{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:50:07Z","timestamp":1777719007033,"version":"3.51.4"},"reference-count":40,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: Somatostatin reduces LH, GH, and insulin, and somatostatin receptors are present at the ovarian level; somatostatin analogs are thus potential candidates for treatment of the polycystic ovary syndrome (PCOS).<\/jats:p><jats:p>Objective: The purpose of this study was to evaluate the effect of octreotide-LAR, a long-acting somatostatin analog, in anovulatory abdominal obese women with PCOS.<\/jats:p><jats:p>Design: A single-blind, placebo-controlled study was performed, lasting for 7 months.<\/jats:p><jats:p>Setting: The patients were ambulatory throughout the study.<\/jats:p><jats:p>Patients: Twenty PCOS subjects were enrolled. Eighteen completed the study.<\/jats:p><jats:p>Interventions: A low-calorie diet was given during the first month, a low-calorie diet plus octreotide-LAR (10 mg; n = 10 subjects) or placebo (n = 10 subjects) was then given, with one im injection every 28 d (for 6 months).<\/jats:p><jats:p>Main Outcome Measures: The main outcome measures were clinical features, computerized tomography measurement of fat distribution, androgens, GH, IGF-I, IGF-binding proteins (IGFBPs), fasting and glucose-stimulated insulin, and ovulation.<\/jats:p><jats:p>Results: Octreotide had no additional effect in reducing body fat or improving fat distribution than placebo. Conversely, octreotide produced an additional decrease in fasting (P = 0.018) and glucose-stimulated (P = 0.038) insulin levels, an increase in IGFBP-2 (P = 0.042) and IGFBP-3 (P = 0.047), and an improvement in hirsutism (P = 0.004). Moreover, a trend toward greater reductions in testosterone (P = 0.061) and androstenedione (P = 0.069) was observed in women treated with octreotide-LAR compared with those given placebo. All women treated with octreotide ovulated at the end of the study compared with only one of those receiving placebo (P &amp;lt; 0.001).<\/jats:p><jats:p>Conclusions: Octreotide-LAR may be usefully applied to hypocalorically dieting, abdominal obese PCOS women to improve hyperandrogenism and the insulin-IGF-I system. Restoration of ovulatory menstrual cycles appears to be another advantage of this treatment.<\/jats:p>","DOI":"10.1210\/jc.2004-2490","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T06:50:02Z","timestamp":1120719002000},"page":"3854-3862","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of Octreotide-LAR in Dieting Women with Abdominal Obesity and Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"90","author":[{"given":"Alessandra","family":"Gambineri","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S. Orsola-Malpighi Hospital (A.G., L.P., R.D.I., U.P., R.P.), 40138 Bologna, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Patton","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S. 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