{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:12:44Z","timestamp":1773421964780,"version":"3.50.1"},"reference-count":27,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p>Neuroendocrine tumors (NETs) can be small and situated almost anywhere throughout the body. Our objective was to investigate whether whole-body (WB) positron emission tomography (PET) with 11C-5-hydroxytryptophan (5-HTP) can be used as a universal imaging technique for NETs and to compare this technique with established imaging methods. Forty-two consecutive patients with evidence of NET and a detected lesion on any conventional imaging (six bronchial, two foregut, 16 midgut, and two thymic carcinoids; one ectopic Cushing\u2019s syndrome; four gastrinomas; one insulinoma; six nonfunctioning endocrine pancreatic tumors; one gastric carcinoid, one paraganglioma; and two endocrine-differentiated pancreatic carcinomas) were studied. The WB-11C-5-HTP-PET examinations were compared with WB-computed tomography (CT) and somatostatin receptor scintigraphy (SRS). Tumor lesions were imaged with PET in 95% of the patients. In 58% of the patients, PET could detect more lesions than SRS and CT and equal numbers in 34%, whereas in three cases, SRS or CT showed more lesions. In 84% (16 of 19 patients), PET could visualize the primary tumor compared with 47 and 42% for SRS and CT, respectively. The surgically removed PET-positive primary tumor sizes were 6\u201330 mm. To conclude, this study indicates that WB-11C-5-HTP-PET can be used as a universal imaging method for detection of NETs. This study also shows that WB-11C-HTP-PET is sensitive in imaging small NET lesions, such as primary tumors, and can in a majority of cases image significantly more tumor lesions than SRS and CT.<\/jats:p>","DOI":"10.1210\/jc.2004-1938","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T21:44:09Z","timestamp":1117057449000},"page":"3392-3400","source":"Crossref","is-referenced-by-count":257,"title":["Whole-Body 11C-5-Hydroxytryptophan Positron Emission Tomography as a Universal Imaging Technique for Neuroendocrine Tumors: Comparison with Somatostatin Receptor Scintigraphy and Computed Tomography"],"prefix":"10.1210","volume":"90","author":[{"given":"H.","family":"Orlefors","sequence":"first","affiliation":[{"name":"Departments of Medical Sciences\/Endocrine Oncology (H.O., K.O., B.S., B.E.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sundin","sequence":"additional","affiliation":[{"name":"Radiology (A.S.), S-751 85 Uppsala, Sweden"},{"name":"Uppsala University PET Center IMANET (A.S., B.L., M.B.), Uppsala University Hospital, S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Garske","sequence":"additional","affiliation":[{"name":"Nuclear Medicine (U.G.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Surgery (C.J.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Oberg","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences\/Endocrine Oncology (H.O., K.O., B.S., B.E.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Skogseid","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences\/Endocrine Oncology (H.O., K.O., B.S., B.E.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Langstrom","sequence":"additional","affiliation":[{"name":"Uppsala University PET Center IMANET (A.S., B.L., M.B.), Uppsala University Hospital, S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bergstrom","sequence":"additional","affiliation":[{"name":"Uppsala University PET Center IMANET (A.S., B.L., M.B.), Uppsala University Hospital, S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences\/Endocrine Oncology (H.O., K.O., B.S., B.E.), S-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071618434166500_R1","first-page":"1857","article-title":"Carcinoid tumors, carcinoid syndrome and related disorders","author":"Oberg","year":"2003","journal-title":"In: Larsen PR, Kronenberg HM, Melmed S, Polonski KS, eds. 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