{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:52:55Z","timestamp":1791345175783,"version":"4.3.1"},"reference-count":36,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:p>Context: A newly discovered hormone resistin has been shown to be increased in women with polycystic ovary syndrome (PCOS).<\/jats:p>\n               <jats:p>Objective: The purpose of this study was to confirm increased resistin concentrations in women with PCOS and to test the direct effect of resistin on human theca cell androgen production.<\/jats:p>\n               <jats:p>Design: Resistin was measured in fasting serum samples by RIA. To test the direct effects of resistin on ovarian androgen biosynthesis, human theca cells were cultured with resistin for 3 d in the presence and absence of forskolin and insulin.<\/jats:p>\n               <jats:p>Patients: Fasting serum samples were obtained from 45 women with PCOS and 74 regularly cycling premenopausal control women in the follicular phase of their menstrual cycles, and ovarian theca cell cultures were established from two control women.<\/jats:p>\n               <jats:p>Results: The mean serum resistin concentration was increased (40%) in women with PCOS. Serum resistin concentrations correlated positively with body mass index and testosterone in PCOS women but not in controls. There were no significant correlations between resistin and fasting insulin or indicators of insulin resistance when corrected for body mass index. In cultured human theca cells, basal 17\u03b1-hydroxylase activity was unchanged by resistin alone, but resistin enhanced 17\u03b1-hydroxylase activity in the presence of forskolin or a combination of forskolin plus insulin. Resistin (\u22651 ng\/ml) augmented forskolin and forskolin plus insulin stimulation of CYP17 mRNA expression in a concentration-dependent manner.<\/jats:p>\n               <jats:p>Conclusion: These data indicate that abnormal resistin secretion in PCOS may play a role in causing ovarian hyperandrogenism.<\/jats:p>","DOI":"10.1210\/jc.2004-2152","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T21:37:43Z","timestamp":1123537063000},"page":"4852-4857","source":"Crossref","is-referenced-by-count":73,"title":["Resistin Stimulation of 17\u03b1-Hydroxylase Activity in Ovarian Theca Cells in Vitro: Relevance to Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"90","author":[{"given":"Iqbal","family":"Munir","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, Cedars-Sinai Medical Center\/David Geffen School of Medicine at the University of California\u2013Los Angeles (I.M., H.-W.Y., T.B., R.A., D.A.M.), Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, Cedars-Sinai Medical Center\/David Geffen School of Medicine at the University of California\u2013Los Angeles (I.M., H.-W.Y., T.B., R.A., D.A.M.), Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Baruth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, Cedars-Sinai Medical Center\/David Geffen School of Medicine at the University of California\u2013Los Angeles (I.M., H.-W.Y., T.B., R.A., D.A.M.), Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Tarkowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Department of Gynecology (R.T.), 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Azziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, Cedars-Sinai Medical Center\/David Geffen School of Medicine at the University of California\u2013Los Angeles (I.M., H.-W.Y., T.B., R.A., D.A.M.), Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Magoffin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, Cedars-Sinai Medical Center\/David Geffen School of Medicine at the University of California\u2013Los Angeles (I.M., H.-W.Y., T.B., R.A., D.A.M.), Los Angeles, California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur J.","family":"Jakimiuk","sequence":"additional","affiliation":[{"name":"Second Department of Gynecology (A.J.J.), 02-507 Warsaw, Poland"},{"name":"University School of Medicine, Lublin, and Department of Obstetrics and Gynecology (A.J.J.), Central Clinical Hospital of Ministry of Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616265953000_R1","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population.","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616265953000_R2","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women.","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616265953000_R3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.2000.00884.x","article-title":"The prevalence of polycystic ovaries in women with type 2 diabetes mellitus.","volume":"52","author":"Conn","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071616265953000_R4","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1073\/pnas.98.2.502","article-title":"A family of tissue-specific resistin-like molecules.","volume":"98","author":"Steppan","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071616265953000_R5","doi-asserted-by":"crossref","first-page":"11252","DOI":"10.1074\/jbc.C100028200","article-title":"A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation.","volume":"276","author":"Kim","year":"2001","journal-title":"J Biol Chem"},{"key":"2020071616265953000_R6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes.","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"2020071616265953000_R7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1172\/JCI16521","article-title":"Adipose-derived resistin and gut-derived resistin-like molecule-\u03b2 selectively impair insulin action on glucose production.","volume":"111","author":"Rajala","year":"2003","journal-title":"J Clin Invest"},{"key":"2020071616265953000_R8","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.2337\/diabetes.53.8.1937","article-title":"Abnormal glucose homeostasis due to chronic hyperresistinemia.","volume":"53","author":"Rangwala","year":"2004","journal-title":"Diabetes"},{"key":"2020071616265953000_R9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2003.12.012","article-title":"Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue.","volume":"218","author":"Kochan","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"2020071616265953000_R10","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2337\/diabetes.50.10.2199","article-title":"Resistin\/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-\u03b3 action in humans.","volume":"50","author":"Savage","year":"2001","journal-title":"Diabetes"},{"key":"2020071616265953000_R11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/bbrc.2001.5173","article-title":"Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.","volume":"285","author":"Nagaev","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071616265953000_R12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0140-6736(02)07281-1","article-title":"Resistin, central obesity, and type 2 diabetes.","volume":"359","author":"McTernan","year":"2002","journal-title":"Lancet"},{"key":"2020071616265953000_R13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/oby.2002.1","article-title":"Resistin gene expression in human adipocytes is not related to insulin resistance.","volume":"10","author":"Janke","year":"2002","journal-title":"Obes Res"},{"key":"2020071616265953000_R14","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1210\/jcem.87.5.8627","article-title":"Increased resistin gene and protein expression in human abdominal adipose tissue.","volume":"87","author":"McTernan","year":"2002","journal-title":"J Clin Endocrinol 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regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects.","volume":"88","author":"Lee","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616265953000_R21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00439-004-1128-4","article-title":"A resistin gene polymorphism is associated with body mass index in women.","volume":"115","author":"Mattevi","year":"2004","journal-title":"Hum Genet"},{"key":"2020071616265953000_R22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.fertnstert.2003.06.021","article-title":"Serum resistin levels in women with polycystic ovary syndrome.","volume":"81","author":"Panidis","year":"2004","journal-title":"Fertil Steril"},{"issue":"Pt 15","key":"2020071616265953000_R23","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1242\/jcs.01196","article-title":"Novel expression of resistin in rat testis: functional role 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