{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:04:26Z","timestamp":1793239466454,"version":"4.5.0"},"reference-count":22,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context: Changes in androgen levels across the adult female life span and the effects of natural menopause and oophorectomy have not been clearly established.<\/jats:p>\n                  <jats:p>Objective: The objective of this study was to document the effects of age on androgen levels in healthy women and to explore the effects of natural and surgical menopause.<\/jats:p>\n                  <jats:p>Design, Setting, and Participants: A cross-sectional study was conducted of 1423 non-healthcare-seeking women, aged 18\u201375 yr, randomly recruited from the community over 15 months.<\/jats:p>\n                  <jats:p>Main Outcome Measures: Serum levels by age of total testosterone (T), calculated free T, dehydroepiandrosterone sulfate, and androstenedione in a reference group of women free of confounding factors. Women in the reference group had no usage of exogenous steroid therapy; no history of tubal ligation, hysterectomy, or bilateral oophorectomy; and no hyperprolactinemia or polycystic ovarian syndrome. The effects of natural and surgical menopause on sex steroid levels were also examined.<\/jats:p>\n                  <jats:p>Results: In the reference population (n = 595), total T, calculated free T, dehydroepiandrosterone sulfate, and androstenedione declined steeply with age (P &amp;lt; 0.001), with the decline of each being greater in the earlier than the later decades. Examination of serum androgen levels by year in women aged 45\u201354 yr showed no independent effect of menopausal status on androgen levels. In women aged 55 yr or older, those who reported bilateral oophorectomy and were not on exogenous steroids had significantly lower total T and free T levels than women 55 yr or older in the reference group.<\/jats:p>\n                  <jats:p>Conclusions: We report that serum androgen levels decline steeply in the early reproductive years and do not vary because a consequence of natural menopause and that the postmenopausal ovary appears to be an ongoing site of testosterone production. These significant variations in androgens with age must be taken into account when normal ranges are reported and in studies of the role of androgens in women.<\/jats:p>","DOI":"10.1210\/jc.2005-0212","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T02:50:02Z","timestamp":1120704602000},"page":"3847-3853","source":"Crossref","is-referenced-by-count":853,"title":["Androgen Levels in Adult Females: Changes with Age, Menopause, and Oophorectomy"],"prefix":"10.1210","volume":"90","author":[{"given":"S. L.","family":"Davison","sequence":"first","affiliation":[{"name":"The Jean Hailes Foundation (S.L.D., R.B., S.R.D.), Clayton, Victoria 3168, Australia;"},{"name":"Department of Biochemistry (S.L.D.), Clayton, Victoria 3800, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bell","sequence":"additional","affiliation":[{"name":"The Jean Hailes Foundation (S.L.D., R.B., S.R.D.), Clayton, Victoria 3168, Australia;"},{"name":"National Health and Medical Research Council Centre of Clinical Research Excellence (R.B., S.D., S.R.D.), Clayton, Victoria 3800, Australia;"},{"name":"Department of Obstetrics and Gynaecology (R.B., S.R.D.), Monash University, Clayton, Victoria 3800, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Donath","sequence":"additional","affiliation":[{"name":"The Jean Hailes Foundation (S.L.D., R.B., S.R.D.), Clayton, Victoria 3168, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Montalto","sequence":"additional","affiliation":[{"name":"Mayne Health Dorevitch Pathology (J.G.M.), Melbourne, Australia, Victoria 3078, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Davis","sequence":"additional","affiliation":[{"name":"The Jean Hailes Foundation (S.L.D., R.B., S.R.D.), Clayton, Victoria 3168, Australia;"},{"name":"National Health and Medical Research Council Centre of Clinical Research Excellence (R.B., S.D., S.R.D.), Clayton, Victoria 3800, Australia;"},{"name":"Department of Obstetrics and Gynaecology (R.B., S.R.D.), Monash University, Clayton, Victoria 3800, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071620545543000_R1","first-page":"1429","article-title":"Twenty-four hour mean plasma testosterone concentration declines with age in normal premenopausal women.","volume":"80","author":"Zumoff","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071620545543000_R2","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1210\/jcem.82.8.4160","article-title":"Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated 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