{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:04Z","timestamp":1787021224066,"version":"build-2736575974"},"reference-count":19,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although anterior pituitary tumors constitute a main clinical feature of multiple endocrine neoplasia type 1 (MEN1), and most types of pituitary tumors have been associated with MEN1, gonadotroph tumors have not previously been recognized clinically as part of this syndrome. We report here a woman who presented with ovarian hyperstimulation due to a gonadotroph tumor that was confirmed biochemically and immunohistochemically. She then developed hyperparathyroidism, and she was found to have three hypercellular parathyroid glands. Subsequently, she developed a temporal lobe metastasis of the gonadotroph tumor, demonstrating that it was a gonadotroph carcinoma. The diagnosis of MEN1 was confirmed by finding a deletion mutation (c.307delC) on the second exon of the MEN1 gene that predicts truncation of the resulting menin protein 15 codons downstream from the deletion (p.Leu103fsX15). This case illustrates that gonadotroph tumors, like other pituitary tumors, can be part of MEN1. The clinical implications of this case are that the clinical and biochemical features of gonadotroph tumors should be considered when evaluating patients for MEN1, and MEN1 should be considered in patients who have gonadotroph tumors.<\/jats:p>","DOI":"10.1210\/jc.2004-1373","type":"journal-article","created":{"date-parts":[[2005,1,10]],"date-time":"2005-01-10T18:18:48Z","timestamp":1105381128000},"page":"570-574","source":"Crossref","is-referenced-by-count":41,"title":["Gonadotroph Tumor Associated with Multiple Endocrine Neoplasia Type 1"],"prefix":"10.1210","volume":"90","author":[{"given":"Maria","family":"Benito","sequence":"first","affiliation":[{"name":"Departments of Medicine (M.B., P.J.S.), Philadelphia, Pennsylvania 19104-6149"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia L.","family":"Asa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology (S.L.A.), University of Toronto, Toronto, Ontario, Canada M5G 2M9; and Christiana Hospital (V.A.W.), Newark, Delaware 19713"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"LiVolsi","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine (V.A.L.), University of Pennsylvania, Philadelphia, Pennsylvania 19104-6149"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie A.","family":"West","sequence":"additional","affiliation":[{"name":"Departments of Medicine (M.B., P.J.S.), Philadelphia, Pennsylvania 19104-6149"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Departments of Medicine (M.B., P.J.S.), Philadelphia, Pennsylvania 19104-6149"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071615531279400_R1","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2.","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615531279400_R2","first-page":"205","article-title":"Pituitary adenomas of the multiple endocrine neoplasia type I syndrome.","volume":"4","author":"Scheithauer","year":"1987","journal-title":"Semin Diagn Pathol"},{"key":"2020071615531279400_R3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/qjmed\/89.9.653","article-title":"Clinical studies of multiple endocrine neoplasia type 1 (MEN1).","volume":"89","author":"Trump","year":"1996","journal-title":"QJM"},{"key":"2020071615531279400_R4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1.","volume":"62","author":"Bassett","year":"1998","journal-title":"Am J Hum Genet"},{"key":"2020071615531279400_R5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1089\/thy.2000.10.1001","article-title":"Treatment of a thyrotropinoma with octreotide-LAR in a patient with multiple endocrine neoplasia-1.","volume":"10","author":"Taylor","year":"2000","journal-title":"Thyroid"},{"key":"2020071615531279400_R6","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1136\/jmg.40.5.e72","article-title":"Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients","volume":"40","author":"Cebrian","year":"2003","journal-title":"J Med Genet"},{"key":"2020071615531279400_R7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1210\/jcem.87.2.8145","article-title":"Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.","volume":"87","author":"Verges","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615531279400_R8","first-page":"591","article-title":"Gonadotroph adenoma in a premenopausal woman secreting follicle-stimulating hormone and causing ovarian hyperstimulation.","volume":"80","author":"Djerassi","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615531279400_R9","first-page":"2165","article-title":"The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph.","volume":"81","author":"Asa","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615531279400_R10","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/foc.2004.16.4.8","article-title":"Pituitary carcinoma: a review of the literature","volume":"16","author":"Ragel","year":"2004","journal-title":"Neurosurg Focus"},{"key":"2020071615531279400_R11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03343963","article-title":"Pituitary carcinoma: report of an exceptional case and review of the literature.","volume":"25","author":"Pichard","year":"2002","journal-title":"J Endocrinol Invest"},{"key":"2020071615531279400_R12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1210\/jcem-62-5-849","article-title":"Luteinizing hormone (LH) and prolactin-releasing pituitary tumor: possible malignant transformation of the LH cell line.","volume":"62","author":"Spertini","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071615531279400_R13","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1227\/00006123-199510000-00027","article-title":"Gonadotropic pituitary carcinoma: case report.","volume":"37","author":"Beauchesne","year":"1995","journal-title":"Neurosurgery"},{"key":"2020071615531279400_R14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1046\/j.1365-2265.1999.00774.x","article-title":"p16 (INK4a, MTS-1) gene polymorphism and methylation status in human pituitary tumours.","volume":"51","author":"Jaffrain-Rea","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071615531279400_R15","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1097\/00006123-200005000-00042","article-title":"Pituitary carcinoma containing gonadotropins: treatment by radical excision and cytotoxic chemotherapy: case report.","volume":"46","author":"McCutcheon","year":"2000","journal-title":"Neurosurgery"},{"key":"2020071615531279400_R16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/02688699550041584","article-title":"Intracranial metastases from pituitary adenoma.","volume":"9","author":"O\u2019Brien","year":"1995","journal-title":"Br J Neurosurg"},{"key":"2020071615531279400_R17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3171\/jns.2003.99.2.0402","article-title":"Gonadotropic pituitary carcinoma: HER-2\/neu expression and gene amplification. Report of two cases.","volume":"99","author":"Roncaroli","year":"2003","journal-title":"J Neurosurg"},{"key":"2020071615531279400_R18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1086\/301953","article-title":"Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders.","volume":"63","author":"Giraud","year":"1998","journal-title":"Am J Hum Genet"},{"key":"2020071615531279400_R19","author":"Asa","year":"1998"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/90\/1\/570\/10812680\/jcem0570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/90\/1\/570\/10812680\/jcem0570.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T22:58:02Z","timestamp":1594940282000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/90\/1\/570\/2835675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2004-1373","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,1]]}}}