{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:49:06Z","timestamp":1785894546452,"version":"3.56.0"},"reference-count":84,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PTH is an important regulator of calcium and phosphate homeostasis and bone remodeling. It is metabolized into PTH fragments, which are measured to a different extent by PTH assays of different generations because of differences in fragments recognized and lack of assay standardization. PTH is measured in the workup of several conditions, and clinical guidelines provide recommendations concerning these measurements. This review provides an overview of the impact of differences between PTH assays, applying distinct clinical guidelines for primary and secondary hyperparathyroidism and perioperative use of PTH measurements. Guidelines deal with PTH measurement in different ways, recommending either trend monitoring, the use of a fold increase of the upper reference limit, or an absolute PTH cutoff value. For classic primary hyperparathyroidism (PHPT), the type of PTH assay used will not affect diagnosis or management because the precise concentration of PTH is less relevant. In chronic kidney disease, the guideline recommends treating secondary hyperparathyroidism above a twofold to ninefold PTH increase, which will result in different clinical decisions depending on the assay used. For patients after bariatric surgery, guidelines state absolute cutoff values for PTH, but the impact of different generation assays is unknown because direct comparison of PTH assays has never been performed. During parathyroid surgery, PTH measurements with a third-generation assay reflect treatment success more rapidly than second-generation assays. Increased awareness among clinicians regarding the complexity of PTH measurements is warranted because it can affect clinical decisions.<\/jats:p>","DOI":"10.1210\/er.2018-00220","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T13:09:43Z","timestamp":1557752983000},"page":"1468-1480","source":"Crossref","is-referenced-by-count":63,"title":["Clinical Guidelines and PTH Measurement: Does Assay Generation Matter?"],"prefix":"10.1210","volume":"40","author":[{"given":"Marjon A","family":"Smit","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-7698","authenticated-orcid":false,"given":"Caroline M J","family":"van Kinschot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"van Noord","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snje\u017eana","family":"Kos","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Maasstad Hospital, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"issue":"11","key":"2019092503513581500_bib1","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s00467-010-1565-3","article-title":"FGF23 and the parathyroid glands","volume":"25","author":"Silver","year":"2010","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"2019092503513581500_bib2","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1074\/jbc.273.8.4308","article-title":"Structure-activity relation of NH2-terminal human parathyroid hormone fragments","volume":"273","author":"Marx","year":"1998","journal-title":"J Biol Chem"},{"issue":"1","key":"2019092503513581500_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2003-0024","article-title":"Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl- terminal ligands","volume":"26","author":"Murray","year":"2005","journal-title":"Endocr Rev"},{"issue":"2","key":"2019092503513581500_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1172\/JCI110053","article-title":"Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes","volume":"67","author":"Segre","year":"1981","journal-title":"J Clin Invest"},{"issue":"2","key":"2019092503513581500_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ando.2015.03.018","article-title":"Problems with the PTH assays","volume":"76","author":"Cavalier","year":"2015","journal-title":"Ann Endocrinol (Paris)"},{"key":"2019092503513581500_bib6","first-page":"1822","article-title":"Chronic kidney disease: mineral bone disorder","volume-title":"Brenner and Rector\u2019s the Kidney","author":"Moe","year":"2016","edition":"10th ed."},{"issue":"1","key":"2019092503513581500_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1210\/jc.2005-1628","article-title":"Acute regulation of circulating parathyroid hormone (PTH) molecular forms by calcium: utility of PTH fragments\/PTH(1-84) ratios derived from three generations of PTH assays","volume":"91","author":"D\u2019Amour","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019092503513581500_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/sj.ki.5001658","article-title":"The need for reliable serum parathyroid hormone measurements","volume":"70","author":"Torres","year":"2006","journal-title":"Kidney Int"},{"issue":"3","key":"2019092503513581500_bib9","first-page":"525","article-title":"The modulation of circulating parathyroid hormone immunoheterogeneity in man by ionized calcium concentration","volume":"74","author":"D\u2019Amour","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2019092503513581500_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/clinchem\/44.4.805","article-title":"A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples","volume":"44","author":"Lepage","year":"1998","journal-title":"Clin Chem"},{"issue":"3","key":"2019092503513581500_bib11","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1523-1755.2005.00493.x","article-title":"Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism","volume":"68","author":"D\u2019Amour","year":"2005","journal-title":"Kidney Int"},{"issue":"2","key":"2019092503513581500_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1373\/clinchem.2009.137323","article-title":"Selected