{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:00:40Z","timestamp":1779890440321,"version":"3.53.1"},"reference-count":43,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pathogenesis of central precocious puberty (PP) and\/or gelastic seizures due to a hypothalamic hamartoma (HH) is still under debate. We evaluated the association of clinical symptoms with morphology and localization of the HH in 34 patients.<\/jats:p>\n               <jats:p>The majority (86.4%) of HHs in patients with isolated PP (n = 22; 68.2% females) revealed a parahypothalamic position without affecting the third ventricle (91%). Half of them were pedunculated, and 40.9% showed a diameter less than 10 mm. In contrast, 11 of 12 patients with seizures, eight of whom were male, presented with a sessile intrahypothalamic hamartoma, 10 of which distorted the third ventricle. Logistic regression analysis revealed an increased relative risk (RR) for epilepsy in males (RR, 4.3; 95% confidence interval, 0.96\u201319). However, combination of the risk factor gender with intrahypothalamic position (RR, 19; 1.3\u2013285) and distortion of the third ventricle (RR, 10; 0.6\u2013164) reduced the risk associated with male gender to 1.1.<\/jats:p>\n               <jats:p>The position of a HH and involvement of the third ventricle are likely to be more predictive for clinical characteristics than size and shape. Male gender was associated with an intrahypothalamic HH and epilepsy, suggesting a sexually dimorphic developmental pattern of this heterotopic mass.<\/jats:p>","DOI":"10.1210\/jc.2002-022018","type":"journal-article","created":{"date-parts":[[2003,10,13]],"date-time":"2003-10-13T17:42:51Z","timestamp":1066066971000},"page":"4590-4595","source":"Crossref","is-referenced-by-count":56,"title":["Association of Morphological Characteristics with Precocious Puberty and\/or Gelastic Seizures in Hypothalamic Hamartoma"],"prefix":"10.1210","volume":"88","author":[{"given":"H.","family":"Jung","sequence":"first","affiliation":[{"name":"Clinical Research, Internal Medicine, and Endocrinology (H.J.), Lilly Deutschland GmbH, Bad Homburg and University Children\u2019s Hospital, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Neumaier","family":"Probst","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology (E.N.P.), University Hospital Hamburg-Eppendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"Hauffa","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital (B.P.H.), Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-J.","family":"Partsch","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital (C.-J.P.), Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dammann","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Pediatrics, Perinatal Infectiology (O.D.), Hanover Medical School, Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071617562653600_R1","first-page":"1897","article-title":"Hamartomas and phacomatoses","author":"Lichtenstein","year":"1971","journal-title":"In: Minckler J, ed. Pathology of the nervous system. 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