{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:01:25Z","timestamp":1777287685887,"version":"3.51.4"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to measure serum T4, free T4, TSH, T3, rT3, T4 sulfate, and thyroxine binding globulin at four time points within the first 24 h of life (cord and 1, 7, and 24 h) in infants between 24 and 34 wk gestation. The infants were subdivided into gestational age groups: 24\u201327 wk (n = 22); 28\u201330 wk (n = 26); and 31\u201334 wk (n = 24). The TSH surge in the first hour of postnatal life was markedly attenuated in infants of 24\u201327 wk gestation [8 compared with 20 (28\u201330 wk) and 23 mU\/liter (31\u201334 wk)]. T4 levels in the most immature group declined over the first 24 h, whereas levels increased in the more mature groups [mean cord and 24-h levels: 65 and 59 (NS) vs. 70 and 84 (P &amp;lt; 0.002) vs. 98 and 125 (NS) nmol\/liter]. Free T4 and T3 showed only small, transient increases in the most immature group and progressively larger and sustained increases in the other gestational groups. rT3 and T4 sulfate levels in cord serum were higher in the most immature infants, and in all groups levels decreased initially and then variably increased. The features of a severely attenuated or failed hypothalamic-pituitary-thyroid response to delivery critically define this 24- to 27-wk group as distinct from more mature preterm infants.<\/jats:p>","DOI":"10.1210\/jc.2003-030317","type":"journal-article","created":{"date-parts":[[2004,6,4]],"date-time":"2004-06-04T21:48:10Z","timestamp":1086385690000},"page":"2824-2831","source":"Crossref","is-referenced-by-count":102,"title":["The Hypothalamic-Pituitary-Thyroid Axis in Preterm Infants; Changes in the First 24 Hours of Postnatal Life"],"prefix":"10.1210","volume":"89","author":[{"given":"Nuala","family":"Murphy","sequence":"first","affiliation":[{"name":"Department of Paediatrics (N.M., T.G.M.), The Rotunda Hospital, Dublin 1, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hume","sequence":"additional","affiliation":[{"name":"Tayside Institute of Child Health (R.H.), Dundee DD1 9SY, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"van Toor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (H.v.T., T.J.V.), Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom G.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Paediatrics (N.M., T.G.M.), The Rotunda Hospital, Dublin 1, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Ogston","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health (S.A.O., F.L.R.W.), University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing-Yung","family":"Wu","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service (S.-Y.W.), Veterans Affairs Medical Center, University of California\u2013Irvine Medical Center, Long Beach, California 90822-5201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo J.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (H.v.T., T.J.V.), Erasmus University Medical School, 3000 DR Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona L. 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