{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:21:59Z","timestamp":1791332519358,"version":"4.3.1"},"reference-count":34,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"DOI":"10.1210\/jc.2005-1220","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T18:32:53Z","timestamp":1139250773000},"page":"621-628","source":"Crossref","is-referenced-by-count":64,"title":["Leptin Replacement Therapy Modulates Circulating Lymphocyte Subsets and Cytokine Responsiveness in Severe Lipodystrophy"],"prefix":"10.1210","volume":"91","author":[{"given":"Elif Arioglu","family":"Oral","sequence":"first","affiliation":[{"name":"Clinical Endocrinology Branch (E.A.O., E.D.J., E.K.C., J.R.Y., P.G.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Javor","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology Branch (E.A.O., E.D.J., E.K.C., J.R.Y., P.G.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes, Digestive, and Kidney Diseases, and Laboratory of Clinical Infectious Diseases (L.D., G.U., S.M.H.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulbu","family":"Uzel","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes, Digestive, and Kidney Diseases, and Laboratory of Clinical Infectious Diseases (L.D., G.U., S.M.H.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine K.","family":"Cochran","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology Branch (E.A.O., E.D.J., E.K.C., J.R.Y., P.G.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice Ryan","family":"Young","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology Branch (E.A.O., E.D.J., E.K.C., J.R.Y., P.G.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"DePaoli","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892; and Amgen, Inc. (A.M.D.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Holland","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes, Digestive, and Kidney Diseases, and Laboratory of Clinical Infectious Diseases (L.D., G.U., S.M.H.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Gorden","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology Branch (E.A.O., E.D.J., E.K.C., J.R.Y., P.G.), Thousand Oaks, California 91320"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116315965900_R1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","article-title":"Leptin.","volume":"62","author":"Ahima","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"2019041116315965900_R2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajcn\/33.1.13","article-title":"Cell-mediated immunity in genetically obese C57BL\/6J (ob\/ob) mice.","volume":"33","author":"Chandra","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"2019041116315965900_R3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1172\/JCI108933","article-title":"Immune response in the mutant diabetic C57BL\/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays.","volume":"61","author":"Fernandes","year":"1978","journal-title":"J Clin Invest"},{"key":"2019041116315965900_R4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMoa012437","article-title":"Leptin-replacement therapy for lipodystrophy.","volume":"346","author":"Oral","year":"2002","journal-title":"N Engl J Med"},{"key":"2019041116315965900_R5","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/jcem.87.7.8591","article-title":"Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy.","volume":"87","author":"Oral","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.metabol.2004.08.021","article-title":"The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients.","volume":"54","author":"Musso","year":"2005","journal-title":"Metabolism"},{"key":"2019041116315965900_R7","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.2337\/diabetes.54.7.1994","article-title":"Long-term efficacy of leptin replacement in patients with generalized lipodystrophy.","volume":"54","author":"Javor","year":"2005","journal-title":"Diabetes"},{"key":"2019041116315965900_R8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI0215693","article-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency.","volume":"110","author":"Farooqi","year":"2002","journal-title":"J Clin Invest"},{"key":"2019041116315965900_R9","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1210\/jc.2004-1823","article-title":"Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-\u03b1 receptor levels in humans with relative leptin deficiency.","volume":"90","author":"Chan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R10","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1210\/jcem.84.10.5999","article-title":"Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects.","volume":"84","author":"Ozata","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R11","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.4049\/jimmunol.168.8.4018","article-title":"Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia.","volume":"168","author":"Mancuso","year":"2002","journal-title":"J Immunol"},{"key":"2019041116315965900_R12","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1086\/515670","article-title":"Abnormal regulation of interferon-\u03b3, interleukin-12, and tumor necrosis factor-\u03b1 in human interferon-\u03b3 receptor 1 deficiency.","volume":"178","author":"Holland","year":"1998","journal-title":"J Infect Dis"},{"key":"2019041116315965900_R13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.metabol.2003.10.019","article-title":"Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy.","volume":"53","author":"Moran","year":"2004","journal-title":"Metabolism"},{"key":"2019041116315965900_R14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/cimm.1999.1490","article-title":"Human