{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:50:39Z","timestamp":1773309039551,"version":"3.50.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:p>To develop reference ranges for the Questions on Life Satisfaction Hypopituitarism Module (QLS-H), a new quality of life questionnaire for patients with hypopituitarism, data from 8177 adults were collected in France, Germany, Italy, The Netherlands, Spain, the United Kingdom, and the United States QLS-H scores declined with age, were lower in females than males, and differed significantly among countries. From these reference ranges we derived equations for z-scores, which adjust for age, gender, and country. QLS-H results from 957 adults with GH deficiency (GHD) participating in clinical trials were analyzed. At baseline, QLS-H scores were lower in females and differed significantly among countries. QLS-H scores significantly increased after GH treatment (6\u20138 months), but differences by country persisted. Calculating z-scores for patients eliminated all gender and most country differences. Pooled z-scores (mean \u00b1 sd) from all patients increased from \u22120.99 \u00b1 1.39 at baseline to \u22120.14 \u00b1 1.30 after GH treatment. Quality of life assessment in adults with GHD requires the use of z-scores to correct for age, gender, and country differences. This approach allows pooling of data from different cohorts and comparison with general populations. QLS-H scores in adults with GHD were significantly decreased at baseline and were almost normalized after 6\u20138 months of GH therapy.<\/jats:p>","DOI":"10.1210\/jc.2002-021792","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T01:04:09Z","timestamp":1063328649000},"page":"4158-4167","source":"Crossref","is-referenced-by-count":55,"title":["Decreased Quality of Life in Adult Patients with Growth Hormone Deficiency Compared with General Populations Using the New, Validated, Self-Weighted Questionnaire, Questions on Life Satisfaction Hypopituitarism Module"],"prefix":"10.1210","volume":"88","author":[{"given":"Werner F.","family":"Blum","sequence":"first","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly & Co. 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