reaction monitoring-mass spectrometric immunoassay responsive to parathyroid hormone and related variants","volume":"56","author":"Lopez","year":"2010","journal-title":"Clin Chem"},{"issue":"5","key":"2019092503513581500_bib13","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1021\/ac051711o","article-title":"Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low-picomolar levels by mass spectrometry","volume":"78","author":"Zhang","year":"2006","journal-title":"Anal Chem"},{"issue":"4","key":"2019092503513581500_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1210\/jcem-53-4-709","article-title":"Detection and characterization of small midregion parathyroid hormone fragment(s) in normal and hyperparathyroid glands and sera by immunoextraction and region-specific radioimmunoassays","volume":"53","author":"Roos","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2019092503513581500_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/rcm.1290090402","article-title":"Peptide mapping of recombinant human parathyroid hormone by enzymatic digestion and subsequent fast-atom bombardment mass spectrometry","volume":"9","author":"Nabuchi","year":"1995","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"11","key":"2019092503513581500_bib16","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1021\/cb5004515","article-title":"N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity","volume":"9","author":"Kumar","year":"2014","journal-title":"ACS Chem Biol"},{"issue":"12","key":"2019092503513581500_bib17","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1373\/clinchem.2003.021592","article-title":"Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1-84) is overproduced in primary and secondary hyperparathyroidism","volume":"49","author":"D\u2019Amour","year":"2003","journal-title":"Clin Chem"},{"issue":"12","key":"2019092503513581500_bib18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41594-018-0151-4","article-title":"High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist","volume":"25","author":"Ehrenmann","year":"2018","journal-title":"Nat Struct Mol Biol"},{"issue":"5","key":"2019092503513581500_bib19","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1016\/S0021-9258(17)43241-8","article-title":"Phosphorylation of parathyroid hormone by human and bovine parathyroid glands","volume":"259","author":"Rabbani","year":"1984","journal-title":"J Biol Chem"},{"issue":"6","key":"2019092503513581500_bib20","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1210\/endo-115-6-2375","article-title":"Absence of biological effects of oxidized parathyroid hormone-(1-34) in dogs and rats","volume":"115","author":"Galceran","year":"1984","journal-title":"Endocrinology"},{"issue":"4-5","key":"2019092503513581500_bib21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000350149","article-title":"Modeling of oxidized PTH (oxPTH) and non-oxidized PTH (n-oxPTH) receptor binding and relationship of oxidized to non-oxidized PTH in children with chronic renal failure, adult patients on hemodialysis and kidney transplant recipients","volume":"37","author":"Hocher","year":"2013","journal-title":"Kidney Blood Press Res"},{"issue":"2","key":"2019092503513581500_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1515\/cclm-2017-0313","article-title":"Oxidation of PTH: in vivo feature or effect of preanalytical conditions","volume":"56","author":"Ursem","year":"2018","journal-title":"Clin Chem Lab Med"},{"issue":"8","key":"2019092503513581500_bib23","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1373\/clinchem.2007.085506","article-title":"An N-terminal molecular form of parathyroid hormone (PTH) distinct from hPTH(1 84) is overproduced in parathyroid carcinoma","volume":"53","author":"Rubin","year":"2007","journal-title":"Clin Chem"},{"issue":"6","key":"2019092503513581500_bib24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1365-2265.2005.02286.x","article-title":"Overproduction of an amino-terminal form of PTH distinct from human PTH(1-84) in a case of severe primary hyperparathyroidism: influence of medical treatment and surgery","volume":"62","author":"R\u00e4kel","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"2019092503513581500_bib25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1515\/cclm-2014-0150","article-title":"LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations","volume":"52","author":"Couchman","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"5","key":"2019092503513581500_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3343\/alm.2017.37.5.381","article-title":"Comparison of intact PTH and bio-intact PTH assays among non-dialysis dependent chronic kidney disease patients","volume":"37","author":"Einbinder","year":"2017","journal-title":"Ann Lab Med"},{"issue":"4","key":"2019092503513581500_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","article-title":"Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function","volume":"16","author":"Gao","year":"2001","journal-title":"J Bone Miner Res"},{"key":"2019092503513581500_bib28","unstructured":"American Association for Clinical Chemistry. The need to harmonize clinical laboratory test results. Available at: www.harmonization.net\/media\/1026\/harmonization_white_paper_715.pdf. Accessed 17 December 2018."