{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:32:42Z","timestamp":1791131562580,"version":"4.1.0"},"reference-count":17,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of resistin in obesity and insulin resistance in humans is controversial. Therefore, resistin protein was quantitated by ELISA in serum of 27 lean [13 women\/14 men, body mass index (BMI) 21.7 \u00b1 0.4 kg\/m2, age 33 \u00b1 2 yr] and 50 obese (37 women\/13 men, BMI 49.8 \u00b1 1.5 kg\/m2, age 47 \u00b1 1 yr) subjects. There was more serum resistin protein in the obese (mean \u00b1 sem: 5.3 \u00b1 0.4 ng\/ml; range 1.8\u201317.9) than lean subjects (3.6 \u00b1 0.4 ng\/ml; range 1.5\u20139.9; P = 0.001). The elevation of serum resistin in obese humans was confirmed by Western blot as was expression of resistin protein in human adipose tissue and isolated adipocytes. There was a significant positive correlation between resistin and BMI (r = 0.37; P = 0.002). Multiple regression analysis with predictors BMI and resistin explained 25% of the variance in homeostasis model assessment of insulin resistance score. BMI was a significant predictor of insulin resistance (P = 0.0002), but resistin adjusted for BMI was not (P = 0.11). The data demonstrate that resistin protein is present in human adipose tissue and blood, and that there is significantly more resistin in the serum of obese subjects. Serum resistin is not a significant predictor of insulin resistance in humans.<\/jats:p>","DOI":"10.1210\/jc.2002-021808","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T13:11:05Z","timestamp":1068124265000},"page":"5452-5455","source":"Crossref","is-referenced-by-count":355,"title":["Serum Resistin (FIZZ3) Protein Is Increased in Obese Humans"],"prefix":"10.1210","volume":"88","author":[{"given":"Mikako","family":"Degawa-Yamauchi","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism (M.D.-Y., J.E.B., R.V.C.), Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Bovenkerk","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (M.D.-Y., J.E.B., R.V.C.), Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth Elisa","family":"Juliar","sequence":"additional","affiliation":[{"name":"Division of Biostatistics (B.E.J.), Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Medicine, and Department of Surgery (W.W., K.K.), Indiana University School of Medicine, Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Medicine, and Department of Surgery (W.W., K.K.), Indiana University School of Medicine, Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RoseMarie","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery (R.M.J.), St. Vincent\u2019s Hospital, Carmel, Indiana 46032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories (Q.Z.), Indianapolis, Indiana 46285"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"Considine","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism (M.D.-Y., J.E.B., R.V.C.), Indianapolis, Indiana 46202-5111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613554450300_R1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes.","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"2020071613554450300_R2","doi-asserted-by":"crossref","first-page":"11252","DOI":"10.1074\/jbc.C100028200","article-title":"A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte 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Physiol"},{"key":"2020071613554450300_R12","doi-asserted-by":"crossref","first-page":"25651","DOI":"10.1074\/jbc.C100189200","article-title":"Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor \u03b3 agonists.","volume":"276","author":"Way","year":"2001","journal-title":"J Biol Chem"},{"key":"2020071613554450300_R13","first-page":"E626","article-title":"Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats","volume":"282","author":"Levy","year":"2002","journal-title":"Am J Physiol"},{"key":"2020071613554450300_R14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1172\/JCI16521","article-title":"Adipose-derived resistin and gut-derived resistin-like molecule-\u03b2 selectively impair insulin action on glucose production.","volume":"111","author":"Rajala","year":"2003","journal-title":"J Clin 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