{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:54:38Z","timestamp":1792151678873,"version":"4.4.0"},"reference-count":15,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p>PTH (7\u201384) has antagonistic effects on the calcemic and phosphaturic actions of PTH (1\u201384) whole molecule (bioPTH). Human plasma contains bioPTH and PTH (7\u201384)-like fragments. Using bioPTH-specific and nonspecific assays, we found that the patients with pseudohypoparathyroidism (PHP) type I with PTH-resistant hypocalcemia and hyperphosphatemia had the increased plasma levels of bioPTH and PTH (7\u201384)-like fragments than normal subjects (26.8 \u00b1 13.2 vs. 2.37 \u00b1 0.75 pmol\/liter, P &amp;lt; 0.01 and 16.2 \u00b1 8.8 vs. 0.82 \u00b1 0.47 pmol\/liter, P &amp;lt; 0.01, respectively). Calcitriol treatment increased phosphaturic response to PTH (1\u201334) (P &amp;lt; 0.05), and there was a negative correlation between phosphaturic response and the PTH levels (P &amp;lt; 0.05). These results suggested that the increased bioPTH and PTH (7\u201384)-like fragment levels may be related to the impaired phosphaturic response to PTH (1\u201334) in PHP type I. We also examined bioPTH-calcium dynamics in PHP type Ib patients and found that set-point calcium was 0.928 \u00b1 0.045 mmol\/liter and the baseline to maximal ratio of bioPTH was 0.96 \u00b1 0.04. Calcitriol treatment increased set-point calcium to 1.129 \u00b1 0.028 mmol\/liter (P &amp;lt; 0.01) and suppressed baseline to maximal ratio of bioPTH to 0.35 \u00b1 0.21 (P &amp;lt; 0.01). These bio-PTH calcium dynamics studies revealed the maximally stimulated baseline PTH secretion in PHP type Ib and demonstrated the effects of calcitriol on PTH-calcium curve shift and the degree of relative stimulation of baseline secretion.<\/jats:p>","DOI":"10.1210\/jc.2002-021610","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T22:14:18Z","timestamp":1051827258000},"page":"2250-2255","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Levels of Parathyroid Hormone (1\u201384) Whole Molecule and Parathyroid Hormone (7\u201384)-Like Fragments in Pseudohypoparathyroidism Type I"],"prefix":"10.1210","volume":"88","author":[{"given":"Yuriko","family":"Hatakeyama","sequence":"first","affiliation":[{"name":"Division of Laboratory Medicine (Y.H., S.Y., Y.S., T.I.), Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Mizunashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (K.M.), Senen General Hospital, Tagajo 985-0842, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohtaro","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Sendai Open Hospital (Y.F.), Miyagino-ku, Sendai 984-0814, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemitsu","family":"Yabuki","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine (Y.H., S.Y., Y.S., T.I.), Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine (Y.H., S.Y., Y.S., T.I.), Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine (Y.H., S.Y., Y.S., T.I.), Tohoku University School of Medicine, Aoba-ku, Sendai 980-8574, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616555801400_R1","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jcem.84.11.6236","article-title":"A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure.","volume":"84","author":"John","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616555801400_R2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","article-title":"Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1\u201384: 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