{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T05:29:36Z","timestamp":1671773376322},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>Melatonin (MLT), the pineal gland hormone involved in the regulation of circadian rhythms, shows characteristic diurnal variation. Its physiological role in humans is not clear. Exposure to high altitudes may disrupt the circadian rhythm and lead to various endocrine changes. MLT in humans has not been studied under these conditions. Urinary 6-hydroxy-MLT sulfate (aMT6s) excretion was analyzed during the day (0700\u20132200 h) and night (2200\u20130700 h) phases. A cohort of 33 healthy volunteers, aged 19\u201365 yr, was studied during an ascent to a high altitude in the Himalayas on three occasions (at a lower altitude, at 3400 m, and after reaching maximal altitudes of 5600\u20136100 m). aMT6s excretion during the daytime remained unchanged during exposure to high altitudes. As expected, nocturnal values were higher than diurnal values at each point in time. However, there was a significant increase in nocturnal MLT excretion after the ascent to high altitudes. Ascent to high altitudes is associated with increased nocturnal excretion of aMT6s. The mechanism and physiological significance of this MLT increase are unclear.<\/jats:p>","DOI":"10.1210\/jc.2003-032214","type":"journal-article","created":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T03:32:28Z","timestamp":1094614348000},"page":"4388-4390","source":"Crossref","is-referenced-by-count":12,"title":["Increase in 6-Hydroxymelatonin Excretion in Humans during Ascent to High Altitudes"],"prefix":"10.1210","volume":"89","author":[{"given":"Herwig","family":"Frisch","sequence":"first","affiliation":[{"name":"Department of Pediatrics (H.F., F.W., K.S.), 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Waldhauser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (H.F., F.W., K.S.), 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Waldho\u0308r","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Department of Epidemiology (T.W.), 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mu\u0308llner-Eidenbo\u0308ck","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology (A.M.-E.), University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritam","family":"Neupane","sequence":"additional","affiliation":[{"name":"Emergency and Outpatient Department, Patan Hospital (P.N.), Lalitpur, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (H.F., F.W., K.S.), 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071616262558200_R1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJM199701163360306","article-title":"Melatonin in humans.","volume":"336","author":"Brezinski","year":"1997","journal-title":"N Engl J Med"},{"key":"2020071616262558200_R2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jnr.10136","article-title":"Plasma melatonin, pinealocyte morphology, and surface receptors\/antigen expression on macrophages\/microglia in the pineal gland following a high-altitude exposure.","volume":"67","author":"Kaur","year":"2002","journal-title":"J Neurosci Res"},{"key":"2020071616262558200_R3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2265.1995.tb01887.x","article-title":"The effects of high altitude on hypothalamic-pituitary secretory dynamics in men.","volume":"43","author":"Ramirez","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071616262558200_R4","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1210\/jcem-60-6-1166","article-title":"Immunoassay of 6-hydroxymelatonin sulfate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol.","volume":"60","author":"Arendt","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616262558200_R5","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/clinchem\/33.8.1343","article-title":"Melatonin secretion in humans assessed by measuring its metabolite, 6-sulfatoxymelatonin.","volume":"33","author":"Bojkowski","year":"1987","journal-title":"Clin Chem"},{"key":"2020071616262558200_R6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1210\/jcem.85.2.6349","article-title":"Measurement of urinary melatonin: a useful tool for monitoring serum melatonin after its oral administration.","volume":"85","author":"Kovacs","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616262558200_R7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1210\/jcem-69-3-663","article-title":"The short-term secretion pattern of human serum melatonin indicates apulsatile hormone release.","volume":"69","author":"Trinchard Lugan","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616262558200_R8","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1016\/S0021-9258(18)93998-0","article-title":"The metabolism of melatonin (N-acetyl-5-methoxytryptamine) and 5-methoxytryptamine.","volume":"236","author":"Kveder","year":"1961","journal-title":"J Biol Chem"},{"key":"2020071616262558200_R9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1210\/jcem-66-3-648","article-title":"Alterations in nocturnal serum melatonin levels in humans with growth and aging.","volume":"66","author":"Waldhauser","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616262558200_R10","first-page":"349","article-title":"Drugs affecting melatonin secretion in man","author":"Touitou","year":"1987","journal-title":"In: Trentini G, De Gaetani C, Pevet P, eds. 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