{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:25:39Z","timestamp":1791228339436,"version":"4.1.0"},"reference-count":74,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Aging, body composition, and sex steroids jointly determine GH production. However, the actions of any given factor are confounded by the effects of the other two.<\/jats:p>\n               <jats:p>Hypothesis: Age and abdominal visceral fat (AVF) mass govern GH secretion via individually distinctive mechanisms, which can be unmasked by short-term sex steroid deprivation.<\/jats:p>\n               <jats:p>Design\/Subjects: In a university setting, healthy pre- and postmenopausal volunteers underwent GnRH agonist-induced down-regulation for 6 wk to deplete ovarian sex steroids. GH secretion was evaluated by frequent blood sampling, saline vs. dual secretagogue infusions, an irregularity statistic, variable waveform deconvolution analysis, and a simplified feedback model. Computerized tomography was used to estimate AVF mass.<\/jats:p>\n               <jats:p>Outcomes\/Measures: In the sex steroid-deficient milieu, postmenopausal compared with premenopausal women exhibited 1) lower concentrations of IGF-I (P = 0.028) and GH (P &amp;lt; 0.05); 2) reduced pulsatile, but elevated basal, GH secretion (P &amp;lt; 0.05); 3) more irregular GH patterns (P = 0.027); 4) an attenuated GH response to simultaneous GHRH\/GH-releasing peptide-2 stimulation (P &amp;lt; 0.01); and 5) more rapid onset of GH release within secretory bursts (P &amp;lt; 0.01). In contrast, AVF negatively forecast GH responses to l-arginine\/GH-releasing peptide-2 (r2 = 0.45; P &amp;lt; 0.001) and l-arginine\/GHRH (r2 = 0.57; P = 0.007). From these marked contrasts, model-based analyses predicted distinguishable mechanisms by which aging and AVF alter pulsatile GH production.<\/jats:p>\n               <jats:p>Conclusion: Under limited confounding by sex steroids, age and body composition modulate GH secretion via highly selective peptidyl pathways in healthy women.<\/jats:p>","DOI":"10.1210\/jc.2005-0854","type":"journal-article","created":{"date-parts":[[2005,11,8]],"date-time":"2005-11-08T00:27:48Z","timestamp":1131409668000},"page":"6006-6013","source":"Crossref","is-referenced-by-count":23,"title":["Distinctive Inhibitory Mechanisms of Age and Relative Visceral Adiposity on Growth Hormone Secretion in Pre- and Postmenopausal Women Studied under a Hypogonadal Clamp"],"prefix":"10.1210","volume":"90","author":[{"given":"Johannes D.","family":"Veldhuis","sequence":"first","affiliation":[{"name":"Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic (J.D.V., D.E., K.M.), Rochester, Minnesota 55905;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Erickson","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic (J.D.V., D.E., K.M.), Rochester, Minnesota 55905;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Mielke","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic (J.D.V., D.E., K.M.), Rochester, Minnesota 55905;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon S.","family":"Farhy","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine (L.S.F.), Virginia 22904-4135;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Keenan","sequence":"additional","affiliation":[{"name":"Statistics (D.M.K.), University of Virginia, Charlottesville, Virginia 22904-4135;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril Y.","family":"Bowers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tulane University Health Sciences Center (C.Y.B.), New Orleans, Louisiana 70112"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071616062328600_R1","first-page":"E1108","article-title":"Abdominal adiposity rather than age and sex predicts the mass and patterned regularity of growth hormone secretion in mid-life healthy adults","volume":"272","author":"Vahl","year":"1997","journal-title":"Am J Physiol"},{"key":"2020071616062328600_R2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1210\/jcem-60-3-513","article-title":"The influence of 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