{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:12:22Z","timestamp":1792156342290,"version":"4.4.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: Hypoactive sexual desire disorder (HSDD) is one of the most common sexual problems reported by women, but few studies have been conducted to evaluate treatments for this condition.<\/jats:p><jats:p>Objective: The objective of this study was to evaluate the efficacy and safety of a testosterone patch in surgically menopausal women with HSDD.<\/jats:p><jats:p>Design: The design was a randomized, double-blind, parallel-group, placebo-controlled, 24-wk study (the Intimate SM 1 study).<\/jats:p><jats:p>Setting: The study was performed at private or institutional practices.<\/jats:p><jats:p>Patients: The subjects studied were women, aged 26\u201370 yr, with HSDD after bilateral salpingo-oophorectomy who were receiving concomitant estrogen therapy. Placebo (n = 279) or testosterone 300 \u03bcg\/d (n = 283) was administered. There were 19 patients who withdrew due to adverse events in the placebo group and 24 in the 300 \u03bcg\/d testosterone group.<\/jats:p><jats:p>Intervention: Testosterone (300 \u03bcg\/d) or placebo patches were applied twice weekly.<\/jats:p><jats:p>Main Outcome Measure(s): The primary end point was the change in the frequency of total satisfying sexual activity at 24 wk. Secondary end points included other sexual functioning end points and safety assessments.<\/jats:p><jats:p>Results: At 24 wk, there was an increase from baseline in the frequency of total satisfying sexual activity of 2.10 episodes\/4 wk in the testosterone group, which was significantly greater than the change of 0.98 episodes\/4 wk in the placebo group (P = 0.0003). The testosterone group also experienced statistically significant improvements in sexual desire and a decrease in distress. The overall safety profile was similar in both treatment groups.<\/jats:p><jats:p>Conclusion: In the Intimate SM 1 study, the testosterone patch improved sexual function and decreased distress in surgically menopausal women with HSDD and was well tolerated in this trial.<\/jats:p>","DOI":"10.1210\/jc.2004-1747","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T22:28:36Z","timestamp":1126132116000},"page":"5226-5233","source":"Crossref","is-referenced-by-count":387,"title":["Testosterone Patch Increases Sexual Activity and Desire in Surgically Menopausal Women with Hypoactive Sexual Desire Disorder"],"prefix":"10.1210","volume":"90","author":[{"given":"James","family":"Simon","sequence":"first","affiliation":[{"name":"Women\u2019s Health Research Center (J.S.), Laurel, Maryland 20707;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center (G.B.), Los Angeles, California 90048;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Nachtigall","sequence":"additional","affiliation":[{"name":"New York University School of Medicine (L.N.), New York, New York 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulf","family":"Utian","sequence":"additional","affiliation":[{"name":"Rapid Medical Research (W.U.), Cleveland, Ohio 44122;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Katz","sequence":"additional","affiliation":[{"name":"Katz, Kade, and Hewitt, Inc. 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