{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:06:57Z","timestamp":1791418017863,"version":"4.3.3"},"reference-count":35,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1210\/jc.2004-1039","type":"journal-article","created":{"date-parts":[[2005,3,9]],"date-time":"2005-03-09T23:59:24Z","timestamp":1110412764000},"page":"1519-1524","source":"Crossref","is-referenced-by-count":455,"title":["Fibroblast Growth Factor-23 Relationship to Dietary Phosphate and Renal Phosphate Handling in Healthy Young Men"],"prefix":"10.1210","volume":"90","author":[{"given":"Serge L.","family":"Ferrari","sequence":"first","affiliation":[{"name":"Service of Bone Diseases [World Health Organization Collaborating Center for Osteoporosis Prevention], Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bonjour","sequence":"additional","affiliation":[{"name":"Service of Bone Diseases [World Health Organization Collaborating Center for Osteoporosis Prevention], Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u0301","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Service of Bone Diseases [World Health Organization Collaborating Center for Osteoporosis Prevention], Department of Rehabilitation and Geriatrics, Geneva University Hospital, Geneva 1211, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116125490700_R1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI108815","article-title":"Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply.","volume":"60","author":"Rizzoli","year":"1977","journal-title":"J Clin Invest"},{"key":"2019041116125490700_R2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/3540133275_4","article-title":"Phosphate transport in the kidney.","volume":"100","author":"Bonjour","year":"1984","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"2019041116125490700_R3","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/S0021-9258(17)35773-3","article-title":"Sodium-dependent phosphate transport inhibited by parathyroid hormone and cyclic AMP stimulation in an opossum kidney cell line.","volume":"261","author":"Caverzasio","year":"1986","journal-title":"J Biol Chem"},{"key":"2019041116125490700_R4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1471-4892(02)00137-6","article-title":"Disorders of phosphate metabolism in chronic renal disease.","volume":"2","author":"Edwards","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"2019041116125490700_R5","first-page":"272","article-title":"Tubular adaptation of inorganic phosphate (Pi) transport in response to variations in dietary Pi in rats.","volume":"6","author":"Bonjour","year":"1976","journal-title":"Curr Probl Clin Biochem"},{"key":"2019041116125490700_R6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/jbmr.5650040411","article-title":"The renal phosphate transport defect in normal mice parabiosed to X-linked hypophosphatemic mice persists after parathyroidectomy.","volume":"4","author":"Meyer Jr","year":"1989","journal-title":"J Bone Miner Res"},{"key":"2019041116125490700_R7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/endo-127-1-453","article-title":"Stimulatory effect of insulin-like growth factor-1 on renal Pi transport and plasma 1,25-dihydroxyvitamin D3.","volume":"127","author":"Caverzasio","year":"1990","journal-title":"Endocrinology"},{"key":"2019041116125490700_R8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF01213364","article-title":"Growth factors and renal regulation of phosphate transport.","volume":"7","author":"Caverzasio","year":"1993","journal-title":"Pediatr Nephrol"},{"key":"2019041116125490700_R9","first-page":"206","article-title":"IGF-1, a key regulator of renal phosphate transport and 1,25-dihydroxyvitamin D3 production during growth.","volume":"6","author":"Caverzasio","year":"1991","journal-title":"News Physiol Sci"},{"key":"2019041116125490700_R10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00424-002-0839-4","article-title":"Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders.","volume":"444","author":"Tenenhouse","year":"2002","journal-title":"Pflugers Arch"},{"issue":"4 Pt 2","key":"2019041116125490700_R11","first-page":"F527","article-title":"Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney","volume":"275","author":"Tenenhouse","year":"1998","journal-title":"Am J Physiol"},{"key":"2019041116125490700_R12","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/physrev.2000.80.4.1373","article-title":"Proximal tubular phosphate reabsorption: molecular mechanisms.","volume":"80","author":"Murer","year":"2000","journal-title":"Physiol Rev"},{"key":"2019041116125490700_R13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s004240050573","article-title":"Cellular mechanisms involved in the acute adaptation of OK cell Na\/Pi-cotransport to high- or low-Pi medium.","volume":"435","author":"Pfister","year":"1998","journal-title":"Pflugers Arch"},{"key":"2019041116125490700_R14","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1073\/pnas.95.4.1909","article-title":"Parathyroid hormone leads to the lysosomal degradation of the renal type II Na\/Pi cotransporter.","volume":"95","author":"Pfister","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041116125490700_R15","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.00016.2003","article-title":"FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization","volume":"285","author":"Quarles","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2019041116125490700_R16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1523-1755.2004.00355.x","article-title":"The