leptin stimulates proliferation and activation of human circulating monocytes.","volume":"194","author":"Santos-Alvarez","year":"1999","journal-title":"Cell Immunol"},{"key":"2019041116315965900_R15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/29795","article-title":"Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.","volume":"394","author":"Lord","year":"1998","journal-title":"Nature"},{"key":"2019041116315965900_R16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1172\/JCI6762","article-title":"Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob\/ob mice.","volume":"104","author":"Howard","year":"1999","journal-title":"J Clin Invest"},{"key":"2019041116315965900_R17","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/2619","article-title":"Lowered leptin slims immune response.","volume":"4","author":"Flier","year":"1998","journal-title":"Nat Med"},{"key":"2019041116315965900_R18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4049\/jimmunol.168.2.875","article-title":"Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis.","volume":"168","author":"Busso","year":"2002","journal-title":"J Immunol"},{"key":"2019041116315965900_R19","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.166.10.5909","article-title":"Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.","volume":"166","author":"Matarese","year":"2001","journal-title":"J Immunol"},{"key":"2019041116315965900_R20","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2337\/diabetes.51.5.1356","article-title":"Leptin accelerates autoimmune diabetes in female NOD mice.","volume":"51","author":"Matarese","year":"2002","journal-title":"Diabetes"},{"key":"2019041116315965900_R21","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1053\/gast.2002.33631","article-title":"Leptin: a pivotal mediator of intestinal inflammation in mice.","volume":"122","author":"Siegmund","year":"2002","journal-title":"Gastroenterology"},{"key":"2019041116315965900_R22","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/1521-4141(200105)31:5<1324::AID-IMMU1324>3.0.CO;2-Y","article-title":"Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males.","volume":"31","author":"Matarese","year":"2001","journal-title":"Eur J Immunol"},{"key":"2019041116315965900_R23","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1210\/jc.2003-030803","article-title":"Leptin and the proinflammatory state associated with human obesity.","volume":"89","author":"Hukshorn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R24","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1210\/jc.2004-1921","article-title":"Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.","volume":"90","author":"Chan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R25","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1210\/jc.2003-032140","article-title":"Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy.","volume":"89","author":"Javor","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.185.1.171","article-title":"Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia.","volume":"185","author":"Sarraf","year":"1997","journal-title":"J Exp Med"},{"key":"2019041116315965900_R27","first-page":"R204","article-title":"IL-1\u03b2 mediates leptin induction during inflammation","volume":"274","author":"Faggioni","year":"1998","journal-title":"Am J Physiol"},{"key":"2019041116315965900_R28","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.4049\/jimmunol.167.8.4593","article-title":"High-dose leptin activates human leukocytes via receptor expression on monocytes.","volume":"167","author":"Zarkesh-Esfahani","year":"2001","journal-title":"J Immunol"},{"key":"2019041116315965900_R29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1096\/fasebj.12.1.57","article-title":"Leptin regulates proinflammatory immune responses.","volume":"12","author":"Loffreda","year":"1998","journal-title":"FASEB J"},{"key":"2019041116315965900_R30","first-page":"R136","article-title":"Leptin deficiency enhances sensitivity to endotoxin-induced lethality","volume":"276","author":"Faggioni","year":"1999","journal-title":"Am J Physiol"},{"key":"2019041116315965900_R31","first-page":"783","article-title":"Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes.","volume":"86","author":"Gabay","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116315965900_R32","doi-asserted-by":"crossref","first-page":"C386","DOI":"10.1152\/ajpcell.1999.276.2.C386","article-title":"Phenotypic abnormalities in macrophages from leptin-deficient, obese mice","volume":"276","author":"Lee","year":"1999","journal-title":"Am J Physiol"},{"key":"2019041116315965900_R33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1084\/jem.189.1.207-a","article-title":"Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor.","volume":"189","author":"Takahashi","year":"1999","journal-title":"J Exp Med"},{"key":"2019041116315965900_R34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes.","volume":"115","author":"Wellen","year":"2005","journal-title":"J Clin Invest"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/2\/621\/10778868\/jcem0621.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:45:12Z","timestamp":1555033512000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/2\/621\/2843462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,1]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2005-1220","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,1]]}}}