},{"issue":"11","key":"2019092503513581500_bib29","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/ndt\/gfr614","article-title":"Variation in parathyroid hormone immunoassay results--a critical governance issue in the management of chronic kidney disease","volume":"26","author":"Sturgeon","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"2019092503513581500_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cca.2016.10.016","article-title":"Perspective and priorities for improvement of parathyroid hormone (PTH) measurement: a view from the IFCC Working Group for PTH","volume":"467","author":"Sturgeon","year":"2017","journal-title":"Clin Chim Acta"},{"issue":"8","key":"2019092503513581500_bib31","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1515\/cclm-2013-1027","article-title":"Standardization of DiaSorin and Roche automated third generation PTH assays with an International Standard: impact on clinical populations","volume":"52","author":"Cavalier","year":"2014","journal-title":"Clin Chem Lab Med"},{"issue":"6","key":"2019092503513581500_bib32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clinbiochem.2012.12.019","article-title":"Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum","volume":"46","author":"Krastins","year":"2013","journal-title":"Clin Biochem"},{"issue":"6","key":"2019092503513581500_bib33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1074\/mcp.T400003-MCP200","article-title":"Trypsin cleaves exclusively C-terminal to arginine and lysine residues","volume":"3","author":"Olsen","year":"2004","journal-title":"Mol Cell Proteomics"},{"issue":"10","key":"2019092503513581500_bib34","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1515\/cclm-2013-0315","article-title":"Sampling and storage conditions influencing the measurement of parathyroid hormone in blood samples: a systematic review","volume":"51","author":"Hanon","year":"2013","journal-title":"Clin Chem Lab Med"},{"issue":"9","key":"2019092503513581500_bib35","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/jcp.2004.022186","article-title":"Differences between serum and plasma for intact parathyroid hormone measurement in patients with chronic renal failure in routine clinical practice","volume":"58","author":"Twomey","year":"2005","journal-title":"J Clin Pathol"},{"issue":"6","key":"2019092503513581500_bib36","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1515\/cclm-2016-0606","article-title":"False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences","volume":"55","author":"Piketty","year":"2017","journal-title":"Clin Chem Lab Med"},{"issue":"7","key":"2019092503513581500_bib37","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2215\/CJN.09471209","article-title":"Variability of parathyroid hormone and other markers of bone mineral metabolism in patients receiving hemodialysis","volume":"5","author":"Gardham","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"2019092503513581500_bib38","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1515\/CCLM.2008.275","article-title":"Analytical quality goals for parathyroid hormone based on biological variation","volume":"46","author":"Viljoen","year":"2008","journal-title":"Clin Chem Lab Med"},{"issue":"2","key":"2019092503513581500_bib39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4158\/EP.12.2.137","article-title":"Reference range for serum parathyroid hormone","volume":"12","author":"Aloia","year":"2006","journal-title":"Endocr Pract"},{"issue":"4","key":"2019092503513581500_bib40","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/ndt\/gfq541","article-title":"Changes in parathyroid hormone, body mass index and the association with mortality in dialysis patients","volume":"26","author":"Drechsler","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"2019092503513581500_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1530\/EJE-15-0595","article-title":"Serum PTH reference values established by an automated third-generation assay in vitamin D-replete subjects with normal renal function: consequences of diagnosing primary hyperparathyroidism and the classification of dialysis patients","volume":"174","author":"Souberbielle","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2019092503513581500_bib42","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1365-2265.2011.04285.x","article-title":"Impact of vitamin D-related serum PTH reference values on the diagnosis of mild primary hyperparathyroidism, using bivariate calcium\/PTH reference regions","volume":"76","author":"Fill\u00e9e","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2019092503513581500_bib43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s40618-016-0553-2","article-title":"How the reference values for serum parathyroid hormone concentration are (or should be) established","volume":"40","author":"Souberbielle","year":"2017","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"2019092503513581500_bib44","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1210\/jc.2013-3349","article-title":"Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values","volume":"99","author":"Touvier","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2019092503513581500_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clinbiochem.2018.02.019","article-title":"Establishment of reference values in a healthy population and interpretation of serum PTH concentrations in hemodialyzed patients according to the KDIGO Guidelines using the Lumipulse\u00ae G whole PTH (3rd generation) assay","volume":"54","author":"Cavalier","year":"2018","journal-title":"Clin Biochem"},{"issue":"7","key":"2019092503513581500_bib46","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-114-7-593","article-title":"NIH conference. Diagnosis and management of asymptomatic primary hyperparathyroidism: consensus development conference statement","volume":"114","author":"NIH conference","year":"1991","journal-title":"Ann Intern Med"},{"issue":"10","key":"2019092503513581500_bib47","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/jc.2014-1415","article-title":"Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop","volume":"99","author":"Silverberg","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019092503513581500_bib48","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of