang","family":"Shi","sequence":"first","affiliation":[{"name":"Endocrine Research (Y.S., S.I.T.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon I.","family":"Taylor","sequence":"first","affiliation":[{"name":"Endocrine Research (Y.S., S.I.T.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Lai","family":"Tan","sequence":"first","affiliation":[{"name":"Infectious Diseases (S.-L.T.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"Sonenberg","sequence":"first","affiliation":[{"name":"Department of Biochemistry and McGill Cancer Center (N.S.), McGill University, Montre\u0301al, Quebe\u0301c H3G 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"2020071612203758700_R1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic.","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"},{"key":"2020071612203758700_R2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism.","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"2020071612203758700_R3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0140-6736(01)05415-0","article-title":"Type 1 diabetes: new perspectives on disease pathogenesis and treatment.","volume":"358","author":"Atkinson","year":"2001","journal-title":"Lancet"},{"key":"2020071612203758700_R4","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/414792a","article-title":"\u03b2-Cell death during progression to diabetes.","volume":"414","author":"Mathis","year":"2001","journal-title":"Nature"},{"key":"2020071612203758700_R5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1043-2760(00)00329-5","article-title":"Searching for type 2 diabetes genes in the post-genome era.","volume":"11","author":"Permutt","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"2020071612203758700_R6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/414788a","article-title":"Diabetes mellitus and genetically programmed defects in \u03b2-cell function.","volume":"414","author":"Bell","year":"2001","journal-title":"Nature"},{"key":"2020071612203758700_R7","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/S0021-9258(19)42691-4","article-title":"Effect of glucose on initiation and elongation rates in isolated rat pancreatic islets.","volume":"249","author":"Permutt","year":"1974","journal-title":"J Biol Chem"},{"key":"2020071612203758700_R8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj2350459","article-title":"Translational control of insulin biosynthesis. 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