{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:35:08Z","timestamp":1782311708832,"version":"3.54.5"},"reference-count":33,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:p>The aim of the study was to assess the effect of transdermal testosterone on free testosterone concentrations in saliva and on short-term growth and bone turnover in boys with growth or pubertal delay.<\/jats:p>\n               <jats:p>A prospective, randomized, crossover study was conducted over 26 wk with 4 wk of run-in, 8 wk of treatment I (8 or 12 h), 4 wk of washout, 8 wk of treatment II (8 or 12 h), and 4 wk of final washout.<\/jats:p>\n               <jats:p>The main outcome measures were salivary testosterone profiles during the different study periods; weekly change in lower leg length (LLL) as measured by knemometry, i.e. LLL velocity; absolute and percentage change in bone alkaline phosphatase (bALP) levels; and deoxypyridinoline cross-links measured in urine.<\/jats:p>\n               <jats:p>Eight boys who took part in the study had a median age of 13.5 yr (range, 12.4\u201314.9 yr), testicular volume of 3 ml (range, 2\u20136 ml), height sd score of \u22122.4 (range, \u22121.44 to \u22123.35), and bone age delay of 2 yr (range, 1\u20133.2 yr).<\/jats:p>\n               <jats:p>Median salivary testosterone during 8- and 12-h treatments [179 pg\/ml (range, 7\u20133579 pg\/ml) and 150 pg\/ml (range, 12\u20133472 pg\/ml) (not significant)] was significantly higher than during the run-in and washout blocks (P &amp;lt; 0.0001) [9 pg\/ml (range, &amp;lt;7 to 122 pg\/ml) and 13 pg\/ml (range, &amp;lt;7 to 285 pg\/ml) (not significant)]. LLL velocity in the treatment blocks (median, 0.64 mm\/wk; range, 0.1\u20131.08 mm\/wk) was significantly higher than during the run-in and washout periods (median, 0.48 mm\/wk; range, \u22120.06 to 0.92 mm\/wk) (P &amp;lt; 0.001). The main rise in bALP occurred during the first treatment block with a median percentage change in bALP of 44.2% (range, \u22124 to 87%) and a smaller percentage change in bALP at the end of the second treatment block of 9.8% (range, \u22124 to 55%). The increases in bALP were not significantly different between the 8- and 12-h treatment periods, and there was no significant decline during the washout periods.<\/jats:p>\n               <jats:p>Overnight transdermal testosterone application, as Virormone (5 mg), may be a potentially acceptable method of induction of puberty and stimulates short-term growth and bone turnover.<\/jats:p>","DOI":"10.1210\/jc.2003-031086","type":"journal-article","created":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T00:24:18Z","timestamp":1076027058000},"page":"681-687","source":"Crossref","is-referenced-by-count":45,"title":["Transdermal Testosterone Application: Pharmacokinetics and Effects on Pubertal Status, Short-Term Growth, and Bone Turnover"],"prefix":"10.1210","volume":"89","author":[{"given":"A.","family":"Mayo","sequence":"first","affiliation":[{"name":"Department of Paediatrics (A.M.), Royal Aberdeen Children\u2019s Hospital, Aberdeen AB25 2ZG, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Macintyre","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry (H.M., A.M.W.), Glasgow Royal Infirmary, Glasgow G4 0SF, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry (H.M., A.M.W.), Glasgow Royal Infirmary, Glasgow G4 0SF, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Bone and Endocrine Research Group, Department of Child Health (S.F.A.), Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071617383785700_R1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/adc.71.4.285","article-title":"Treatment of the short, sexually immature adolescent boy.","volume":"71","author":"Kelnar","year":"1994","journal-title":"Arch Dis Child"},{"key":"2020071617383785700_R2","first-page":"115","article-title":"Comparative pharmacokinetics of androgen preparations: application of computer analysis and simulation","author":"Behre","year":"1990","journal-title":"In: Niesclag E, Behre HM, eds. Testosterone action, deficiency, substitution. 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