Endocrine Surgeons guidelines for definitive management of primary hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg"},{"issue":"10","key":"2019092503513581500_bib49","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1210\/jc.2014-1414","article-title":"Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop","volume":"99","author":"Eastell","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019092503513581500_bib50","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop","volume":"99","author":"Bilezikian","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019092503513581500_bib51","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1210\/jc.2002-021266","article-title":"Clinical utility of an immunoradiometric assay for parathyroid hormone (1\u201384) in primary hyperparathyroidism","volume":"88","author":"Silverberg","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019092503513581500_bib52","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1373\/clinchem.2003.026328","article-title":"Potential clinical utility of a new IRMA for parathyroid hormone in postmenopausal patients with primary hyperparathyroidism","volume":"50","author":"Carnevale","year":"2004","journal-title":"Clin Chem"},{"issue":"12","key":"2019092503513581500_bib53","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1210\/jc.2005-0715","article-title":"Third- or second-generation parathyroid hormone assays: a remaining debate in the diagnosis of primary hyperparathyroidism","volume":"90","author":"Boudou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2019092503513581500_bib54","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1210\/jc.2006-2802","article-title":"Normocalcemic primary hyperparathyroidism: further characterization of a new clinical phenotype","volume":"92","author":"Lowe","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019092503513581500_bib55","doi-asserted-by":"crossref","first-page":"E453","DOI":"10.1210\/jc.2013-3730","article-title":"The third\/second generation PTH assay ratio as a marker for parathyroid carcinoma: evaluation using an automated platform","volume":"99","author":"Cavalier","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019092503513581500_bib56","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1523-1755.2005.00513.x","article-title":"Specific measurement of PTH (1-84) in various forms of renal osteodystrophy (ROD) as assessed by bone histomorphometry","volume":"68","author":"Lehmann","year":"2005","journal-title":"Kidney Int"},{"issue":"4","key":"2019092503513581500_bib57","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/j.ajkd.2015.06.023","article-title":"Diagnostic accuracy of bone turnover markers and bone histology in patients with CKD treated by dialysis","volume":"67","author":"Sprague","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"2019092503513581500_bib58","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1093\/ndt\/gfr535","article-title":"Interpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values","volume":"27","author":"Cavalier","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"Pt 1","key":"2019092503513581500_bib59","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1258\/acb.2011.011094","article-title":"Current parathyroid hormone immunoassays do not adequately meet the needs of patients with chronic kidney disease","volume":"49","author":"Almond","year":"2012","journal-title":"Ann Clin Biochem"},{"issue":"2","key":"2019092503513581500_bib60","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.ki.5001606","article-title":"Inter-method variability in PTH measurement: implication for the care of CKD patients","volume":"70","author":"Souberbielle","year":"2006","journal-title":"Kidney Int"},{"key":"2019092503513581500_bib61","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group","year":"2009","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"2019092503513581500_bib62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO Chronic Kidney Disease\u2013Mineral and Bone Disorder (CKD-MBD) Guideline Update: what\u2019s changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int"},{"issue":"5","key":"2019092503513581500_bib63","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1046\/j.1523-1755.2003.00915.x","article-title":"Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis","volume":"63","author":"Salusky","year":"2003","journal-title":"Kidney Int"},{"issue":"2","key":"2019092503513581500_bib64","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2215\/CJN.09580911","article-title":"PTH--a particularly tricky hormone: why measure it at all in kidney patients","volume":"8","author":"Garrett","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"2019092503513581500_bib65","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000455289","article-title":"Why current PTH assays mislead clinical decision making in patients with secondary hyperparathyroidism","volume":"136","author":"Hocher","year":"2017","journal-title":"Nephron"},{"issue":"15","key":"2019092503513581500_bib66","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJMoa031633","article-title":"Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis","volume":"350","author":"Block","year":"2004","journal-title":"N Engl J Med"},{"key":"2019092503513581500_bib67","unstructured":"National Institute for Health and Care Excellence . Cinacalcet for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapy. Available at: www.nice.org.uk\/Guidance\/ta117. Accessed 17 December 2018."