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Disorders of collagen (osteogenesis imperfecta and Paget\u2019s disease of bone), mineral content, composition and distribution (fluorosis and osteomalacia); diseases of high remodeling (postmenopausal osteoporosis, hyperparathyroidism, and hyperthyroidism) and low remodeling (osteopetrosis, pycnodysostosis); and other diseases (idiopathic male osteoporosis, corticosteroid-induced osteoporosis) produce abnormalities in the material composition and structure that lead to bone fragility. Observations in patients and in animal models provide insights on the biomechanical consequences of these illnesses and the nature of the qualities of bone that determine its strength.<\/jats:p>","DOI":"10.1210\/er.2006-0029","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T17:20:47Z","timestamp":1175620847000},"page":"151-164","source":"Crossref","is-referenced-by-count":171,"title":["Insights into Material and Structural Basis of Bone Fragility from Diseases Associated with Fractures: How Determinants of the Biomechanical Properties of Bone Are Compromised by Disease"],"prefix":"10.1210","volume":"28","author":[{"given":"P.","family":"Chavassieux","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Research Unit 831 and Universite\u0301 Claude Bernard-Lyon 1 (P.C., P.D.D.), 69372 Lyon Cedex 08, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Seeman","sequence":"first","affiliation":[{"name":"Departments of Medicine and Endocrinology (E.S.), Austin Health, University of Melbourne, Heidelberg 3084, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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