{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:55:35Z","timestamp":1776833735959,"version":"3.51.2"},"reference-count":30,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravenous infusions with the bisphosphonate compound pamidronate decrease bone pain and reportedly can lead to refilling of dysplastic lesions in adults with fibrous dysplasia (FD) of bone. Here we describe the effects of this treatment approach in 18 children and adolescents (age at start of therapy, 6.2\u201317.5 yr; eight girls) with polyostotic FD, who received pamidronate for 1.2\u20139.1 yr (median, 3.8 yr). Treatment cycles with pamidronate (1\u20131.5 mg\/kg\u00b7d on 3 consecutive days) were given every 4 months. Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy. There was no radiographic evidence of filling of lytic lesions or thickening of the bone cortex surrounding the lesions in any patient. Histomorphometric results in dysplastic bone tissue of patients receiving pamidronate (n = 7; time of therapy, 1.4\u20134.8 yr) were similar to those of patients without medical therapy (n = 9). No serious side effects were noted. In conclusion, pamidronate therapy appears to be safe in children and adolescents with polyostotic FD. However, we found no clear evidence that pamidronate has an effect on dysplastic lesions in such patients.<\/jats:p>","DOI":"10.1210\/jc.2003-030050","type":"journal-article","created":{"date-parts":[[2003,10,13]],"date-time":"2003-10-13T17:42:51Z","timestamp":1066066971000},"page":"4569-4575","source":"Crossref","is-referenced-by-count":164,"title":["Effect of Pamidronate Treatment in Children with Polyostotic Fibrous Dysplasia of Bone"],"prefix":"10.1210","volume":"88","author":[{"given":"Horacio","family":"Plotkin","sequence":"first","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Zeitlin","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Munns","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Travers","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis H.","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, Que\u0301bec, Canada H3G 1A6; and the Departments of Surgery and Pediatrics, McGill University, Montre\u0301al, Que\u0301bec, Canada H3H 1P3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"issue":"Suppl 2","key":"2020071616561733700_R1","first-page":"79","article-title":"Fibrous dysplasia","volume":"57","author":"Schoenau","year":"2002","journal-title":"Horm Res"},{"key":"2020071616561733700_R2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJM199506083322304","article-title":"Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.","volume":"332","author":"Candeliere","year":"1995","journal-title":"N Engl J Med"},{"key":"2020071616561733700_R3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1359\/jbmr.2001.16.5.806","article-title":"Renal phosphate wasting in fibrous dysplasia of bone is part of a generalized renal tubular dysfunction similar to that seen in tumor-induced osteomalacia.","volume":"16","author":"Collins","year":"2001","journal-title":"J Bone Miner Res"},{"key":"2020071616561733700_R4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s007740170012","article-title":"Hypophosphatemic rickets accompanying McCune-Albright syndrome: evidence that a humoral factor causes hypophosphatemia.","volume":"19","author":"Yamamoto","year":"2001","journal-title":"J Bone Miner Metab"},{"key":"2020071616561733700_R5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s002640050069","article-title":"Polyostotic fibrous dysplasia. 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