{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:09:21Z","timestamp":1791234561923,"version":"4.1.0"},"reference-count":19,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"DOI":"10.1210\/jc.2003-030542","type":"journal-article","created":{"date-parts":[[2004,3,5]],"date-time":"2004-03-05T01:53:04Z","timestamp":1078451584000},"page":"1423-1428","source":"Crossref","is-referenced-by-count":54,"title":["Expression of the Apical Iodide Transporter in Human Thyroid Tissues: A Comparison Study with Other Iodide Transporters"],"prefix":"10.1210","volume":"89","author":[{"given":"Ludovic","family":"Lacroix","sequence":"first","affiliation":[{"name":"Departments of Clinical Biology (L.L., T.I., J.-M.B.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pourcher","sequence":"additional","affiliation":[{"name":"Commissariat a\u0300 l\u2019Energie Atomique-LRC16V (T.P.), Universite\u0301 Nice Sophia-Antipolis, CNRS-UMR6078, F-06238 Villefranche-sur-Mer, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Magnon","sequence":"additional","affiliation":[{"name":"Commissariat a\u0300 l\u2019Energie Atomique-LRC29V, and Centre National de la Recherche Scientifique (CNRS)-UMR1582 (C.M.), Institut Gustave-Roussy, 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bellon","sequence":"additional","affiliation":[{"name":"Statistics (N.B.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Talbot","sequence":"additional","affiliation":[{"name":"Pathology (M.T., B.C.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosak","family":"Intaraphairot","sequence":"additional","affiliation":[{"name":"Departments of Clinical Biology (L.L., T.I., J.-M.B.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Caillou","sequence":"additional","affiliation":[{"name":"Pathology (M.T., B.C.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schlumberger","sequence":"additional","affiliation":[{"name":"Nuclear Medicine (M.S.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Bidart","sequence":"additional","affiliation":[{"name":"Departments of Clinical Biology (L.L., T.I., J.-M.B.), 94805 Villejuif Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116134141100_R1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/biof.5520100228","article-title":"Molecular and cellular mechanisms of transepithelial iodide transport in the thyroid.","volume":"10","author":"Nilsson","year":"1999","journal-title":"Biofactors"},{"key":"2019041116134141100_R2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/bbrc.1996.1358","article-title":"Cloning of the human sodium lodide symporter.","volume":"226","author":"Smanik","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041116134141100_R3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology.","volume":"80","author":"De La Vieja","year":"2000","journal-title":"Physiol Rev"},{"key":"2019041116134141100_R4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/7783","article-title":"The Pendred syndrome gene encodes a chloride-iodide transport protein.","volume":"21","author":"Scott","year":"1999","journal-title":"Nat Genet"},{"key":"2019041116134141100_R5","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1210\/jcem.84.7.5973","article-title":"Sulfate transport is not impaired in pendred syndrome thyrocytes.","volume":"84","author":"Kraiem","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1210\/endo.141.2.7303","article-title":"Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells.","volume":"141","author":"Royaux","year":"2000","journal-title":"Endocrinology"},{"key":"2019041116134141100_R7","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1210\/jcem.87.7.8679","article-title":"Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells.","volume":"87","author":"Yoshida","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R8","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1210\/jcem.87.7.8797","article-title":"Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.","volume":"87","author":"Rodriguez","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0968-0004(01)01904-1","article-title":"Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.","volume":"26","author":"Riedel","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"2019041116134141100_R10","first-page":"3228","article-title":"Expression of the Na\/I symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes.","volume":"84","author":"Lazar","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/thy.2000.10.211","article-title":"Expressions of human sodium iodide symporter mRNA in primary and metastatic papillary thyroid carcinomas.","volume":"10","author":"Park","year":"2000","journal-title":"Thyroid"},{"key":"2019041116134141100_R12","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1089\/105072501316973073","article-title":"Sodium iodide symporter and pendrin expression in human thyroid tissues.","volume":"11","author":"Mian","year":"2001","journal-title":"Thyroid"},{"key":"2019041116134141100_R13","first-page":"2697","article-title":"Predominant intracellular overexpression of the Na(+)\/I(\u2212) symporter (NIS) in a large sampling of thyroid cancer cases.","volume":"86","author":"Dohan","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R14","first-page":"2028","article-title":"Expression of pendrin and the Pendred syndrome (PDS) gene in human thyroid tissues.","volume":"85","author":"Bidart","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R15","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1210\/jcem.87.4.8372","article-title":"Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues.","volume":"87","author":"Porra","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R16","article-title":"Histological typing of thyroid tumors. In: International histological classification of tumors","author":"Hedinger","year":"1998"},{"key":"2019041116134141100_R17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0303-7207(91)90018-N","article-title":"Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiation.","volume":"82","author":"Brabant","year":"1991","journal-title":"Mol Cell Endocrinol"},{"key":"2019041116134141100_R18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/jcem-69-2-304","article-title":"Imaging and relative quantification of 127I in human thyroid follicles by analytical ion microscope: characterization of benign thyroid epithelial tumors.","volume":"69","author":"Fragu","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116134141100_R19","first-page":"237","article-title":"Molecular basis of tumors arising in thyroid follicular cells.","volume":"53","author":"Wynford-Thomas","year":"1999","journal-title":"Ann Chir"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/89\/3\/1423\/10744018\/jcem1423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T05:44:57Z","timestamp":1555047897000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/89\/3\/1423\/2844571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,1]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2003-030542","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,1]]}}}