},{"issue":"3","key":"2019092503513581500_bib68","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s11695-017-2932-y","article-title":"High incidence of secondary hyperparathyroidism in bariatric patients: comparing different procedures","volume":"28","author":"Wei","year":"2018","journal-title":"Obes Surg"},{"issue":"4","key":"2019092503513581500_bib69","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/jc.2014-4341","article-title":"Two-year changes in bone density after Roux-en-Y gastric bypass surgery","volume":"100","author":"Yu","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019092503513581500_bib70","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/EJE-17-0014","article-title":"Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study","volume":"176","author":"Shanbhogue","year":"2017","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2019092503513581500_bib71","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jocd.2017.03.001","article-title":"Obesity, bariatric surgery, and vitamin D","volume":"21","author":"Borges","year":"2018","journal-title":"J Clin Densitom"},{"issue":"4","key":"2019092503513581500_bib72","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s11695-009-0068-4","article-title":"Fewer nutrient deficiencies after laparoscopic sleeve gastrectomy (LSG) than after laparoscopic Roux-Y-gastric bypass (LRYGB)-a prospective study","volume":"20","author":"Gehrer","year":"2010","journal-title":"Obes Surg"},{"issue":"5","key":"2019092503513581500_bib73","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.soard.2016.12.018","article-title":"American society for metabolic and bariatric surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 update: micronutrients","volume":"13","author":"Parrott","year":"2017","journal-title":"Surg Obes Relat Dis"},{"issue":"11","key":"2019092503513581500_bib74","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1210\/jc.2009-2128","article-title":"Endocrine and nutritional management of the post-bariatric surgery patient: an Endocrine Society Clinical Practice Guideline","volume":"95","author":"Heber","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019092503513581500_bib75","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4158\/EP12437.GL","article-title":"Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery","volume":"19","author":"Mechanick","year":"2013","journal-title":"Endocr Pract"},{"issue":"1","key":"2019092503513581500_bib76","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11695-013-1079-8","article-title":"Interdisciplinary European guidelines on metabolic and bariatric surgery","volume":"24","author":"Fried","year":"2014","journal-title":"Obes Surg"},{"issue":"12","key":"2019092503513581500_bib77","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/jbmr.3553","article-title":"Fracture risk after gastric bypass surgery: a retrospective cohort study","volume":"33","author":"Axelsson","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2019092503513581500_bib78","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/jbmr.2226","article-title":"Bone metabolism after bariatric surgery","volume":"29","author":"Yu","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2019092503513581500_bib79","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00268-004-7708-6","article-title":"Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome","volume":"28","author":"Irvin III","year":"2004","journal-title":"World J Surg"},{"key":"2019092503513581500_bib80","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cca.2017.12.012","article-title":"Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays","volume":"477","author":"Cavalier","year":"2018","journal-title":"Clin Chim Acta"},{"issue":"2","key":"2019092503513581500_bib81","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0039-6060(03)00387-8","article-title":"Comparison of parathyroid hormone levels from the intact and whole parathyroid hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism","volume":"135","author":"Yamashita","year":"2004","journal-title":"Surgery"},{"issue":"6","key":"2019092503513581500_bib82","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.surg.2004.06.053","article-title":"Early prediction of postthyroidectomy hypocalcemia by one single iPTH measurement","volume":"136","author":"Lombardi","year":"2004","journal-title":"Surgery"},{"issue":"4","key":"2019092503513581500_bib83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1445-2197.2007.04018.x","article-title":"Australian Endocrine Surgeons Guidelines AES06\/01. Postoperative parathyroid hormone measurement and early discharge after total thyroidectomy: analysis of Australian data and management recommendations","volume":"77","author":"AES Guidelines 06\/01 Group","year":"2007","journal-title":"ANZ J Surg"},{"issue":"7","key":"2019092503513581500_bib84","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1089\/thy.2017.0309","article-title":"American thyroid association statement on postoperative hypoparathyroidism: diagnosis, prevention, and management in adults","volume":"28","author":"Orloff","year":"2018","journal-title":"Thyroid"}],"container-title":["Endocrine Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/edrv\/advance-article-pdf\/doi\/10.1210\/er.2018-00220\/28598818\/er.2018-00220.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/edrv\/article-pdf\/40\/6\/1468\/30050988\/er.2018-00220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T23:05:25Z","timestamp":1663455925000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/edrv\/article\/40\/6\/1468\/5487988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/er.2018-00220","relation":{},"ISSN":["0163-769X","1945-7189"],"issn-type":[{"value":"0163-769X","type":"print"},{"value":"1945-7189","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,5,13]]}}}