{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:11:09Z","timestamp":1772752269904,"version":"3.50.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:p>Context: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutations suggest that the situation is more complex.<\/jats:p>\n               <jats:p>Objective: The objective was to define bone areal and volumetric densities and morphometry in hypopituitary adults.<\/jats:p>\n               <jats:p>Design: The study was a cross-sectional case-controlled study performed between 1999 and 2001.<\/jats:p>\n               <jats:p>Setting: The study was undertaken at an endocrine tertiary referral center.<\/jats:p>\n               <jats:p>Patients: Thirty patients with GHD, 24 with GH insufficiency (GHI) [peak GH, 3\u20137 \u03bcg\/liter (9\u201321 mU\/liter)], and 30 age- and sex-matched controls were included for study.<\/jats:p>\n               <jats:p>Main Outcome Measures: DXA and peripheral quantitative computed tomography (pQCT) derived bone density and morphometry were measured.<\/jats:p>\n               <jats:p>Results: No densitometric or morphometric abnormalities were detected in GHD patients who acquired their deficiency during adult life. GHD adults of childhood-onset (CO-GHD) showed decreased bone mineral density at the lumbar spine and hip on DXA. pQCT of the radius showed that CO-GHD patients have normal trabecular bone mineral density and only a 2% decrease in cortical density. Radial bone area was reduced 14.5%, cortical thickness 20%, and cortical cross-sectional area 23%, culminating in a reduction in cortical bone of 25%. The \u201capparent\u201d low DXA bone density in CO-GHD adults therefore relates primarily to reduced cortical thickness and smaller bone area. DXA and pQCT data derived from adults with GHI revealed no evidence of densitometric or morphometric abnormalities.<\/jats:p>\n               <jats:p>Conclusions: 1) Adult-onset GHD patients have normal bone density and size. 2) CO-GHD adults have marginally reduced cortical density but significantly reduced cortical bone as a result of reduced cortical thickness and bone size. 3) GHI has no measurable impact on the skeleton.<\/jats:p>","DOI":"10.1210\/jc.2005-0897","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T23:32:53Z","timestamp":1139268773000},"page":"432-438","source":"Crossref","is-referenced-by-count":51,"title":["A Densitometric and Morphometric Analysis of the Skeleton in Adults with Varying Degrees of Growth Hormone Deficiency"],"prefix":"10.1210","volume":"91","author":[{"given":"Robert D.","family":"Murray","sequence":"first","affiliation":[{"name":"Department of Endocrinology (R.D.M., S.M.S.), Christie Hospital, Manchester M20 4BX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Clinical Radiology (J.E.A.), Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PL, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Shalet","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (R.D.M., S.M.S.), Christie Hospital, Manchester M20 4BX, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071616434772100_R1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. 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