phosphatonin pathway: new insights in phosphate homeostasis.","volume":"65","author":"Schiavi","year":"2004","journal-title":"Kidney Int"},{"key":"2019041116125490700_R17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","article-title":"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.","volume":"26","year":"2000","journal-title":"Nat Genet"},{"key":"2019041116125490700_R18","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1074\/jbc.M207872200","article-title":"Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1\u03b1,25-dihydroxyvitamin D3 production.","volume":"278","author":"Saito","year":"2003","journal-title":"J Biol Chem"},{"key":"2019041116125490700_R19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00424-003-1084-1","article-title":"Effect of hydrolysis-resistant FGF23\u2013R179Q on dietary phosphate regulation of the renal type-II Na\/Pi transporter.","volume":"446","author":"Segawa","year":"2003","journal-title":"Pflugers Arch"},{"key":"2019041116125490700_R20","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1073\/pnas.101545198","article-title":"Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.","volume":"98","author":"Shimada","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041116125490700_R21","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa020881","article-title":"Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.","volume":"348","author":"Jonsson","year":"2003","journal-title":"N Engl J Med"},{"key":"2019041116125490700_R22","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1210\/jc.2002-021105","article-title":"Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets\/osteomalacia.","volume":"87","author":"Yamazaki","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116125490700_R23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1359\/jbmr.2003.18.7.1227","article-title":"Serum FGF23 levels in normal and disordered phosphorus homeostasis.","volume":"18","author":"Weber","year":"2003","journal-title":"J Bone Miner Res"},{"key":"2019041116125490700_R24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI18399","article-title":"FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting.","volume":"112","author":"Riminucci","year":"2003","journal-title":"J Clin Invest"},{"key":"2019041116125490700_R25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI109312","article-title":"Resistance to the phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxyvitamin D3.","volume":"63","author":"Gloor","year":"1979","journal-title":"J Clin Invest"},{"key":"2019041116125490700_R26","first-page":"2043","article-title":"Bone mineral mass and calcium and phosphate metabolism in young men: relationships with vitamin D receptor allelic polymorphisms.","volume":"84","author":"Ferrari","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116125490700_R27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","article-title":"Nomogram for derivation of renal threshold phosphate concentration.","volume":"2","author":"Walton","year":"1975","journal-title":"Lancet"},{"key":"2019041116125490700_R28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/8756-3282(91)90055-N","article-title":"Evaluation of bone resorption and renal tubular reabsorption of calcium and phosphate in malignant and nonmalignant hypercalcemia.","volume":"12","author":"Buchs","year":"1991","journal-title":"Bone"},{"key":"2019041116125490700_R29","first-page":"276","article-title":"Repeatability and precision in measurement: an introduction to medical statistics","author":"Bland","year":"1991","journal-title":"Oxford, UK: Oxford University Press;"},{"key":"2019041116125490700_R30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis.","volume":"19","author":"Shimada","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2019041116125490700_R31","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI114043","article-title":"Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men.","volume":"83","author":"Portale","year":"1989","journal-title":"J Clin Invest"},{"key":"2019041116125490700_R32","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1046\/j.1523-1755.2003.00328.x","article-title":"Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers.","volume":"64","author":"Larsson","year":"2003","journal-title":"Kidney Int"},{"key":"2019041116125490700_R33","first-page":"1921","article-title":"Effects of short-term calcium depletion and repletion on biochemical markers of bone turnover in young adult women.","volume":"83","author":"Akesson","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116125490700_R34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI18563","article-title":"Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.","volume":"112","author":"Berndt","year":"2003","journal-title":"J Clin Invest"},{"key":"2019041116125490700_R35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bone.2003.10.005","article-title":"MEPE has the properties of an osteoblastic phosphatonin and minhibin.","volume":"34","author":"Rowe","year":"2004","journal-title":"Bone"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/90\/3\/1519\/10744977\/jcem1519.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T19:24:19Z","timestamp":1625599459000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/90\/3\/1519\/2836790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,1]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2004-1039","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,1]]}}}