{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:27:19Z","timestamp":1758925639778},"reference-count":30,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Little is known about the crosstalk between the decidua and myometrium in relation to human labor. The hormone oxytocin (OT) is considered to be a key mediator of uterine contractility during parturition, exerting some of its effects through calcium channels.<\/jats:p>\n               <jats:p>Objective: The objective was to characterize the effect of OT on the T-type calcium channel in human decidual stromal cells before and after the onset of labor.<\/jats:p>\n               <jats:p>Design: The nystatin-perforated patch-clamp technique was used to record inward T-type calcium current (ICa(T)) from acutely dispersed decidual stromal cells obtained from women at either elective cesarean section [CS (nonlabor)] or after normal spontaneous vaginal delivery [SVD (labor)].<\/jats:p>\n               <jats:p>Setting: These studies took place at the University of Nottingham Medical School.<\/jats:p>\n               <jats:p>Results: I Ca(T) of both SVD and CS cells were blocked by nickel (IC50 of 5.6 \u03bcm) and cobalt chloride (1 mm) but unaffected by nifedipine (10 \u03bcm). OT (1 nm to 3.5 \u03bcm) inhibited ICa(T) of SVD cells in a concentration-dependent manner, with a maximal inhibition of 79.0% compared with 26.2% in decidual cells of the CS group. OT-evoked reduction of ICa(T) was prevented by preincubation with the OT antagonist L371,257 in the SVD but not CS group. OT, in a concentration-dependent manner, displaced the steady-state inactivation curve for ICa(T) to the left in the SVD group with no significant effect on curves of the CS group.<\/jats:p>\n               <jats:p>Conclusion: Inhibition of ICa(T) by OT in decidual cells obtained during labor may signify important functional remodeling of uterine signaling during this period.<\/jats:p>","DOI":"10.1210\/jc.2005-0480","type":"journal-article","created":{"date-parts":[[2005,7,7]],"date-time":"2005-07-07T06:50:02Z","timestamp":1120719002000},"page":"4191-4197","source":"Crossref","is-referenced-by-count":6,"title":["Oxytocin Inhibits T-Type Calcium Current of Human Decidual Stromal Cells"],"prefix":"10.1210","volume":"90","author":[{"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Cell Signalling (B.L., S.J.H.), University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Institute of Cell Signalling (B.L., S.J.H.), University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheela N.","family":"Khan","sequence":"additional","affiliation":[{"name":"Centre for Reproduction and Early Life (R.N.K.), Institute for Clinical Research, University of Nottingham, Nottingham NG7 2RD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071616565426600_R1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/humrep\/14.6.1599","article-title":"Human decidual stromal cells express a-smooth muscle actin and show ultrastructural similarities with myofibroblasts.","volume":"14","author":"Oliver","year":"1999","journal-title":"Hum Reprod"},{"key":"2020071616565426600_R2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1210\/jc.2002-021224","article-title":"Contractile activity of human decidual stromal cells.","volume":"88","author":"Kimatrai","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071616565426600_R3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0002-9378(16)33248-3","article-title":"Decidua: a possible source of amniotic fluid prolactin.","volume":"127","author":"Riddick","year":"1977","journal-title":"Am J Obstet Gynecol"},{"key":"2020071616565426600_R4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI116169","article-title":"Synthesis of OT in amnion, chorion and decidua may influence the timing of human parturition.","volume":"91","author":"Chibbar","year":"1993","journal-title":"J Clin Invest"},{"key":"2020071616565426600_R5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1034\/j.1600-0412.2002.810709.x","article-title":"Development and clinical experience with the new evidence-based tocolytic atosiban.","volume":"81","author":"Husslein","year":"2002","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2020071616565426600_R6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jsgi.2004.02.008","article-title":"Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women.","volume":"11","author":"Pierzynski","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"2020071616565426600_R7","doi-asserted-by":"crossref","first-page":"F224","DOI":"10.1136\/adc.2002.019752","article-title":"Neurocognitive outcome after very preterm birth","volume":"89","author":"Marlow","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2020071616565426600_R8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa041367","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth.","volume":"352","author":"Marlow","year":"2005","journal-title":"N Engl J Med"},{"key":"2020071616565426600_R9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1124\/pr.55.4.8","article-title":"International Union of Pharmacology. 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